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1. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

de Rábago, Eugenia Gonzalez, Blanco Morales, Elena Alonso, Fernández López, J. Carlos, Villar, Natividad Oreiro, Sandoval, Antonio Atanes, Blanco García, Francisco J., De Miquel, Cayetano Alegre, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, Torón, José García, Moreno Gil, María P., Mas, Antonio J., Espiño, Pilar, Ros, Inmaculada, Ibañez, Mónica, Murillo, Claudia, Piqueras, José A., Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Gutiérrez, Benjamín Fernández, Abasolo, Lydia, Fábregas, María D., Nolla, Joan M., Arias, Miriam García, García Vadillo, Jesús A., de Vicuña, Rosario García, Nebro, Antonio Fernández, Belmonte López, Maria Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, González, Ruth López, Garrido, Daniel Pielfort, Alvarez, Juana Sampedro, García Aparicio, Ángel María, Gómez, Rebeca Belmonte, Bautista, Pastora Granados, Sanz, Azucena Hernández, Sánchez González, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Zorzo, Fernando Jimenez, Ubeda, Eugenio Giménez, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Erausquin, Celia, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Lozano, Carlos Rodríguez, Herráez, Jesús Babío, López Longo, Francisco J., Gerona, Delia, Fernández, Carlos González, Carreño, Luis, Monteagudo, Indalecio, del Pino, Javier, Sánchez González, María Dolores, Corrales, Alfonso, Peiró, María Enriqueta, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, magro, Cesar, Escribano, Ana Ruibal, Expósito, Sergio Ros, Nievas, Ginés Sánchez, Navarro, Enrique Júdez, Fernández, Manuela Sianes, García Morales, María Ángeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, Alvarez, Beatriz González, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodríguez, Jiménez, Luis María, Redondo, Javier Rivera, Hernández, Teresa González, González Polo, Francisco J., Almagro, Raúl Menor, Moreno, José M., Serret, Emilio Giner, Barroso, Carla Lannuzzelli, Méndez, Laura Cebrián, Navío, María Teresa, Carballido, Cristina Fernández, Pagán, Encarnación, del Castillo, Pablo Mesa, Naredo, Esperanza, Cruz, Ana, Turrión, Ana, Mateo, Isabel, Sánchez, Julio, Galindo, María, González, Javier García, Collantes, Eduardo, Ruíz, Desireé, Font, Pilar, Bonilla, Gema, Meseguer, Antonio López, Moreno, Manuel J., Martínez, M<ce:sup loc='post">a</ce:sup> José Moreno, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Beteta, Linares, Luis F., Morcillo, Mercedes, González Gómez, María L., Aramburu, José M., Rivera, Natalia A., Berrizbeitia, Olaia Fernández, García Vivar, María Luz, Riera, Manel, León, Yolanda María, Maymó, Joan, Amirall, Miriam, Escolano, Silvia Iniesta, Serrano, Silvia Sánchez, Lis Bona, María Pilar, Fiter, Jordi, Melón, Julia Fernández, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquín, Bañegil, Inmaculada, Díaz, César, Valls, Ramón, Castellví, Iván, Bonet, María, Ruzafa, Estefania Moreno, Alen, Jaime Calvo, Sandoval, Trinidad Pérez, Evrard, Eva Revuelta, Godo, Javier R., Espartero, Cruz Fernández, Navarro Blasco, Francisco J., González, José Antonio, Miranda-Filloy, José A., García-Gómez, Carmen, Martín-Martínez, Maria A., Castañeda, Santos, Sanchez-Alonso, Fernando, Uriarte-Ecenarro, Miren, González-Juanatey, Carlos, Romera-Baures, Montserrat, Santos-Rey, José, Pinto-Tasende, José Antonio, Quesada-Masachs, Estefanía, Tornero-Molina, Jesús, Martínez-González, Olga, Cobo-Ibáñez, Tatiana, Chamizo-Carmona, Eugenio, Manrique-Arija, Sara, Fábregas-Canales, Dolores, Díaz-González, Federico, Llorca, Javier, and González-Gay, Miguel A.

