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3. COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study

Author

Sanchez-Larsen, Alvaro, Conde-Blanco, Estefanía, Viloria-Alebesque, Alejandro, Sánchez-Vizcaíno Buendía, Cristina, Espinosa Oltra, Tatiana, Alvarez-Noval, Amanda, Aledo-Serrano, Angel, Martin-Garcia, Raquel, Ramos-Araque, María E., Campos, Dulce, Valle-Peñacoba, Gonzalo, Sierra-Gómez, Alicia, De Ceballos-Cerrajería, Pablo, Agundez-Sarasola, Marta, Khawaja, Mariam, Hampel, Kevin G., Serra-Martínez, Maria, Arbós-Barber, Clara, Gómez-Ibáñez, Asier, Villino-Boquete, Rafael, Cabezudo-García, Pablo, Rodríguez-Lavado, Ignacio, Principe, Alessandro, and Sopelana-Garay, David

Published
2021
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9. Gamma amplitude is coupled to opposed hippocampal theta-phase states during the encoding and retrieval of episodic memories in humans

Author

Saint Amour di Chanaz, Ludovico, primary, Pérez-Bellido, Alexis, additional, Wu, Xiongbo, additional, Lozano-Soldevilla, Diego, additional, Pacheco-Estefan, Daniel, additional, Lehongre, Katia, additional, Conde-Blanco, Estefanía, additional, Roldan, Pedro, additional, Adam, Claude, additional, Lambrecq, Virginie, additional, Frazzini, Valerio, additional, Donaire, Antonio, additional, Carreño, Mar, additional, Navarro, Vincent, additional, Valero-Cabré, Antoni, additional, and Fuentemilla, Lluís, additional

Published
2023
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10. Influence of personality profile in patients with drug‐resistant epilepsy on quality of life following surgical treatment: A 1‐year follow‐up study

Author

Iurina, Elena, primary, Bailles, Eva, additional, Carreño, Mar, additional, Donaire, Antonio, additional, Rumià, Jordi, additional, Boget, Teresa, additional, Bargalló, Núria, additional, Setoain, Xavier, additional, Roldan, Pedro, additional, Conde‐Blanco, Estefanía, additional, Centeno, María, additional, and Pintor, Luis, additional

Published
2022
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11. Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study

Author

Spitzer, Hannah, primary, Ripart, Mathilde, additional, Whitaker, Kirstie, additional, D’Arco, Felice, additional, Mankad, Kshitij, additional, Chen, Andrew A, additional, Napolitano, Antonio, additional, De Palma, Luca, additional, De Benedictis, Alessandro, additional, Foldes, Stephen, additional, Humphreys, Zachary, additional, Zhang, Kai, additional, Hu, Wenhan, additional, Mo, Jiajie, additional, Likeman, Marcus, additional, Davies, Shirin, additional, Güttler, Christopher, additional, Lenge, Matteo, additional, Cohen, Nathan T, additional, Tang, Yingying, additional, Wang, Shan, additional, Chari, Aswin, additional, Tisdall, Martin, additional, Bargallo, Nuria, additional, Conde-Blanco, Estefanía, additional, Pariente, Jose Carlos, additional, Pascual-Diaz, Saül, additional, Delgado-Martínez, Ignacio, additional, Pérez-Enríquez, Carmen, additional, Lagorio, Ilaria, additional, Abela, Eugenio, additional, Mullatti, Nandini, additional, O’Muircheartaigh, Jonathan, additional, Vecchiato, Katy, additional, Liu, Yawu, additional, Caligiuri, Maria Eugenia, additional, Sinclair, Ben, additional, Vivash, Lucy, additional, Willard, Anna, additional, Kandasamy, Jothy, additional, McLellan, Ailsa, additional, Sokol, Drahoslav, additional, Semmelroch, Mira, additional, Kloster, Ane G, additional, Opheim, Giske, additional, Ribeiro, Letícia, additional, Yasuda, Clarissa, additional, Rossi-Espagnet, Camilla, additional, Hamandi, Khalid, additional, Tietze, Anna, additional, Barba, Carmen, additional, Guerrini, Renzo, additional, Gaillard, William Davis, additional, You, Xiaozhen, additional, Wang, Irene, additional, González-Ortiz, Sofía, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Kälviäinen, Reetta, additional, Gambardella, Antonio, additional, Labate, Angelo, additional, Desmond, Patricia, additional, Lui, Elaine, additional, O’Brien, Terence, additional, Shetty, Jay, additional, Jackson, Graeme, additional, Duncan, John S, additional, Winston, Gavin P, additional, Pinborg, Lars H, additional, Cendes, Fernando, additional, Theis, Fabian J, additional, Shinohara, Russell T, additional, Cross, J Helen, additional, Baldeweg, Torsten, additional, Adler, Sophie, additional, and Wagstyl, Konrad, additional

