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In the last years we have seen an ever increasing number of patients with haematologic disorders who need hematopoietic stem cell transplantation (HSCT). The whole sector of HSCT results, infact to be in a continous scientific and technological clinical progress, offering a very advanced care. Despite this, some aspects are underconsidered, some of which could be fundamental to determine the success of the care pathway, such as the experience of the illness by the patient. Using a Narrative Based Medicine approach we wanted to investigate clinical, psychosocial and organizational aspects of the patient's journey whilst undergoing HSCT.

Supplemental Digital Content is available in the text, Infections are a leading cause of morbidity and mortality in children with acute leukemia. Central-line (CL) devices increase this population's risk of serious infections. Within the context of a quality improvement (QI) project, we tested the effect of caregiver education on CL management on the CL-associated bloodstream infection (CLABSI) rate among children with acute leukemia seen at a large referral center in Italy. The intervention consisted of 9 in-person sessions for education and practice using mannequins and children. One hundred and twenty caregivers agreed to participate in the initiative. One hundred and five (87.5%) completed the training, 5 (4.1%) withdrew after the first session, and 10 (8.3%) withdrew during practical sessions. After educational intervention, the overall CLABSI rate was reduced by 46% (from 6.86 to 3.70/1000 CL-days). CLABSI rate was lower in children whose caregivers completed the training (1.74/1000 CL-days, 95% CI 0.43–6.94) compared with those who did not receive any training (12.2/1000 CL-days, 95% CI 7.08–21.0, P

Background: An early hearing detection and intervention program (EHDI) is the first step for the habilitation of children with permanent hearing impairment (PHI). Actually, early intervention programs have increasingly shifted toward family involvement, emphasizing that the child’s family should take an active role in the habilitation process. Therefore, familiar empowerment is the best way to improve a child’s emerging abilities. The aim of this study was to investigate parental self-efficacy beliefs and involvement as well as the language skills of deaf or hard of hearing DHH children who were habilitated with hearing aids and followed using the T.A.T.A web app (NeonaTal Assisted TelerehAbilitation), an example of asynchronous telepractice. Methods: The study describes the early stages of the habilitation program of 15 PHI children followed through the T.A.T.A. web app, which empowers families through a weekly questionnaire submitted during the first 270 to 360 days of their child’s life, for 14 weeks. The family involvement rate scale (FIRS) was used to evaluate parental compliance, and all children received in-person visits at the beginning and at the end of the training period. Results: The children showed greater auditory perceptual skills at the end of the training period on the basis of both the Infant Listening Progress Profile (ILiP) score and the Categories of Auditory Performance (CAP) and FIRS scales. In other words, the auditory skills improved with age as well as with parental participation. Conclusions: The T.A.T.A. web app promotes a proactive management and a tailored habilitation through an active familiar involvement, easily achieved in clinical routine and in emergency settings without additional costs.

The so-called Posthuman question - the birth of organisms generated by the encounter of biological and artificial entities (humanoid robots, cyborgs and so on) - is now on the agenda of science and, more generally, of contemporary society. This is an issue of enormous importance, which not only poses ethical questions but also, and above all, methodological questions about how it will be achieved on a scientific plane. How such entities will be born and what their functions will be? For example, what kind of consciousness will they be equipped with, in view of the function of consciousness for distinguishing the Self from others, which is the foundation of the interactive life of relationships? Many scholars believe that rapid technological progress will lead to the emergence of organisms that will simulate the functions of the mind, learn from their experiences, decode real-world information, and plan their actions and choices based on their own values elaborated from vast amounts of data and metadata. In the not-too-distant future, it is believed that these entities will acquire awareness and, consequently, decisional freedom, and perhaps even their own unique morals. In this paper, we try to show that the path towards this goal cannot avoid clarification of the problems that neuroscience has ahead of it. These problems concern: a) the way in which consciousness comes about on the basis of well-defined brain processes; b) how it represents its own organization and not a simple brain function; c) how simultaneously contains multiple distinct contents, each with its own intentionality; d) how it expresses dynamic evolutionary relations and not a set of phenomena that may be isolated; e) finally, how its order is not rigidly hierarchical, but is supported by a multiplicity of horizontal levels, each of which is in structural and functional continuum with different phenomenal events. The empirical and theoretical research effort on this topic provides an intensive contribution to the development of IC Technologies.

