3,606 results on '"Conjunctival diseases"'
Search Results
2. Primary basal cell carcinoma of the caruncle: case report and review of the literature.
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Roque-Choque, Elizabeth Cecilia, Villalobos-Espinoza, Jorge Ramiro, Silva-Ocas, Isabel, Alvarado-Villacorta, Rosa, and Muro-Mansilla, Pedro
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BASAL cell carcinoma ,LITERATURE reviews ,SEBACEOUS glands ,SURGICAL margin ,ADJUVANT chemotherapy - Abstract
We present a rare case of primary caruncle basal cell carcinoma (BCC), a condition with limited occurrences. Our patient, an 80-year-old woman without prior ocular pathological history, presented a 2x2mm pedunculated blackish nodular lesion on the caruncle of her left eye, without local conjunctival or cutaneous involvement. Histological analysis following complete excision confirmed the presence of basal cell carcinoma within the caruncle. Over a span of 30 months, no recurrence has been observed. While scant cases are documented in the literature, we conducted a review of these instances. Despite its infrequent manifestation, this condition should be taken into account when evaluating caruncular tumors, given its tendency to invade the orbit. Complete excision with free surgical margins is the treatment of choice, and adjuvant radiotherapy or chemotherapy might be considered. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) (ALTESSE)
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- 2023
4. Case Report: Crying Blood.
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Idowu, Oluwatobi O, Kaidonis, Georgia, Husain, Sameera, and Winn, Bryan J
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Patient Safety ,Blood ,Cautery ,Conjunctival Diseases ,Contact Lenses ,Crying ,Female ,Granuloma ,Pyogenic ,Humans ,Lacrimal Apparatus Diseases ,Tears ,Young Adult ,Medical and Health Sciences ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
SignificanceHemolacria (bloody tears) is a rare clinical presentation with varied underlying etiologies. Thorough clinical evaluation is essential to diagnosis and management.PurposeThis study aimed to report unilateral hemolacria in a known contact lens wearer with an occult, palpebral, conjunctival pyogenic granuloma and review the literature.Case reportA 21-year-old female contact lens wearer presented to the clinic after three episodes of sudden painless bloody tears from the right eye. She was referred to the oculoplastic clinic for evaluation. On everting her right upper lid, a fleshy, nontender, ovoid, pedunculated mass was found attached to the palpebral conjunctiva of the right, nasal, upper tarsus. Surgical excision was performed in the office, and pathological examination of the lesion was consistent with pyogenic granuloma.ConclusionsUnilateral hemolacria should raise clinical suspicion for a hidden conjunctival lesion such as pyogenic granuloma, although other more sinister causes of hemolacria must also be considered. Thorough evaluation including eyelid eversion is critical in identifying and managing occult conjunctival lesions.
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- 2021
5. Analysis of the histopathological results of patients submitted to pterygium excision
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Marcelo Vicente De Andrade Sobrinho, Felipe Belucio de Souza, Gustavo Lustosa Neves, Rodrigo Dechichi Zuppi, Giovanna Soares Nutels, and Amilcar Castro De Mattos
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biopsy ,conjunctival diseases ,eye abnormalities ,pathology ,pterygium ,Ophthalmology ,RE1-994 - Abstract
Purpose: The objective of this study was to evaluate the prevalence of premalignant and malignant lesions in patients clinically diagnosed with pterygium who underwent excision procedures performed by 1st-year residents in ophthalmology at a teaching hospital between 2018 and 2021. Methods: A cross-sectional analysis was conducted on 274 medical records of patients diagnosed with pterygium who underwent excision procedures from 2018 to 2021 at Hospital PUC-Campinas in Campinas, São Paulo, Brazil. Fifty-four medical records were excluded due to missing essential data. Among the 220 records included for analysis, 239 histopathological results were considered, as 19 patients underwent pterygium excision in both eyes. Results: Out of 239 histopathological results analyzed, 236 (98.74%) were compatible with pterygium, 2 (0.8%) with epithelial dysplasia, and 1 (0.4%) with actinic keratosis. Conclusion: A histopathological study is essential for the accurate differential diagnosis of pterygium. Although the frequency of ocular surface squamous neoplasia is low, premalignant and malignant lesions must be ruled out. Correct diagnosis must be made to allow proper follow-up of the patients and prevent life-threatening lesions.
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- 2024
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6. Microbiological alterations in the conjunctiva of hot tub-soaking ophthalmologists (MACHO): a randomized double-blind clinical trial
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Lee, Michele D, Pasricha, Neel, Driver, Todd H, Lopez, Sarah E, and Seitzman, Gerami D
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Biological Sciences ,Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Clinical Research ,Eye Disease and Disorders of Vision ,Clinical Trials and Supportive Activities ,bacterial ,conjunctiva ,conjunctival diseases ,conjunctivitis ,cornea ,corneal ulcer ,eye disease ,hot tub ,keratitis - Abstract
BackgroundTo determine if there is a difference in the quantity of microbial flora of the conjunctiva in individuals practicing head submersion ("dunk") versus no head submersion ("no-dunk") during hot tub use.MethodsIn this double-blind randomized clinical trial, healthy volunteers aged ≥ 18 years were recruited. Participants were randomized to head submersion versus no head submersion during a 15-minute hot tub soak. Study personnel, masked to the dunk or no-dunk group assignment, obtained conjunctival cultures before and immediately after hot tub use. De-identified specimens were submitted to the clinical microbiology laboratory for culture and analysis. The main outcome measure was the difference in the quantity of organisms cultured from the conjunctiva before and after hot tub exposure, as determined using a defined ordinal scale. A two-tailed Student's t-test was performed to compare the total microbial colony counts between the two arms. Simpson's diversity was used to measure the changes in organism diversity between the arms.ResultsOf 36 enrolled subjects, 19 were randomly assigned to the dunk and 17 were assigned to the no-dunk groups. Water samples obtained from all hot tubs were culture negative. Eleven of 19 eyes (58%) from the dunk group and eight of 17 eyes (47%) from the no-dunk group had negative conjunctival bacterial cultures before and after hot tub exposure. However, six of 19 eyes (32%) and four of 17 eyes (24%) of the dunk and no-dunk groups, respectively, were culture-positive after, but not before hot tub exposure. The quantity of organisms before and after hot tub exposure was not significantly different between the two arms (P = 0.12). However, the dunk group only showed a small increase in the quantity of organisms after as compared to before hot tub use (P = 0.03). None of the samples from subjects or hot tubs were culture-positive for Acanthamoeba.ConclusionsHead submersion in a public hot tubs during a 15-minute soak does not appear to change conjunctival flora, as determined by culture plate yield, this does not eliminate the association between hot tub use and devastating and painful corneal blindness. Therefore, our recommendation is to remove contact lenses prior to hot tub use, avoid head submersion in a hot tub, and urgently seek ophthalmological help if any eye pain and/or decrease in vision is experienced after hot tub use.
- Published
- 2020
7. Conjunctival Rebound After Scleral Lens Wear
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MKWalker, Instructor
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- 2021
8. Ocular Microvascular Changes in Patients With Sepsis
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Research Council of Lithuania and Andrius Pranskunas, MD
- Published
- 2020
9. Cytokine Profile of Conjunctivitis, Performed Through Tears Analysis Among Patients Treated With Dupilumab (CYCLADDE)
- Published
- 2019
10. Clinical signs of trachoma and laboratory evidence of ocular Chlamydia trachomatis infection in a remote Queensland community: a serial cross‐sectional study.
