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5. Transient uterine hypercontractility causes oxidative stress in the fetal brain and sex-dependent mitochondrial and behavioral abnormalities in adolescent male rat offspring

Author

Palanisamy, Arvind, Giri, Tusar, Jiang, Jia, Bice, Annie, Quirk, James D., Conyers, Sara B., Maloney, Susan E., Bauer, Adam Q., Garbow, Joel R., and Wozniak, David F.

Subjects
reproductive and urinary physiology
Abstract

The neurodevelopmental impact of transient ischemic-hypoxemic insult during labor is poorly understood. Here, using an oxytocin-induced uterine hypercontractility paradigm, we confirm transient uteroplacental compromise, increased oxidative stress in the fetal brain, and enduring social behavioral impairment in male offspring with persistent upregulation of mitochondrial proteins in the anterior cingulate cortex. Our findings, therefore, indicate persistent mitochondrial dysfunction as a possible mechanistic link between intrauterine asphyxia and neurodevelopmental disorders.

Published
2019
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6. Transient uterine hypercontractility causes fetal cerebral oxidative stress and enduring mitochondrial and behavioral abnormalities in adolescent male rat offspring

Author

Palanisamy, Arvind, primary, Giri, Tusar, additional, Jiang, Jia, additional, Bice, Annie, additional, Quirk, James D., additional, Conyers, Sara B., additional, Maloney, Susan E., additional, Raghuraman, Nandini, additional, Bauer, Adam Q., additional, Garbow, Joel R., additional, and Wozniak, David F., additional

Published
2019
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