376 results on '"Contestabile, Roberto"'
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2. Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila
3. Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
4. Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6)
5. Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives
6. The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein.
7. The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target.
8. Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase
9. Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium Aphanothece halophytica provide a rationale for salt tolerance
10. Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase
11. Allosteric feedback inhibition of pyridoxine 5′-phosphate oxidase from Escherichia coli
12. Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway
13. Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes
14. One substrate-many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse
15. Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation
16. Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor
17. Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy
18. A Comprehensive Computational Analysis of Mycobacterium Genomes Pinpoints the Genes Co-occurring with YczE, a Membrane Protein Coding Gene Under the Putative Control of a MocR, and Predicts its Function
19. Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
20. A gene‐nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila
21. 4′-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity
22. Crystal Structure of Glutamate-1-Semialdehyde Aminomutase: An α 2-dimeric vitamin B6-dependent Enzyme with Asymmetry in Structure and Active Site Reactivity
23. Structural properties of the linkers connecting the N- and C- terminal domains in the MocR bacterial transcriptional regulators
24. Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming
25. Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
26. The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
27. THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH
28. The aspartate aminotransferase-like domain of Firmicutes MocR transcriptional regulators
29. On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5′-phosphate
30. Molecular basis of E. colil-threonine aldolase catalytic inactivation at low pH
31. Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for β-hydroxy-α-amino acid biosynthesis
32. Characterization of theEscherichia colipyridoxal 5′‐phosphate homeostasis protein ( YggS ): Role of lysine residues in PLP binding and protein stability
33. Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability
34. Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection
35. Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity
36. Salmonella typhimurium PtsJ is a novel MocR‐like transcriptional repressor involved in regulating the vitamin B6 salvage pathway
37. Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K
38. Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex
39. Vitamin B 6 salvage enzymes: Mechanism, structure and regulation
40. Serine hydroxymethyltransferase: A model enzyme for mechanistic, structural, and evolutionary studies
41. In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
42. Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
43. Serine Hydroxymethyltransferase: Role of the Active Site Lysine in the Mechanism of the Enzyme
44. Knowns and Unknowns of Vitamin B 6 Metabolism in Escherichia coli
45. PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc
46. Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex
47. Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy
48. Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder
49. Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii
50. How pyridoxal 5′-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
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