Published
2017
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2. Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

Author

Martin-Martinez, M. A., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Garcia-Gomez, C., Lopez-Gonzalez, R., Babio-Herraiz, J., Juan-Mas, A., Moreno-Gil, M. P., Sanchez-Gonzalez, C. O., Romera-Baures, M., Pinto-Tasende, J. A., Tornero-Molina, J., Fabregas-Canales, D., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Quesada, Estefania, Steiner, Martina, Munoz, Santiago, Cobo, Tatiana, Gamero, Fernando, Garcia Toron, Jose, Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Pina, Jose M., Nolla, Joan M., Garcia Arias, Miriam, Garcia Vadillo, Jesus A., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Manrique Arija, Sara, Belmonte Lopez, Maria A., Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Pielfort Garrido, Daniel, Garcia Aparicio, Angel M., Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Bachiller, Javier, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Garcia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria A., Labiano Bastero, Isabel, Garcia Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Jimenez, Luis M., Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Navio, Maria T., Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Maria Jose, Beteta Fernandez, Maria D., Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria L., Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria P., Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Gonzalez, Jose A., and Miranda-Filloy, Jose A.

Subjects
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, incidence, cohort study, CARMA project, cardiovascular diseases
Abstract

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

Published
2019

4. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

García-Gómez, Carmen, primary, Martín-Martínez, Maria A., additional, Castañeda, Santos, additional, Sanchez-Alonso, Fernando, additional, Uriarte-Ecenarro, Miren, additional, González-Juanatey, Carlos, additional, Romera-Baures, Montserrat, additional, Santos-Rey, José, additional, Pinto-Tasende, José Antonio, additional, Quesada-Masachs, Estefanía, additional, Tornero-Molina, Jesús, additional, Martínez-González, Olga, additional, Cobo-Ibáñez, Tatiana, additional, Chamizo-Carmona, Eugenio, additional, Manrique-Arija, Sara, additional, Fábregas-Canales, Dolores, additional, Díaz-González, Federico, additional, Llorca, Javier, additional, González-Gay, Miguel A., additional, de Rábago, Eugenia Gonzalez, additional, Blanco Morales, Elena Alonso, additional, Fernández López, J. Carlos, additional, Villar, Natividad Oreiro, additional, Sandoval, Antonio Atanes, additional, Blanco García, Francisco J., additional, De Miquel, Cayetano Alegre, additional, González Fernández, María J., additional, Codina, Ramón Huguet, additional, Yoldi, Beatriz, additional, Ramentol, Mercedes, additional, Ávila, Gabriela, additional, Barril, Sara Marsal, additional, Steiner, Martina, additional, Muñoz, Santiago, additional, Gamero, Fernando, additional, Torón, José García, additional, Moreno Gil, María P., additional, Mas, Antonio J., additional, Espiño, Pilar, additional, Ros, Inmaculada, additional, Ibañez, Mónica, additional, Murillo, Claudia, additional, Piqueras, José A., additional, Sanmartí, Raimon, additional, Berman, Horacio, additional, Cabrera, Sonia, additional, Ruiz, Virginia, additional, Patón, Oscar Fontseré, additional, Gutiérrez, Benjamín Fernández, additional, Abasolo, Lydia, additional, Fábregas, María D., additional, Nolla, Joan M., additional, Arias, Miriam García, additional, García Vadillo, Jesús A., additional, de Vicuña, Rosario García, additional, Nebro, Antonio Fernández, additional, Belmonte López, Maria Angeles, additional, Ureña, Inmaculada, additional, Irigoyen, María V., additional, Cagigal, Virginia Coret, additional, González, Ruth López, additional, Garrido, Daniel Pielfort, additional, Alvarez, Juana Sampedro, additional, García Aparicio, Ángel María, additional, Gómez, Rebeca