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21 results on '"Conejo, Pablo Rojo"'

1. Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

Author

Judd, Ali, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Julia, Del Amo, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella d’Arminio, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, Jose M, Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Quiros-Roldan, Eugenia, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, de Wit, Stéphane, Costagliola, Dominique, d’Arminio-Monforte, Antonella, del Amo, Julia, Raben, Dorthe, Chêne, Geneviève, Rojo, Conejo Pablo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M, Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Grabar, Sophie, Guiguet, Marguerite, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Miro, Jose M, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, and Schomaker, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Sexually Transmitted Infections, Rare Diseases, Emerging Infectious Diseases, Infectious Diseases, HIV/AIDS, Infection, Adolescent, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Risk Factors, Sarcoma, Kaposi, Viral Load, Young Adult, AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord, HIV, Kaposi sarcoma, antiretroviral therapy, cohort study, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundWe compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.MethodsWe included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs).ResultsWe included 208140 patients from 57 countries. Over a period of 1066572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73-7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34-3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09-6.96) than in women. Comparing patients with current CD4 cell counts ≥700 cells/µL with those whose counts were

Published
2017

2. Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)

Author

Doria, Margherita, Zicari, Sonia, Cotugno, Nicola, Dominguez-Rodriguez, Sara, Ruggiero, Alessandra, Pascucci, Giuseppe R., Tagarro, Alfredo, Conejo, Pablo Rojo, Nastouli, Eleni, Gartner, Kathleen, Cameron, Mark, Richardson, Brian, Foster, Caroline, Williams, Sion L., Rinaldi, Stefano, Rossi, Anita De, Giaquinto, Carlo, Rossi, Paolo, Pahwa, Savita, and Palma, Paolo

Subjects
Perinatal infection -- Drug therapy -- Patient outcomes, HIV infection in children -- Drug therapy -- Patient outcomes, Highly active antiretroviral therapy -- Patient outcomes, Killer cells -- Health aspects, Teenagers -- Health aspects, Youth -- Health aspects, Pediatric research, Health
Abstract

Introduction: HIV infection causes pathological changes in the natural killer (NK) cell compartment that can be only partially restored by antiretroviral therapy (ART). We investigated NK cells phenotype and function in children with perinatally acquired HIV (PHIV) and long-term viral control (five years) due to effective ART in a multicentre cross-sectional European study (CARMA, EPIICAL consortium). The impact of age at ART start and viral reservoir was also evaluated. Methods: Peripheral blood mononuclear cells (PBMCs) from 40 PHIV who started ART within two years of life (early treated patients (ET), 6 months), with at least five years of HIV-1 suppression ( Results: A significantly higher frequency of [CD56.sup.neg] NK cells was found in LT compared with ET. We further found in LT a positive correlation of [CD56.sup.neg] NK cells with HIV-1 DNA. LT also displayed increased expression of the NKG2D and NKp46 activating receptors and perforin compared with ET. Moreover, [CD107a.sup.+] and [IFN-[gamma].sup.+] frequencies in non-stimulated NK were associated with HIV-1 DNA in LT patients. Finally RNA-Seq analysis showed in LT an up-regulation of genes related to NKactivating pathways and susceptibility to apoptosis compared with ET. Conclusions: We show that early initiation of ART during infancy preserves the NK compartment and is associated with lower HIV-1 reservoir. Such condition persists over adolescence due to long-term viral control achieved through effective ART. Keywords: cohort studies; HIV care continuum; immunology; paediatrics; ARV; viral suppression Additional information may be found under the Supporting Information tab for this article., 1 | INTRODUCTION HIV-1-induced immunological impairment begins during acute infection and is only partially restored in children with perinatally acquired HIV (PHIV) if antiretroviral therapy (ART) is introduced during the [...]

Published
2021
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3. Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease

Author

Fernandez-Cooke, Elisa, Calvo, Cristina, Sánchez-Manubens, Judith, Antón, Jordi, Santos, Javier Aracil, Cuadros, Esmeralda Nuñez, Navarro Gómez, Maria Luisa, Pérez, David Moreno, Cantero Pérez, María Martín, Cuadros Pérez, Esmeralda Nuñez, Gallego Pérez, Begoña Carazo, García, Fernando Sánchez, Lovillo, Marisol Camacho, Marqués, Renata, Laura, Olaf Neth, Silveira, Fernández, Forte, Miguel Sánchez, Montes, Ángeles Ortega, Martínez Campos, Leticia Isabel, Mancheño, Beatriz Bravo, Camacho, Margarita, Medina Claros, Antonio F., Salido, Carlos, Rico, María Torres, Saez, Beatriz Ruiz, de la Puebla Lechuga, Elena Fernadez, Cruz, M<ce:sup loc='post">a</ce:sup> José Lirola, Carrasco, Kety Maya, González, Moisés Rodríguez, Jover, Enrique Blanca, Fernández, José Uberos, Ibáñez Alcalde, María Mercedes, Hidalgo, Miguel Lafuente, Montañés, Lorenzo Jiménez, Alonso, Matilde Bustillo, Casas, Ariadna Ayerza, Zapico, Bárbara Montes, Méndez, Carlos Pérez, Aracama, Javier Fernández, Rodríguez, Lucía, Ibáñez Fernández, María Aleida, Campo, Sandra Navarro, Bori, Silvia Escribà, Mir Perelló, María Concepción, Sánchez, M<ce:sup loc='post">a</ce:sup> Ángeles de la Fuente, García, Patricia Aparicio, Briales, Carlos, Crespí, Joaquín Castilla, Colino Gil, María Elena, Cabrera, Nerea Delgado, Naranjo, Ana Bello, Páez, Jesús Poch, Yáñez, Moneyba García, García, Montse González, Viadero, Maite, Montero, Beatriz Jiménez, García, Olga Domínguez, Pinedo, Begoña Losada, Martín, Gema Iñigo, Escribano Gómez, Lucía María, Cepillo, Antonio, Lillo, Miguel Lillo, Buedo, María Isabel, Rey, Laura del, Rodríguez, Elena Urbaneja, Rodríguez, Sara Rellán, Cantero, Teresa, Izquierdo, Beatriz Plata, García-Cuenllas Álvarez, Luisa, Erroz, Ignacio Oulego, Santaolalla, Elena Pérez, Martín, Carlos Alcalde, Malfaz, Fernando Centeno, Gutiérrez, Elena Pérez, Casso, M<ce:sup loc='post">a</ce:sup> Soledad Jiménez, Prada, Fredy, Bou, Rosa, Iglesias, Estibaliz, Calzada, Joan, Garsaball, Olga Calavia, Rue, Marc Tobeña, García, Gemma Giralt, Lobato, Zulema, Gordillo, Neus Rius, Torres, Montserrat Pascual, Hernández, María Méndez, García, Lourdes, Villar, Sergio Flores, Ruiz, Silvia Yevenes, Domingo, Laura Minguell, Ballester, Anna, Miralles, Ana, Soler, Berta Pujol, Vidal, Anton Foguet, Castellví, Pere Sala, Aguiar, Angelita Serrano, Siurana Rodríguez, José Manuel, Iranzo, Anna Sangorrin, Pérez, Roser Álvarez, Cajas, Paula Ribes, Genaró i Jornet, Pere, Tejada, Ana Grande, Zarallo, Cristina, Martinón-Torres, Federico, Calle, Irene Rivero, Grande, Antonio Justicia, Sousa, María López, Vilas, Alejandro Souto, Abel, Bernardo López, de Miguel Esteban, Elisa, Méndez, Bibiana Riaño, Blázquez, Daniel, Conejo, Pablo Rojo, Lozano, Carlos Grasa, Toral, Belén, De la Torre, Leticia Albert, de Inocencio, Jaime, Santos, Mar, Díaz-Delgado de la Peña, Rafael, Ramos, Paz Collado, Raga, Teresa, Latorre, Libertad, Guillén, Sara, Caballero, Ignacio Callejas, Prieto Tato, Luis Manuel, Guzmán Monagas, María Fernanda, López, Isabel Jiménez, Villagrá, Sandra, Arreo, Viviana, Pérez, Roi Piñeiro, Parte, María de la, Tamariz-Martes, Amalia, Romano, Marta Llorente, Hernández Rupérez, Maria Belén, Sombrero, Henar Rojo, Cerro, Estefanía García, Cano, Irene Maté, Alonso, Marta Villares, Osuna Marco, Marta Pilar, Veron, Julia Jensen, Reales, Cristina Zarallo, Rodríguez Mesa, María Dolores, Esteban, Santiago Rueda, Ramos Amador, José Tomás, Menchén, Cristina González, Jiménez Jiménez, Ana Belén, Galán, Pilar, Campos, Dolores Pérez, Bueno, M<ce:sup loc='post">a</ce:sup> Mercedes, Marcos, David Crespo, Otheo de Tejada Barásoain, Enrique, Sifuentes Giraldo, Walter Alberto, Gámir Gámir, María Luz, José Cilleruelo Ortega, María, López, Agustín López, Vaquerizo, Cristina Sánchez, Usano Carrasco, Ana Isabel, Gómez, Ester Moreno, Carvajal del Castillo, Olga, Del Pozo Menéndez, Beatriz, Navarro, Katie Badillo, Baquero, Fernando, Bronte, Lucía Deiros, Fraga, Pablo Fernández, Domínguez, Nieves, Rodríguez, Beatriz Mercader, García, Francisco Castro, Chamorro, Águeda Herrera, Rodríguez, Paula Alcañiz, García, Moisés Sorlí, Rex Nicolás, María Concepción, Romero, Elena Vera, Olorón, Patricia Martínez, Cilveti, Beatriz Rocandio, Berridi, Amaia, Santos-Díez Vázquez, Laura, Fernández, Olaia, Calvo, Inmaculada, Tudela, Belén Fernández, Benavent, Manuel Oltra, Archilés, Marta Dapena, Ferrer, Franciasco Sanchez, Gavilán, César, Fos, Ignacio Izquierdo, Serrano Robles, María Isabel, Sánchez, Yolanda Herranz, Pinto, Enrique Villalobos, Garulo, Daniel Clemente, Pie, Stella, Calvo, Manuel Marrero, Olmos García, José María, Barrios-Tascón, Ana, Miura, Masaru, Domínguez-Rodríguez, Sara, Fernández-Cooke, Elisa, Sarquella-Brugada, Georgia, and Tagarro, Alfredo

