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308 results on '"Condorelli, Daniele Filippo"'

6. Gastric ghrelin cells in obese patients are hyperactive

Author

Castorina, Sergio, Barresi, Vincenza, Luca, Tonia, Privitera, Giovanna, De Geronimo, Vincenzo, Lezoche, Giovanni, Cosentini, Ilaria, Di Vincenzo, Angelica, Barbatelli, Giorgio, Giordano, Antonio, Taus, Marina, Nicolai, Albano, Condorelli, Daniele Filippo, and Cinti, Saverio

Published
2021
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8. Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer.

Author

Scuderi, Chiara, Di Bella, Virginia, Privitera, Anna Provvidenza, Giustolisi, Francesca Maria, Barresi, Vincenza, and Condorelli, Daniele Filippo

Subjects
COLORECTAL cancer, LINCRNA, CHROMOSOME abnormalities, COLON tumors, NON-coding RNA, CIRCULAR RNA
Abstract

Chromosomal instability is a hallmark of colorectal carcinogenesis and produces an accumulation of different forms of aneuploidies or broad copy number aberrations. Colorectal cancer is characterized by gain-type broad copy number aberrations, specifically in Chr20, Chr8q, Chr13 and Chr7, but their roles and mechanisms in cancer progression are not fully understood. It has been suggested that broad copy number gains might contribute to tumor development through the so-called caricature transcriptomic effect. We intend to investigate the impact of broad copy number gains on long non-coding RNAs' expression in colorectal cancer, given their well-known role in oncogenesis. The influence of such chromosomal aberrations on lncRNAs' transcriptome profile was investigated by SNP and transcriptome arrays in our series of colorectal cancer samples and cell lines. The correlation between aneuploidies and transcriptomic profiles led us to obtain a class of Over-UpT lncRNAs, which are transcripts upregulated in CRC and further overexpressed in colon tumors bearing specific chromosomal aberrations. The identified lncRNAs can contribute to a wide interaction network to establish the cancer driving effect of gain-type aneuploidies. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus.

Author

Andrioli, Anna, Fabene, Paolo Francesco, Mudò, Giuseppa, Barresi, Vincenza, Di Liberto, Valentina, Frinchi, Monica, Bentivoglio, Marina, and Condorelli, Daniele Filippo

Subjects
GENE expression, STATUS epilepticus, MICROGLIA, DOWNREGULATION, NEURODEGENERATION, IN situ hybridization, PILOCARPINE
Abstract

Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, and epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused on the response of Cxs to status epilepticus (SE), which is in turn an epileptogenic insult. The expression of neuronal Cx36 and astrocytic Cx30 and Cx43 mRNAs was investigated in the brain of rats in the first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease in Cx43 and Cx30 mRNA levels, significantly marked 24 h after SE onset in neocortical areas and the hippocampus, and in most thalamic domains, whereas Cx36 mRNA did not exhibit obvious changes. Regional evaluation with quantitative real-time-RT-PCR confirmed Cx43 and Cx30 mRNA downregulation 24 h after SE, when ongoing neuronal cell death was found in the same brain regions. Immunolabeling showed at the same time point marked a decrease in Cx43, microglia activation, and interleukin-1β induction in some microglial cells. The data showed a transient downregulation of astroglial Cxs in the cortical and thalamic areas in which SE triggers neurodegenerative events in concomitance with microglia activation and cytokine expression. This could potentially represent a protective response of neuroglial networks to SE-induced acute damage. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Gastric ghrelin cells in obese patients are hyperactive

Author

Castorina, Sergio, primary, Barresi, Vincenza, additional, Luca, Tonia, additional, Privitera, Giovanna, additional, De Geronimo, Vincenzo, additional, Lezoche, Giovanni, additional, Cosentini, Ilaria, additional, Di Vincenzo, Angelica, additional, Barbatelli, Giorgio, additional, Giordano, Antonio, additional, Taus, Marina, additional, Nicolai, Albano, additional, Condorelli, Daniele Filippo, additional, and Cinti, Saverio, additional

Published
2020
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27. Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1, SCO1 and COX11 in colorectal cancer

Author

Barresi, Vincenza, Trovato‐Salinaro, Angela, Spampinato, Giorgia, Musso, Nicolò, Castorina, Sergio, Rizzarelli, Enrico, and Condorelli, Daniele Filippo

