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1. Unprescribed cannabinoids and multiple sclerosis: a multicenter, cross-sectional, epidemiological study in Lombardy, Italy

Author

Giossi, Riccardo, Mercenari, Martina, Filippi, Massimo, Zanetta, Chiara, Antozzi, Carlo Giuseppe, Brambilla, Laura, Confalonieri, Paolo, Crisafulli, Sebastiano Giuseppe, Tomas Roldan, Eugenia, Annovazzi, Pietro, Conti, Marta Zaffira, Barrilà, Caterina, Ronzoni, Marco, Grobberio, Monica, Negri, Attilio, Gustavsen, Stefan, and Torri Clerici, Valentina

Published
2024
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2. Correction to: Unprescribed cannabinoids and multiple sclerosis: a multicenter, cross-sectional, epidemiological study in Lombardy, Italy

Author

Giossi, Riccardo, Mercenari, Martina, Filippi, Massimo, Zanetta, Chiara, Antozzi, Carlo Giuseppe, Brambilla, Laura, Confalonieri, Paolo, Crisafulli, Sebastiano Giuseppe, Tomas Roldan, Eugenia, Annovazzi, Pietro, Conti, Marta Zaffira, Barrilà, Caterina, Ronzoni, Marco, Grobberio, Monica, Negri, Attilio, Gustavsen, Stefan, and Torri Clerici, Valentina

Published
2024
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3. Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Author

Schiavetti, Irene, Carmisciano, Luca, Ponzano, Marta, Cordioli, Cinzia, Cocco, Eleonora, Marfia, Girolama Alessandra, Inglese, Matilde, Filippi, Massimo, Radaelli, Marta, Bergamaschi, Roberto, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Confalonieri, Paolo, Perini, Paola, Trojano, Maria, Lanzillo, Roberta, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Group, MuSC‐19 Study, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Beatrice Maria Rossi, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Morra, Vincenzo Brescia, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d’Ambrosio, Alessandro, D’Amico, Emanuele, Danni, Maura Chiara, d’Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, De Mercanti, Stefania Federica, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Fabio Maria, Della Cava, Marco, and Di Lemme, Sonia

Subjects
Neurosciences, Multiple Sclerosis, Brain Disorders, Pain Research, Neurodegenerative, Good Health and Well Being, Humans, Aged, COVID-19, Ageusia, SARS-CoV-2, Anosmia, MuSC-19 Study Group, demyelinating diseases, disease-modifying treatment, multiple sclerosis, neurological disorders, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeClinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation.MethodLogistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number.ResultsFrom March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p

Published
2022

4. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author

Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Morra, Vincenzo Brescia, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Rossi Beatrice Maria, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Battaglia, Mario A, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Brescia, Morra Vincenzo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d'Ambrosio, Alessandro, and D'Amico, Emanuele

Subjects
Clinical Research, Neurosciences, Multiple Sclerosis, Brain Disorders, Autoimmune Disease, Neurodegenerative, Climate-Related Exposures and Conditions, Good Health and Well Being, Sustainable Cities and Communities, Air Pollution, COVID-19, Humans, Particulate Matter, SARS-CoV-2, MuSC-19 study group, air pollution, coronavirus, multiple sclerosis, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeSome studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS.MethodsData were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity.ResultsIn all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009).ConclusionsEven if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.

Published
2022

5. Patients with multiple sclerosis choose a collaborative role in making treatment decision: results from the Italian multicenter SWITCH study

Author

Patti, Francesco, Chisari, Clara Grazia, Toscano, Simona, Annovazzi, Pietro, Banfi, Paola, Bergamaschi, Roberto, Clerici, Raffaella, Conti, Marta Zaffira, Cortese, Antonio, Fantozzi, Roberta, Ferraro, Diana, Fischetti, Mariano, Frigo, Maura, Gatto, Maurizia, Immovilli, Paolo, Leoni, Stefania, Malucchi, Simona, Maniscalco, Giorgia, Marfia, Girolama Alessandra, Paolicelli, Damiano, Perini, Paola, Serrati, Carlo, Totaro, Rocco, Turano, Gabriella, Valentino, Paola, Zaffaroni, Mauro, Zuliani, Cristina, and Centonze, Diego