Published
2021
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4. Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Author

Irwin, Adam, Akula, Akhila, Bamford, Alasdair, Chang, Amanda, da Silva, Andre, Whitelaw, Andrew, Dramowski, Angela, Vasudevan, Anil Kumar, Sharma, Anita, Justicia, Antonio, Chikkappa, Ashok, Slowinska-Jarzabek, Barbara, Rippberger, Bianca, Zhao, Changan, Tersigni, Chiara, Cheng, Chinglan, Harkensee, Christian, Jing, Chuamei, Zhu, Chunmei, Li, Chunyan, Tagliabue, Claudia, Epalza, Cristina, Jacqueline, Daglish, Tian, Daiyin, Jinka, Dasaratha, Gkentzi, Despoina, Dharmapalan, Dhanya, Benadof, Dona, Papadimitriou, Eleni, Iosifidis, Elias, Roilides, Emmanuel, Yarci, Erbu, Majda-Stanisławska, Ewa, Gowin, Ewelina, Chappell, Faye, Torres, Federico Martinon, Collett-White, Francis, Liu, Gang, Lu, Gen, Syrogiannopoulos, George, Pitsava, Georgia, Alvarez-Uria, Gerardo, Renk, Hana, Mahmood, Hana, Saxen, Harri, Finlayson, Heather, Green, Helen, Rabie, Helena, Kandraju, Hemasree, Zhang, Hong, Okokon, Ita, Cross, Jack, Herberg, Jethro, Li, Jianping, Zhang, Jiaosheng, Deng, Jikui, Liu, Jing, Qian, Jing, Yang, Jinhong, Sicińska, Joanna, Hübner, Johannes, Fukuoka, Kahoru, Yao, Kaihu, Cheung, Kaman, Ojeda, Karla, Kaffe, Katerina, Kreitmeyer, Katharina, Doerholt, Katja, Grimwood, Keith, Ledoare, Kirsty, Vazouras, Konstantinos, Shen, Kunling, Tang, Lanfang, Zhang, Lehai, Lin, Li, Ashkenazi-Hoffnung, Liat, Wu, Lijuan, Wang, Lijun, Teston, Lilian, Galli, Luisa, Speirs, Lynne, Tsolia, Maria, Hufnagel, Markus, Knuf, Markus, Duse, Marzia, Ding, Mingjie, Rozic, Mojca, Premru, Mueller, O'Connell, Natasha, Rieber, Nikolaus, Spyridis, Nikos, Tunga, Onkaraiah, Conejo, Pablo Rojo, McMaster, Paddy, Lumbiganon, Pagakrong, Pansa, Paola, D'Argenio, Patrizia, Moriarty, Paul, Nikolic, Petra, Wang, Ping, Paopongsawan, Pongsatorn, Cao, Qing, Deng, Qiulian, Laxminarayan, Ramanan, Kanithi, Ravishankar, Jimenez, Rodolfo, Cao, Sancheng, Singh, Sanjeev, Rees, Sarah, Praveen, Saroey, Kekomaki, Satu, Hackett, Scott, Ashkenazi, Shai, Chang, Si Min, Drysdale, Simon, Koning, Sonia, Subramanian, Sreeram, Murki, Srinivas, Vergnano, Stefania, Gandra, Sumanth, Esposito, Susanna, Anugulruengkitt, Suvaporn, Puthanakit, Thanyawee, Behrends, Uta, Papaevangelous, Vana, Jian, Victoria, Li, Wei, Zhao, Wei, Wang, Wei, Zhang, Wenshuang, Mu, Xiaoping, Dong, Xiaoyie, Jiang, Xiyuan, Chen, Xu, Wang, Yi, Zheng, Yuejie, Horikoshi, Yuho, Aboderin, Aaron, Olayinka, Adebola, Dedeic-Ljubovic, Amela, McCorry, Ann, Enimil, Anthony, Neubert, Antje, solano, antonio, Pignatari, Antonio, Poojary, Aruna, Kambaralieva, Baktygul, McCullagh, Bernadette, Carevi, Biljana, Van Herendael, Bruno, Gormley, Cairine, Carvajal, Camila, Ramírez, Carlos, Fitzgerald, David, Sabuda, Deana, Konopnicki, Deborah, Lacej, Denada, Pierard, Denis, Rios, Edgar, Marshall, Emily, Firre, Eric, van Elzakker, Erika, Shaqiri, Erjona, Darwish Elhajji, Feras, Gawrys, Gerard, Markovic, Goran, Kunsihima, Hiroyuki, Chen, Hui Hiong, Sviestina, Inese, Pristas, Irina, Hoxha, Iris, Korinteli, Irma, Mareković, Ivana, Soltani, Jafar, Labarca, Jaime, AlSalman, Jameela, Horvatic, Jasminka, Frimpong, Juliet Ampomah, Pagava, Karaman, Kei, Kasahara, Okinaka, Keiji, Iregbu, Kenneth, Ghazaryan, Lilit, Raka, Lul, Gessner-Wharton, Mallory, Aldeyab, Mamoon, Cooper, Mandelin, del Castillo, Marcelo, Hojman, Martin, Hudson, Melissa, Alshehri, Mohamed, Ling, Moi Lin, Greer, Nickie, Oduyebo, Oyinlola, Buijtels, Patricia, TEROL BARRERO, PEDRO, Zarb, Peter, Schelstraete, PEtra, Nwajiobi-Princewill, Princewill Ifeanyi Philip, Khanna, Priya, Quiros, Rodolfo, Simovic, Sanja, Thompson, Sarah, Chan, Si Min, Burokiene, Sigita, Rachina, Svetlana, Usonis, Vytautas, Cornistein, Wanda, Holemans, Xavier, Gu, Yoshiaki, Brothers, Adam, Hersh, Adam, Fernandez, Alfred, Tribble, Alison, Hurst, Amanda, Green, Andrea, Hammer, Benjamin, Lee, Betty P, Kuzmic, Brenik, Shapiro, Craig, Boge, Craig, Haslam, David, Berman, David, Naeem, Fouzia, Johnson, George, Schwenk, Hayden, Orr, Hillary, Maples, Holly, Olsen, Jared, Gerber, Jeffrey, Girotto, Jennifer, Zweiner, Jennifer, Goldman, Jennifer, Gillon, Jessica, Tansmore, Jessica, Manaloor, John, Courter, Joshua, Mongkolrattanothai, Kanokporn, Patel, Karisma, Merkel, Kathryn, Namtu, Katie, Flett, Kelly, Lee, Kelly, Nichols, Kristen, Klein, Kristin, Handy, Lori, Castagnini, Luis, Mazade, Marc, Heger, Margaret, Fernandez, Marisol, Chang, Michael, Crawford, Michelle, Nelson, Miranda, Bennett, Nicholas, Jaggi, Preeti, Hamdy, Rana, Banerjee, Ritu, Olivero, Rosemary, Patel, Sameer, Arnold, Sandra, Ogrin, Sara, Jones, Sarah, Parker, Sarah, Kubes, Sarah, Hymes, Saul, Weissman, Scott, Chan, Shannon, Henderson, Sheryl, Metjian, Talene, Hsia, Yingfen, Lee, Brian R, Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, and Sharland, Mike

Published
2019
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5. Immunisation practices in centres caring for children with perinatally acquired HIV: A call for harmonisation