Belmonte, additional, Bautista, Pastora Granados, additional, Sanz, Azucena Hernández, additional, Sánchez González, Carmen O., additional, Bachiller, Javier, additional, Zea, Antonio, additional, Manero, Francisco J., additional, Zorzo, Fernando Jimenez, additional, Ubeda, Eugenio Giménez, additional, Gracía, Jesús Marzo, additional, Audera, Chesús Beltrán, additional, Medrano, Marta, additional, Pecondón, Ángela, additional, Erausquin, Celia, additional, Ojeda, Soledad, additional, Quevedo, Juan Carlos, additional, Francisco, Félix, additional, Lozano, Carlos Rodríguez, additional, Herráez, Jesús Babío, additional, López Longo, Francisco J., additional, Gerona, Delia, additional, Fernández, Carlos González, additional, Carreño, Luis, additional, Monteagudo, Indalecio, additional, del Pino, Javier, additional, Sánchez González, María Dolores, additional, Corrales, Alfonso, additional, Peiró, María Enriqueta, additional, Senabre, José M., additional, Rosas, José C., additional, Rotés, Isabel, additional, Moreno, Estefanía, additional, Erra, Alba, additional, Grado, Dolors, additional, Calvo, Javier, additional, Rueda, Amalia, additional, Möller, Ingrid, additional, Rodríguez, Isabel, additional, Barbadillo, Carmen, additional, Raya, Enrique, additional, Morales, Pilar, additional, Nieto, Ana, additional, Jiménez, Inmaculada, additional, magro, Cesar, additional, Escribano, Ana Ruibal, additional, Expósito, Sergio Ros, additional, Nievas, Ginés Sánchez, additional, Navarro, Enrique Júdez, additional, Fernández, Manuela Sianes, additional, García Morales, María Ángeles, additional, Bastero, Isabel Labiano, additional, Consuegra, Gloria García, additional, Palmou, Natalia, additional, Pardo, Silvia Martínez, additional, Pujol, Manel, additional, Alonso, Elena Riera, additional, Salvador, Georgina, additional, Alvarez, Beatriz González, additional, Cantabrana, Alberto, additional, Bustabad, Sagrario, additional, Delgado, Esmeralda, additional, Muñoz, Alejandro, additional, Montero, Sergio Rodríguez, additional, Jiménez, Luis María, additional, Redondo, Javier Rivera, additional, Hernández, Teresa González, additional, González Polo, Francisco J., additional, Almagro, Raúl Menor, additional, Moreno, José M., additional, Serret, Emilio Giner, additional, Barroso, Carla Lannuzzelli, additional, Méndez, Laura Cebrián, additional, Navío, María Teresa, additional, Carballido, Cristina Fernández, additional, Pagán, Encarnación, additional, del Castillo, Pablo Mesa, additional, Naredo, Esperanza, additional, Cruz, Ana, additional, Turrión, Ana, additional, Mateo, Isabel, additional, Sánchez, Julio, additional, Galindo, María, additional, González, Javier García, additional, Collantes, Eduardo, additional, Ruíz, Desireé, additional, Font, Pilar, additional, Bonilla, Gema, additional, Meseguer, Antonio López, additional, Moreno, Manuel J., additional, Martínez, Ma José Moreno, additional, Fernández, Ma Dolores Beteta, additional, Linares, Luis F., additional, Morcillo, Mercedes, additional, González Gómez, María L., additional, Aramburu, José M., additional, Rivera, Natalia A., additional, Berrizbeitia, Olaia Fernández, additional, García Vivar, María Luz, additional, Riera, Manel, additional, León, Yolanda María, additional, Maymó, Joan, additional, Amirall, Miriam, additional, Escolano, Silvia Iniesta, additional, Serrano, Silvia Sánchez, additional, Lis Bona, María Pilar, additional, Fiter, Jordi, additional, Melón, Julia Fernández, additional, Espadaler, Luis, additional, Maiz, Olga, additional, Belzunegui, Joaquín, additional, Bañegil, Inmaculada, additional, Díaz, César, additional, Valls, Ramón, additional, Castellví, Iván, additional, Bonet, María, additional, Ruzafa, Estefania Moreno, additional, Alen, Jaime Calvo, additional, Sandoval, Trinidad Pérez, additional, Evrard, Eva Revuelta, additional, Godo, Javier R., additional, Espartero, Cruz Fernández, additional, Navarro Blasco, Francisco J., additional, González, José Antonio, additional, and Miranda-Filloy, José A., additional