Published
2023
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6. Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

Author

Rifino, Nicola, Censori, Bruno, Agazzi, Emanuela, Alimonti, Dario, Bonito, Virginio, Camera, Giorgia, Conti, Marta Zaffira, Foresti, Camillo, Frigeni, Barbara, Gerevini, Simonetta, Grimoldi, Maria, La Gioia, Sara, Partziguian, Tania, Quadri, Stefano, Riva, Riccardo, Servalli, Maria Cristina, Sgarzi, Manlio, Storti, Benedetta, Vedovello, Marcella, Venturelli, Elisabetta, Viganò, Martina, Callegaro, Annapaola, Arosio, Marco, and Sessa, Maria

Published
2021
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7. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi

Published
2022
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8. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional

Published
2021
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9. Additional file 4 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author

Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa

Abstract

Additional file 4: Figure S2. The absolute number of total lymphocytes (A), naïve Treg (B), TregCM (C), TregEM (D), CD120b+ nTreg (E), and Tr1 (F) after IFN-β treatment was investigated at T0: before therapy initiation and T6, T12, T18, and T24: after 6, 12, 18, and 24 months of IFN-β, respectively. Estimated means are shown, connected by continuous lines, along with error bars representing the 95% confidence interval. Black lines indicate statistically significant decreases, while red lines indicate statistically significant increases.

Published
2020
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10. Additional file 5 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author

Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa

Abstract

Additional file 5: Figure S3. Correlation between Cyt-1 and Cyt-2 mRNA expression after stimulation. Scatterplot representing the correlations between Cyt-1 and Cyt-2 values at the indicated time points and conditions. Black lines were obtained by linear regression.

Published
2020
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11. Additional file 3 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author

Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa

Subjects
hemic and immune systems
Abstract

Additional file 3: Figure S1. The gating strategy ensures the quality and continuity of data acquired for the whole blood and allows the identification of: (A) single-cell lymphocytes, which can be distinguished by their forward scatter/side scatter properties;(B) after lymphocyte gating, doublets are excluded, followed by exclusion of dead or autofluorescent cells; (C) naive, central memory (CM), and effector memory (EM) CD4+ cells based on the expression of C45RA and CCR7 markers; (D) CD4+ Tr1 cells based on the expression of CD18 and high level of CD49b expression; (E) CD4+ Treg cells based on positive expression of CD25 and low/negative expression of CD127; and (F) Treg subsets population (naïve Treg, TregCM, and TregEM) based on the expression of C45RA and CCR7 markers. (G and H) CD120b (TNFR2) expressing cells (black line) within nTreg population (dark grey) compared to naïve CD4+ lymphocytes (grey) and monocytes (light grey), which are respectively negative and positive for the expression of CD120b antigen.

Published
2020
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12. Additional file 6 of Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Author

Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Clerici, Valentina Torri, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, and Imberti, Luisa

Abstract

Additional file 6: Figure S4. Subdivision of patients according to the variations of each Treg subset at T24. Patients were grouped based on the increase (↑), maintenance or slight increase (=/↑), or decrease (↓) of the different Treg subset percentages after 24 months of IFN-β therapy. Therefore, only 86 patients that completed the follow-up were included in the analysis. TregCM ↑: ≥ 6%, =/↑: -1 to

Published
2020
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14. Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