Published
2022
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12. Interpretable surface-based detection of focal cortical dysplasias:a Multi-centre Epilepsy Lesion Detection study

Author

Spitzer, Hannah, Ripart, Mathilde, Whitaker, Kirstie, D’Arco, Felice, Mankad, Kshitij, Chen, Andrew A., Napolitano, Antonio, De Palma, Luca, De Benedictis, Alessandro, Foldes, Stephen, Humphreys, Zachary, Zhang, Kai, Hu, Wenhan, Mo, Jiajie, Likeman, Marcus, Davies, Shirin, Güttler, Christopher, Lenge, Matteo, Cohen, Nathan T., Tang, Yingying, Wang, Shan, Chari, Aswin, Tisdall, Martin, Bargallo, Nuria, Conde-Blanco, Estefanía, Pariente, Jose Carlos, Pascual-Diaz, Saül, Delgado-Martínez, Ignacio, Pérez-Enríquez, Carmen, Lagorio, Ilaria, Abela, Eugenio, Mullatti, Nandini, O’Muircheartaigh, Jonathan, Vecchiato, Katy, Liu, Yawu, Caligiuri, Maria Eugenia, Sinclair, Ben, Vivash, Lucy, Willard, Anna, Kandasamy, Jothy, McLellan, Ailsa, Sokol, Drahoslav, Semmelroch, Mira, Kloster, Ane G., Opheim, Giske, Ribeiro, Letícia, Yasuda, Clarissa, Rossi-Espagnet, Camilla, Hamandi, Khalid, Tietze, Anna, Barba, Carmen, Guerrini, Renzo, Gaillard, William Davis, You, Xiaozhen, Wang, Irene, González-Ortiz, Sofía, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kälviäinen, Reetta, Gambardella, Antonio, Labate, Angelo, Desmond, Patricia, Lui, Elaine, O’Brien, Terence, Shetty, Jay, Jackson, Graeme, Duncan, John S., Winston, Gavin P., Pinborg, Lars H., Cendes, Fernando, Theis, Fabian J., Shinohara, Russell T., Cross, J. Helen, Baldeweg, Torsten, Adler, Sophie, Wagstyl, Konrad, Spitzer, Hannah, Ripart, Mathilde, Whitaker, Kirstie, D’Arco, Felice, Mankad, Kshitij, Chen, Andrew A., Napolitano, Antonio, De Palma, Luca, De Benedictis, Alessandro, Foldes, Stephen, Humphreys, Zachary, Zhang, Kai, Hu, Wenhan, Mo, Jiajie, Likeman, Marcus, Davies, Shirin, Güttler, Christopher, Lenge, Matteo, Cohen, Nathan T., Tang, Yingying, Wang, Shan, Chari, Aswin, Tisdall, Martin, Bargallo, Nuria, Conde-Blanco, Estefanía, Pariente, Jose Carlos, Pascual-Diaz, Saül, Delgado-Martínez, Ignacio, Pérez-Enríquez, Carmen, Lagorio, Ilaria, Abela, Eugenio, Mullatti, Nandini, O’Muircheartaigh, Jonathan, Vecchiato, Katy, Liu, Yawu, Caligiuri, Maria Eugenia, Sinclair, Ben, Vivash, Lucy, Willard, Anna, Kandasamy, Jothy, McLellan, Ailsa, Sokol, Drahoslav, Semmelroch, Mira, Kloster, Ane G., Opheim, Giske, Ribeiro, Letícia, Yasuda, Clarissa, Rossi-Espagnet, Camilla, Hamandi, Khalid, Tietze, Anna, Barba, Carmen, Guerrini, Renzo, Gaillard, William Davis, You, Xiaozhen, Wang, Irene, González-Ortiz, Sofía, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kälviäinen, Reetta, Gambardella, Antonio, Labate, Angelo, Desmond, Patricia, Lui, Elaine, O’Brien, Terence, Shetty, Jay, Jackson, Graeme, Duncan, John S., Winston, Gavin P., Pinborg, Lars H., Cendes, Fernando, Theis, Fabian J., Shinohara, Russell T., Cross, J. Helen, Baldeweg, Torsten, Adler, Sophie, and Wagstyl, Konrad