Author

Menson, Esse N., Muñoz-Fernández, M. Ángeles, Della Negra, Marinella, Shingadia, Delane, Levy, Jack, Marczynska, Magdalena, Conejo, Pablo Rojo, Klein, Nigel, Ananworanich, Jintanat, Ziegler, John Bernard, Lyall, Hermione, Di Biagio, Antonio, Giacomet, Vania, Gattinara, Guido Castelli, De Sousa Marques, Heloisa Helena, Cotugno, Nicola, Salo, Eeva, Volokha, Alla, Mardarescu, Mariana, Reliquet, Veronique, Bernardi, Stefania, Giaquinto, Carlo, Bamford, Alasdair, Manno, Emma C., Mellado, Maria Jose, Spoulou, Vana, Marques, Laura, Scherpbier, Henriette J., Niehues, Tim, Oldakowska, Agnieszka, Rossi, Paolo, and Palma, Paolo

Published
2016
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7. Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen

Author

De Luca, Andrea, Flandre, Philippe, Dunn, David, Zazzi, Maurizio, Wensing, Annemarie, Santoro, Maria Mercedes, Günthard, Huldrych F., Wittkop, Linda, Kordossis, Theodoros, Garcia, Federico, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, De Wit, Stéphane, Brockmeyer, Norbert H., Imaz, Arkaitz, Mussini, Cristina, Obel, Niels, Perno, Carlo Federico, Roca, Bernardino, Reiss, Peter, Schülter, Eugen, Torti, Carlo, van Sighem, Ard, Zangerle, Robert, Descamps, Diane, De Luca, Andrea, Flandre, Philippe, Descamps, Diane, Castagna, Antonella, Cozzi-Lepri, Alessandro, Churchill, Duncan, Dunn, David, De Wit, Stéphane, Brockmeyer, Norbert H., Garcia, Federico, Imaz, Arkaitz, Kordossis, Theodoros, Mussini, Cristina, Obel, Niels, Roca, Bernardino, Torti, Carlo, van Sighem, Ard, Wensing, Annemarie, Zangerle, Robert, Wittkop, Linda, Reiss, Peter, Ceccherini-Silberstein, Francesca, Santoro, Maria Mercedes, Perno, Carlo Federico, Günthard, Huldrych, Schülter, Eugen, Zazzi, Maurizio, Wittkop, Linda, Descamps, Diane, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, del Amo, Julia, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella dʼArminio, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, Jose M., Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, de Wit, Stéphane, Miró, Jose M., Costagliola, Dominique, dʼArminio-Monforte, Antonella, Castagna, Antonella, del Amo, Julia, Mocroft, Amanda, Raben, Dorthe, Chêne, Geneviève, Judd, Ali, Conejo, Pablo Rojo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Wittkop, Linda, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Raben, Dorthe, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Bucher, Heiner, Cozzi-Lepri, Alessandro, Dabis, François, Monforte, Antonella dʼArminio, Davies, Mary-Anne, del Amo, Julia, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Judd, Ali, Kirk, Ole, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Meyer, Laurence, Miró, Jose M., Mocroft, Amanda, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Thorne, Claire, Torti, Carlo, van der Valk, Marc, Wittkop, Linda, Wyss, Natasha, Aubert, V., Battegay, M., Bernasconi, E., Böni, J., Bucher, H. C., Burton-Jeangros, C., Calmy, A., Cavassini, M., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C. A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, B. Martinez, Metzner, K., Müller, N., Nadal, D., Nicca, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schöni-Affolter, F., Schmid, P., Schüpbach, J., Speck, R., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., and Yerly, S.

Published
2016
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8. Determinants of precocious B-cell aging in European adolescents living with perinatally acquired HIV-1 after over 10 years of suppressive therapy

Author

Ruggiero, Alessandra, primary, Pascucci, Giuseppe Rubens, additional, Cotugno, Nicola, additional, Domínguez-Rodríguez, Sara, additional, Rinaldi, Stefano, additional, Tagarro, Alfredo, additional, Conejo, Pablo Rojo, additional, Foster, Caroline, additional, Bamford, Alasdair, additional, De Rossi, Anita, additional, Nastouli, Eleni, additional, Klein, Nigel, additional, Morrocchi, Elena, additional, Fatou, Benoit, additional, Smolen, Kinga K., additional, Ozonoff, Al, additional, Luzuriaga, Katherine, additional, Steen, Hanno, additional, Giaquinto, Carlo, additional, Goulder, Philip, additional, Rossi, Paolo, additional, Levy, Ofer, additional, Pawha, Savita, additional, and Palma, Paolo, additional

Published
2021
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9. Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease

Author

Barrios-Tascón, Ana, primary, Miura, Masaru, additional, Domínguez-Rodríguez, Sara, additional, Fernández-Cooke, Elisa, additional, Sarquella-Brugada, Georgia, additional, Tagarro, Alfredo, additional, Fernandez-Cooke, Elisa, additional, Calvo, Cristina, additional, Sánchez-Manubens, Judith, additional, Antón, Jordi, additional, Santos, Javier Aracil, additional, Cuadros, Esmeralda Nuñez, additional, Navarro Gómez, Maria Luisa, additional, Pérez, David Moreno, additional, Cantero Pérez, María Martín, additional, Cuadros Pérez, Esmeralda Nuñez, additional, Gallego Pérez, Begoña Carazo, additional, García, Fernando Sánchez, additional, Lovillo, Marisol Camacho, additional, Marqués, Renata, additional, Laura, Olaf Neth, additional, Silveira, Fernández, additional, Forte, Miguel Sánchez, additional, Montes, Ángeles Ortega, additional, Martínez Campos, Leticia Isabel, additional, Mancheño, Beatriz Bravo, additional, Camacho, Margarita, additional, Medina Claros, Antonio F., additional, Salido, Carlos, additional, Rico, María Torres, additional, Saez, Beatriz Ruiz, additional, de la Puebla Lechuga, Elena Fernadez, additional, Cruz, Ma José Lirola, additional, Carrasco, Kety Maya, additional, González, Moisés Rodríguez, additional, Jover, Enrique Blanca, additional, Fernández, José Uberos, additional, Ibáñez Alcalde, María Mercedes, additional, Hidalgo, Miguel Lafuente, additional, Montañés, Lorenzo Jiménez, additional, Alonso, Matilde Bustillo, additional, Casas, Ariadna Ayerza, additional, Zapico, Bárbara Montes, additional, Méndez, Carlos Pérez, additional, Aracama, Javier Fernández, additional, Rodríguez, Lucía, additional, Ibáñez Fernández, María Aleida, additional, Campo, Sandra Navarro, additional, Bori, Silvia Escribà, additional, Mir Perelló, María Concepción, additional, Sánchez, Ma Ángeles de la Fuente, additional, García, Patricia Aparicio, additional, Briales, Carlos, additional, Crespí, Joaquín Castilla, additional, Colino Gil, María Elena, additional, Cabrera, Nerea Delgado, additional, Naranjo, Ana Bello, additional, Páez, Jesús Poch, additional, Yáñez, Moneyba García, additional, García, Montse González, additional, Viadero, Maite, additional, Montero, Beatriz Jiménez, additional, García, Olga Domínguez, additional, Pinedo, Begoña Losada, additional, Martín, Gema Iñigo, additional, Escribano Gómez, Lucía María, additional, Cepillo, Antonio, additional, Lillo, Miguel Lillo, additional, Buedo, María Isabel, additional, Rey, Laura del, additional, Rodríguez, Elena Urbaneja, additional, Rodríguez, Sara Rellán, additional, Cantero, Teresa, additional, Izquierdo, Beatriz Plata, additional, García-Cuenllas Álvarez, Luisa, additional, Erroz, Ignacio Oulego, additional, Santaolalla, Elena Pérez, additional, Martín, Carlos Alcalde, additional, Malfaz, Fernando Centeno, additional, Gutiérrez, Elena Pérez, additional, Casso, Ma Soledad Jiménez, additional, Prada, Fredy, additional, Bou, Rosa, additional, Iglesias, Estibaliz, additional, Calzada, Joan, additional, Garsaball, Olga Calavia, additional, Rue, Marc Tobeña, additional, García, Gemma Giralt, additional, Lobato, Zulema, additional, Gordillo, Neus Rius, additional, Torres, Montserrat Pascual, additional, Hernández, María Méndez, additional, García, Lourdes, additional, Villar, Sergio Flores, additional, Ruiz, Silvia Yevenes, additional, Domingo, Laura Minguell, additional, Ballester, Anna, additional, Miralles, Ana, additional, Soler, Berta Pujol, additional, Vidal, Anton Foguet, additional, Castellví, Pere Sala, additional, Aguiar, Angelita Serrano, additional, Siurana Rodríguez, José Manuel, additional, Iranzo, Anna Sangorrin, additional, Pérez, Roser Álvarez, additional, Cajas, Paula Ribes, additional, Genaró i Jornet, Pere, additional, Tejada, Ana Grande, additional, Zarallo, Cristina, additional, Martinón-Torres, Federico, additional, Calle, Irene Rivero, additional, Grande, Antonio Justicia, additional, Sousa, María López, additional, Vilas, Alejandro Souto, additional, Abel, Bernardo López, additional, de Miguel Esteban, Elisa, additional, Méndez, Bibiana Riaño, additional, Blázquez, Daniel, additional, Conejo, Pablo Rojo, additional, Lozano, Carlos Grasa, additional, Toral, Belén, additional, De la Torre, Leticia Albert, additional, de Inocencio, Jaime, additional, Santos, Mar, additional, Díaz-Delgado de la Peña, Rafael, additional, Ramos, Paz Collado, additional, Raga, Teresa, additional, Latorre, Libertad, additional, Guillén, Sara, additional, Caballero, Ignacio Callejas, additional, Prieto Tato, Luis Manuel, additional, Guzmán Monagas, María Fernanda, additional, López, Isabel Jiménez, additional, Villagrá, Sandra, additional, Arreo, Viviana, additional, Pérez, Roi Piñeiro, additional, Parte, María de la, additional, Tamariz-Martes, Amalia, additional, Romano, Marta Llorente, additional, Hernández Rupérez, Maria Belén, additional, Sombrero, Henar Rojo, additional, Cerro, Estefanía García, additional, Cano, Irene Maté, additional, Alonso, Marta Villares, additional, Osuna Marco, Marta Pilar, additional, Veron, Julia Jensen, additional, Reales, Cristina Zarallo, additional, Rodríguez Mesa, María Dolores, additional, Esteban, Santiago Rueda, additional, Ramos Amador, José Tomás, additional, Menchén, Cristina González, additional, Jiménez Jiménez, Ana Belén, additional, Galán, Pilar, additional, Campos, Dolores Pérez, additional, Bueno, Ma Mercedes, additional, Marcos, David Crespo, additional, Otheo de Tejada Barásoain, Enrique, additional, Sifuentes Giraldo, Walter Alberto, additional, Gámir Gámir, María Luz, additional, José Cilleruelo Ortega, María, additional, López, Agustín López, additional, Vaquerizo, Cristina Sánchez, additional, Usano Carrasco, Ana Isabel, additional, Gómez, Ester Moreno, additional, Carvajal del Castillo, Olga, additional, Del Pozo Menéndez, Beatriz, additional, Navarro, Katie Badillo, additional, Baquero, Fernando, additional, Bronte, Lucía Deiros, additional, Fraga, Pablo Fernández, additional, Domínguez, Nieves, additional, Rodríguez, Beatriz Mercader, additional, García, Francisco Castro, additional, Chamorro, Águeda Herrera, additional, Rodríguez, Paula Alcañiz, additional, García, Moisés Sorlí, additional, Rex Nicolás, María Concepción, additional, Romero, Elena Vera, additional, Olorón, Patricia Martínez, additional, Cilveti, Beatriz Rocandio, additional, Berridi, Amaia, additional, Santos-Díez Vázquez, Laura, additional, Fernández, Olaia, additional, Calvo, Inmaculada, additional, Tudela, Belén Fernández, additional, Benavent, Manuel Oltra, additional, Archilés, Marta Dapena, additional, Ferrer, Franciasco Sanchez, additional, Gavilán, César, additional, Fos, Ignacio Izquierdo, additional, Serrano Robles, María Isabel, additional, Sánchez, Yolanda Herranz, additional, Pinto, Enrique Villalobos, additional, Garulo, Daniel Clemente, additional, Pie, Stella, additional, Calvo, Manuel Marrero, additional, and Olmos García, José María, additional