Author

Rifino, Nicola, primary, Censori, Bruno, additional, Agazzi, Emanuela, additional, Alimonti, Dario, additional, Bonito, Virginio, additional, Camera, Giorgia, additional, Conti, Marta Zaffira, additional, Foresti, Camillo, additional, Frigeni, Barbara, additional, Gerevini, Simonetta, additional, Grimoldi, Maria, additional, La Gioia, Sara, additional, Partziguian, Tania, additional, Quadri, Stefano, additional, Riva, Riccardo, additional, Servalli, Maria Cristina, additional, Sgarzi, Manlio, additional, Storti, Benedetta, additional, Vedovello, Marcella, additional, Venturelli, Elisabetta, additional, Viganò, Martina, additional, Callegaro, Annapaola, additional, Arosio, Marco, additional, and Sessa, Maria, additional

Published
2020
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15. Clinical and patient determinants of changing therapy in relapsing-remitting multiple sclerosis (SWITCH study)

Author

Patti, Francesco, primary, Chisari, Clara Grazia, additional, D'Amico, Emanuele, additional, Annovazzi, Pietro, additional, Banfi, Paola, additional, Bergamaschi, Roberto, additional, Clerici, Raffaella, additional, Conti, Marta Zaffira, additional, Cortese, Antonio, additional, Fantozzi, Roberta, additional, Fischetti, Mariano, additional, Frigo, Maura, additional, Gatto, Maurizia, additional, Immovilli, Paolo, additional, Leoni, Stefania, additional, Malucchi, Simona, additional, Maniscalco, Giorgia, additional, Marfia, Girolama Alessandra, additional, Paolicelli, Damiano, additional, Perini, Paola, additional, Serrati, Carlo, additional, Sola, Patrizia, additional, Totaro, Rocco, additional, Turano, Gabriella, additional, Valentino, Paola, additional, Zaffaroni, Mauro, additional, Zuliani, Cristina, additional, and Centonze, Diego, additional

Published
2020
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16. Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients.

Author

Chiarini, Marco, Capra, Ruggero, Serana, Federico, Bertoli, Diego, Sottini, Alessandra, Giustini, Viviana, Scarpazza, Cristina, Rovaris, Marco, Torri Clerici, Valentina, Ferraro, Diana, Galgani, Simonetta, Solaro, Claudio, Conti, Marta Zaffira, Visconti, Andrea, Imberti, Luisa, and SURROGATE Study Group

Subjects
SUPPRESSOR cells, T cells, MULTIPLE sclerosis, NATALIZUMAB, TREATMENT effectiveness
Abstract

Background: The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In the present study, we evaluated the short and long-term effects of interferon-β treatment on different subsets of regulatory T cells in relapsing-remitting multiple sclerosis patients biologically responsive to treatment because of mixovirus resistance protein A inducibility.Methods: In this prospective longitudinal study, subsets of natural regulatory T cells (naïve, central memory and effector memory) and inducible regulatory T cells (Tr1), as well as in vitro-induced regulatory T cells (Tr1-like cells), were simultaneously quantified by flow cytometry in samples prepared from 148 therapy-naïve multiple sclerosis patients obtained before and after 6, 12, 18, and 24 months of interferon-β-1a treatment. mRNA for interleukin-10 and Tr1-related genes (CD18, CD49b, and CD46, together with Cyt-1 and Cyt-2 CD46-associated isoforms) were quantified in Tr1-like cells.Results: Despite profound inter-individual variations in the modulation of all regulatory T-cell subsets, the percentage of natural regulatory T cells increased after 6, 12, and 24 months of interferon-β treatment. This increase was characterized by the expansion of central and effector memory regulatory T-cell subsets. The percentage of Tr1 significantly enhanced at 12 months of therapy and continued to be high at the subsequent evaluation points. Patients experiencing relapses displayed a higher percentage of naïve regulatory T cells and a lower percentage of central memory regulatory T cells and of Tr1 before starting interferon-β therapy. In addition, an increase over time of central memory and of Tr1 was observed only in patients with stable disease. However, in vitro-induced Tr1-like cells, prepared from patients treated for 24 months, produced less amount of interleukin-10 mRNA compared with pre-treatment Tr1-like cells.Conclusion: Interferon-β induces the expansion of T regulatory subsets endowed with a high suppressive activity, especially in clinically stable patients. The overall concurrent modulation of natural and inducible regulatory T-cell subsets might explain the therapeutic effects of interferon-β in multiple sclerosis patients. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Assessment of the incremental diagnostic value of florbetapir F 18 imaging in patients with cognitive impairment: The incremental diagnostic value of amyloid PET with [ 18 F]-florbetapir (INDIA-FBP) study

