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2. HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia.

Author

Tamouza R, Busson M, Fortier C, Diagne I, Diallo D, Sloma I, Contouris H, Krishnamoorthy R, Labie D, Girot R, and Charron D

Subjects
Adult, Anemia, Sickle Cell epidemiology, Bacterial Infections epidemiology, Black People, Comorbidity, Female, Histocompatibility Antigens Class I, Humans, Male, Mali epidemiology, Paris epidemiology, Polymerase Chain Reaction, Retrospective Studies, Senegal epidemiology, HLA-E Antigens, Alleles, Anemia, Sickle Cell genetics, Anemia, Sickle Cell microbiology, Bacterial Infections genetics, HLA Antigens genetics, Homozygote
Abstract

Severe bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen-E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens.

Published
2007
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