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Lynch, Kathleen D, Morotti, Wendy, Brian, Garry, Ketchup, Lenore, Kingston, Kozue, Starr, Mitchell, Ware, Robert S, Everill, Beth, Asgar, Nazihah, O'Keefe, Anne, Whop, Lisa J, Kaldor, John M, and Lambert, Stephen B
- Abstract
Objectives: To compare the findings of standard clinical assessments and of complementary clinical and laboratory methods for determining whether community‐wide treatment for trachoma is warranted in a remote Queensland community. Design: Three cross‐sectional screening surveys, 2019–2021, complemented by laboratory pathology testing. Setting: Small community in northwest Queensland with geographic and cultural ties to Northern Territory communities where trachoma persists. Participants: Children aged 1–14 years; opportunistic screening of people aged 15 years or more. Main outcome measures: Prevalence of clinical signs of trachoma, Chlamydia trachomatis infection, ocular non‐chlamydial infections, and seropositivity for antibodies to the C. trachomatis Pgp3 protein. Results: During the three surveys, 73 examinations of 58 children aged 1–4 years, 309 of 171 aged 5–9 years, and 142 of 105 aged 10–14 years for trachoma were undertaken, as were 171 examinations of 164 people aged 15 years or more; 691 of 695 examinations were of Aboriginal or Torres Strait Islander people (99%), 337 were of girls or young women (48%). Clinical signs consistent with trachomatous inflammation–follicular were identified in 5–9‐year‐old children 23 times (7%), including in eleven with non‐chlamydial infections and one with a C. trachomatis infection. One child (10–14 years) met the criteria for trachomatous scarring. Two of 272 conjunctival swab samples (all ages) were polymerase chain reaction‐positive for C. trachomatis (0.7%). Two of 147 people aged 15 years or more examined in 2019 had trichiasis, both aged 40 years or more. Seven of 53 children aged 1–9 years in 2019 and seven of 103 in 2021 were seropositive for anti‐Pgp3 antibodies. Conclusions: Despite the prevalence of clinical signs consistent with trachomatous inflammation–follicular among 5–9‐year‐old children exceeding the 5% threshold for community‐wide treatment, laboratory testing indicated that childhood exposure to ocular C. trachomatis is rare in this community. Laboratory testing should be integrated into Australian trachoma guidelines. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Observation on efficacy of pterygium excision combined with autologous limbal epithelial bulbar conjunctival transplantation in the treatment of patients with pterygium
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Le-Wen Jiang, Song-Tao Liu, and Liang Gao
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pterygium ,conjunctival diseases ,amniotic membrane transplantation ,ophthalmologic surgical procedures ,aesthetic degree ,clinical efficacy ,Ophthalmology ,RE1-994 - Abstract
AIM: To observe the efficacy of pterygium excision combined with autologous limbal epithelial bulbar conjunctival transplantation in the treatment of patients with pterygium. METHODS:Prospective controlled study. A total of 102 patients(102 eyes)with pterygium treated in the hospital between October 2015 and October 2019 were selected as study subjects, and they were divided into observation group and control group according to the random number table method, with 51 cases in each group. The control group was treated with pterygium excision combined with amniotic membrane transplantation, and the observation group was given pterygium excision combined with autologous limbal epithelial bulbar conjunctival transplantation. The perioperative indicators(intraoperative blood loss, surgical time, corneal epithelial repair time)and clinical efficacy at 3mo after surgery were compared between the two groups, and the disease recovery-related indicators [tear film break-up time(BUT), uncorrected visual acuity(UCVA), Schirmer Ⅰ test(SⅠt), corneal astigmatism degree(CAD)] before and 3mo after surgery, postoperative aesthetic degree and recurrence during follow-up were recorded.RESULTS:The corneal epithelial repair time in observation group was shorter than that in control group(4.14±1.35 vs 4.72±1.37d,P0.05). At 3mo after surgery, there was no statistical difference in the effective rate of treatment between the two groups(86.3% vs 78.4%, P>0.05). At 3mo after surgery, the BUT, UCVA and SⅠt in the two groups were significantly enhanced compared with those before surgery(all P0.05). The CAD in the two groups was significantly lower than that before surgery(P0.05). At 3mo after surgery, the scores of dimensions of aesthetic scale for pterygium treatment(ocular recovery, subjective symptoms)were significantly higher in observation group than those in control group(all P0.05). There was no statistically significant difference in recurrence rate between the two groups during follow-up(P>0.05).CONCLUSION: Pterygium excision combined with autologous limbal epithelial bulbar conjunctival transplantation can effectively treat pterygium and prevent recurrence, and it has faster postoperative recovery and better aesthetic degree compared to pterygium excision combined with amniotic membrane transplantation.
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- 2022
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12. Ocular surface inflammation impairs structure and function of meibomian gland
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Mizoguchi, Shin, Iwanishi, Hiroki, Arita, Reiko, Shirai, Kumi, Sumioka, Takayoshi, Kokado, Masahide, Jester, James V, and Saika, Shizuya
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Conjunctival Diseases ,Contact Lenses ,Corneal Edema ,Cytokines ,Epithelium ,Corneal ,Eyelid Diseases ,Humans ,Meibomian Glands ,Tears ,Meibomian gland ,Ocular surface inflammation ,Contact lens ,Conjunctivitis ,Rosacea ,Chemical burn ,Medical Biochemistry and Metabolomics ,Neurosciences ,Opthalmology and Optometry ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin.
- Published
- 2017
13. Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye
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Hospital Dr Sotero del Rio
- Published
- 2018
14. The in vitro efficacy of eye drops containing a bacteriophage solution specific for Staphylococcus spp. isolated from dogs with bacterial conjunctivitis
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Renata Urban-Chmiel, Ireneusz Balicki, Katarzyna Świąder, Anna Nowaczek, Ewelina Pyzik, Dagmara Stępień-Pyśniak, Agnieszka Marek, Andrzej Puchalski, Andrzej Wernicki, Ewa Poleszak, and Marta Dec
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Antibiotic resistance ,Conjunctival diseases ,Experimental medicine ,Bacterial infections ,Ophthalmology ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background The purpose of the study was to evaluate the in vitro antibacterial effect of experimental eye drops with bacteriophages in elimination of Staphylococcus spp. isolated from dogs with bacterial conjunctivitis.. The bacterial material was collected from dogs with independent clinical signs of bacterial conjunctivitis. Staphylococcus spp. were identified by phenotypic and genotypic methods (MALDI-TOF MS mass spectrometry). Antibiotic resistance was determined by the disc-diffusion method. Phage activity (Plaque forming units, PFU) was determined on double-layer agar plates. Phages with lytic titres > 108 PFU were used to prepare eye drops. The stability of the antibacterial titre was evaluated for preparations stored in sealed bottles as well as after opening and reclosing. Results The tests confirmed the occurrence of Staphylococcus spp. strains as etiological agents of bacterial conjunctivitis in dogs. A high percentage of strains were resistant to more than three antibiotics. The experimental phage eye drops used in the study exhibited 100% efficacy in vitro against the tested Staphylococcus isolates. Particularly noteworthy is the long duration of activity and constant antibacterial lytic titre of ≥108 PFU/mL of two eye drop solutions, nos. 7 and 12, after the bottle had been opened (21 days) and after hermetically sealed packaging (28 days) at 4–8 °C. Conclusions The results represent the first stage of research and require continuation in vivo. If positive effects are obtained in animals, the results can be used in applied research in humans and animals.
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- 2020
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15. Long-term Safety and Efficacy of Latanoprostene Bunod 0.024% in Japanese Subjects with Open-Angle Glaucoma or Ocular Hypertension: The JUPITER Study
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Kawase, Kazuhide, Vittitow, Jason L, Weinreb, Robert N, Araie, Makoto, and For the JUPITER Study Group
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Neurosciences ,Patient Safety ,Neurodegenerative ,Aging ,Clinical Research ,Clinical Trials and Supportive Activities ,Eye Disease and Disorders of Vision ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Eye ,Antihypertensive Agents ,Conjunctival Diseases ,Dinoprost ,Drug Monitoring ,Female ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Japan ,Long Term Adverse Effects ,Male ,Middle Aged ,Ophthalmic Solutions ,Prostaglandins F ,Synthetic ,Tonometry ,Ocular ,Treatment Outcome ,Intraocular pressure ,Nitric oxide ,Ocular hypertension ,Open-angle glaucoma ,Ophthalmology ,Prostaglandin ,JUPITER Study Group ,Pharmacology and Pharmaceutical Sciences ,General Clinical Medicine - Abstract
IntroductionLatanoprostene bunod (LBN) is a novel nitric oxide (NO)-donating prostaglandin F2α analog. We evaluated the long-term safety and intraocular pressure (IOP)-lowering efficacy of LBN ophthalmic solution 0.024% over 1 year in Japanese subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).MethodsThis was a single-arm, multicenter, open-label, clinical study. Subjects aged 20 years and older with a diagnosis of OAG or OHT instilled 1 drop of LBN ophthalmic solution 0.024% in the affected eye(s) once daily in the evening for 52 weeks and were evaluated every 4 weeks. Safety assessments included vital signs, comprehensive ophthalmic exams, and treatment-emergent adverse events (AEs). Absolute and percent reductions from baseline in IOP were also determined.ResultsOf 130 subjects enrolled, 121 (93.1%) completed the study. Mean age was 62.5 years, and mean (standard deviation) baseline IOP was 19.6 (2.9) and 18.7 (2.6) mmHg in study eyes and treated fellow eyes, respectively. Overall, 76/130 (58.5%) and 78/126 (61.9%) subjects experienced ≥1 AEs in study eyes and treated fellow eyes, respectively. In both study eyes and treated fellow eyes, the most common AEs were conjunctival hyperemia, growth of eyelashes, eye irritation, and eye pain. At 52 weeks, 9% of treated eyes had an increase in iris pigmentation compared with baseline based on iris photographs. No safety concerns emerged based on vital signs or other ocular assessments. Mean reductions from baseline in IOP of 22.0% and 19.5% were achieved by week 4 in study and treated fellow eyes, respectively. These reductions were maintained through week 52 (P