Author

Boccardi, Marina, Altomare, Daniele, Ferrari, Clarissa, Festari, Cristina, Guerra, Ugo Paolo, Paghera, Barbara, Pizzocaro, Claudio, Lussignoli, Giulia, Geroldi, Cristina, Zanetti, Orazio, Cotelli, Maria Sofia, Turla, Marinella, Borroni, Barbara, Rozzini, Luca, Mirabile, Dario, Defanti, Carlo, Gennuso, Michele, Prelle, Alessandro, Gentile, Simona, Morandi, Alessandro, Vollaro, Stefano, Volta, Giorgio Dalla, Bianchetti, Angelo, Conti, Marta Zaffira, Cappuccio, Melania, Carbone, Pasqualina, Bellandi, Daniele, Abruzzi, Luciano, Bettoni, Luigi, Villani, Daniele, Raimondi, Maria Clara, Lanari, Alessia, Ciccone, Alfonso, Facchi, Emanuela, Di Fazio, Ignazio, Rozzini, Renzo, Boffelli, Stefano, Manzoni, Laura, Salvi, Giovanni Pietro, Cavaliere, Sabina, Belotti, Gloria, Avanzi, Stefano, Pasqualetti, Patrizio, Muscio, Cristina, Padovani, Alessandro, Frisoni, Giovanni B., Antelmi, Luigi, Galluzzi, Samantha, Pievani, Michela, Redolfi, Alberto, Tarallo, ANNA ROSA, Arora, Anupa, Bertocchi, Monica, Chitò, Eugenia, Moretti, Davide V., Giubbini, Raffaele, Rodella, Carlo, Camoni, Luca, Massetti, Valentina, Andreoli, Michela, Bellelli, Giuseppe, Fascendini, Sara, Mattioli, Flavia, Turco, Renato, Vezzadini, Giuliana, Raimondi, Vanessa, Mondini, Sara, Zanacchi, Elisa Carolina, Grigolo, Marta, Pezzini, Alessandra, Bilotti, Giacinta, Bigni, Barbara, Zavarise, Paola, Ngonga, Gael, Anzola, Gian Paolo, Turrone, Rosanna, Guizzetti, Gianluca, Zanetti, Marina, Boccardi, Marina, Altomare, Daniele, Ferrari, Clarissa, Festari, Cristina, Frisoni, Giovanni, Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Guerra, U, Paghera, B, Pizzocaro, C, Lussignoli, G, Geroldi, C, Zanetti, O, Cotelli, M, Turla, M, Borroni, B, Rozzini, L, Mirabile, D, Defanti, C, Gennuso, M, Prelle, A, Gentile, S, Morandi, A, Vollaro, S, Volta, G, Bianchetti, A, Conti, M, Cappuccio, M, Carbone, P, Bellandi, D, Abruzzi, L, Bettoni, L, Villani, D, Raimondi, M, Lanari, A, Ciccone, A, Facchi, E, Di Fazio, I, Rozzini, R, Boffelli, S, Manzoni, L, Salvi, G, Cavaliere, S, Belotti, G, Avanzi, S, Pasqualetti, P, Muscio, C, Padovani, A, Frisoni, G, Antelmi, L, Galluzzi, S, Pievani, M, Redolfi, A, Tarallo, A, Arora, A, Bertocchi, M, Chito, E, Moretti, D, Giubbini, R, Rodella, C, Camoni, L, Massetti, V, Andreoli, M, Bellelli, G, Fascendini, S, Mattioli, F, Turco, R, Vezzadini, G, Raimondi, V, Mondini, S, Zanacchi, E, Grigolo, M, Pezzini, A, Bilotti, G, Bigni, B, Zavarise, P, Ngonga, G, Anzola, G, Turrone, R, Guizzetti, G, and Zanetti, M

