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7 results on '"Contarini, Giorgia"'

1. NaCl enhances CD8+ T cell effector functions in cancer immunotherapy

Author

Scirgolea, Caterina, Sottile, Rosa, De Luca, Marco, Susana, Alberto, Carnevale, Silvia, Puccio, Simone, Ferrari, Valentina, Lise, Veronica, Contarini, Giorgia, Scarpa, Alice, Scamardella, Eloise, Feno, Simona, Camisaschi, Chiara, De Simone, Gabriele, Basso, Gianluca, Giuliano, Desiree, Mazza, Emilia Maria Cristina, Gattinoni, Luca, Roychoudhuri, Rahul, Voulaz, Emanuele, Di Mitri, Diletta, Simonelli, Matteo, Losurdo, Agnese, Pozzi, Davide, Tsui, Carlson, Kallies, Axel, Timo, Sara, Martano, Giuseppe, Barberis, Elettra, Manfredi, Marcello, Rescigno, Maria, Jaillon, Sebastien, and Lugli, Enrico

Published
2024
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4. Quantitative assessment of minimal residual disease for monitoring of paediatric patients with relapsed/refractory anaplastic large‐cell lymphoma treated with brentuximab vedotin: A case series.

Author

Contarini, Giorgia, Carraro, Elisa, Lovisa, Federica, Martire, Gaia, Lo Nigro, Luca, Sala, Alessandra, Pillon, Marta, and Mussolin, Lara

Subjects
*ANAPLASTIC large-cell lymphoma, *CHILD patients, *POSITRON emission tomography computed tomography, *PATIENT monitoring, *HODGKIN'S disease, *ANAPLASTIC thyroid cancer
Abstract

This article discusses the use of brentuximab vedotin (BV) for the treatment of relapsed or refractory anaplastic large-cell lymphoma (ALCL) in pediatric patients. The study focuses on the role of minimal residual disease (MRD) monitoring using droplet digital PCR (dPCR) to assess treatment response and predict relapse. The results suggest that multiple cycles of BV are necessary to achieve complete remission, and MRD positivity may serve as an early indicator of relapse. The study acknowledges its limitations due to its retrospective nature and small sample size. The research was supported by various funding sources and the authors declare no conflicts of interest. [Extracted from the article]

Published
2024
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5. NaCl enhances CD8+T cell effector functions in cancer immunotherapy

Author

Scirgolea, Caterina, Sottile, Rosa, De Luca, Marco, Susana, Alberto, Carnevale, Silvia, Puccio, Simone, Ferrari, Valentina, Lise, Veronica, Contarini, Giorgia, Scarpa, Alice, Scamardella, Eloise, Feno, Simona, Camisaschi, Chiara, De Simone, Gabriele, Basso, Gianluca, Giuliano, Desiree, Mazza, Emilia Maria Cristina, Gattinoni, Luca, Roychoudhuri, Rahul, Voulaz, Emanuele, Di Mitri, Diletta, Simonelli, Matteo, Losurdo, Agnese, Pozzi, Davide, Tsui, Carlson, Kallies, Axel, Timo, Sara, Martano, Giuseppe, Barberis, Elettra, Manfredi, Marcello, Rescigno, Maria, Jaillon, Sebastien, and Lugli, Enrico

Abstract

CD8+T cells control tumors but inevitably become dysfunctional in the tumor microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction to promote cancer regression. NaCl supplementation during CD8+T cell culture induced effector differentiation, IFN-γ production and cytotoxicity while maintaining the gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized mouse model. In mice, a high-salt diet reduced the growth of experimental tumors in a CD8+T cell-dependent manner by inhibiting terminal differentiation and enhancing the effector potency of CD8+T cells. Mechanistically, NaCl enhanced glutamine consumption, which was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8+T cells undergoing antigen recognition in tumors and predicting favorable responses to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a regulator of CD8+T cell effector function, with potential implications for cancer immunotherapy.

Published
2024
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6. Plasma small‐extracellular vesicles enriched in miR‐122‐5p promote disease aggressiveness in pediatric anaplastic large‐cell lymphoma.

Author

Damanti, Carlotta Caterina, Ferrone, Lavinia, Gaffo, Enrico, Garbin, Anna, Tosato, Anna, Contarini, Giorgia, Gallingani, Ilaria, Angioni, Roberta, Molon, Barbara, Borile, Giulia, Carraro, Elisa, Pillon, Marta, Scarmozzino, Federico, Dei Tos, Angelo Paolo, Pizzi, Marco, Ciscato, Francesco, Rasola, Andrea, Biffi, Alessandra, Bortoluzzi, Stefania, and Lovisa, Federica

Published
2023
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7. Quantification of Minimal Disease by Digital PCR in ALK-Positive Anaplastic Large Cell Lymphoma: A Step towards Risk Stratification in International Trials?

Author

Damm-Welk, Christine, primary, Lovisa, Federica, additional, Contarini, Giorgia, additional, Lüdersen, Jette, additional, Carraro, Elisa, additional, Knörr, Fabian, additional, Förster, Jan, additional, Zimmermann, Martin, additional, Sala, Alessandra, additional, Vinti, Luciana, additional, Tondo, Annalisa, additional, Pillon, Marta, additional, Woessmann, Wilhelm, additional, and Mussolin, Lara, additional

Published
2022
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