Published
2021
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11. Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Author

Hsia, Yingfen, Lee, Brian R, Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, Sharland, Mike, Irwin, Adam, Akula, Akhila, Bamford, Alasdair, Chang, Amanda, da Silva, Andre, Whitelaw, Andrew, Dramowski, Angela, Vasudevan, Anil Kumar, Sharma, Anita, Justicia, Antonio, Chikkappa, Ashok, Slowinska-Jarzabek, Barbara, Rippberger, Bianca, Zhao, Changan, Tersigni, Chiara, Cheng, Chinglan, Harkensee, Christian, Jing, Chuamei, Zhu, Chunmei, Li, Chunyan, Tagliabue, Claudia, Epalza, Cristina, Jacqueline, Daglish, Tian, Daiyin, Jinka, Dasaratha, Gkentzi, Despoina, Dharmapalan, Dhanya, Benadof, Dona, Papadimitriou, Eleni, Iosifidis, Elias, Roilides, Emmanuel, Yarci, Erbu, Majda-Stanisławska, Ewa, Gowin, Ewelina, Chappell, Faye, Torres, Federico Martinon, Collett-White, Francis, Liu, Gang, Lu, Gen, Syrogiannopoulos, George, Pitsava, Georgia, Alvarez-Uria, Gerardo, Renk, Hana, Mahmood, Hana, Saxen, Harri, Finlayson, Heather, Green, Helen, Rabie, Helena, Kandraju, Hemasree, Zhang, Hong, Okokon, Ita, Cross, Jack, Herberg, Jethro, Li, Jianping, Zhang, Jiaosheng, Deng, Jikui, Liu, Jing, Qian, Jing, Yang, Jinhong, Sicińska, Joanna, Hübner, Johannes, Fukuoka, Kahoru, Yao, Kaihu, Cheung, Kaman, Ojeda, Karla, Kaffe, Katerina, Kreitmeyer, Katharina, Doerholt, Katja, Grimwood, Keith, Ledoare, Kirsty, Vazouras, Konstantinos, Shen, Kunling, Tang, Lanfang, Zhang, Lehai, Lin, Li, Ashkenazi-Hoffnung, Liat, Wu, Lijuan, Wang, Lijun, Teston, Lilian, Galli, Luisa, Speirs, Lynne, Tsolia, Maria, Hufnagel, Markus, Knuf, Markus, Duse, Marzia, Ding, Mingjie, Rozic, Mojca, Premru, Mueller, O'Connell, Natasha, Rieber, Nikolaus, Spyridis, Nikos, Tunga, Onkaraiah, Conejo, Pablo Rojo, McMaster, Paddy, Lumbiganon, Pagakrong, Pansa, Paola, D'Argenio, Patrizia, Moriarty, Paul, Nikolic, Petra, Wang, Ping, Paopongsawan, Pongsatorn, Cao, Qing, Deng, Qiulian, Laxminarayan, Ramanan, Kanithi, Ravishankar, Jimenez, Rodolfo, Cao, Sancheng, Singh, Sanjeev, Rees, Sarah, Praveen, Saroey, Kekomaki, Satu, Hackett, Scott, Ashkenazi, Shai, Chang, Si Min, Drysdale, Simon, Koning, Sonia, Subramanian, Sreeram, Murki, Srinivas, Vergnano, Stefania, Gandra, Sumanth, Esposito, Susanna, Anugulruengkitt, Suvaporn, Puthanakit, Thanyawee, Behrends, Uta, Papaevangelous, Vana, Jian, Victoria, Li, Wei, Zhao, Wei, Wang, Wei, Zhang, Wenshuang, Mu, Xiaoping, Dong, Xiaoyie, Jiang, Xiyuan, Chen, Xu, Wang, Yi, Zheng, Yuejie, Horikoshi, Yuho, Aboderin, Aaron, Olayinka, Adebola, Dedeic-Ljubovic, Amela, McCorry, Ann, Enimil, Anthony, Neubert, Antje, solano, antonio, Pignatari, Antonio, Poojary, Aruna, Kambaralieva, Baktygul, McCullagh, Bernadette, Carevi, Biljana, Van Herendael, Bruno, Gormley, Cairine, Carvajal, Camila, Ramírez, Carlos, Fitzgerald, David, Sabuda, Deana, Konopnicki, Deborah, Lacej, Denada, Pierard, Denis, Rios, Edgar, Marshall, Emily, Firre, Eric, van Elzakker, Erika, Shaqiri, Erjona, Darwish Elhajji, Feras, Gawrys, Gerard, Markovic, Goran, Kunsihima, Hiroyuki, Chen, Hui Hiong, Sviestina, Inese, Pristas, Irina, Hoxha, Iris, Korinteli, Irma, Mareković, Ivana, Soltani, Jafar, Labarca, Jaime, AlSalman, Jameela, Horvatic, Jasminka, Frimpong, Juliet Ampomah, Pagava, Karaman, Kei, Kasahara, Okinaka, Keiji, Iregbu, Kenneth, Ghazaryan, Lilit, Raka, Lul, Gessner-Wharton, Mallory, Aldeyab, Mamoon, Cooper, Mandelin, del Castillo, Marcelo, Hojman, Martin, Hudson, Melissa, Alshehri, Mohamed, Ling, Moi Lin, Greer, Nickie, Oduyebo, Oyinlola, Buijtels, Patricia, TEROL BARRERO, PEDRO, Zarb, Peter, Schelstraete, Petra, Nwajiobi-Princewill, Princewill Ifeanyi Philip, Khanna, Priya, Quiros, Rodolfo, Simovic, Sanja, Thompson, Sarah, Chan, Si Min, Burokiene, Sigita, Rachina, Svetlana, Usonis, Vytautas, Cornistein, Wanda, Holemans, Xavier, Gu, Yoshiaki, Brothers, Adam, Hersh, Adam, Fernandez, Alfred, Tribble, Alison, Hurst, Amanda, Green, Andrea, Hammer, Benjamin, Lee, Betty P, Kuzmic, Brenik, Shapiro, Craig, Boge, Craig, Haslam, David, Berman, David, Naeem, Fouzia, Johnson, George, Schwenk, Hayden, Orr, Hillary, Maples, Holly, Olsen, Jared, Gerber, Jeffrey, Girotto, Jennifer, Zweiner, Jennifer, Goldman, Jennifer, Gillon, Jessica, Tansmore, Jessica, Manaloor, John, Courter, Joshua, Mongkolrattanothai, Kanokporn, Patel, Karisma, Merkel, Kathryn, Namtu, Katie, Flett, Kelly, Lee, Kelly, Nichols, Kristen, Klein, Kristin, Handy, Lori, Castagnini, Luis, Mazade, Marc, Heger, Margaret, Fernandez, Marisol, Chang, Michael, Crawford, Michelle, Nelson, Miranda, Bennett, Nicholas, Jaggi, Preeti, Hamdy, Rana, Banerjee, Ritu, Olivero, Rosemary, Patel, Sameer, Arnold, Sandra, Ogrin, Sara, Jones, Sarah, Parker, Sarah, Kubes, Sarah, Hymes, Saul, Weissman, Scott, Chan, Shannon, Henderson, Sheryl, Metjian, Talene, GARPEC and Global-PPS networks, on behalf of the, GARPEC Network, Global-PPS Network, Children's Hospital, HUS Children and Adolescents, and Clinicum