Subjects
Male, medicine.medical_specialty, Positron-Emission Tomography/methods/standards, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Cognitive Dysfunction, Female, Humans, Male, Positron-Emission Tomography, Predictive Value of Tests, Aniline Compounds, Ethylene Glycols, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, ddc:616.89, 0302 clinical medicine, Alzheimer Disease, Predictive Value of Tests, Medical imaging, 80 and over, Medicine, Humans, Cognitive Dysfunction, Cognitive decline, Cognitive impairment, Amyloid beta-Peptides/metabolism, Aged, Aged, 80 and over, Amyloid beta-Peptides, Aniline Compounds, medicine.diagnostic_test, business.industry, Amyloidosis, Alzheimer Disease/diagnosis/diagnostic imaging/metabolism, Cognitive Dysfunction/diagnosis/diagnostic imaging/metabolism, medicine.disease, aged, aged, 80 and over, alzheimer disease, amyloid beta-peptides, cognitive dysfunction, female, humans, male, positron-emission tomography, predictive value of tests, aniline compounds, ethylene glycols, Surgery, Female, Positron-Emission Tomography, Ethylene Glycols, Neurology (clinical), Positron emission tomography, Predictive value of tests, Radiology, Alzheimer's disease, Abnormality, business, 030217 neurology & neurosurgery
Abstract

IMPORTANCE Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected in vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility is debated. OBJECTIVE To evaluate the incremental diagnostic value of amyloid PET with florbetapir F 18 in addition to the routine clinical diagnostic assessment of patients evaluated for cognitive impairment. DESIGN, SETTING, AND PARTICIPANTS The Incremental Diagnostic Value ofAmyloid PET With [18F]-Florbetapir (INDIA-FBP) Study is a multicenter study involving 18 AD evaluation units from eastern Lombardy, Northern Italy, 228 consecutive adults with cognitive impairmentwere evaluated for AD and other causes of cognitive decline, with a prescan diagnostic confidence of AD between 15%and 85%. Participants underwent routine clinical and instrumental diagnostic assessment. A prescan diagnosiswas made, diagnostic confidencewas estimated, and drug treatmentwas provided. At the time of thisworkup, an amyloid PET/computed tomographic scanwas performed, and the resultwas communicated to physicians afterworkup completion. Physicianswere asked to review the diagnosis, diagnostic confidence, and treatment after the scan. The studywas conducted from August 5, 2013, to December 31, 2014. MAIN OUTCOMES AND MEASURES Primary outcomeswere prescan to postscan changes of diagnosis, diagnostic confidence, and treatment. RESULTS Of the 228 participants, 107 (46%) were male; mean (SD) age was 70.5 (7) years. Diagnostic change occurred in 46 patients (79%) having both a previous diagnosis of AD and an amyloid-negative scan (P < .001) and in 16 (53%) of those with non-AD diagnoses and an amyloid-positive scan (P < .001). Diagnostic confidence in AD diagnosis increased by 15.2%in amyloid-positive (P < .001; effect size Cohen d = 1.04) and decreased by 29.9%in amyloid-negative (P < .001; d = -1.19) scans. Acetylcholinesterase inhibitors and memantine hydrochloride were introduced in 61 (65.6%) patients with positive scan results who had not previously received those drugs, and the use of the drugs was discontinued in 6 (33.3%) patients with negative scan results who were receiving those drugs (P < .001). CONCLUSIONS AND RELEVANCE Amyloid PET in addition to routine assessment in patients with cognitive impairment has a significant effect on diagnosis, diagnostic confidence, and drug treatment. The effect on health outcomes, such as morbidity and mortality, remains to be assessed.

