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Your search keyword '"Conway, Kate M E"' showing total 5 results
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5 results on '"Conway, Kate M E"'

2. MHCII+CD80+ thymic eosinophils increase in abundance during neonatal development in mice and their accumulation is microbiota-dependent

Author

Gatti, Dominique M, primary, Gauthier, Courtney M, additional, Moeller, Brandon E, additional, FitzPatrick, Rachael D, additional, Kennedy, Mia H E, additional, Pluzhnikova, Victoria, additional, Conway, Kate M E, additional, Smazynski, Julian, additional, Chow, Robert L, additional, and Reynolds, Lisa A, additional

Published
2023
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3. MHCII+CD80+ thymic eosinophils increase in abundance during neonatal development in mice and their accumulation is microbiota dependent.

Author

Gatti, Dominique M, Gauthier, Courtney M, Moeller, Brandon E, FitzPatrick, Rachael D, Kennedy, Mia H E, Pluzhnikova, Victoria, Conway, Kate M E, Smazynski, Julian, Chow, Robert L, and Reynolds, Lisa A

Subjects
EOSINOPHILS, MAJOR histocompatibility complex, PUERPERIUM
Abstract

Eosinophils are present in the thymus of mammals, yet their function at this site during homeostatic development is unknown. We used flow cytometry to determine the abundance and phenotype of eosinophils (here defined as SSchigh SiglecF+ CD11b+ CD45+ cells) in the thymus of mice during the neonatal period, the later postnatal period, and into adulthood. We show that both the total number of thymic eosinophils and their frequency among leukocytes increase over the first 2 wk of life and that their accumulation in the thymus is dependent on the presence of an intact bacterial microbiota. We report that thymic eosinophils express the interleukin-5 receptor (CD125), CD80, and IDO, and that subsets of thymic eosinophils express CD11c and major histocompatibility complex II (MHCII). We found that the frequency of MHCII-expressing thymic eosinophils increases over the first 2 wk of life, and that during this early-life period the highest frequency of MHCII-expressing thymic eosinophils is located in the inner medullary region. These data suggest a temporal and microbiota-dependent regulation of eosinophil abundance and functional capabilities in the thymus. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete, Treponema pallidum

Author

Houston, Simon, primary, Schovanek, Ethan, additional, Conway, Kate M. E., additional, Mustafa, Sarah, additional, Gomez, Alloysius, additional, Ramaswamy, Raghavendran, additional, Haimour, Ayman, additional, Boulanger, Martin J., additional, Reynolds, Lisa A., additional, and Cameron, Caroline E., additional

Published
2022
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5. Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge

Author

Brosschot, Tara P., primary, Lawrence, Katherine M., additional, Moeller, Brandon E., additional, Kennedy, Mia H. E., additional, FitzPatrick, Rachael D., additional, Gauthier, Courtney M., additional, Shin, Dongju, additional, Gatti, Dominique M., additional, Conway, Kate M. E., additional, and Reynolds, Lisa A., additional

Published
2021
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