- Published
- 2016
16. Conjunctival pyogenic granuloma during pregnancy.
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Zahid Şekkeli, Mehmet, Banu Hoşal, Melek, Öcal, Elif, and Heper, Aylin
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GRANULOMA ,KAPOSI'S sarcoma ,HISTOPATHOLOGY ,PREGNANCY ,IMMUNOSTAINING ,SARCOIDOSIS - Abstract
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- Published
- 2021
- Full Text
- View/download PDF
17. The in vitro efficacy of eye drops containing a bacteriophage solution specific for Staphylococcus spp. isolated from dogs with bacterial conjunctivitis.
- Author
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Urban-Chmiel, Renata, Balicki, Ireneusz, Świąder, Katarzyna, Nowaczek, Anna, Pyzik, Ewelina, Stępień-Pyśniak, Dagmara, Marek, Agnieszka, Puchalski, Andrzej, Wernicki, Andrzej, Poleszak, Ewa, and Dec, Marta
- Subjects
- *
EYE drops , *CONJUNCTIVITIS , *STAPHYLOCOCCUS , *BACTERIOPHAGES , *DOGS , *DRUG resistance in bacteria - Abstract
Background: The purpose of the study was to evaluate the in vitro antibacterial effect of experimental eye drops with bacteriophages in elimination of Staphylococcus spp. isolated from dogs with bacterial conjunctivitis. The bacterial material was collected from dogs with independent clinical signs of bacterial conjunctivitis. Staphylococcus spp. were identified by phenotypic and genotypic methods (MALDI-TOF MS mass spectrometry). Antibiotic resistance was determined by the disc-diffusion method. Phage activity (Plaque forming units, PFU) was determined on double-layer agar plates. Phages with lytic titres > 108 PFU were used to prepare eye drops. The stability of the antibacterial titre was evaluated for preparations stored in sealed bottles as well as after opening and reclosing. Results: The tests confirmed the occurrence of Staphylococcus spp. strains as etiological agents of bacterial conjunctivitis in dogs. A high percentage of strains were resistant to more than three antibiotics. The experimental phage eye drops used in the study exhibited 100% efficacy in vitro against the tested Staphylococcus isolates. Particularly noteworthy is the long duration of activity and constant antibacterial lytic titre of ≥108 PFU/mL of two eye drop solutions, nos. 7 and 12, after the bottle had been opened (21 days) and after hermetically sealed packaging (28 days) at 4-8 °C. Conclusions: The results represent the first stage of research and require continuation in vivo. If positive effects are obtained in animals, the results can be used in applied research in humans and animals. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
18. Cornea and Ocular Surface Disease
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Robertson, Danielle M, Alexander, Larry J, Bonanno, Joseph A, Fleiszig, Suzanne MJ, and McNamara, Nancy
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Biomedical Research ,Conjunctival Diseases ,Corneal Diseases ,Dry Eye Syndromes ,Eye Infections ,Eyelid Diseases ,Humans ,Optometry ,cornea ,anterior segment ,infection ,diabetes ,dry eye ,endothelium ,physiology ,Medical and Health Sciences ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
: Clinician-scientists bridge the gap between basic research and patient care. At the 2012 Annual Meeting, a symposium highlighting the application of cutting-edge optometric research within the anterior segment was held to present and discuss some of the recent basic scientific advances that will both shape and guide the development of future clinical care practices. This article summarizes this work, bringing together four experts, all clinician-scientists in the field of cornea and ocular surface. Collectively, this work provides new insights to clinicians and researchers alike, as well as brings forth a greater appreciation of the impact of ongoing optometric bench research in advancing clinical care.
- Published
- 2014
19. Mechanical Complications Induced by Silicone Hydrogel Contact Lenses
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Lin, Meng C and Yeh, Thao N
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Bioengineering ,Patient Safety ,Conjunctival Diseases ,Contact Lenses ,Extended-Wear ,Corneal Diseases ,Eyelid Diseases ,Humans ,Hydrogels ,Silicones ,Silicone hydrogel ,Contact lenses ,Mechanical complications ,Mechanical adverse events ,Mucin balls ,Superior epithelial arcuate lesions ,SEAL ,Corneal erosions ,Contact lens-induced papillary conjunctivitis ,Conjunctival epithelial flaps ,Lid wiper epitheliopathy ,Meibomian gland dropout ,Opthalmology and Optometry ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
With the introduction of silicone hydrogel (SiHy) lenses over a decade ago, clinicians have seen both improvements and challenges in contact lens (CL) wear. Regardless of lens design or material, the presence of a CL on the ocular surface induces mechanical complications. Although some of these complications have diminished in frequency and severity with newer generations of SiHy lenses, others persist at previously reported levels. The aim of this review is to provide up-to-date information on mucin balls, superior epithelial arcuate lesions, corneal erosions, CL-induced papillary conjunctivitis, conjunctival epithelial flaps, lid wiper epitheliopathy, and meibomian gland dropout. The conclusions in this review should provide a sound basis for identifying the future areas of research to help minimize mechanically driven adverse events during CL wear with SiHy lenses.
- Published
- 2013
20. Glaucoma drainage devices in children: an updated review.
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Vasconcelos AT, Massote JA, Senger C, Barbieri LP, Cronemberger S, and Paula JS
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- Child, Humans, Intraocular Pressure, Prosthesis Implantation methods, Retrospective Studies, Treatment Outcome, Glaucoma Drainage Implants adverse effects, Glaucoma surgery, Conjunctival Diseases
- Abstract
Implantation of glaucoma drainage devices is a valuable therapeutic option, particularly in children with glaucoma refractory to primary surgical treatment. Glaucoma drainage devices are typically used when conjunctival scarring hampers filtration surgery or prior angle procedures are not effective in controlling intraocular pressure. Despite known complications, the use of glaucoma drainage devices in children has increased in recent years, even as the primary surgical option. In this review, we evaluate the results of recent studies involving the implantation of glaucoma drainage devices in children, discussing new advances, and comparing the success rates and complications of different devices.
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- 2024
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21. Clinical images: Calabar swelling caused by Loa loa mimicking polyarthritis.
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Jannot X, Gerber V, Hallynck X, Willaume T, and Mertz P
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- Animals, Humans, Loa, Loiasis diagnosis, Conjunctival Diseases
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- 2024
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22. Association of Conjunctival Ulceration With Pembrolizumab.
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Kuhar B, Bailey J, and Aeum J
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- Humans, Antibodies, Monoclonal, Humanized, Conjunctival Diseases
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- 2024
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23. Sutureless amniotic membrane (ProKera®) in the management of symblepharon after Steven-Johnson syndrome: A case report.
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Lin CW, Wang JJ, Lai CH, and Wu PL
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- Humans, Amnion, Cicatrix, Vision Disorders, Conjunctival Diseases, Eyelid Diseases
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- 2024
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24. Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease.