Published
2016

19. Glatiramer acetate-induced hepatitis in a young female patient with multiple sclerosis

Author

La Gioia, Sara, Bacis, Giuseppe, Sonzogni, Aurelio, Frigeni, Barbara, Conti, Marta Zaffira, Vedovello, Marcella, and Rottoli, Mariarosa

Abstract

We report the first Italian case of glatiramer acetate-related acute hepatotoxicity. A 25-years-old woman suffering from multiple sclerosis presented acute hepatitis after eight months of treatment. Neither infective, nor autoimmune markers were detected. Liver biopsy histology was consistent with drug-induced acute injury. Liver function tests became normal after eight weeks of treatment discontinuation. This report points out the importance of monitoring liver function during the first year of treatment with glatiramer acetate.

Published
2024
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20. Erythroblastaemia in natalizumab-treated patients with multiple sclerosis

Author

La Gioia, Sara, primary, Seghezzi, Michela, additional, Barcella, Valeria, additional, Dominoni, Paola, additional, Mecca, Tommaso, additional, Frigeni, Barbara, additional, Conti, Marta Zaffira, additional, Vedovello, Marcella, additional, Vidali, Matteo, additional, Rottoli, Mariarosa, additional, and Buoro, Sabrina, additional

Published
2016
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21. Non-amnestic mild cognitive impairment and sleep complaints: a bidirectional relationship?

Author

Rozzini, Luca, Conti, Marta Zaffira, Riva, Maddalena, Ceraso, Anna, Caratozzolo, Salvatore, Zanetti, Marina, and Padovani, Alessandro

Abstract

Background: Prior studies documented that several sleep disorders may coexist in patients affected by Mild Cognitive Impairment (MCI) and Alzheimer disease (AD), and have a strong bidirectional relationship with cognitive decline.Aim: To assess the self-reported sleep quality and daytime sleepiness among subjects affected by MCI and AD at early-stage and healthy controls, and to verify if sleep disturbances might be an indicator of specific cognitive deficits.Methods: 139 patients (102 MCI, 37 AD) underwent comprehensive neuropsychological, functional, and behavioral assessment, which also included Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). 80 healthy elderly subjects were used as controls. MCI patients have been divided into Good Sleepers and Bad Sleepers, depending on their reported sleep quality (PSQI global score ≤5/>5).Results: MCI patients experienced more subjective daytime sleepiness than AD matches. As for the subjective sleep quality among MCI patients, 54% of Bad Sleepers met diagnostic criteria for non-amnestic MCI; vice-versa, 73% of Good Sleepers were diagnosed with amnestic-MCI (p = 0.005), independently of depression and anxiety.Conclusions: MCI patients complain of daytime sleepiness and dysfunction more than AD patients; among MCI patients, Bad Sleepers appear mainly characterized by a non-amnestic cognitive profile. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Assessment of the Incremental Diagnostic Value of Florbetapir F 18 Imaging in Patients With Cognitive Impairment: The Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Study

Author

Boccardi, Marina, Altomare, Daniele, Ferrari, Clarissa, Festari, Cristina, Guerra, Ugo Paolo, Paghera, Barbara, Pizzocaro, Claudio, Lussignoli, Giulia, Geroldi, Cristina, Zanetti, Orazio, Cotelli, Maria Sofia, Turla, Marinella, Borroni, Barbara, Rozzini, Luca, Mirabile, Dario, Defanti, Carlo, Gennuso, Michele, Prelle, Alessandro, Gentile, Simona, Morandi, Alessandro, Vollaro, Stefano, Volta, Giorgio Dalla, Bianchetti, Angelo, Conti, Marta Zaffira, Cappuccio, Melania, Carbone, Pasqualina, Bellandi, Daniele, Abruzzi, Luciano, Bettoni, Luigi, Villani, Daniele, Raimondi, Maria Clara, Lanari, Alessia, Ciccone, Alfonso, Facchi, Emanuela, Di Fazio, Ignazio, Rozzini, Renzo, Boffelli, Stefano, Manzoni, Laura, Salvi, Giovanni Pietro, Cavaliere, Sabina, Belotti, Gloria, Avanzi, Stefano, Pasqualetti, Patrizio, Muscio, Cristina, Padovani, Alessandro, and Frisoni, Giovanni B.

