1,427 results on '"Conn, P. Jeffrey"'
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2. Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits
3. D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
4. GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders
5. mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice
6. Metabotropic mGlu1Receptor Regulation of Cortical Inhibition and Cognitive Function: Implications in Adolescent Cocaine Exposure
7. Prefrontal cortex parvalbumin interneurons exhibit decreased excitability and potentiated synaptic strength after ethanol reward learning
8. Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate.
9. Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor.
10. mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
11. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders
12. Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus
13. D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
14. Activation of metabotropic glutamate receptor 3 modulates thalamo-accumbal transmission and rescues schizophrenia-like physiological and behavioral deficits.
15. Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates
16. Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators
17. Receptors | Glutamate Receptors, Metabotropic
18. The First 50 Years of Molecular Pharmacology
19. M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder
20. Bringing together the academic drug discovery community
21. The therapeutic potential of metabotropic glutamate receptor modulation for schizophrenia
22. Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function
23. Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulators
24. Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents
25. Metabotropic glutamate receptor 3 activation modulates thalamic inputs to the nucleus accumbens and rescues schizophrenia-like physiological and behavioral deficits
26. M1 Positive Allosteric Modulators Enhance Domains of Cognitive Function by Activation of ssT-expressing Interneurons in the Prefrontal Cortex
27. Metabotropic mGlu1Receptor Regulation of Cortical Inhibition and Cognitive Function: Implications in Adolescent Cocaine Exposure
28. Metabotropic glutamate receptors in GtoPdb v.2023.1
29. N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity
30. Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment
31. The Contribution of Protease-Activated Receptor 1 to Neuronal Damage Caused by Transient Focal Cerebral Ischemia
32. Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine
33. Activation of the Genetically Defined m1 Muscarinic Receptor Potentiates N-methyl-D-Aspartate (NMDA) Receptor Currents in Hippocampal Pyramidal Cells
34. Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington’s disease
35. mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell
36. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
37. Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner
38. Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice
39. Leveraging bias to your advantage
40. Effects of VU0410120, a novel GlyT1 inhibitor, on measures of sociability, cognition and stereotypic behaviors in a mouse model of autism
41. Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)
42. Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics
43. Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists
44. Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists
45. Metabotropic glutamate receptor 3 as a potential therapeutic target for psychiatric and neurological disorders
46. Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction
47. Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia
48. Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
49. Metabotropic Glutamate Receptor Ligands as Novel Therapeutic Agents
50. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia
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