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Gangaputra S, Newcomb C, Armour R, Choi D, Ying GS, Groth S, Begum H, Fitzgerald T, Artornsombudh P, Daniel E, Bhatt N, Foster S, Jabs D, Levy-Clarke G, Nussenblatt R, Rosenbaum JT, Sen HN, Suhler E, Thorne J, Dreger K, Buchanich J, and Kempen JH
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- Adult, Humans, Child, Retrospective Studies, Treatment Outcome, Visual Acuity, Vision Disorders, Cataract complications, Cataract Extraction methods, Phacoemulsification, Uveitis complications, Uveitis diagnosis, Uveitis surgery, Conjunctival Diseases
- Abstract
Purpose: To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease., Setting: Tertiary care academic centres., Design: Multicentre retrospective cohort study., Methods: A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was used to gather clinical data. Multivariable logistic regression models with adjustment for intereye correlations were performed to evaluate the prognostic factors for VA outcomes. Main outcome measure was VA after cataract surgery., Results: Uveitic eyes independent of anatomical location showed improved VA from baseline (mean 20/200) to within 3 months (mean 20/63) of cataract surgery and maintained through at least 5 years of follow-up (mean 20/63). Eyes that achieved 20/40 or better VA at 1 year were more likely to have scleritis (OR=1.34, p<0.0001) or anterior uveitis (OR=2.2, p<0.0001), VA 20/50 to 20/80 (OR 4.76 as compared with worse than 20/200, p<0.0001) preoperatively, inactive uveitis (OR=1.49, p=0.03), have undergone phacoemulsification (OR=1.45 as compared with extracapsular cataract extraction, p=0.04) or have had intraocular lens placement (OR=2.13, p=0.01). Adults had better VA immediately after surgery, with only 39% (57/146) paediatric eyes at 20/40 or better at 1 year., Conclusions: Our results suggest that adult and paediatric eyes with uveitis typically have improved VA following cataract surgery and remain stable thereafter for at least 5 years., Competing Interests: Competing interests: JTR: AbbVie (consultant); Gilead (consultant); Janssen (consultant); Eyevensys (consultant); UpToDate (author/royalties); Pfizer (financial support); Novartis (consultant); Roche (consultant); Alcon Research Institute (financial support); Horizon (financial support and consultant); Revolo (consultant); Neoleukin (consultant); Affibody (consultant); Celgene-Bristol Myers (Data Monitoring Committee); Eli Lilly (Clinical Endpoints Committee). GL-C: AbbVie (consultant, lecture fees); Allergan (grant support); Mallinckrodt (consultant, grant support); Sanofi (grant support, lecture fees). ES: Eyevensys (consultant); Santen (consultant); EyeGate (consultant, financial support); AbbVie (consultant, financial support); Clearside (consultant, financial support); EyePoint (consultant, financial support). SGa: Merit CRO (consultant); NEI (grant support); RPB (grant support). SGr: Olleyes (grant support). JT: AbbVie (consultant); ADVISE/MERIT, NEI (grant support); Gilead (consultant); Roche (consultant); Tarsier Pharma (equity owner); UpToDate (consultant). JHK: Gilead (consultant); Betaliq (equity owner); Tarsier Pharma (equity owner)., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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25. Dacryops and clinical diagnostic challenges
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Waleed K. Alsarhani, Azza Maktabi, Eman Al-Sharif, Adel H. Alsuhaibani, Yasser H. Al-Faky, and Hind M. Alkatan
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Adult ,medicine.medical_specialty ,Lacrimal Apparatus Diseases ,medicine.diagnostic_test ,Cysts ,business.industry ,Mechanical ptosis ,Lacrimal Apparatus ,Accessory Lacrimal Gland ,Retrospective cohort study ,Physical examination ,General Medicine ,Lacrimal gland ,Dermatology ,Conjunctival Diseases ,Ophthalmology ,medicine.anatomical_structure ,Humans ,Medicine ,CONJUNCTIVAL SCARRING ,business ,Retrospective Studies - Abstract
The study aims to describe the clinical and histopathologic features of different types of dacryops and their clinical diagnostic challenges.This is a retrospective cohort study of all surgically excised cases of dacryops in 2 tertiary eye hospitals in Riyadh, Saudi Arabia.The study included 58 dacryops specimens from 55 patients with an average age of 41.2 years (range, 4-78 years). The most common location was the upper lid (60.3%), whereas the least expected location was the caruncle (6.9%). The most common site of dacryops occurrence was in the accessory lacrimal gland (55.2%), the main lacrimal gland (32.8%), and then ectopic dacryops (12%). All patients presented with lid swelling alone except for 3 patients who experienced secondary mechanical ptosis. On physical examination, conjunctival scarring existed in 4 patients (6.9%). Preoperative diagnosis of dacryops was accurate in 44.8% of the cases. Dacryops of the main lacrimal gland was accurately diagnosed clinically in all cases compared with other locations, which was statistically significant (p0.001). The causes of inaccurate clinical diagnoses were hidrocystoma (26.9%), inclusion cyst (11.5%), and dermoid cyst (7.7%), whereas the remaining cases were diagnosed as cysts without a specific subtype (53.9%). Recurrence of the lesion was observed in 2 cases (3.5%). No clinical or histopathologic factors were associated with a risk of recurrence.Dacryops can represent a diagnostic challenge to ophthalmologists. Familiarity with clinical presentations and findings is required to diagnose dacryops outside the main lacrimal gland.
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- 2022
26. Comparação dos meios de preparação e preservação de membrana amniótica humana para uso no tratamento de doenças da superfície ocular.
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von Harbach Ferenczy, Peter Alexander and Barbosa de Souza, Luciene
- Subjects
- *
AMNION , *MORPHOLOGY , *GROWTH factors , *EPITHELIAL cells , *EXTRACELLULAR matrix - Abstract
Currently, the amniotic membrane (AM) has obtained importance due to its ability to reduce inflammation, helping in the healing and epithelialization processes, having antimicrobial and antiviral properties and low immunogenicity. Its indications in ophthalmology have increased considerably in the past two decades. Objective: To describe the basic structure and biological properties of the AM, the components of the extracellular matrix and growth factors, the consequences of different techniques used in its preservation, and sterilization methods for the epithelium removal. To compare the costs of the different preservation solutions currently employed. Study design: literature review. Methods: Research in BVS databases, PubMed, Cochrane, Scielo and Lilacs with keywords: amniotic membrane transplantation, corneal reconstruction, conjunctival diseases. Results: The literature is vast in describing the effects of different agents and techniques used in the preparation of MA, including its preservation, sterilization and desepithelization. The naked membrane is the choice to reconstruct the ocular surface, as it facilitates the healing course. Regarding the preservatives, glycerol is the most used worldwide due its low cost and easy handling. Conclusion: Comparing different techniques guides us in developing a MA preparation protocol for ophthalmic use. The naked membrane facilitates the healing process compared with the presence of epithelial cells. The glycerol is the most used preservation method because of its low cost and easy handling. [ABSTRACT FROM AUTHOR]
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- 2020
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27. Conjunctival Epithelial Flap in Continuous Contact Lens Wear
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Graham, Andrew D, Truong, Tan N, and Lin, Meng C
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Eye Disease and Disorders of Vision ,Prevention ,Aetiology ,2.1 Biological and endogenous factors ,Conjunctival Diseases ,Contact Lenses ,Epithelium ,Equipment Design ,Female ,Gases ,Humans ,Hydrogel ,Polyethylene Glycol Dimethacrylate ,Incidence ,Kaplan-Meier Estimate ,Male ,Permeability ,Proportional Hazards Models ,Risk Assessment ,Silicones ,Time Factors ,Young Adult ,conjunctiva ,contact lens ,continuous wear ,silicone hydrogel ,gas permeable ,conjunctival epithelial flap ,survival analysis ,Medical and Health Sciences ,Ophthalmology & Optometry - Abstract
PurposeComposed of sheets of cells detached from the underlying conjunctiva, conjunctival epithelial flap (CEF) is a recently reported phenomenon associated with contact lens wear with potential consequences for ocular health. Although CEF is generally asymptomatic, it is not known to what extent it might increase the longer-term risk of discomfort, inflammatory response, or infection. In this study, we use survival analysis methods to obtain unbiased estimates of the probability of developing CEF, the mean survival time free of CEF, and the effects of age, gender, ethnicity, and contact lens type.MethodsTwo hundred four subjects were recruited for a continuous wear (CW) study of silicone hydrogel (SiH) and gas permeable (GP) contact lenses. Subjects were examined by optometrists throughout contact lens adaptation and CW periods. Statistical methods included the Kaplan-Meier nonparametric estimator of the survival function and the Cox proportional hazards model for estimating the relative effects of covariates.ResultsOf the 204 subjects, 72 (35%) developed CEF. In 64% of cases, CEFs were observed bilaterally. The majority of cases (90.3%) presented with CEF in the superior conjunctiva. Mean survival time free of CEF was longer for GP lenses (94.3 days) than for SiH lenses (76.5 days), and the probability of developing CEF was significantly greater for SiH lenses (p = 0.002). Although there was some evidence that women and non-Asians remain free of CEF longer, the effects of age, gender, and ethnicity were not statistically significant.ConclusionsThere was a significantly increased risk of CEF in subjects wearing SiH lenses, compared with GP lenses. Subjects wearing SiH lenses remained free of CEF for a shorter time on average. Further study is needed to determine whether the increased incidence of CEF in CW with SiH lenses poses an increased risk of adverse ocular response or infection.