Abstract

IMPORTANCE: Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected in vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility is debated. OBJECTIVE: To evaluate the incremental diagnostic value of amyloid PET with florbetapir F 18 in addition to the routine clinical diagnostic assessment of patients evaluated for cognitive impairment. DESIGN, SETTING, AND PARTICIPANTS: The Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Study is a multicenter study involving 18 AD evaluation units from eastern Lombardy, Northern Italy, 228 consecutive adults with cognitive impairment were evaluated for AD and other causes of cognitive decline, with a prescan diagnostic confidence of AD between 15% and 85%. Participants underwent routine clinical and instrumental diagnostic assessment. A prescan diagnosis was made, diagnostic confidence was estimated, and drug treatment was provided. At the time of this workup, an amyloid PET/computed tomographic scan was performed, and the result was communicated to physicians after workup completion. Physicians were asked to review the diagnosis, diagnostic confidence, and treatment after the scan. The study was conducted from August 5, 2013, to December 31, 2014. MAIN OUTCOMES AND MEASURES: Primary outcomes were prescan to postscan changes of diagnosis, diagnostic confidence, and treatment. RESULTS: Of the 228 participants, 107 (46%) were male; mean (SD) age was 70.5 (7) years. Diagnostic change occurred in 46 patients (79%) having both a previous diagnosis of AD and an amyloid-negative scan (P &lt; .001) and in 16 (53%) of those with non-AD diagnoses and an amyloid-positive scan (P &lt; .001). Diagnostic confidence in AD diagnosis increased by 15.2% in amyloid-positive (P &lt; .001; effect size Cohen d = 1.04) and decreased by 29.9% in amyloid-negative (P &lt; .001; d = −1.19) scans. Acetylcholinesterase inhibitors and memantine hydrochloride were introduced in 61 (65.6%) patients with positive scan results who had not previously received those drugs, and the use of the drugs was discontinued in 6 (33.3%) patients with negative scan results who were receiving those drugs (P &lt; .001). CONCLUSIONS AND RELEVANCE: Amyloid PET in addition to routine assessment in patients with cognitive impairment has a significant effect on diagnosis, diagnostic confidence, and drug treatment. The effect on health outcomes, such as morbidity and mortality, remains to be assessed.

Published
2016
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25. Patients with multiple sclerosis choose a collaborative role in making treatment decision: results from the Italian multicenter SWITCH study

Author

Patti, Francesco, Chisari, Clara Grazia, Toscano, Simona, Annovazzi, Pietro, Banfi, Paola, Bergamaschi, Roberto, Clerici, Raffaella, Conti, Marta Zaffira, Cortese, Antonio, Fantozzi, Roberta, Ferraro, Diana, Fischetti, Mariano, Frigo, Maura, Gatto, Maurizia, Immovilli, Paolo, Leoni, Stefania, Malucchi, Simona, Maniscalco, Giorgia, Marfia, Girolama Alessandra, Paolicelli, Damiano, Perini, Paola, Serrati, Carlo, Totaro, Rocco, Turano, Gabriella, Valentino, Paola, Zaffaroni, Mauro, Zuliani, Cristina, and Centonze, Diego

Abstract

•Cognitive profile and physician-based and patients-reported outcomes could have a considerable impact on the disease management and on treatment decision making•According to the Control Preference Scale, more than 50% of patients who needed to change therapy chose a “collaborative” role in making treatment decision.•Cognitive profile with SDMT seems to influence patients’ preference on treatment decision.

Published
2022
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