Abstract

One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on structural MRI but are often amenable to surgical resection. We aimed to develop an open-source, interpretable, surface-based machine-learning algorithm to automatically identify FCDs on heterogeneous structural MRI data from epilepsy surgery centres worldwide. The Multi-centre Epilepsy Lesion Detection (MELD) Project collated and harmonized a retrospective MRI cohort of 1015 participants, 618 patients with focal FCD-related epilepsy and 397 controls, from 22 epilepsy centres worldwide. We created a neural network for FCD detection based on 33 surface-based features. The network was trained and cross-validated on 50% of the total cohort and tested on the remaining 50% as well as on 2 independent test sites. Multidimensional feature analysis and integrated gradient saliencies were used to interrogate network performance. Our pipeline outputs individual patient reports, which identify the location of predicted lesions, alongside their imaging features and relative saliency to the classifier. On a restricted ‘gold-standard’ subcohort of seizure-free patients with FCD type IIB who had T1 and fluid-attenuated inversion recovery MRI data, the MELD FCD surface-based algorithm had a sensitivity of 85%. Across the entire withheld test cohort the sensitivity was 59% and specificity was 54%. After including a border zone around lesions, to account for uncertainty around the borders of manually delineated lesion masks, the sensitivity was 67%. This multicentre, multinational study with open access protocols and code has developed a robust and interpretable machine-learning algorithm for automated detection of focal cortical dysplasias, giving physicians greater confidence in the identification of subtle M