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- 2009
28. Clinicopathologic analysis of conjunctivochalasis and paste-pinch-cut conjunctivoplasty for management
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Sepideh Siadati, Charles G. Eberhart, Tiffany S. Liu, and Esen K. Akpek
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medicine.medical_specialty ,genetic structures ,Conjunctival Diseases ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,Ophthalmology ,Chart review ,Humans ,Medicine ,Retrospective Studies ,Inflammation ,Goblet cell ,business.industry ,Outcome measures ,General Medicine ,LISSAMINE GREEN ,Conjunctivochalasis ,medicine.disease ,eye diseases ,Squamous metaplasia ,Staining ,medicine.anatomical_structure ,Tears ,030221 ophthalmology & optometry ,Dry Eye Syndromes ,Fluorescein ,sense organs ,business ,Conjunctiva - Abstract
Objective To correlate the histopathologic results of conjunctival specimens with clinical findings in patients with conjunctivochalasis and report the results of the paste-pinch-cut technique for management. Design Retrospective chart review. Methods SETTING: Single tertiary ophthalmological centre (Ocular Surface Diseases and Dry Eye Clinic, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Md.). Methods Twenty-five patients (32 eyes) with clinically significant conjunctivochalasis. All patients were referred for clinically significant dry eye without previous diagnosis of chalasis. Sixteen patients had an underlying inflammatory systemic condition. Intervention or Observation Procedure(s): Patients underwent surgery with paste-pinch-cut technique. Subjective dry eye symptoms and ocular surface staining scores (corneal and conjunctival staining using fluorescein and lissamine green respectively) were assessed at every visit. Main outcome measures Change in patient symptoms and ocular surface staining scores and histopathologic findings in conjunctival specimens. Results After surgery, significant improvement was achieved in dry-eye symptoms as well as both corneal and conjunctival staining scores in 29 eyes on reduced topical therapy. Only 3 eyes had persisting conjunctival lissamine staining. Light microscopic examination disclosed mild to moderate lymphoplasmocytic inflammation of the conjunctivae with areas of epithelial goblet cell loss, squamous metaplasia, stromal edema, and fibrosis. Conclusion Conjunctivochalasis appears to be associated with significant inflammation in the setting of dry eye and underlying inflammatory systemic conditions. Although topical anti-inflammatory treatment could be attempted in the initial management, surgical excision should be considered in the absence of clinical response.
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- 2022
29. Case Series of Patients With Hereditary Benign Intraepithelial Dyskeratosis
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Mason, Seely, Kevin, Jackson, Austin, Meeker, and Melissa, Daluvoy
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Cornea ,Ophthalmology ,Skin Abnormalities ,Humans ,Prostheses and Implants ,Conjunctival Diseases ,Epithelium ,Corneal Diseases ,Retrospective Studies - Abstract
The purpose of this retrospective case series was to compare the outcomes of different treatment options for patients diagnosed with hereditary benign intraepithelial dyskeratosis (HBID).The study is designed as a single-institution retrospective chart review of patients who were clinically diagnosed with HBID during their care at the Duke Eye Center. Patient demographics were obtained, and disease course after different therapies was analyzed.Seventeen patients were diagnosed with HBID. 52.9% (9/17) of patients identified with HBID reported Native American ancestry. Medical therapy alone failed to reduce the size or number of corneal lesions in any patient identified in this study. Ten of the 17 patients required surgical intervention. Two eyes received corneal biopsies, 3 eyes received a full conjunctival lesion excision with amniotic membrane grafting, 12 eyes received superficial keratectomy with amniotic membrane grafting, and 1 eye received keratoprosthesis. Lesion recurrence was seen in 9 of the 10 patients treated with surgical excision with an average time to recurrence of 1.5 and 2 months for conjunctival excisions and superficial keratectomy, respectively, when excluding patients who missed scheduled postoperative follow-up appointments.Hereditary benign intraepithelial dyskeratosis is a rare and poorly understood disorder that predominantly affects people with Native American ancestry. Medical therapy only provides symptomatic relief, and patients who receive surgical excision almost always develop recurrence. As a result, we recommend future investigations focus on identifying the optimal surgical technique and timing to limit the morbidity of HBID and improve outcomes.
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- 2022
30. Conjunctival Microbiome-Host Responses Are Associated With Impaired Epithelial Cell Health in Both Early and Late Stages of Trachoma
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Harry Pickering, Christine D. Palmer, Joanna Houghton, Pateh Makalo, Hassan Joof, Tamsyn Derrick, Adriana Goncalves, David C. W. Mabey, Robin L. Bailey, Matthew J. Burton, Chrissy H. Roberts, Sarah E. Burr, and Martin J. Holland
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trachoma ,immune response ,microbiome ,innate immunity ,conjunctival diseases ,Microbiology ,QR1-502 - Abstract
Background: Trachoma, a neglected tropical disease, is the leading infectious cause of blindness and visual impairment worldwide. Host responses to ocular chlamydial infection resulting in chronic inflammation and expansion of non-chlamydial bacteria are hypothesized risk factors for development of active trachoma and conjunctival scarring.Methods: Ocular swabs from trachoma endemic populations in The Gambia were selected from archived samples for 16S sequencing and host conjunctival gene expression. We recruited children with active trachoma and adults with conjunctival scarring, alongside corresponding matched controls.Findings: In children, active trachoma was not associated with significant changes in the ocular microbiome. Haemophilus enrichment was associated with antimicrobial responses but not linked to active trachoma. Adults with scarring trachoma had a reduced ocular bacterial diversity compared to controls, with increased relative abundance of Corynebacterium. Increased abundance of Corynebacterium in scarring disease was associated with innate immune responses to the microbiota, dominated by altered mucin expression and increased matrix adhesion.Interpretation: In the absence of current Chlamydia trachomatis infection, changes in the ocular microbiome associate with differential expression of antimicrobial and inflammatory genes that impair epithelial cell health. In scarring trachoma, expansion of non-pathogenic bacteria such as Corynebacterium and innate responses are coincident, warranting further investigation of this relationship. Comparisons between active and scarring trachoma supported the relative absence of type-2 interferon responses in scarring, whilst highlighting a common suppression of re-epithelialization with altered epithelial and bacterial adhesion, likely contributing to development of scarring pathology.
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- 2019
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31. Patient Adherence to Immunosuppressive Therapy in Treatment of Chronic Inflammatory Eye Disease.
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Bharadwaj AD, Kravets S, Hallak J, Bhat P, and Lobo-Chan AM
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- Humans, Retrospective Studies, Immunosuppression Therapy, Medication Adherence, Chronic Disease, Immunosuppressive Agents therapeutic use, Conjunctival Diseases
- Abstract
Title: Patient Adherence to Immunosuppressive Therapy for Chronic Inflammatory Eye Disease., Purpose: To investigate adherence rates to immunosuppressive therapy (IMT) for treatment of noninfectious inflammatory eye disease (IED), adherence and disease control, and factors associated with nonadherence., Method: Retrospective review of medical charts from 2015 to 2020 was conducted on patients with IED at 6 months, 1 and 2 years after initiation of IMT., Results: Of 183 patients, adherence rates at 6 months and 1 year were 70% and 58% by 2 years. Eighty-two percent, 78%, and 65% of patients with disease quiescence were adherent at 6 months, 1 and 2 years, respectively. Adherent patients have 1.86 (95% CI 1.09, 3.20) times greater likelihood for disease control compared to nonadherent. Primary reason for nonadherence was patient self-discontinuation. No specific factors were associated with nonadherence., Conclusion: Patients on IMT for IED had steady adherence rates up to 1 year, with decreased adherence at 2 years. Adherence to IMT significantly correlates with disease quiescence.
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- 2024
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32. Adaptation of an eHealth Intervention: iSupport for Carers of People with Rare Dementias.
