1. Urine 8-isoprostane in relation to adiposity and insulin resistance in individuals at high cardiometabolic risk
- Author
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Della CorteGiuseppina, GiaccoRosalba, RivelleseAngela Albarosa, CostabileGiuseppina, Della PepaGiuseppe, ConteFrancesca Serena, Di MarinoLucrezia, BozzettoLutgarda, AnnuzziGiovanni, VetraniClaudia, Costabile, Giuseppina, DELLA PEPA, Giuseppe, Bozzetto, Lutgarda, Annuzzi, Giovanni, Vetrani, Claudia, Giacco, Rosalba, DELLA CORTE, Giuseppina, Conte, Francesca Serena, DI MARINO, Lucrezia, and Rivellese, ANGELA ALBAROSA
- Subjects
Adult ,Male ,medicine.medical_specialty ,obesity ,Waist ,Endocrinology, Diabetes and Metabolism ,Abdominal Fat ,Adipose tissue ,lipoprotein lipase ,Urine ,Overweight ,medicine.disease_cause ,Dinoprost ,Risk Assessment ,insulin-resistance ,Insulin resistance ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Triglycerides ,Adiposity ,Aged ,Metabolic Syndrome ,Sex Characteristics ,business.industry ,Body Weight ,Cholesterol, HDL ,Age Factors ,Anthropometry ,Middle Aged ,medicine.disease ,Obesity ,Oxidative Stress ,Endocrinology ,Cross-Sectional Studies ,hormone-sensitive lipase ,Female ,Metabolic syndrome ,medicine.symptom ,Insulin Resistance ,Waist Circumference ,business ,Oxidative stress - Abstract
Background: Oxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity. However, in vivo data concerning these relationships are scarce and conflicting. Therefore, the aim of this study was to investigate the association of oxidative stress with abdominal adiposity and insulin resistance in individuals at high cardiometabolic risk. Methods: A total of 116 overweight/obese individuals participating in the HealthGrain and Etherpaths European Projects, having waist circumference (WC) and any other component of the metabolic syndrome, were included in this cross-sectional evaluation. 8-Isoprostane concentrations in 24-hr urine were measured as marker of oxidative stress in vivo. Baseline anthropometric and metabolic parameters were analyzed according to quartiles of 8-isoprostanes. Linear regression (LR) analysis was used to assess clinical correlates of oxidative stress. Results: Urinary 8-isoprostane levels were 52% higher in men than in women (P
- Published
- 2015