Published
2022

13. Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia:A MELD study

Author

Wagstyl, Konrad, Whitaker, Kirstie, Raznahan, Armin, Seidlitz, Jakob, Vértes, Petra E., Foldes, Stephen, Humphreys, Zachary, Hu, Wenhan, Mo, Jiajie, Likeman, Marcus, Davies, Shirin, Lenge, Matteo, Cohen, Nathan T., Tang, Yingying, Wang, Shan, Ripart, Mathilde, Chari, Aswin, Tisdall, Martin, Bargallo, Nuria, Conde-Blanco, Estefanía, Pariente, Jose Carlos, Pascual-Diaz, Saül, Delgado-Martínez, Ignacio, Pérez-Enríquez, Carmen, Lagorio, Ilaria, Abela, Eugenio, Mullatti, Nandini, O'Muircheartaigh, Jonathan, Vecchiato, Katy, Liu, Yawu, Caligiuri, Maria, Sinclair, Ben, Vivash, Lucy, Willard, Anna, Kandasamy, Jothy, McLellan, Ailsa, Sokol, Drahoslav, Semmelroch, Mira, Kloster, Ane, Opheim, Giske, Yasuda, Clarissa, Zhang, Kai, Hamandi, Khalid, Barba, Carmen, Guerrini, Renzo, Gaillard, William Davis, You, Xiaozhen, Wang, Irene, González-Ortiz, Sofía, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kalviainen, Reetta, Gambardella, Antonio, Labate, Angelo, Desmond, Patricia, Lui, Elaine, O'Brien, Terry, Shetty, Jay, Jackson, Graeme, Duncan, John S., Winston, Gavin P., Pinborg, Lars, Cendes, Fernando, Cross, Judith Helen, Baldeweg, Torsten, Adler, Sophie, Wagstyl, Konrad, Whitaker, Kirstie, Raznahan, Armin, Seidlitz, Jakob, Vértes, Petra E., Foldes, Stephen, Humphreys, Zachary, Hu, Wenhan, Mo, Jiajie, Likeman, Marcus, Davies, Shirin, Lenge, Matteo, Cohen, Nathan T., Tang, Yingying, Wang, Shan, Ripart, Mathilde, Chari, Aswin, Tisdall, Martin, Bargallo, Nuria, Conde-Blanco, Estefanía, Pariente, Jose Carlos, Pascual-Diaz, Saül, Delgado-Martínez, Ignacio, Pérez-Enríquez, Carmen, Lagorio, Ilaria, Abela, Eugenio, Mullatti, Nandini, O'Muircheartaigh, Jonathan, Vecchiato, Katy, Liu, Yawu, Caligiuri, Maria, Sinclair, Ben, Vivash, Lucy, Willard, Anna, Kandasamy, Jothy, McLellan, Ailsa, Sokol, Drahoslav, Semmelroch, Mira, Kloster, Ane, Opheim, Giske, Yasuda, Clarissa, Zhang, Kai, Hamandi, Khalid, Barba, Carmen, Guerrini, Renzo, Gaillard, William Davis, You, Xiaozhen, Wang, Irene, González-Ortiz, Sofía, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kalviainen, Reetta, Gambardella, Antonio, Labate, Angelo, Desmond, Patricia, Lui, Elaine, O'Brien, Terry, Shetty, Jay, Jackson, Graeme, Duncan, John S., Winston, Gavin P., Pinborg, Lars, Cendes, Fernando, Cross, Judith Helen, Baldeweg, Torsten, and Adler, Sophie

Abstract

Objective: Drug-resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unknown. We created a neuroimaging cohort of patients with individually mapped FCDs to determine factors associated with lesion location and predictors of postsurgical outcome. Methods: The MELD (Multi-centre Epilepsy Lesion Detection) project collated a retrospective cohort of 580 patients with epilepsy attributed to FCD from 20 epilepsy centers worldwide. Magnetic resonance imaging-based maps of individual FCDs with accompanying demographic, clinical, and surgical information were collected. We mapped the distribution of FCDs, examined for associations between clinical factors and lesion location, and developed a predictive model of postsurgical seizure freedom. Results: FCDs were nonuniformly distributed, concentrating in the superior frontal sulcus, frontal pole, and temporal pole. Epilepsy onset was typically before the age of 10 years. Earlier epilepsy onset was associated with lesions in primary sensory areas, whereas later epilepsy onset was associated with lesions in association cortices. Lesions in temporal and occipital lobes tended to be larger than frontal lobe lesions. Seizure freedom rates varied with FCD location, from around 30% in visual, motor, and premotor areas to 75% in superior temporal and frontal gyri. The predictive model of postsurgical seizure freedom had a positive predictive value of 70% and negative predictive value of 61%. Significance: FCD location is an important determinant of its size, the age at epilepsy onset, and the likelihood of seizure freedom postsurgery. Our atlas of lesion locations can be used to guide the radiological search for subtle lesions in individual patients. Our atlas of regional seizure freedom rates and associated predictive model can be used to estimate individua