Subjects
medicine.medical_specialty, Adolescent, medicine.drug_class, 030231 tropical medicine, Antibiotics, MEDLINE, Psychological intervention, CHILDREN, World Health Organization, Pediatrics, Essential medicines, 03 medical and health sciences, Antimicrobial Stewardship, 0302 clinical medicine, Antibiotic resistance, POINT PREVALENCE SURVEY, SURVEILLANCE, Medicine and Health Sciences, Medicine, Antimicrobial stewardship, Humans, 030212 general & internal medicine, Medical prescription, Child, Neonatal sepsis, business.industry, lcsh:Public aspects of medicine, STEWARDSHIP, Infant, Newborn, Infant, lcsh:RA1-1270, General Medicine, medicine.disease, 3142 Public health care science, environmental and occupational health, Drug Utilization, 3. Good health, Anti-Bacterial Agents, QUALITY INDICATORS, Family medicine, Child, Preschool, Health Care Surveys, Human medicine, business, Pharmacy Service, Hospital
Abstract

Summary: Background: Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed to present data on patterns of paediatric AWaRe antibiotic use that could be used for local and national stewardship interventions. Methods: 1-day point prevalence survey antibiotic prescription data were combined from two independent global networks: the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children and the Global Point Prevalence Survey on Antimicrobial Consumption and Resistance networks. We included hospital inpatients aged younger than 19 years receiving at least one antibiotic on the day of the survey. The WHO AWaRe classification was used to describe overall antibiotic use as assessed by the variation between use of Access, Watch, and Reserve antibiotics, for neonates and children and for the commonest clinical indications. Findings: Of the 23 572 patients included from 56 countries, 18 305 were children (77·7%) and 5267 were neonates (22·3%). Access antibiotic use in children ranged from 7·8% (China) to 61·2% (Slovenia) of all antibiotic prescriptions. The use of Watch antibiotics in children was highest in Iran (77·3%) and lowest in Finland (23·0%). In neonates, Access antibiotic use was highest in Singapore (100·0%) and lowest in China (24·2%). Reserve antibiotic use was low in all countries. Major differences in clinical syndrome-specific patterns of AWaRe antibiotic use in lower respiratory tract infection and neonatal sepsis were observed between WHO regions and countries. Interpretation: There is substantial global variation in the proportion of AWaRe antibiotics used in hospitalised neonates and children. The AWaRe classification could potentially be used as a simple traffic light metric of appropriate antibiotic use. Future efforts should focus on developing and evaluating paediatric antibiotic stewardship programmes on the basis of the AWaRe index. Funding: GARPEC was funded by the PENTA Foundation. GARPEC-China data collection was funded by the Sanming Project of Medicine in Shenzhen (SZSM2015120330). bioMérieux provided unrestricted funding support for the Global-PPS.

Published
2019

12. 1958. Antiviral Effects, Pharmacokinetics (PK), and Safety of the Respiratory Syncytial Virus (RSV) Fusion Protein Inhibitor, JNJ-53718678 (JNJ-8678), in RSV-infected Infants With Bronchiolitis, in the Phase 1b Study 53718678RSV1005

Author

Martinon-Torres, Federico, primary, Rusch, Sarah, additional, Huntjens, Dymphy, additional, Remmerie, Bart, additional, Vingerhoets, Johan, additional, McFadyen, Katie, additional, Ferrero, Fernando, additional, Baraldi, Eugenio, additional, Conejo, Pablo Rojo, additional, Epalza, Cristina, additional, and Stevens, Marita, additional

Published
2018
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13. Long-term Mortality in HIV-Positive Individuals Virally Suppressed for >3 Years With Incomplete CD4 Recovery

Author

Engsig, Frederik N., Zangerle, Robert, Katsarou, Olga, Dabis, Francois, Reiss, Peter, Gill, John, Porter, Kholoud, Sabin, Caroline, Riordan, Andrew, Fätkenheuer, Gerd, Gutiérrez, Félix, Raffi, Francois, Kirk, Ole, Mary-Krause, Murielle, Stephan, Christoph, de Olalla, Patricia Garcia, Guest, Jodie, Samji, Hasina, Castagna, Antonella, d'Arminio Monforte, Antonella, Skaletz-Rorowski, Adriane, Ramos, Jose, Lapadula, Giuseppe, Mussini, Cristina, Force, Lluís, Meyer, Laurence, Lampe, Fiona, Boufassa, Faroudy, Bucher, Heiner C., De Wit, Stéphane, Burkholder, Greer A., Teira, Ramon, Justice, Amy C., Sterling, Tim R., M. Crane, Heidi, Gerstoft, Jan, Grarup, Jesper, May, Margaret, Chêne, Geneviève, Ingle, Suzanne M., Sterne, Jonathan, Obel, Niels, Burkholder, Greer, Justice, Amy, R Sterling, Tim, Crane, Heidi M., Boulle, Andrew, Brodt, Hans-Reinhard, Casabona, Jordi, Cavassini, Matthias, Costagliola, Dominique, Dabis, François, D'Arminio Monforte, Antonella, del Amo, Julia, Van Sighem, Ard, Hans-Ulrich Haerry, David, Hogg, Robert, Mocroft, Amanda, Kitahata, Mari, Saag, Michael, Williams, Matthew, Ingle, Suzanne, Touloumi, Giota, Warszawski, Josiane, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wit, Ferdinand, Prins, Maria, Gibb, Diana, Del Amo, Julia, Thorne, Claire, Pérez-Hoyos, Santiago, Hamouda, Osamah, Gussenheimer-Bartmeyer, Barbara, Noguera-Julian, Antoni, Antinori, Andrea, Brockmeyer, Norbert, Ramos, José, Battegay, Manuel, Rauch, Andri, Tookey, Pat, Miró, Jose M., de Wit, Stephane, Goetghebuer, Tessa, Torti, Carlo, Garrido, Myriam, Judd, Ali, Conejo, Pablo Rojo, Haerry, David, Weller, Ian, d'Arminio-Monforte, Antonella, Colin, Céline, Schwimmer, Christine, Termote, Monique, Kjaer, Jesper, Campbell, Maria, Raben, Dorthe, Bohlius, Julia, Bouteloup, Vincent, Bucher, Heiner, Cozzi-Lepri, Alessandro, Dorrucci, Maria, Egger, Matthias, Engsig, Frederik, Furrer, Hansjakob, Lambotte, Olivier, Lewden, Charlotte, Lodi, Sara, Lodwick, Rebbeca, Matheron, Sophie, Miro, Jose, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Reekie, Joanne, Scherrer, Alexandra, Smit, Colette, Thiebaut, Rodolphe, and Wittkop, Linda

Abstract

Virally suppressed HIV-positive individuals on combination antiretroviral therapy who do not achieve a CD4 count >200 cells/µL have substantially increased long-term mortality. The increased mortality was seen across different patient groups and for all causes of death

