1. Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall
- Author
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Emrani, Sheina, Libon, David J, Lamar, Melissa, Price, Catherine C, Jefferson, Angela L, Gifford, Katherine A, Hohman, Timothy J, Nation, Daniel A, Delano-Wood, Lisa, Jak, Amy, Bangen, Katherine J, Bondi, Mark W, Brickman, Adam M, Manly, Jennifer, Swenson, Rodney, Au, Rhoda, and Consortium for Clinical and Epidemiological Neuropsychological Data Analysis (CENDA)
- Subjects
Male ,Boston process approach ,Clinical Trials and Supportive Activities ,Clinical Sciences ,digit span ,Serial Learning ,Neuropsychological Tests ,working memory ,Executive Function ,mild cognitive impairment ,Memory ,serial order ,Clinical Research ,80 and over ,Acquired Cognitive Impairment ,Humans ,Consortium for Clinical and Epidemiological Neuropsychological Data Analysis ,Cognitive Dysfunction ,Aged ,Memory Disorders ,Neurology & Neurosurgery ,Neurosciences ,executive functions ,Brain Disorders ,Short-Term ,Mental Recall ,Regression Analysis ,Female ,Dementia ,Cognitive Sciences - Abstract
BackgroundWorking memory (WM) is often assessed with serial order tests such as repeating digits backward. In prior dementia research using the Backward Digit Span Test (BDT), only aggregate test performance was examined.ObjectiveThe current research tallied primacy/recency effects, out-of-sequence transposition errors, perseverations, and omissions to assess WM deficits in patients with mild cognitive impairment (MCI).MethodsMemory clinic patients (n = 66) were classified into three groups: single domain amnestic MCI (aMCI), combined mixed domain/dysexecutive MCI (mixed/dys MCI), and non-MCI where patients did not meet criteria for MCI. Serial order/WM ability was assessed by asking participants to repeat 7 trials of five digits backwards. Serial order position accuracy, transposition errors, perseverations, and omission errors were tallied.ResultsA 3 (group)×5 (serial position) repeated measures ANOVA yielded a significant group×trial interaction. Follow-up analyses found attenuation of the recency effect for mixed/dys MCI patients. Mixed/dys MCI patients scored lower than non-MCI patients for serial position 3 (p
- Published
- 2018