Published
2022

14. Interpretable surface-based detection of focal cortical dysplasias: a MELD study

Author

Spitzer, Hannah, primary, Ripart, Mathilde, additional, Whitaker, Kirstie, additional, Napolitano, Antonio, additional, De Palma, Luca, additional, De Benedictis, Alessandro, additional, Foldes, Stephen, additional, Humphreys, Zachary, additional, Zhang, Kai, additional, Hu, Wenhan, additional, Mo, Jiajie, additional, Likeman, Marcus, additional, Davies, Shirin, additional, Guttler, Christopher, additional, Lenge, Matteo, additional, Cohen, Nathan T., additional, Tang, Yingying, additional, Wang, Shan, additional, Chari, Aswin, additional, Tisdall, Martin, additional, Bargallo, Nuria, additional, Conde-Blanco, Estefanía, additional, Pariente, Jose Carlos, additional, Pascual-Diaz, Saül, additional, Delgado-Martínez, Ignacio, additional, Pérez-Enríquez, Carmen, additional, Lagorio, Ilaria, additional, Abela, Eugenio, additional, Mullatti, Nandini, additional, O’Muircheartaigh, Jonathan, additional, Vecchiato, Katy, additional, Liu, Yawu, additional, Caligiuri, Maria, additional, Sinclair, Ben, additional, Vivash, Lucy, additional, Willard, Anna, additional, Kandasamy, Jothy, additional, McLellan, Ailsa, additional, Sokol, Drahoslav, additional, Semmelroch, Mira, additional, Kloster, Ane, additional, Opheim, Giske, additional, Ribeiro, Letícia, additional, Yasuda, Clarissa, additional, Rossi-Espagnet, Camilla, additional, Hamandi, Khalid, additional, Tietze, Anna, additional, Barba, Carmen, additional, Guerrini, Renzo, additional, Gaillard, William Davis, additional, You, Xiaozhen, additional, Wang, Irene, additional, González-Ortiz, Sofía, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Kalviainen, Reetta, additional, Gambardella, Antonio, additional, Labate, Angelo, additional, Desmond, Patricia, additional, Lui, Elaine, additional, O’Brien, Terence, additional, Shetty, Jay, additional, Jackson, Graeme, additional, Duncan, John, additional, Winston, Gavin, additional, Pinborg, Lars, additional, Cendes, Fernando, additional, Theis, Fabian J., additional, Shinohara, Russell T., additional, Cross, J Helen, additional, Baldeweg, Torsten, additional, Adler, Sophie, additional, and Wagstyl, Konrad, additional

Published
2021
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15. Influence of personality profile in patients with drug‐resistant epilepsy on quality of life following surgical treatment: A 1‐year follow‐up study.

Author

Iurina, Elena, Bailles, Eva, Carreño, Mar, Donaire, Antonio, Rumià, Jordi, Boget, Teresa, Bargalló, Núria, Setoain, Xavier, Roldan, Pedro, Conde‐Blanco, Estefanía, Centeno, María, and Pintor, Luis

Subjects
EPILEPSY surgery, PERSONALITY, DRUG resistance, COMPARATIVE studies, QUALITY of life, MENTAL depression, ANXIETY, SEIZURES (Medicine), LONGITUDINAL method
Abstract

The objectives of this study are to determine the influence of personality profile in patients with drug‐resistant epilepsy on quality of life (QoL) after surgical treatment and compare the results with a non‐surgical control group at the 1‐year follow‐up. We conducted a prospective, comparative, controlled study, including 70 patients suffering from drug‐resistant epilepsy. Demographic, psychiatric, neurological, and psychological data were recorded at the baseline and at the 1‐year follow‐up. Assessment of personality dimensions was performed using the NEO‐FFI‐R questionnaire; severity of anxiety and depression were assessed by the Hospital Anxiety and Depression Scale (HADS), and QoL was evaluated using the QOLIE‐31. At the 1‐year follow‐up, comparing the control and the surgical groups, we detected differences in scores of most items of QoL, which were higher in those patients who had undergone surgery. High levels of Conscientiousness and Openness to experience at the baseline in patients who underwent surgery predicted better post‐surgical outcomes in the QoL scores, whereas high neurotic patients showed worse QoL results. Postoperative changes in QoL in patients were associated with the personality profile at the baseline. QoL measures significantly improved in the surgical group compared with the non‐surgical group but were not associated with baseline or postoperative seizure frequency at 1 year. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study