Published
2017

14. Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients: A Cohort Study

Author

Wang, Qing, De Luca, Andrea, Smith, Colette, Zangerle, Robert, Sambatakou, Helen, Bonnet, Fabrice, Smit, Colette, Schommers, Philipp, Thornton, Alicia, Berenguer, Juan, Peters, Lars, Spagnuolo, Vincenzo, Ammassari, Adriana, Antinori, Andrea, Roldan, Eugenia Quiros, Mussini, Cristina, Miro, Jose M., Konopnicki, Deborah, Fehr, Jan, Campbell, Maria A., Termote, Monique, Bucher, Heiner C., De Wit, Stéphane, Costagliola, Dominique, D'Arminio-Monforte, Antonella, Castagna, Antonella, Del Amo, Julia, Mocroft, Amanda, Raben, Dorthe, Chêne, Geneviève, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Sabin, Caroline, Gibb, Diana, Fätkenheuer, Gerd, Obel, Niels, Thorne, Claire, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, D'Arminio Monforte, Antonella, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Rauch, Andri, Tookey, Pat, Casabona, Jordi, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Teira, Ramon, Garrido, Myriam, Haerry, David, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Judd, Ali, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Sterne, Jonathan, Thiebaut, Rodolphe, Van Der Valk, Marc, Wyss, Natasha, Barger, Diana, Schwimmer, Christine, Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Wang, Q, De Luca, A, Smith, C, Zangerle, R, Sambatakou, H, Bonnet, F, Smit, C, Schommers, P, Thornton, A, Berenguer, J, Peters, L, Spagnuolo, V, Ammassari, A, Antinori, A, Roldan, E, Mussini, C, Miro, J, Konopnicki, D, Fehr, J, Campbell, M, Termote, M, Bucher, H, Puoti, M, University of Zurich, Bucher, Heiner C, Quiros Roldan, E, Miro, Jm, Campbell, Ma, Bucher, Hc, on behalf of The Hepatitis Coinfection and Non Hodgkin Lymphoma project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in, Eurocoord, and Castagna, Antonella

Subjects
Male, Lymphoma, Hepatitis B Surface Antigen, HIV Infections, medicine.disease_cause, Cohort Studies, 10234 Clinic for Infectious Diseases, 0302 clinical medicine, Risk Factors, HIV Infection, 030212 general & internal medicine, Viral, Chronic, media_common, Incidence (epidemiology), Hepatitis B Core Antigen, Lymphoma, Non-Hodgkin, Hazard ratio, virus diseases, General Medicine, Hepatitis C, Hepatitis B, Hepatitis B Core Antigens, Hepatitis Antibodie, 030220 oncology & carcinogenesis, RNA, Viral, Female, hepatitis c and b, Cohort study, Human, Adult, medicine.medical_specialty, Anti-HIV Agents, Biomarkers, Hepatitis Antibodies, Hepatitis B Surface Antigens, Hepatitis B, Chronic, Hepatitis C, Chronic, Humans, Immunoglobulin G, Hepatitis C virus, Non-Hodgkin, 610 Medicine & health, Settore MED/17 - MALATTIE INFETTIVE, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, media_common.cataloged_instance, HIV HCV NHL HBV, European union, Hepatitis B virus, business.industry, Risk Factor, Anti-HIV Agent, Biomarker, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, digestive system diseases, 2724 Internal Medicine, Immunology, RNA, Cohort Studie, business
Abstract

Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatment-naive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic co-infection with HBV and HCV is associated with an increased risk for NHL. Primary Funding Source: European Union Seventh Framework Programme.

Published
2017

15. CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: A multinational, multicohort European study

Author

Wittkop, Linda, Arsandaux, Julie, Trevino, Ana, van der Loeff, Maarten Schim, Anderson, Jane, van Sighem, Ard, Böni, Jürg, Brun-Vezinet, Françoise, Soriano, Vicente, Boufassa, Faroudy, Brockmeyer, Norbert, Calmy, Alexandra, Dabis, François, Jarrin, Inma, Dorrucci, Maria, Duque, Vitor, Fätkenheuer, Gerd, Zangerle, Robert, Ferrer, Elena, Porter, Kholoud, Judd, Ali, Sipsas, Nikolaos V., Lambotte, Olivier, Shepherd, Leah, Leport, Catherine, Morrison, Charles, Mussini, Cristina, Obel, Niels, Ruelle, Jean, Schwarze-Zander, Carolyne, Sonnerborg, Anders, Teira, Ramon, Torti, Carlo, Valadas, Emilia, Colin, Celine, Friis-Møller, Nina, Costagliola, Dominique, Thiebaut, Rodolphe, Chene, Geneviève, Matheron, Sophie, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Krause, Murielle Mary, Ghosn, Jade, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Del Amo, Julia, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella d'Arminio, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Tookey, Pat, Casabona, Jordi, Mirò, Jose M., Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Sabin, Caroline, Garrido, Myriam, Haerry, David, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Amo, Julia del, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Leroy, Valériane, Lodi, Sara, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, van der Valk, Marc, Wyss, Natasha, Epidémiologie et Biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM), Team MORPH3EUS (INSERM U1219 - UB - ISPED), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Infectious Diseases, Hospital Carlos III, Center for Infection and Immunity Amsterdam - CINIMA [Amsterdam, The Netherlands], Homerton University Hospital, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), Universität Zürich [Zürich] = University of Zurich (UZH), Université Paris Diderot - Paris 7 (UPD7), Service de Virologie [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Ruhr-Universität Bochum [Bochum], Geneva University Hospital (HUG), CHU de Bordeaux Pellegrin [Bordeaux], Instituto de Salud Carlos III [Madrid] (ISC), CIBER de Epidemiología y Salud Pública (CIBERESP), Istituto Superiore di Sanità (ISS), Hospitais da Universidade de Coimbra (H.U.C.), University of Coimbra [Portugal] (UC), University Hospital of Cologne [Cologne], Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Hospitalet de Llobregat, University College of London [London] (UCL), National and Kapodistrian University of Athens (NKUA), Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre], Hôpital Bicêtre, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), FHI 360, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Université Catholique de Louvain = Catholic University of Louvain (UCL), University Hospital Bonn, Department of Infectious Diseases, Institution of Medicine, Karolinska University Hospital and Karolinska Institutet, Sierrallana Hospital, Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Universidade de Lisboa = University of Lisbon (ULISBOA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Infectious diseases, Wittkop, L, Arsandaux, J, Trevino, A, van der Loeff, M, Anderson, J, van Sighem, A, Böni, J, Brun-Vezinet, F, Soriano, V, Boufassa, F, Brockmeyer, N, Calmy, A, Dabis, F, Jarrin, I, Dorrucci, M, Duque, V, Fätkenheuer, G, Zangerle, R, Ferrer, E, Porter, K, Judd, A, Sipsas, N, Lambotte, O, Shepherd, L, Leport, C, Morrison, C, Mussini, C, Obel, N, Ruelle, J, Schwarze-Zander, C, Sonnerborg, A, Teira, R, Torti, C, Valadas, E, Colin, C, Friis-Møller, N, Costagliola, D, Thiebaut, R, Chene, G, Matheron, S, Touloumi, G, Warszawski, J, Meyer, L, Krause, M, Ghosn, J, Reiss, P, Wit, F, Prins, M, Bucher, H, Gibb, D, Del Amo, J, Thorne, C, Mocroft, A, Kirk, O, Stephan, C, Pérez-Hoyos, S, Hamouda, O, Bartmeyer, B, Chkhartishvili, N, Noguera-Julian, A, Antinori, A, Monforte, A, Prieto, L, Conejo, P, Soriano-Arandes, A, Battegay, M, Kouyos, R, Tookey, P, Casabona, J, Mirò, J, Castagna, A, Konopnick, D, Goetghebuer, T, Sönnerborg, A, Sabin, C, Garrido, M, Haerry, D, Berenguer, J, Bohlius, J, Bouteloup, V, Cozzi-Lepri, A, Davies, M, Amo, J, Dunn, D, Egger, M, Furrer, H, Guiguet, M, Grabar, S, Leroy, V, Lodi, S, Monge, S, Nakagawa, F, Paredes, R, Phillips, A, Puoti, M, Schomaker, M, Smit, C, Sterne, J, van der Valk, M, Wyss, N, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Istituto Superiore di Sanita [Rome], Gestionnaire, Hal Sorbonne Université, Wittkop, Linda, Arsandaux, Julie, Trevino, Ana, Van Der Loeff V Schim, Maarten, Anderson, Jane, Van Sighem, Ard, Jurg, Boni, Brun-Vezinet, Francoise, Soriano, Vicente, Boufassa, Faroudy, Brockmeyer, Norbert, Calmy, Alexandra, Dabis, Francoi, Jarrin, Inma, Dorrucci, Maria, Duque, Vitor, Fãtkenheuer, Gerd, Zangerle, Robert, Ferrer, Elena, Porter, Kholoud, Judd, Ali, Sipsas, Nikolaos V, Lambotte, Olivier, Shepherd, Leah, Leport, Catherine, Morrison, Charle, Mussini, Cristina, Obel, Niel, Ruelle, Jean, Schwarze-Zander, Carolyne, Sonnerborg, Ander, Teira, Ramon, Torti, Carlo, Valadas, Emilia, Colin, Celine, Friis-Moller, Nina, Costagliola, Dominique, Thiebaut, Rodolphe, Chene, Geneviève, Matheron, Sophie, on behalf of the COHERE in EuroCoord and ACHIeV2e Study, Group, and Castagna, Antonella