Subjects
Copper homeostasis, Colorectal cancer, Alternative transcripts, copper transporter, synthesis of cytochrome c oxidase, Research Articles, Research Article
Abstract

Copper homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones encoded by a group of genes collectively known as copper homeostasis genes (CHGs). In this work, analysis of The Cancer Genome Atlas database for somatic point mutations in colorectal cancer revealed that inactivating mutations are absent or extremely rare in CHGs. Using oligonucleotide microarrays, we found a strong increase in mRNA levels of the membrane copper transporter 1 protein [CTR1; encoded by the solute carrier family 31 member 1 gene (SLC31A1 gene)] in our series of colorectal carcinoma samples. CTR1 is the main copper influx transporter and changes in its expression are able to induce modifications of cellular copper accumulation. The increased SLC31A1 mRNA level is accompanied by a parallel increase in transcript levels for copper efflux pump ATP7A, copper metabolism Murr1 domain containing 1 (COMMD1), the cytochrome C oxidase assembly factors [synthesis of cytochrome c oxidase 1 (SCO1) and cytochrome c oxidase copper chaperone 11 (COX11)], the cupric reductase six transmembrane epithelial antigen of the prostate (STEAP3), and the metal-regulatory transcription factors (MTF1, MTF2) and specificity protein 1 (SP1). The significant correlation between SLC31A1,SCO1, and COX11 mRNA levels suggests that this transcriptional upregulation might be part of a coordinated program of gene regulation. Transcript-level upregulation of SLC31A1,SCO1, and COX11 was also confirmed by the analysis of different colon carcinoma cell lines (Caco-2, HT116, HT29) and cancer cell lines of different tissue origin (MCF7, PC3). Finally, exon-level expression analysis of SLC31A1 reveals differential expression of alternative transcripts in colorectal cancer and normal colonic mucosa.

Published
2016

30. Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells

Author

Zuccarini, Mariachiara, primary, Giuliani, Patricia, additional, Buccella, Silvana, additional, Di Liberto, Valentina, additional, Mudò, Giuseppa, additional, Belluardo, Natale, additional, Carluccio, Marzia, additional, Rossini, Margherita, additional, Condorelli, Daniele Filippo, additional, Rathbone, Michel Piers, additional, Caciagli, Francesco, additional, Ciccarelli, Renata, additional, and Di Iorio, Patrizia, additional

Published
2017
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33. Copper-homeostasis genes in colorectal cancer

Author

Giorgia, Spampinato, TROVATO SALINARO, Angela, Nicolò, Musso, Castorina, Sergio, Enrico, Rizzarelli, Condorelli, Daniele Filippo, and Barresi, Vincenza

Published
2015

39. Principles of Medical Biochemistry, Third edition

Author

Meisenberg, G, Simmons, Wh, Ghigo, D, Barresi, Vincenza, Bertoni, A, Cacciapuoti, G., Capello, D, Coletta, M, Condorelli, Daniele Filippo, Filigheddu, N, Graziani, A, Guarnieri, C, Hirsh, E, Manzoni, M, and Monti, E.

Published
2013

45. Apoptosis and delayed luminescence of human leukemia jurkat T-cells after proton-irradiation and treatments with oxidant agents and flavonoids

Author

Baran, I, Ganea, C, Scordino, A, Privitera, S, Barresi, Vincenza, Musumeci, Francesco, Grasso, Rosaria, Condorelli, Daniele Filippo, Ursu, I, Baran, V, Katona, E, Mocanu, Mm, Ungureanu, R, Tofolean, It, Musso, N, Gulino, M, Cirrone, Gpa, Cuttone, G, Valastro, Lm, Surcel, M, and Ursaciuc, C.

Subjects
proton irradiation, delayed luminescence, oxidant agent
Published
2012

46. Effects of the mitochondrial respiration inhibitor, rotenone, on apoptosis, clonogenic survival and delayed luminescence of human leukemia jurkat T-cells

Author

Baran, I., Ganea, C., Privitera, S., Scordino, Agata, Barresi, Vincenza, Musumeci, Francesco, Grasso, Rosaria, Condorelli, Daniele Filippo, Baran, V., Katona, E., Mocanu, M. M., Ungureanu, R., Tofolean, I. T., Musso, N., Gulino, M., Surcel, M., and Ursaciuc, C.

Subjects
delayed luminescence, mitochondrial respiratory chain, apoptosis
Published
2012

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