1. Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis
- Author
-
Theresa Nguyen, David I. Rosenthal, He Wang, Clifton D. Fuller, Sam Tung, Adam S. Garden, Steven J. Frank, Sweet Ping Ng, William H. Morrison, Beth M. Beadle, Lawrence D. Ginsberg, Ehab Y. Hanna, Courtney Pollard, Shirley Y. Su, Mark Zafereo, Conjun Wang, Shah J. Shah, Gary Brandon Gunn, Erich M. Sturgis, and Jack Phan
- Subjects
Male ,medicine.medical_specialty ,Node metastasis ,medicine.medical_treatment ,Conformal radiotherapy ,Radiosurgery ,Re-Irradiation ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Proton Therapy ,medicine ,Humans ,Head and neck ,Proton therapy ,Retrospective Studies ,Chemotherapy ,business.industry ,Nodal metastasis ,Combined Modality Therapy ,Survival Rate ,Radiation therapy ,Treatment Outcome ,Otorhinolaryngology ,Head and Neck Neoplasms ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Toxicity ,Female ,Lymph Nodes ,Radiology ,Neoplasm Recurrence, Local ,Radiotherapy, Conformal ,business - Abstract
Background The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). Methods A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. Results Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade ≥3 toxicity. Conclusion Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.
- Published
- 2017