Subjects
0301 basic medicine, CD4-Positive T-Lymphocytes, Male, Internationality, [SDV]Life Sciences [q-bio], Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Gastroenterology, Anti-HIV Agents/administration & dosage/adverse effects/therapeutic use, Viral/blood, Cohort Studies, 0302 clinical medicine, CD4 HIV, Pharmacology (medical), 030212 general & internal medicine, Cd4 cell count, ddc:616, Confounding, virus diseases, Middle Aged, Viral Load, 3. Good health, [SDV] Life Sciences [q-bio], Europe, HIV-2/drug effects, Infectious Diseases, HIV-1/drug effects, RNA, Viral, Female, Viral load, Cohort study, Microbiology (medical), Cart, Adult, medicine.medical_specialty, Anti-HIV Agents, 030106 microbiology, 03 medical and health sciences, Internal medicine, medicine, Humans, Pharmacology, business.industry, CD4-Positive T-Lymphocytes/immunology/virology, CD4 Lymphocyte Count, Institutional repository, HIV Infections/blood/drug therapy/immunology/virology, HIV-2, HIV-1, RNA, Panton–Valentine leukocidin, business
Abstract

Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36-52) and 37 years (IQR 31-44), respectively. Median observed pretreatment CD4 cell counts/mm(3) were 203 (95% CI 100-290) in HIV-2+ patients and 223 (95% CI 100-353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12months were + 105 (95% CI 77-134) in HIV-2+ patients and + 202 (95% CI 199-205) in HIV-1+ patients, an observed difference of 97 cells/mm(3) in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm(3)/year lower (95% CI 5-44; P=0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+ patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2

Published
2017

16. Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers

Author

Chereau, Fanny, Madec, Yoann, Sabin, Caroline, Obel, Niels, Ruiz-Mateos, Ezequiel, Chrysos, Georgios, Fidler, Sarah, Lehmann, Clara, Zangerle, Robert, Wittkop, Linda, Reiss, Peter, Hamouda, Osamah, Perez, Vicente Estrada, Leal, Manuel, Mocroft, Amanda, De Olalla, Patricia Garcia, Ammassari, Adriana, Monforte, Antonella D'Arminio, Mussini, Cristina, Segura, Ferran, Castagna, Antonella, Cavassini, Matthias, Grabar, Sophie, Morlat, Philippe, De Wit, Stéphane, Lambotte, Olivier, Meyer, Laurence, Judd, Ali, Touloumi, Giota, Warszawski, Josiane, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Del Amo, Julia, Thorne, Claire, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Tookey, Pat, Casabona, Jordi, Miró, Jose M., Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Teira, Ramon, Garrido, Myriam, Haerry, David, Miró, Jose Ma, Costagliola, Dominique, D'Arminio-Monforte, Antonella, Raben, Dorthe, Chêne, Geneviève, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M., Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Van Der Valk, Marc, Fanny, C, Yoann, M, Caroline, S, Niels, O, Ezequiel, R, Georgios, C, Sarah, F, Clara, L, Robert, Z, Linda, W, Peter, R, Osamah, H, Vicente Estrada, P, Manuel, L, Amanda, M, Patricia Garcia De, O, Adriana, A, Antonella D’Arminio, M, Cristina, M, Ferran, S, Antonella, C, Matthias, C, Sophie, G, Philippe, M, Stéphane De, W, Olivier, L, Laurence, M, Puoti, M, Chereau, F, Madec, Y, Sabin, C, Obel, N, Ruiz-Mateos, E, Chrysos, G, Fidler, S, Lehmann, C, Zangerle, R, Wittkop, L, Reiss, P, Hamouda, O, Perez, Ve, Leal, M, Mocroft, A, De Olalla, Pg, Ammassari, A, Monforte, Ada, Mussini, C, Segura, F, Castagna, A, Cavassini, M, Grabar, S, Morlat, P, De Wit, S, Lambotte, O, Meyer, L, The HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in, Eurocoord, Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (France), HIV Monitoring Foundation, Augustinus Foundation, European Commission, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), University College London Hospitals (UCLH), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Hospital Universitario Virgen del Rocío [Sevilla], Tzaneio General Hospital, Imperial College London, German Center for Infection Research - Partner Site Bonn-Cologne (DZIF), Universität Innsbruck [Innsbruck], Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Robert Koch Institute [Berlin] (RKI), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), CIBER de Epidemiología y Salud Pública (CIBERESP), Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), University of Milan, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Hospital Universitari Parc Taulí of Sabadell, Barcelona, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Université de Lausanne (UNIL), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université libre de Bruxelles (ULB), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université de Lausanne = University of Lausanne (UNIL), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), HAL UPMC, Gestionnaire, AII - Infectious diseases, APH - Aging & Later Life, Global Health, Amsterdam institute for Infection and Immunity, HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCOORD, Imperial College Healthcare NHS Trust- BRC Funding, and Medical Research Council (MRC)

Subjects
Male, HIV Infections, CD8-Positive T-Lymphocytes, Pathology and Laboratory Medicine, Immunodeficiency Viruses, HIV-1/immunology, Public and Occupational Health, lcsh:Science, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Female, HIV-1, Humans, Viral Load, Viremia, Virus Replication, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), virus diseases, CD8-Positive T-Lymphocytes/drug effects, Antiretroviral Therapy, Highly Active/methods, Medical Microbiology, Viral Pathogens, Science & Technology - Other Topics, Human, Blood cells, Immunology, HIV Infections/drug therapy, Virus Replication/immunology, Men WHO Have Sex with Men, Cytotoxic T cells, Microbiology, Viremia/drug therapy, Microbial Pathogens, Science & Technology, lcsh:R, Organisms, Biology and Life Sciences, Anti-HIV Agent, NATURAL-HISTORY, CD8-Positive T-Lymphocyte, Anti-HIV Agents/therapeutic use, HIV CD4 AIDS, T-CELLS, Population Groupings, lcsh:Q, Preventive Medicine, Sexuality Groupings, RNA viruses, RNA LEVELS, lcsh:Medicine, PROGRESSION, ACTIVATION, INFECTION, Cellular types, Medicine and Health Sciences, HIV Infection, Medicine (all), Immune cells, HIV diagnosis and management, ABSENCE, Vaccination and Immunization, Multidisciplinary Sciences, Infectious Diseases, CD4-Positive T-Lymphocyte, Viruses, White blood cells, Pathogens, Research Article, Cell biology, Evolutionary Immunology, Infectious Disease Control, General Science & Technology, T cells, Antiretroviral Therapy, CD4-Positive T-Lymphocytes/drug effects, CD4 Lymphocyte Count/methods, Viral Evolution, Antiviral Therapy, Virology, MD Multidisciplinary, Retroviruses, Evolutionary Biology, Lentivirus, HIV, Viral Load/drug effects, Diagnostic medicine, Organismal Evolution, Animal cells, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, REPLICATION, People and Places, Microbial Evolution, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/virology, CD8-Positive T-Lymphocytes/immunology, HIV Infections/immunology, HIV Infections/virology, Viral Load/immunology, Viremia/immunology, Viremia/virology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, INVERSE PROBABILITY
Abstract

[Objective] HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The objective was to identify factors associated with loss of virological control., [Methods] HICs were identified in COHERE on the basis of ≥5 consecutive viral loads (VL) ≤500 copies/mL over ≥1 year whilst ART-naive, with the last VL ≤500 copies/mL measured ≥5 years after HIV diagnosis. Loss of virological control was defined as 2 consecutive VL >2000 copies/mL. Duration of HIV control was described using cumulative incidence method, considering loss of virological control, ART initiation and death during virological control as competing outcomes. Factors associated with loss of virological control were identified using Cox models. CD4 and CD8 dynamics were described using mixed-effect linear models., [Results] We identified 1067 HICs; 86 lost virological control, 293 initiated ART, and 13 died during virological control. Six years after confirmation of HIC status, the probability of losing virological control, initiating ART and dying were 13%, 37%, and 2%. Current lower CD4/CD8 ratio and a history of transient viral rebounds were associated with an increased risk of losing virological control. CD4 declined and CD8 increased before loss of virological control, and before viral rebounds., [Discussion] Expansion of CD8 and decline of CD4 during HIV control may result from repeated low-level viremia. Our findings suggest that in addition to superinfection, other mechanisms, such as low grade viral replication, can lead to loss of virological control in HICs., The COHERE study group has received unrestricted funding from: Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (ANRS), France; HIV Monitoring Foundation, The Netherlands; and the Augustinus Foundation, Denmark. The research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant agreement n° 260694.