Background: Healthcare rehabilitator skills can be grouped into hard and soft skills. Hard skills are specific and teachable, which can be defined and measured, while soft skills are less tangible and more difficult to quantify. The aim of this study is to investigate the level of knowledge of soft skills among Italian healthcare rehabilitators, and how they were acquired. Design and Methods: Two hundred healthcare rehabilitators, who worked in Southern Italy were enrolled from September 1st to October 31st 2017, and interviewed with Computer-Assisted-Web- Interview (CAWI) software, to assess their level of soft skills. Results: Healthcare rehabilitators showed significant satisfaction with university education (59.5%), particularly for theoretical training (64%), while significant dissatisfaction was found fortechnical- practical training (63.5%), training in patients’ family management (66.5%) and stages participation to improve soft skills (59%). Dissatisfied rehabilitators were found for university education of soft skills (59%), particularly for interpersonal relationships with patients’ family (66.5%) and technical-practical train in (63.5%). Women considered the training courses about soft skills acquisition more useful than men (43.8%). Conclusions: Healthcare rehabilitator training is lacking in the teaching of both technical-practicaland soft skills. It is striking that in a healthcare profession like that of the rehabilitator, where practical and empathic skills are fundamental in the relationship with the patients, such skills are not treated in analogously with theoretical training. Significance for public health This study investigates on the perception about soft skills competence by healthcare rehabilitators working in Southern Italy. In fact, soft skills are an essential component to improvement performance in many professions and especially in healthcare professions such as healthcare rehabilitators, but unfortunately, in university courses, they are not taught sufficiently or equally as hard skills.

Objective: Clinical and psychological HIV-related problems peak during adolescence, which coincides with transition of children and adolescents infected from mothers from pediatric to adult reference centers for HIV infection. Transition often is done without specific programs. We wanted to explore transition as an opportunity to increase the efficacy of care and the psychological well-being through a specific program. Methods: Thirteen vertically infected patients aged 13-20 years were followed up for 24 months by pediatricians, infectious disease specialists, a psychologist, and a nurse. Interventions consisted in joint clinic, simplification of therapy, patient group discussions, HIV infection explanations, and psychological support, lasting 12 months. Efficacy was measured by viro-immunological outcomes and adherence to therapy and psychological tests. Clinical, viro-immunological, and psychological evaluations were performed at 0 (T0) and 12 months (T12) and 6 months after transition to an adult center (T18). Psychological outcomes were assessed using standardized questionnaires for quality of life and self-esteem. Results: In 11/13 participants, pills administrations/day were significantly reduced. Patients with undetectable viral load and CD4+ >25% increased from 61 to 77% and from 61 to 74%, respectively. Six months after transition, all patients exhibited an undetectable viral load. Adolescents' awareness of the severity of the disease and the risk of sexual transmission was generally poor. Patients classified with "severe" psychological distress according to the quality of life index decreased from 38 to 15% and well-being increased. Similar results were observed 6 months after the transition to adult care. No effect was observed on self-esteem index. Conclusions: Specific protocols for transition should be developed to optimize resilience and psychological well-being, including routine psychological support for adolescents with HIV infection transiting from pediatric to adult centers for HIV infection.

The term dyspraxia defines an inability to perform a pragmatically oriented action. It doesn't yet have a precise nosographic location. According to the embodied cognition model, this disorder compromises the development of superior mental functions, the construction and the representation of the Self. In our perspective it isn't possible to reduce dyspraxia to a mere disorder of the execution of an intentional gesture and it must be included in a wider spectrum of pathological processes that compromise the functions and the development of individual mind. With the aim to identify early and to support pupils with possible motor difficulties, our contribution intends to propose a computational analysis model of the dyspraxic movements and to define the construction of a technologically assisted diagnostic system for dyspraxia, thanks to the use of an ecological observation grid (GEO-DE). The observation tool was applied in a sample of 525 subjects, aged between 48 and 72 months in order to identify the groups of motor tasks predictive of dyspraxic phenomena. The analysis of the normalized importance of the independent variables showed that the Linguistic Skill (AL) group is the most important group for the forecast of praxic deficits, it was followed in descending order by the AP (Personal Autonomy), GTI (Transitive and Intransitive Gestures), EC (Balance and Coordination) groups. The innovation in this research is to identify which movement patterns are capable of predicting praxic motor dysfunction, for an automated mixed assessment system that includes teacher evaluation.