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Naunton Morgan B, Windle G, Lamers C, Brotherhood E, and Crutch S
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- Humans, Caregivers, Conjunctival Diseases, Telemedicine, Dementia, Corneal Diseases, Dermoid Cyst
- Abstract
'iSupport' is an online psychoeducation and skills development intervention created by the World Health Organisation to support people with dementia. This project adapted iSupport for carers of people with rare dementias (iSupport RDC), creating a new resource to support the health and wellbeing of this underserved population. The adaptation involved three phases: (1) Co-design methods to generate preliminary adaptations; (2) Analysis of phase one findings informing adaptations to iSupport to develop; iSupport RDC; (3) Post-adaptation survey to ascertain participant agreement with the adaptations in iSupport RDC. Fourteen participants contributed, resulting in 212 suggested adaptations, of which 94 (92%) were considered practical, generalisable, and aligned with iSupport principles. These adaptations encompassed content and design changes, including addressing the challenges of rare dementias (PCA, PPA, LBD, and FTD). iSupport RDC represents a significant adaptation of the WHO iSupport intervention. Its tailored nature acknowledges the unique needs of people caring for someone with a rare dementia, improving their access to specialised resources and support. By extending iSupport to this population, it contributes to advancing dementia care inclusivity and broadening the understanding of rare dementias. A feasibility study is underway to assess iSupport RDCs acceptability, with prospects for cultural adaptations to benefit carers globally.
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- 2023
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33. The Use of Natural Latex Biomembrane in Ocular Surface Reconstruction
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Erika Christina Canarim Martha de Pinho
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- 2010
34. Giant Ocular Lipodermoid Cyst in Encephalocraniocutaneous Lipomatosis: Surgical Treatment and Genetic Analysis.
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Córdoba, Andrea, Graue-Hernández, Enrique O., Navas, Alejandro, Chacon-Camacho, Oscar F., Zenteno, Juan C., Ramirez-Miranda, Arturo, Antonio Bermudez-Magner, Jose, Ordaz-Robles, Thania, Pérez-Solórzano, Sofia, and Olivo-Payne, Andrew
- Subjects
- *
LIPOMATOSIS , *NEUROCUTANEOUS disorders , *CENTRAL nervous system , *CORNEAL opacity , *DERMOID cysts , *CONJUNCTIVA - Abstract
Objective: Rare disease Background: Encephalocraniocutaneous lipomatosis is a rare neurocutaneous disorder characterized by cutaneous, ocular, and central nervous system anomalies; its molecular etiology was recently identified. This report describes the surgical treatment and genetic characterization of a giant ocular lipodermoid cyst secondary to encephalocraniocutaneous lipomatosis. Case Report: An 11-year-old girl with past medical history of absence seizures presented with a reddish protruding mass in her right eye involving the temporal conjunctiva and the peripheral temporal cornea; eyelid closure was not possible due to mass protrusion. She also presented skin tags at the level of the external canthus and 3 alopecic areas at the level of the scalp compatible with nevus psiloliparus. No family history was reported. A dermoid cyst was suspected and excisional biopsy was performed under general anesthesia. A large conjunctival and lamellar corneoscleral resection was done, followed by a corneal tectonic graft. Molecular analysis was carried out, including PCR and Sanger sequencing on DNA obtained from the mass. After surgery, the patient achieved complete eyelid closure, reduction of ocular surface symptoms, and improved aesthetic appearance. Histological analysis confirmed a lipodermoid cyst; genetic tests confirmed a mosaic activating mutation in FGFR1 (c.1638C>A, p.Asn546Lys). The diagnosis was encephalocraniocutaneous lipomatosis. Conclusions: ECCL is a rare condition; an accurate diagnosis comprising clinical and genetic aspects can facilitate the monitoring of possible complications, improve the multidisciplinary treatment, and provide valuable information for future therapy developments. In this case, the patient’s quality of life improved significantly, ocular symptoms disappeared, and a good esthetic appearance was achieved. [ABSTRACT FROM AUTHOR]
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- 2019
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35. Descripción de morbilidad visual y ocular analizada en la Región Central de Colombia acorde con los reportes RIPS (2013-2015).
- Author
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Gil, Jesús Daniel, Herrera Osorio, Jessica Alejandra, and Narváez Rumie, Olivia Margarita
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MEDICAL care ,MEDICAL records ,CONJUNCTIVA ,VISION disorders ,POPULATION aging ,DISEASES ,VISUAL accommodation - Abstract
Copyright of Revista Ciencia y Poder Aéreo is the property of Escuela de Postgrados de la Fuerza Aerea Colombiana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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36. Graft-versus-Host Disease: Review.
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Batista Abud, Tulio, Di Zazzo, Antonio, de Oliveira, Lauro Augusto, and de Sousa, Luciene Barbosa
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- *
GRAFT versus host disease , *HEMATOPOIETIC stem cell transplantation , *LACRIMAL apparatus , *EYE diseases - Abstract
Graft-versus-host Disease (GVHD) is a major complication with high morbidity and mortality rates on patients undergoing hematopoietic stem cell transplantation. The ocular involvement, named ocular GVHD, may affect all structures of the eyes, but the lacrimal unit (lacrimal glands and ocular surface) is the main target of the inflammatory response mediated by the donor T cells. The development of dry eye disease is the main clinical ocular manifestation, and the association of a variety of therapeutics options is necessary. The aim of the review is to describe the clinical manifestations, diagnostic criteria, impact in quality of life, the current treatment and future perspectives of this disease that demands a multidisciplinary follow-up. [ABSTRACT FROM AUTHOR]
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- 2019
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37. Doença do Enxerto-versus- hospedeiro ocular: Revisão.
- Author
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Batista Abud, Tulio, Di Zazzo, Antonio, de Oliveira, Lauro Augusto, and de Sousa, Luciene Barbosa
- Subjects
- *
HEMATOPOIETIC stem cell transplantation , *LACRIMAL apparatus , *GRAFT versus host disease , *EYE diseases , *T cells - Abstract
Graft-versus-host Disease (GVHD) is a major complication with high morbidity and mortality rates on patients undergoing hematopoietic stem cell transplantation. The ocular involvement, named ocular GVHD, may affect all structures of the eyes, but the lacrimal unit (lacrimal glands and ocular surface) is the main target of the inflammatory response mediated by the donor T cells. The development of dry eye disease is the main clinical ocular manifestation, and the association of a variety of therapeutics options is necessary. The aim of the review is to describe the clinical manifestations, diagnostic criteria, impact in quality of life, the current treatment and future perspectives of this disease that demands a multidisciplinary follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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38. Does the conjunctivochalasis accompanied by pseudoexfoliation syndrome affect the ocular surface and anterior segment structures?
- Author
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Hakan Öztürk and Bediz Özen
- Subjects
Cornea ,Aging ,Ophthalmology ,Tears ,Humans ,Dry Eye Syndromes ,Exfoliation Syndrome ,Conjunctival Diseases ,Intraocular Pressure - Abstract
Purpose: Probability of coexistence of conjunctivochalasis and pseudoexfoliation syndrome (PES) in same individual may increase with aging. We investigated effects of conjunctivochalasis accompanied by PES on ocular surface (OS) and anterior segment (AS) structures.Methods: Cases with only conjunctivochalasis were determined as group-1 (n=62), cases with conjunctivochalasis accompanied by PES as group-2 (n=45), and healthy cases as group-3 (n=56). OS and AS parameters of groups were compared.Results: Compared to group-1, group-2 had higher grade-3 conjunctivochalasis (17.7% vs 46.7%, p=0.039), greater mean grade of conjunctivochalasis (MGC) (1.72±0.24 vs 2.29±0.32, p=0.036), higher total conjunctivochalasis score (TCS) (4.27±1.13 vs 6.12±1.35, p=0.025), shorter tear-film break-up time (TBUT) (9.17±2.53 vs 5.41±1.32, p=0.010), greater OS disease index (OSDI)-score (16.28±3.15 vs 27.36±4.12, p=0.037). Compared to group-3, both group-1 and group-2 had shorter TBUT (group 3-1: p=0.004; group 3-2: p0.05). In group-1 and group-2, as age increased, both MGC (r=0.349, p=0.043; r=0.403, p=0.022, respectively) and TCS (r=0.322, p=0.046; r=0.372, p=0.031) increased. In group-2, as both MGC and TCS increased, TBUT (r=-0.370, p=0.034; r=-0.401, p=0.025) decreased and OSDI score (r=0.338, p=0.045; r=0.362, p=0.040) increased.Conclusions: To our knowledge, this was the first study comprehensively investigating effects of conjunctivochalasis accompanied by PES on OS and AS structures together. We found that conjunctivochalasis might cause OS disease, while presence of PES in conjunctivochalasis cases might worsen OS disease and conjunctivochalasis findings.