Published
2017
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5. Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross‐Sectional Study

Author

Fernández‐Carballido, Cristina, Martín‐Martínez, María A., García‐Gómez, Carmen, Castañeda, Santos, González‐Juanatey, Carlos, Sánchez‐Alonso, Fernando, García de Vicuña, Rosario, Erausquin‐Arruabarrena, Celia, López‐Longo, Javier, Sánchez, María D., Corrales, Alfonso, Quesada‐Masachs, Estefanía, Chamizo, Eugenio, Barbadillo, Carmen, Bachiller‐Corral, Javier, Cobo‐Ibañez, Tatiana, Turrión, Ana, Giner, Emilio, Llorca, Javier, González‐Gay, Miguel A., Gonzalez de Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernández Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco García, Francisco J., Alegre De Miquel, Cayetano, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, García Torón, José, Espino, Pilar, Ros, Inmaculada, Ibáñez, Mónica, Murillo, Claudia, Molina, Jesús Tornero, Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Fernández Gutierrez, Benjamín, Abasolo, Lydia, Pina, Jose Manuel, Nolla, Joan M., García Arias, Miriam, Uriarte‐Ecenarro, Mirem, García Vadillo, Jesús A., Fernández Nebro, Antonio, Manrique Arija, Sara, Belmonte López, María Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, Garrido, Daniel Pielfort, García Aparicio, Angel María, Belmonte Gómez, Rebeca, Bautista, Pastora Granados, Hernandez Sanz, Azucena, Manero, Francisco J., Jimenez Zorzo, Fernando, Giménez Ubeda, Eugenio, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Rodríguez Lozano, Carlos, Gerona, Delia, González Fernández, Carlos, Carreño, Luis, Monteagudo, Indalecio, Pino, Javier, Peiró, María Enriqueta, Fernández‐Carballido, Cristina, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Expósito, Sergio Ros, Sánchez Nievas, Ginés, Navarro, Enrique Júdez, Sianes Fernández, Manuela, García Morales, María Angeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, González Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodriguez, and Jimenez, Luis María

Abstract

To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This was a cross‐sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0–27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and Pvalues. We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28‐ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = –0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.

Published
2020
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6. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C., Martin-Martinez, M. A., Fernandez-Carballido, C., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Gonzalez-Fernandez, M. J., Sanmarti, R., Garcia-Vadillo, J. A., Fernandez-Gutierrez, B., Garcia-Arias, M., Manero, F. J., Senabre, J. M., Rueda-Cid, A., Ros-Exposito, S., Pina-Salvador, J. M., Erra-Duran, A., Moller-Parera, I., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Munoz, Santiago, Gamero, Fernando, Garcia Toron, Jose, Moreno Gil, Maria P., Mas, Antonio J., Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Piqueras, Jose A., Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Fabregas, Maria D., Romera Baures, Montserrat, Nolla, Joan M., Gonzalez-Alvaro, Isidoro, Tomero Muriel, Eva G., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Belmonte Lopez, Maria Angeles, Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Lopez Gonzalez, Ruth, Pielfort Garrido, Daniel, Sampedro Alvarez, Juana, Garcia Aparicio, Angel Maria, Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Sanchez Gonzalez, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Gracia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Babio Herraez, Jesus, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Carreno, Luis, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria Angeles, Labiano Bastero, Isabel, Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Maria Jimenez, Luis, Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Teresa Navio, Maria, Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Mateo, Isabel, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Ma Jose, Beteta Fernandez, Ma Dolores, Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Aramburu, Jose M., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria Luz, Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria Pilar, Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Antonio Gonzalez, Jose, and Miranda-Filloy, Jose A.

Subjects
psoriatic arthritis, lipids, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

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