Over a century ago, psychoanalysis created an unprecedented challenge: to show that the effects of the unconscious are more powerful than those of consciousness. In an inverted scheme at present time, neurosciences challenge psychoanalysis with experimental and clinical models that are clarifying crucial aspects of the human mind. Freud himself loved to say that psychological facts do not fluctuate in the air and that perhaps one day, biologists and psychoanalysts would give a common explanation for psychic processes. Today, the rapid development of neuroimaging methods has ushered in a new season of research. Crucial questions are becoming more apparent. For instance, how can the brain generate conscious states? Does consciousness only involve limited area of the brain? These are insistent questions in a time where the tendency of neuroscience to naturalize our relationship life is ever more urgent. Consequently, these questions are also pressing: Does morality originate in the brain? Can we still say “being free” or freedom? Why does morality even exist? Lastly, is there a biologically founded universal morality? This paper will try to demonstrate how neurophysiology itself shows the implausibility of a universal morality.

The recent outbreak of coronavirus disease 2019 (COVID-19) has been extremely stressful and has produced fear and anxiety throughout the population, representing a psychological emergency. This work aimed at presenting a mental health first aid service established within an Italian university public hospital context to address four different population targets (i.e., people vulnerable to mental health problems, health-care professionals, people in isolation, and general citizenship). Specifically, the organizational structure comprising four different areas (i.e., management, clinical, communication, and research) and first data collected from the foundation of the service until 3 May 2020 are presented. Findings indicated that anxiety and fear of contagion were the main motivations prompting both the general population and health-care professionals to ask for a psychological help. Furthermore, findings indicate that clients’ current quality of life was perceived as lower than in the past but also that imagined in the future, highlighting the importance of psychological first aid interventions. This service may represent an example for helping mental health professionals in developing similar services in their local realities, promoting health and individual and community resilience.

The "born to read" initiative entails a dialogic reading to children in poor socio-economical conditions aimed at fostering cognitive and relational skills. Reading is professionally delivered by experts to promote psycho-social development of children and their parents. In this study the project was extended to include children positive at early screening for hearing impairment. A total of 26 children were included and 14 parents were taught to read aloud and emphatically. Reading session were delivered for at least 10 minutes at least 3 times/week, usually at bedtime, for one year. The Griffiths scale were applied to explore the expressive and receptive language skills (Scale C) and eye and hand coordination (Scale D), as measures of linguistic and neurocognitive skills. Program sustainability and reactions by the parents were also investigated. All 14 families successfully received the training, becoming capable of reading aloud and emphatically and provided reading sessions for the entire duration of the study. Children receiving the intervention performed slightly better than controls and those who were exposed to increased number of sessions, performed even better although the differences with controls were not significant. Parents enjoyed reading to their children. They expressed satisfaction and gratitude for being able to play an active and productive role in children rehabilitation. The results of this pilot study suggest that the born to read initiative may be considered in adjunct to medical and psychological interventions to enhance the benefits of early screening of hearing function.

Objective. To investigate whether supporting fathers to recognize the relevance of their role in the success of breastfeeding and teaching them how to prevent and to manage the most common lactation problems would result in more women breastfeeding.Methods. A controlled trial, in which the participating fathers were allocated in 2-month blocks to a child care training session, was conducted of 280 mothers considering breastfeeding and their 280 partners at a university obstetric department in Naples, Italy. Support and advice about breastfeeding was provided to all of the mothers. Among the fathers of the intervention group, the training session included the management of breastfeeding; among those of the control group, it did not. Primary outcome was the prevalence of full breastfeeding at 6 months. Secondary outcomes were the proportion of women who perceived their milk to be insufficient, who stopped breastfeeding because of problems, and who reported to have received help in breastfeeding management by their partners.Results The prevalence of full breastfeeding at 6 months was 25% (35 of 140) in the intervention group and 15% (21 of 140) in the control group and that of any breastfeeding at 12 months was 19% (27) and 11% (16), respectively. Perceived milk insufficiency was significantly more frequent among the mothers of the control group (38 [27%] of 140 vs 12 [8.6%] of 140), as well as breastfeeding interruption because of problems with lactation (25 [18%] of 140 vs 6 [4%] of 140). Moreover, significantly more women in the intervention group reported receiving support and relevant help with infant feeding management from their partners (128 [91%] of 140 vs 48 [34%] of 140). Among the women who had reported difficulties with lactation in the intervention and control groups (96 [69%] and 89 [64%], respectively), the prevalence of full breastfeeding at 6 months was 24% and 4.5%, respectively.Conclusions Teaching fathers how to prevent and to manage the most common lactation difficulties is associated with higher rates of full breastfeeding at 6 months.