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- 2022
39. Clinical and histopathological features of conjunctival 'Teddy bear' granuloma: A case series
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Alejandra Lozano-Bustillo, Dolores Ríos y Valles-Valles, Ivette Hernández-Ayuso, and Abelardo A. Rodríguez-Reyes
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Male ,Granuloma, Foreign-Body ,Periodic Acid ,COVID-19 ,General Medicine ,Conjunctivitis ,Conjunctival Diseases ,Cicatrix ,Ophthalmology ,Adrenal Cortex Hormones ,Child, Preschool ,Formaldehyde ,Communicable Disease Control ,Eosine Yellowish-(YS) ,Humans ,Female ,Child ,Hematoxylin ,Pandemics - Abstract
Purpose To describe the clinical features, histopathological findings, and prognosis of conjunctival Teddy bear granuloma (TBG) diagnosed in a Mexican ophthalmologic referral center in a period of 64 years. Methods We reviewed clinical and histopathological material from all patients with documented conjunctival TBG. Patient′s age, gender, location, clinical signs and symptoms, duration, treatment and, specimen size, were evaluated. Formalin-fixed paraffin embedded 5 microns hematoxylin-eosin stained slides and periodic acid-Schiff special stain as well as examination under polarized light microscopy were performed in all cases. Results A total of 5 conjunctival TBG were collected. The ages of the patients ranged between 2 and 11 with a mean of 6 years. Female to male ratio was 4:1. The right inferior fornix was involved in 4 cases (80%) with clinical diagnosis of conjunctival mass of unknown etiology. Treatment consisted of surgical removal by slit-lamp biomicroscopy (3 cases) and in the operating room (2 cases). No complications were informed in a short follow-up period. Histopathologically, numerous cross-sections of synthetic and non-synthetic fibers surrounded by multinucleated foreign body giant cells, epithelioid histiocytes, lymphocytes, plasma cells and sparse neutrophils were seen. Polarization light microscopy demonstrated numerous birefringent colorful foreign fibers. The follow-up period of the patients ranged between 1 and 32 weeks with a mean of 10 weeks. Conclusions Most patients with TBG are children with vague, non-specific symptoms troubling precise clinical diagnosis. Treatment of choice involves surgical excision of the foreign body granuloma followed by topical corticosteroids. All surgical specimens obtained must be sent for histopathological examination. Special awareness is recommended during COVID-19 pandemic lockdown to prevent potential exposure to fibers that may cause conjunctival TBG.
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- 2022
40. Subconjunctival Hemorrhage in Leptospirosis
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Emilie C. Rijnink and Prataap K. Chandie Shaw
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Lung Diseases ,Humans ,Hemorrhage ,Leptospirosis ,General Medicine ,Conjunctival Diseases - Published
- 2022
41. Conjunctival pyogenic granuloma during pregnancy
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Melek Banu Hoşal, Aylin Okçu Heper, Mehmet Zahid Şekkeli, and Elif Öcal
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Adult ,Pathology ,medicine.medical_specialty ,Conjunctiva ,Conjunctival Diseases ,Granuloma piogênico ,Lesion ,Pregnancy ,Humans ,Medicine ,Sarcoma, Kaposi ,Granuloma, pyogenic ,Case reports ,business.industry ,Pyogenic granuloma ,General Medicine ,RE1-994 ,Conjunctivitis ,medicine.disease ,Complicações na gravidez ,Posterior segment of eyeball ,Ophthalmology ,Doenças da túnica conjuntiva ,medicine.anatomical_structure ,Relato de casos ,Pregnancy complications ,Granuloma ,Female ,Eyelid ,Sarcoma ,medicine.symptom ,business - Abstract
Pyogenic granuloma is a common benign, vascular lesion of the skin and mucosa. Our case was a 34-year-old woman at 28 weeks of gestation. She presented with a complaint of a growing and occasionally bleeding mass on the left lower eyelid conjunctiva for approximately 3 months. On examination, a red, pedunculated fragile lesion on the medial lower eyelid conjunctiva was observed. Ophthalmologic examination revealed that visual acuity was 20/20 in both eyes. Anterior and posterior segment examination was normal bilaterally. The lesion was excised completely under local anesthesia and sent for pathological examination. Histopathological examination revealed multiple vascular structures with small-diameters in the fibrous stroma. Vessels showed strong CD31 expression in immunohistochemical staining. Kaposi sarcoma was excluded due to negative HHV-8 staining. These findings were diagnostic of pyogenic granuloma. The frequency of pyogenic granuloma increases during pregnancy and surgical excision is important in diagnosis and treatment of these patients. This is the first reported case of conjunctival pyogenic granuloma during pregnancy. RESUMO O granuloma piogênico é uma lesão vascular benígna comum da pele e da mucosa. Neste caso, uma mulher de 34 anos com 28 semanas de gestação, apresentou queixa de massa em crescimento e sangramento ocasional na conjuntiva inferior da pálpebra esquerda por cerca de 3 meses. No exame, detectou-se uma lesão frágil, pedunculada vermelha na conjuntiva na porção medial da pálpebra inferior No exame oftalmológico, a acuidade visual foi 20/20 em ambos os olhos. O exame dos segmentos anterior e posterior foi normal bilateralmente. A lesão foi excisada totalmente com anestesia local e enviada para exame patológico. No exame histopatológico, múltiplas estruturas vasculares de pequeno diâmetro foram observadas no estroma fibroso. Os vasos apresentaram forte expressão de CD31 na coloração imuno-histoquímica. O sarcoma de Kaposi foi excluído devido à negatividade da coloração do HHV-8. Esses achados foram diagnósticos para granuloma piogênico. A frequência de granuloma piogênico aumenta durante a gestação e a excisão cirúrgica é importante no diagnóstico e tratamento desses pacientes. Este é o primeiro caso relatado de granuloma piogênico conjuntival ocorrido durante a gestação.
- Published
- 2021
42. Symblepharon Formation in the Setting of Steven-Johnson Syndrome.
- Author
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Cheung E and Zhang XC
- Subjects
- Humans, Cicatrix, Vision Disorders, Conjunctival Diseases, Stevens-Johnson Syndrome diagnosis
- Abstract
Competing Interests: Declaration of Competing Interest No conflicts of interest.
- Published
- 2023
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43. Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction
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Yasemin Aslan Katırcıoğlu, Ahmet Kaderli, Evin Şingar Özdemir, Firdevs Örnek, MÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, and Kaderli, Ahmet
- Subjects
Amniotic membrane transplantation ,Adult ,Male ,Mitomycin ,Middle Aged ,Conjunctival Diseases ,Adjuvant treatments ,Symblepharon ,Ophthalmology ,Eyelid Diseases ,Mitomycin-C ,Humans ,Female ,Amnion ,Conjunctiva ,Fornix stenosis ,Retrospective Studies - Abstract
Objectives: To evaluate the clinical results of amniotic membrane transplantation alone or in combination with adjuvant therapies in conjunctival fornix reconstruction. The clinical results of patients who presented to our clinic between 2002 and 2016 due to conjunctival fornix obliteration and underwent amniotic membrane transplantation alone or in combination with additional treatments were retrospectively analyzed. The Foster and Mondino classifications were used to grade fornix obliteration. In all cases, the area of conjunctival defect formed after symblepharon lysis was covered with amniotic membrane. In advanced fornix obliteration, amniotic membrane transplantation was combined with 0.04% mitomycin-C (MMC), oral mucosal transplantation, fornix formation (anchoring) sutures, symblepharon ring, eyelid surgery, fibrin glue, and limbal autograft. Deep and scarless restoration of the fornix was considered surgical success. Results: Twenty-two men and 5 women with a mean age of 45.54±4.17 years were included in the study. The etiology of fornix obliteration was mechanical trauma in 16 cases, chemical burn in 6 cases, recurrent pterygium in 3 cases, thermal burn in 1 case, and recurrent chalazion surgery in 1 case. Indications for amniotic membrane transplantation were socket insufficiency in 12 cases, cosmetic reasons in 4 cases, keratoplasty preparation in 3 cases, ptosis in 3 cases, entropion in 2 cases, strabismus in 2 cases, and diplopia in 1 case. The mean follow-up period was 45.04±8.4 months. Twenty-four of 27 cases (88.8%) were successful, while 3 (12.2%) failed due to recurrence of symblepharon. Conclusion: Amniotic membrane transplantation is a successful method when used alone in the reconstruction of early-stage conjunctival fornix obliteration and provides safe and effective results in advanced-stage fornix obliteration when performed in combination with topical 0.04% MMC, oral mucosal transplantation, and limbal autograft surgeries.
