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Reusable glass bottles are experiencing a resurgence, driven notably by societal concerns and regulations. While single-use glass bottles generally have higher environmental footprint compared to plastic bottles, reusable systems could reduce both impacts related to single-use (e.g., climate change, energy consumption) and plastics (e.g., microplastic pollution). The environmental benefits of reusable bottles can vary across systems and this can be overlooked by stakeholders who rely on generic results for communication and a limited number of parameters to design their systems. This study addresses this gap by developing a systematic analysis of the variability of life cycle assessment results, within the specific case study of a new beverage. As a result, a list of key parameters to consider for the specific case study is set, enabling to propose targeted mitigation strategies. The commonly used generic key parameters are complemented with context-specific key parameters, empowering stakeholders to develop efficient systems and communicate their environmental performance accurately. Different configurations are likely to be influenced by other key parameters, and require specific mitigation strategies. In this perspective, stakeholders need assistance in: (1) designing context-specific strategies, and (2) translating – complex and plural – life cycle assessment results into actionable decisions.