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31 results on '"Cong, Wenjuan"'

4. Prevalence of antibiotic prescribing in COVID-19 patients in China and other low- and middle-income countries during the pandemic (December 2019—March 2021): a systematic review and meta-analysis

Author

Cong, Wenjuan, primary, Cheng, Hung-Yuan, additional, Stuart, Beth, additional, Liu, Binjuan, additional, Tang, Yunyi, additional, Wang, Yi, additional, AIhusein, Nour, additional, Wang, Hexing, additional, Manchundiya, Amit, additional, and Lambert, Helen, additional

Published
2023
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8. Impacts of Antibiotic Residues in the Environment on Bacterial Resistance and Human Health in Eastern China: An Interdisciplinary Mixed-Methods Study Protocol

Author

Cai, Shenghan, primary, Wang, Na, additional, Xu, Like, additional, Yan, Fei, additional, Jiang, Qingwu, additional, Zhao, Xinping, additional, Wang, Wei, additional, Wang, Hexing, additional, Jiang, Lufang, additional, Cong, Wenjuan, additional, Sheppard, Samuel K., additional, Weeks, Jason, additional, Kasprzyk-Hordern, Barbara, additional, Fu, Chaowei, additional, and Lambert, Helen, additional

Published
2022
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12. Cluster randomised controlled trial to assess a tailored intervention to reduce antibiotic prescribing in rural China: study protocol

Author

Cong, Wenjuan, primary, Chai, Jing, additional, Zhao, Linhai, additional, Cabral, Christie, additional, Yardley, Lucy, additional, Yao, Guiqing Lily, additional, Zhang, Tingting, additional, Cheng, Jing, additional, Shen, XingRong, additional, Liu, Rong, additional, Little, Paul, additional, Stuart, Beth, additional, Hu, Xiaowen, additional, Sun, Ye-Huan, additional, Oliver, Isabel, additional, Zheng, Bo, additional, Lambert, Helen, additional, and Wang, DeBin, additional

Published
2022
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14. RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

Author

Pan, Xiaoyan, primary, Shi, Jian, additional, Hu, Xue, additional, Wu, Yan, additional, Zeng, Liang, additional, Yao, Yanfeng, additional, Shang, Weijuan, additional, Liu, Kunpeng, additional, Gao, Ge, additional, Guo, Weiwei, additional, Peng, Yun, additional, Chen, Shaohong, additional, Gao, Xiaoxiao, additional, Peng, Cheng, additional, Rao, Juhong, additional, Zhao, Jiaxuan, additional, Gong, Cheng, additional, Zhou, Hui, additional, Lu, Yudong, additional, Wang, Zili, additional, Hu, Xiliang, additional, Cong, WenJuan, additional, Fang, Lijuan, additional, Yan, Yongxiang, additional, Zhang, Jing, additional, Xiong, Hui, additional, Yi, Jizu, additional, Yuan, Zhiming, additional, Zhou, Pengfei, additional, Shan, Chao, additional, and Xiao, Gengfu, additional

Published
2021
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22. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection

Author

Ma, Yipeng, Cong, Wenjuan, Huang, Hao, Sun, Liang, Mai, Anh Hung, Boonen, Kurt, Maryam, Wahedi, De Borggraeve, Wim, Luo, Guoan, Liu, Qingfei, Schoofs, Liliane, Van Kuppeveld, Frank, Neyts, Johan, Mirabelli, Carmen, Luyten, Walter, dI&I I&I-1, and dI&I I&I-1

Subjects
0301 basic medicine, Fukinolic acid, Cimicifuga, Traditional Chinese medicine, Virus Replication, Mass Spectrometry, chemistry.chemical_compound, 0302 clinical medicine, Enterovirus 71, Caffeic acid, Pharmacology (medical), 030212 general & internal medicine, Medicine, Chinese Traditional, Medicinal plants, Phenylacetates, biology, Traditional medicine, Pharmacology. Therapy, 3C Viral Proteases, General Medicine, Boraginaceae, Arnebia euchroma, Cysteine Endopeptidases, Infectious Diseases, Microbiology (medical), medicine.drug_class, 030106 microbiology, Coronacrisis-Taverne, Microbial Sensitivity Tests, Antiviral Agents, Viral Proteins, 03 medical and health sciences, Caffeic Acids, Enterovirus Infections, medicine, Humans, Nuclear Magnetic Resonance, Biomolecular, Biology, Cimicifuga heracleifolia, Plant Extracts, Succinates, biology.organism_classification, In vitro, Enterovirus A, Human, Rhizome, chemistry, Human medicine, Antiviral drug, Cimicifugic acid
Abstract