- Published
- 2022
44. Error in Figure Caption
- Subjects
Pruritus ,Correction ,Humans ,Eyelids ,Exophthalmos ,Conjunctival Diseases - Abstract
A 54-year-old woman presented with an erythematous right lower eyelid lesion with a vermiform appearance, accompanied by pruritus and pain. She recently had exposure to farm animals, including dogs and cats. What would you do next?
- Published
- 2022
45. Ophthalmic Assessment in Patients With Darier Disease
- Author
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Helwe Hammad, Michael Ziv, Daniel Briscoe, Shiraz Vered, Eldad Adler, Algit Yeshurun, Roni P. Dodiuk-Gad, and Lena Abayev
- Subjects
Adult ,Male ,medicine.medical_specialty ,Conjunctiva ,Visual acuity ,Adolescent ,genetic structures ,Visual Acuity ,Meibomian gland ,Refraction, Ocular ,Slit Lamp Microscopy ,Conjunctival Diseases ,Corneal Diseases ,Ophthalmic pathology ,03 medical and health sciences ,0302 clinical medicine ,Darier Disease ,Surveys and Questionnaires ,Cornea ,Prevalence ,Humans ,Medicine ,Prospective Studies ,Blepharitis ,Prospective cohort study ,Aged ,030304 developmental biology ,Aged, 80 and over ,0303 health sciences ,business.industry ,Middle Aged ,medicine.disease ,Dermatology ,eye diseases ,Ophthalmology ,medicine.anatomical_structure ,Eyelid Diseases ,030221 ophthalmology & optometry ,Dry Eye Syndromes ,Female ,sense organs ,medicine.symptom ,business - Abstract
Purpose To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease. Design Prospective observational case series. Methods Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted. Results According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age. Conclusions The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease.
- Published
- 2021
46. Man with swollen eye
- Author
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Chi-Wei Lee and Shih-Chia Yang
- Subjects
Male ,Chemosis ,medicine.medical_specialty ,Neurology ,Lymphoma ,genetic structures ,Vision Disorders ,Vital signs ,Pain ,Prefrontal Cortex ,Physical examination ,Critical Care and Intensive Care Medicine ,Conjunctival Diseases ,Carotid-Cavernous Sinus Fistula ,Blurred vision ,medicine ,Exophthalmos ,Humans ,Aged ,medicine.diagnostic_test ,business.industry ,General surgery ,ORBITAL PAIN ,General Medicine ,Emergency department ,medicine.disease ,eye diseases ,Emergency Medicine ,Orbital Neoplasms ,sense organs ,Orbital cellulitis ,medicine.symptom ,business - Abstract
A previously healthy 69-year-old man presented to the emergency department with right orbital pain and blurred vision for 1 day. He denied fever or recent trauma history. On examination, he had subconjunctival haemorrhage, chemosis and proptosis (figure 1). His neurologic examination revealed right-sided ophthalmoplegia. His vital signs were stable, and the rest of the physical examination and laboratory study were unremarkable. Figure 1 Photograph of the patient showing chemosis and proptosis of his right eye. What is the most likely diagnosis for this patient? 1. Orbital cellulitis. 2. Orbital …
- Published
- 2021
47. The Results of Preoperative Use of Topical Brimonidine in Strabismus Surgery
- Author
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Fikret Ucar and Servet Cetinkaya
- Subjects
Male ,0301 basic medicine ,Eye Hemorrhage ,medicine.medical_specialty ,Adolescent ,Administration, Topical ,Surgical Hemostasis ,Hemorrhage ,Hyperemia ,Intraoperative bleeding ,Conjunctival Diseases ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Brimonidine Tartrate ,Preoperative Care ,Adrenergic alpha-2 Receptor Agonists ,Photography ,Humans ,Medicine ,Pharmacology (medical) ,Postoperative Period ,Child ,Intraoperative Complications ,Strabismus ,Retrospective Studies ,Pharmacology ,business.industry ,Incidence ,Brimonidine ,Hemostasis, Surgical ,humanities ,Surgery ,body regions ,Ophthalmology ,030104 developmental biology ,Case-Control Studies ,Hemostasis ,030221 ophthalmology & optometry ,Female ,Ophthalmic Solutions ,business ,medicine.drug ,Strabismus surgery - Abstract
Purpose: In this study, we wanted to retrospectively evaluate the effect of the use of topical brimonidine on intraoperative bleeding and surgical hemostasis before strabismus surgery. Methods: Bri...
- Published
- 2021
48. Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease
- Author
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Hyeon-Jeong, Yoon, Ga-Young, Song, and Kyung Chul, Yoon
- Subjects
Cicatrix ,Multidisciplinary ,Myelodysplastic Syndromes ,Calcineurin Inhibitors ,Chronic Disease ,Hematopoietic Stem Cell Transplantation ,Graft vs Host Disease ,Humans ,Conjunctival Diseases ,Retrospective Studies - Abstract
We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69) groups. Factors associated with oGVHD severity and poor vision outcomes were examined using multivariate logistic regression. In the severe oGVHD group, the disease activity pattern tended to be persistent, whereas flare-up episodes were more frequent and occurred over shorter intervals in this group. Myelodysplastic syndrome (MDS) and lung GVHD were more common and systemic calcineurin inhibitors were used more frequently in the severe group than in the non-severe group. Finally, 5-year survival rates were poorer in the severe group. Multivariate analysis revealed that MDS, lung GVHD involvement, and no history of systemic calcineurin inhibitor use were risk factors for severe oGVHD. Risk factors for poor vision outcomes were conjunctival scarring and persistent epithelial defects. In conclusion, MDS, lung GVHD, and no history of systemic calcineurin inhibitors are associated with severe oGVHD. Conjunctival scarring and persistent epithelial defects are risk factors for poor vision outcomes.
- Published
- 2022
49. [OCULAR SURFACE INFECTION COMPLICATED BY ALLERGIC CONJUNCTIVAL DISEASES]
- Author
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Jun, Shoji
- Subjects
Hypersensitivity ,Humans ,Conjunctiva ,Conjunctival Diseases ,Conjunctivitis, Allergic - Published
- 2022
50. Prevalence and Causes of Subconjunctival Hemorrhage in Children
- Author
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Alomi O. Parikh, Cindy W. Christian, Brian Forbes, and Gil Binenbaum
- Subjects
Inflammation ,Eye Hemorrhage ,Adolescent ,Infant ,General Medicine ,Conjunctival Diseases ,Cross-Sectional Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Emergency Medicine ,Prevalence ,Humans ,Child ,Retrospective Studies - Abstract
Subconjunctival hemorrhage (SCH) is a reported sign of occult abusive injury, but there are limited published data about SCH during childhood. We sought to determine the prevalence and causes of SCH in children.This is a retrospective cross-sectional study of children seen by pediatric ophthalmologists in an outpatient setting over 4 years. Primary outcomes were prevalence and causes of SCH, based on history, physical ocular and nonocular findings, and laboratory and imaging studies. Subconjunctival hemorrhage prevalence was determined including and excluding eye surgery to reduce bias in the prevalence estimate.We studied 33,990 children, who underwent 86,277 examinations (median age, 5 years; range, 2 days to 18 years; 9282 younger than 2 years, 13,447 age 2-7 years, 11,261 age 8-18 years). There were 949 cases of SCH (1.1%; 95% confidence interval, 1.0-1.2). When surgery was excluded, there were 313 cases (prevalence, 0.4%; 95% confidence interval, 0.3-0.4), of which 261 (83%) were due to trauma; 40 (13%) ocular surface inflammation, including infectious conjunctivitis; 7 (2%) orbital or conjunctival lesion; 3 (1%) vessel rupture from choking or cough; and 2 (1%) coagulopathy related. Across all ages, including less than 2 years, trauma and inflammation together accounted for 94% to 97% of all cases of SCH.Subconjunctival hemorrhage is uncommon in children. The great majority of cases are due to trauma. All children with SCH, including infants and young children, should be closely examined to identify other ocular or nonocular signs of trauma.
- Published
- 2022
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