Author

Wagstyl, Konrad, primary, Whitaker, Kirstie, additional, Raznahan, Armin, additional, Seidlitz, Jakob, additional, Vértes, Petra E., additional, Foldes, Stephen, additional, Humphreys, Zachary, additional, Hu, Wenhan, additional, Mo, Jiajie, additional, Likeman, Marcus, additional, Davies, Shirin, additional, Lenge, Matteo, additional, Cohen, Nathan T., additional, Tang, Yingying, additional, Wang, Shan, additional, Ripart, Mathilde, additional, Chari, Aswin, additional, Tisdall, Martin, additional, Bargallo, Nuria, additional, Conde‐Blanco, Estefanía, additional, Pariente, Jose Carlos, additional, Pascual‐Diaz, Saül, additional, Delgado‐Martínez, Ignacio, additional, Pérez‐Enríquez, Carmen, additional, Lagorio, Ilaria, additional, Abela, Eugenio, additional, Mullatti, Nandini, additional, O'Muircheartaigh, Jonathan, additional, Vecchiato, Katy, additional, Liu, Yawu, additional, Caligiuri, Maria, additional, Sinclair, Ben, additional, Vivash, Lucy, additional, Willard, Anna, additional, Kandasamy, Jothy, additional, McLellan, Ailsa, additional, Sokol, Drahoslav, additional, Semmelroch, Mira, additional, Kloster, Ane, additional, Opheim, Giske, additional, Yasuda, Clarissa, additional, Zhang, Kai, additional, Hamandi, Khalid, additional, Barba, Carmen, additional, Guerrini, Renzo, additional, Gaillard, William Davis, additional, You, Xiaozhen, additional, Wang, Irene, additional, González‐Ortiz, Sofía, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Kalviainen, Reetta, additional, Gambardella, Antonio, additional, Labate, Angelo, additional, Desmond, Patricia, additional, Lui, Elaine, additional, O'Brien, Terry, additional, Shetty, Jay, additional, Jackson, Graeme, additional, Duncan, John S., additional, Winston, Gavin P., additional, Pinborg, Lars, additional, Cendes, Fernando, additional, Cross, Judith Helen, additional, Baldeweg, Torsten, additional, and Adler, Sophie, additional

Published
2021
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17. Author Correction: Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy

Author

Conde-Blanco, Estefanía, primary, Pascual-Diaz, Saül, additional, Carreño, Mar, additional, Muñoz-Moreno, Emma, additional, Pariente, José Carlos, additional, Boget, Teresa, additional, Manzanares, Isabel, additional, Donaire, Antonio, additional, Centeno, María, additional, Graus, Francesc, additional, and Bargalló, Nuria, additional

Published
2021
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19. Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy

Author

Conde-Blanco, Estefanía, primary, Pascual-Diaz, Saül, additional, Carreño, Mar, additional, Muñoz-Moreno, Emma, additional, Pariente, José Carlos, additional, Boget, Teresa, additional, Manzanares, Isabel, additional, Donaire, Antonio, additional, Centeno, María, additional, Graus, Francesc, additional, and Bargalló, Nuria, additional

Published
2021
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20. The emerging role of the advanced practice epilepsy nurse: A comparative study between two countries

Author

Manzanares, Isabel, primary, Sevilla Guerra, Sonia, additional, Peña‐Ceballos, Javier, additional, Carreño, Mar, additional, Palanca, María, additional, Lombraña, María, additional, Conde‐Blanco, Estefanía, additional, Centeno, María, additional, Donaire, Antonio, additional, Gil‐Lopez, Francisco, additional, Khawaja, Mariam, additional, López Poyato, Mireia, additional, and Zabalegui, Adelaida, additional

Published
2021
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21. MELD Project: Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia

Author

Wagstyl, Konrad, primary, Whitaker, Kirstie, additional, Raznahan, Armin, additional, Seidlitz, Jakob, additional, Vértes, Petra E, additional, Foldes, Stephen, additional, Humphreys, Zachary, additional, Hu, Wenhan, additional, Mo, Jiajie, additional, Likeman, Marcus, additional, Davies, Shirin, additional, Lenge, Matteo, additional, Cohen, Nathan T, additional, Tang, Yingying, additional, Wang, Shan, additional, Ripart, Mathilde, additional, Chari, Aswin, additional, Tisdall, Martin, additional, Bargallo, Nuria, additional, Conde-Blanco, Estefanía, additional, Pariente, Jose Carlos, additional, Pascual-Diaz, Saül, additional, Delgado-Martínez, Ignacio, additional, Pérez-Enríquez, Carmen, additional, Lagorio, Ilaria, additional, Abela, Eugenio, additional, Mullatti, Nandini, additional, O’Muircheartaigh, Jonathan, additional, Vecchiato, Katy, additional, Liu, Yawu, additional, Caligiuri, Maria, additional, Sinclair, Ben, additional, Vivash, Lucy, additional, Willard, Anna, additional, Kandasamy, Jothy, additional, McLellan, Ailsa, additional, Sokol, Drahoslav, additional, Semmelroch, Mira, additional, Kloster, Ane, additional, Opheim, Giske, additional, Yasuda, Clarissa, additional, Zhang, Kai, additional, Hamandi, Khalid, additional, Barba, Carmen, additional, Guerrini, Renzo, additional, Gaillard, William Davis, additional, You, Xiaozhen, additional, Wang, Irene, additional, González-Ortiz, Sofía, additional, Severino, Mariasavina, additional, Striano, Pasquale, additional, Tortora, Domenico, additional, Kalviainen, Reetta, additional, Gambardella, Antonio, additional, Labate, Angelo, additional, Desmond, Patricia, additional, Lui, Elaine, additional, O’Brien, Terry, additional, Shetty, Jay, additional, Jackson, Graeme, additional, Duncan, John S, additional, Winston, Gavin P, additional, Pinborg, Lars, additional, Cendes, Fernando, additional, Cross, J Helen, additional, Baldeweg, Torsten, additional, and Adler, Sophie, additional

Published
2021
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23. External trigeminal nerve stimulation for drug resistant epilepsy: A randomized controlled trial

Author

Gil-López, Francisco, primary, Boget, Teresa, additional, Manzanares, Isabel, additional, Donaire, Antonio, additional, Conde-Blanco, Estefanía, additional, Baillés, Eva, additional, Pintor, Luis, additional, Setoaín, Xavier, additional, Bargalló, Núria, additional, Navarro, Judith, additional, Casanova, Jordi, additional, Valls, Josep, additional, Roldán, Pedro, additional, Rumià, Jordi, additional, Casanovas, Georgina, additional, Domenech, Gema, additional, Torres, Ferrán, additional, and Carreño, Mar, additional

Published
2020
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24. Satisfaction with Epilepsy Care Questionnaire--Spanish Version

Author

Manzanares, Isabel, primary, Guerra, Sonia Sevilla, additional, Lombraña, María, additional, Gil-López, Francisco, additional, Conde-Blanco, Estefanía, additional, Zabalegui, Adelaida, additional, Pfäfflin, Margarete, additional, May, Theordor W., additional, Kostov, Belchin, additional, Moreno-Poyato, Antonio, additional, Donaire, Antonio, additional, Guio, Laura, additional, Beltran, Olga, additional, Cuzco, Cecilia, additional, and Carreño, Mar, additional

Published
2020
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25. Spanish version of the Satisfaction with Epilepsy Care questionnaire: Adaptation and psychometric properties

Author

Manzanares, Isabel, primary, Sevilla Guerra, Sonia, additional, Lombraña, María, additional, Gil-López, Francisco, additional, Conde-Blanco, Estefanía, additional, Zabalegui, Adelaida, additional, Pfäfflin, Margarete, additional, May, Theordor W., additional, Kostov, Belchin, additional, Moreno-Poyato, Antonio, additional, Donaire, Antonio, additional, Guio, Laura, additional, Beltran, Olga, additional, Cuzco, Cecilia, additional, and Carreño, Mar, additional

Published
2020
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26. Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study.