Human enterovirus 71 (EV-A71) infections cause a wide array of diseases ranging from diarrhoea and rashes to hand-foot-and-mouth disease and, in rare cases, severe neurological disorders. No specific antiviral drug therapy is currently available. Extracts from 75 Chinese medicinal plants selected for antiviral activity based on the Chinese pharmacopeia and advice from traditional Chinese medicine clinicians were tested for activity against EV-A71. The aqueous extract of the rhizome of Cimicifuga heracleifolia (Sheng Ma) and Arnebia euchroma (Zi Cao) showed potent antiviral activity. The active fractions were isolated by bioassay-guided purification, and identified by a combination of high-resolution mass spectrometry and nuclear magnetic resonance. Fukinolic acid and cimicifugic acid A and J, were identified as active anti-EV-A71 compounds for C. heracleifolia, whereas for A. euchroma, two caffeic acid derivatives were tentatively deduced. Commercially available fukinolic acid analogues such as L-chicoric acid and D-chicoric also showed in vitro micromolar activity against EV-A71 lab-strain and clinical isolates. ispartof: International Journal Of Antimicrobial Agents vol:53 issue:2 pages:128-136 ispartof: location:Netherlands status: published

Published
2019

23. A complex intervention to reduce antibiotic prescribing in rural China: a cluster randomised controlled trial

Author

Shen, Xingrong, Stuart, Beth, Cui, Enci, Liu, Rong, Zhang, Tingting, Chai, Jing, Cong, Wenjuan, Hu, Xiaowen, Oliver, Isabel, Yao, Guiqing, Little, Paul, Lambert, Helen, Yardley, Lucy, Cabral, Christie, and Wang, Debin

Abstract

Excessive use of antibiotics is a widespread problem. We aim to evaluate the efficacy of a multifaceted intervention for reducing antibiotic use in patients with respiratory tract infections (RTIs).

Published
2024
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24. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection

Author

dI&I I&I-1, Ma, Yipeng, Cong, Wenjuan, Huang, Hao, Sun, Liang, Mai, Anh Hung, Boonen, Kurt, Maryam, Wahedi, De Borggraeve, Wim, Luo, Guoan, Liu, Qingfei, Schoofs, Liliane, Van Kuppeveld, Frank, Neyts, Johan, Mirabelli, Carmen, Luyten, Walter, dI&I I&I-1, Ma, Yipeng, Cong, Wenjuan, Huang, Hao, Sun, Liang, Mai, Anh Hung, Boonen, Kurt, Maryam, Wahedi, De Borggraeve, Wim, Luo, Guoan, Liu, Qingfei, Schoofs, Liliane, Van Kuppeveld, Frank, Neyts, Johan, Mirabelli, Carmen, and Luyten, Walter

Published
2019

31. Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.

Author

Shi, Jun, Cong, Wenjuan, Wang, Yiming, Liu, Qingfei, and Luo, Guoan

Subjects
MICROEMULSIONS, TRANSDERMAL medication, HUPERZINE A, PHOSPHATES, ALZHEIMER'S disease treatment, OLEIC acid, SURFACE active agents
Abstract

The aim of the present study was to construct an innovative microemulsion-based patch for simultaneously transdermal delivery of huperzine A (HA) and ligustrazine phosphate (LP). The pseudo-ternary phase diagrams for microemulsion region were developed using oleic acid as oil, Cremophor RH40 as a surfactant, and ethanol as a cosurfactant. 1,8-cineole was added to the microemulsion as a penetration enhancer. The microemulsion-based transdermal patches were prepared by the lamination technique. The permeation studies were performed in vitro to evaluate the abilities of various microemulsions and transdermal patches to deliver HA and LP across the rat abdominal skin, showing that microemulsions increased the permeation rates of HA and LP compared with the control, and the penetration kinetics of the transdermal patch was in a zero order process. The results of the pharmacodynamic studies indicated that the transdermal combination therapy of HA and LP showed more benefits for fighting against amnesia in comparison with monotherapy. The anti-amnesic effects were also confirmed in scopolamine-induced amnesia rats after transdermal administration at multiple doses for 9 consecutive days, and the efficacy exhibited a dose-dependent manner. As a conclusion, the microemulsion-based transdermal patch containing HA and LP might provide a feasible strategy for the prevention of Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2012
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