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24 results on '"Conroy, M.C."'

6. CI-959

Author

Unangst, P.C., primary, Connor, D.T., additional, Low, J.E., additional, and Conroy, M.C., additional

Published
1994
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7. The pharmacologic effects of 5-[3,5-BIS(1,1-dimethylethyl)-4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation

Author

Schrier, D.J., primary, Baragi, V.M., additional, Connor, D.T., additional, Dyer, R.D., additional, Jordan, J.H., additional, Imre, K.M., additional, Lesch, M.E., additional, Mullican, M.D., additional, Okonkwo, G.C.N., additional, and Conroy, M.C., additional

Published
1994
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10. Antimicrobial susceptibilities of Pasteurella strains isolated from humans

Author

Lion, C., Conroy, M.C., Carpentier, A.M., and Lozniewski, A.

Subjects
*ANTI-infective agents, *PASTEURELLA, *CEFOTAXIME, *AZITHROMYCIN
Abstract

Abstract: The in vitro susceptibilities of 192 consecutive clinical strains of Pasteurella spp. isolated between 1996 and 2003 from soft tissue pus (n =146), respiratory tract specimens (n =38) and blood (n =8) were studied by an agar dilution method. All isolates were susceptible to minocycline, cefotaxime, ofloxacin, ciprofloxacin and levofloxacin. Most strains were susceptible to moxifloxacin, amoxicillin, azithromycin and clarithromycin, whereas lower susceptibility rates to telithromycin (89.4%) were observed among respiratory tract isolates. [Copyright &y& Elsevier]

Published
2006
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17. Validation of Diffusion Methods for Macrolide Susceptibility Testing of Helicobacter pylori

Author

Grignon, B., Tankovic, J., Mégraud, F., Glupczynski, Y., Husson, M.O., Conroy, M.C., Emond, J.P., Loulergue, J., Raymond, J., and Fauchère, J.L.

Abstract

Helicobacter pylori resistance to macrolides is increasing, and the need for susceptibility testing has become crucial. The only standardized method is agar dilution, which is not adapted to clinical practice. The present work aimed: (1) to optimize the technical conditions and to assess the reproducibility of the E-test and disk diffusion method for macrolides susceptibility testing of H. pylori, and (2) to assess the performances of these two phenotypic methods in detecting strains harboring a resistance mechanism to macrolides. We used 191 isolates collected in nine centers of France and Belgium. Phenotypic tests were performed on Mueller-Hinton agar supplemented with 10% horse blood, inoculated with a 2-day-old H. pylori suspension (108 CFU/ml), and incubated for 72 hr at 37°C under microaerophilic conditions. The reproducibility studied on two randomly selected strains was better for disk diffusion than for the E-test for both clarithromycin and erythromycin. For a subset of 10 strains, the MICs of erythromycin and clarithromycin did not differ from more than one two-fold dilution when determined by E-test or agar dilution method. The breakpoints were for MICs: 1 mg/L for both clarithromycin and erythromycin and for inhibition diameters, 22 mm for clarithromycin and 17 mm for erythromycin. There was a 100% concordance between susceptibility to erythromycin and clarithromycin. However, the susceptible and resistant populations were better separated by testing erythromycin. Of 34 resistant strains, two lacked the A2142G and A2143G point mutations in 23S rRNA by PCR-RFLP. None of 15 tested sensitive strains were positive for one of these two point mutations. For clinical practice, we recommend to assess macrolide susceptibility of H. pylori by using one of these two phenotypic methods under the described technical conditions.

Published
2002
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