Published
2017

17. Delayed HIV diagnosis and initiation of antiretroviral therapy: inequalities by educational level, COHERE in EuroCoord

Author

Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, Franã§ois, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Sabin, Caroline, Gibb, Diana, Fã¤tkenheuer, Gerd, Del Amo, Julia, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pã©rez hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Noguera julian, Antoni, Antinori, Andrea, D'arminio monforte, Antonella, Brockmeyer, Norbert, Ramos, Josã, Conejo, Pablo Rojo, Soriano, Toni, Battegay, Manuel, Rauch, Andri, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Mirã², Jose M., Konopnick, Deborah, Goetghebuer, Tessa, Torti, Carlo, Teira, Ramon, Garrido, Myriam, Haerry, David, De Wit, Stã©phane, Costagliola, Dominique, Grarup, Jesper, Chãªne, Genevieve, Cohort, Paediatric, Judd, Ali, Bohlius, Julia, Bouteloup, Vincent, Cozzi lepri, Alessandro, Dorrucci, Maria, Egger, Matthias, Engsig, Frederik, Furrer, Hansjakob, Lambotte, Olivier, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Van Der Valk, Marc, Wittkop, Linda, Wyss, Natasha, CASTAGNA, ANTONELLA, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Infectious diseases, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, Franã§oi, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Sabin, Caroline, Gibb, Diana, Fã¤tkenheuer, Gerd, Del Amo, Julia, Obel, Niel, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pã©rez hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Noguera julian, Antoni, Antinori, Andrea, D'arminio monforte, Antonella, Brockmeyer, Norbert, Ramos, Josã, Conejo, Pablo Rojo, Soriano, Toni, Battegay, Manuel, Rauch, Andri, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Mirã², Jose M., Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Torti, Carlo, Teira, Ramon, Garrido, Myriam, Haerry, David, De Wit, Stã©phane, Costagliola, Dominique, Grarup, Jesper, Chãªne, Genevieve, Cohort, Paediatric, Judd, Ali, Bohlius, Julia, Bouteloup, Vincent, Cozzi lepri, Alessandro, Dorrucci, Maria, Egger, Matthia, Engsig, Frederik, Furrer, Hansjakob, Lambotte, Olivier, Lodi, Sara, Matheron, Sophie, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Van Der Valk, Marc, Wittkop, Linda, and Wyss, Natasha

Subjects
Adult, Male, Cart, Health Knowledge, Attitudes, Practice, Pediatrics, medicine.medical_specialty, Delayed Diagnosis, Higher education, Immunology, HIV Infections, 610 Medicine & health, Socioeconomic Factor, Logistic regression, Education, Cohort Studies, Acquired immunodeficiency syndrome (AIDS), 360 Social problems & social services, Late diagnosi, medicine, Humans, Immunology and Allergy, HIV Infection, business.industry, Delayed Diagnosi, International Standard Classification of Education, Hiv, Odds ratio, Patient Acceptance of Health Care, medicine.disease, Confidence interval, Antiretroviral therapy, CD4 Lymphocyte Count, Europe, Infectious Diseases, Anti-Retroviral Agents, Socioeconomic Factors, Socioeconomic inequitie, Anti-Retroviral Agent, Cohort Studie, business, Human, Cohort study
Abstract

OBJECTIVES In Europe and elsewhere, health inequalities among HIV-positive individuals are of concern. We investigated late HIV diagnosis and late initiation of combination antiretroviral therapy (cART) by educational level, a proxy of socioeconomic position. DESIGN AND METHODS We used data from nine HIV cohorts within COHERE in Austria, France, Greece, Italy, Spain and Switzerland, collecting data on level of education in categories of the UNESCO/International Standard Classification of Education standard classification: non-completed basic, basic, secondary and tertiary education. We included individuals diagnosed with HIV between 1996 and 2011, aged at least 16 years, with known educational level and at least one CD4 cell count within 6 months of HIV diagnosis. We examined trends by education level in presentation with advanced HIV disease (AHD) (CD4

Published
2014
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18. Immunisation practices in centres caring for children with perinatally acquired HIV: A call for harmonisation

Author

Bamford, Alasdair, primary, Manno, Emma C., additional, Mellado, Maria Jose, additional, Spoulou, Vana, additional, Marques, Laura, additional, Scherpbier, Henriette J., additional, Niehues, Tim, additional, Oldakowska, Agnieszka, additional, Rossi, Paolo, additional, Palma, Paolo, additional, Menson, Esse N., additional, Muñoz-Fernández, M. Ángeles, additional, Della Negra, Marinella, additional, Shingadia, Delane, additional, Levy, Jack, additional, Marczynska, Magdalena, additional, Conejo, Pablo Rojo, additional, Klein, Nigel, additional, Ananworanich, Jintanat, additional, Ziegler, John Bernard, additional, Lyall, Hermione, additional, Di Biagio, Antonio, additional, Giacomet, Vania, additional, Gattinara, Guido Castelli, additional, De Sousa Marques, Heloisa Helena, additional, Cotugno, Nicola, additional, Salo, Eeva, additional, Volokha, Alla, additional, Mardarescu, Mariana, additional, Reliquet, Veronique, additional, Bernardi, Stefania, additional, and Giaquinto, Carlo, additional

Published
2016
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19. Children and young people with perinatal HIV in Europe: epidemiological situation in 2014 and implications for the future

Author

del Amo, Julia, Conejo, Pablo Rojo, Sabin, Caroline, Warszawski, Josiane, Gennotte, Anne-Francoise, Nadal, David, Gibb, Diana, Judd, Ali, Thorne, Claire, Olson, Ashley, Lodi, Sara, Pantazis, Nikos, Termote, Monique, Ledergerber, Bruno, Kristensen, Dennis, Brandt, Rikke Salbøl, Saidi, Yacine, Burns, Fiona, Chêne, Geneviève, Costagliola, Dominique, Giaquinto, Carlo, Grarup, Jesper, Kirk, Ole, Meyer, Laurence, Bailey, Heather, Anne, Alain Volny, Panteleev, Alex, Phillips, Andrew, Porter, Kholoud, Aboulker, Jean-Pierre, Albert, Jan, Asandi, Silvia, Monforte, Antonella d'Arminio, de Wit, Stéphane, Reiss, Peter, Gatell, José, Clínic, Fundació Privada, Bíomèdica, Recerca, Hamouda, Osamah, Karpov, Igor, Lundgren, Jens, Malyuta, Ruslan, Møller, Claus, Prins, Maria, Rakhmanova, Aza, Rockstroh, Jürgen, Rosinska, Magda, Sandhu, Manjinder, Touloumi, Giota, Cooper, David, Global Health, and Infectious diseases

Subjects
Adult, medicine.medical_specialty, Adolescent, Epidemiology, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Perinatal hiv, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Virology, Environmental health, Surveys and Questionnaires, Journal Article, Medicine, Humans, 030212 general & internal medicine, 030505 public health, business.industry, Research Support, Non-U.S. Gov't, Public Health, Environmental and Occupational Health, Infant, Newborn, Infectious Disease Transmission, Vertical, Europe, Cohort, Female, 0305 other medical science, business
Abstract

Accurate ascertainment of the number of children living with human immunodeficiency virus (HIV) is important to plan paediatric and adolescent health services. In Europe, the first generation of perinatally HIV-infected survivors are transferring to adult care and their health needs are unknown. We undertook an online survey of HIV cohort studies participating in the EuroCoord Network of Excellence to ascertain the number of perinatally HIV-infected (pHIV) patients included, to compare it with those published by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) and to assess the ability of countries to follow up pHIV patients after transfer to adult care. At the end of 2013, 16 countries in EuroCoord reported 8,229 pHIV patients in follow-up in cohorts, compared with 5,160 cumulative diagnoses reported by the ECDC in the same area. Follow-up of pHIV patients after transfer to adult care varied. It is likely that the number of diagnoses of perinatal HIV reported to ECDC is an underestimate, although this varies by country. Further work is needed to refine estimates and encourage follow-up in adult HIV cohorts to investigate long-term outcomes and improve the care of the next generation of children with HIV.

Published
2015

21. Impact of highly active antiretroviral therapy on the morbidity and mortality in Spanish human immunodeficiency virus-infected children

Author

GRANADOS, JOS?? MANUEL S??NCHEZ, primary, AMADOR, JOS?? TOM??S RAMOS, additional, DE MIGUEL, SIRA FERN??NDEZ, additional, TOM??, MAR??A ISABEL GONZ??LEZ, additional, CONEJO, PABLO ROJO, additional, VIVAS, PALOMA FERRANDO, additional, POLL??N, JULI??N CLEMENTE, additional, CONTRERAS, JES??S RUIZ, additional, and ESPERT, ANGEL NOGALES, additional

Published
2003
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