Author

Wagstyl, Konrad, Whitaker, Kirstie, Raznahan, Armin, Seidlitz, Jakob, Vértes, Petra E., Foldes, Stephen, Humphreys, Zachary, Hu, Wenhan, Mo, Jiajie, Likeman, Marcus, Davies, Shirin, Lenge, Matteo, Cohen, Nathan T., Tang, Yingying, Wang, Shan, Ripart, Mathilde, Chari, Aswin, Tisdall, Martin, Bargallo, Nuria, and Conde‐Blanco, Estefanía

Subjects
EPILEPSY, PARTIAL epilepsy, SEIZURES (Medicine), OCCIPITAL lobe, FRONTAL lobe, FOCAL cortical dysplasia, CEREBRAL cortex
Abstract

Objective: Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unknown. We created a neuroimaging cohort of patients with individually mapped FCDs to determine factors associated with lesion location and predictors of postsurgical outcome. Methods: The MELD (Multi‐centre Epilepsy Lesion Detection) project collated a retrospective cohort of 580 patients with epilepsy attributed to FCD from 20 epilepsy centers worldwide. Magnetic resonance imaging‐based maps of individual FCDs with accompanying demographic, clinical, and surgical information were collected. We mapped the distribution of FCDs, examined for associations between clinical factors and lesion location, and developed a predictive model of postsurgical seizure freedom. Results: FCDs were nonuniformly distributed, concentrating in the superior frontal sulcus, frontal pole, and temporal pole. Epilepsy onset was typically before the age of 10 years. Earlier epilepsy onset was associated with lesions in primary sensory areas, whereas later epilepsy onset was associated with lesions in association cortices. Lesions in temporal and occipital lobes tended to be larger than frontal lobe lesions. Seizure freedom rates varied with FCD location, from around 30% in visual, motor, and premotor areas to 75% in superior temporal and frontal gyri. The predictive model of postsurgical seizure freedom had a positive predictive value of 70% and negative predictive value of 61%. Significance: FCD location is an important determinant of its size, the age at epilepsy onset, and the likelihood of seizure freedom postsurgery. Our atlas of lesion locations can be used to guide the radiological search for subtle lesions in individual patients. Our atlas of regional seizure freedom rates and associated predictive model can be used to estimate individual likelihoods of postsurgical seizure freedom. Data‐driven atlases and predictive models are essential for evidence‐based, precision medicine and risk counseling in epilepsy. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Epilepsy and lockdown: A survey of patients normally attending a Spanish centre.

Author

Conde Blanco, Estefanía, Manzanares, Isabel, Centeno, María, Khawaja, Mariam, Betrán, Olga, Donaire, Antonio, and Carreño, Mar

Subjects
*STAY-at-home orders, *PATIENT surveys, *EPILEPSY, *SLEEP disorders, *PEOPLE with epilepsy
Abstract

Background: Lockdown due to the SARS‐CoV‐2 pandemic became a challenge to maintain care for patients with epilepsy; we aimed to find out how the pandemic affected them. Methods: We sent an online 22‐item questionnaire to patients from our outpatient clinic, a reference centre in Spain for drug‐resistant epilepsy, inquiring about the effects of lockdown, from March to May 2020. Results: We sent the survey to 627 patients; 312 (58% women) sent a complete response and were included. Of all respondents, 57% took >2 antiseizure medications. One‐third of respondents (29%) declared an associated cognitive or motor disability. A minority had confirmed infection with SARS‐CoV‐2 (1.92%). Seizure frequency remained like usual in 56% of patients, while 31.2% reported an increase. Less than 10% needed emergent assistance. Almost half reported anxiety or depression, and 25% increased behavioural disorders. Mood (F: 5.40; p: 0.002) and sleep disorders (F = 2.67; p: 0.05) were associated with increase in seizure frequency. Patients were able to contact their physicians when needed and were open to a future telematic approach to follow‐up visits. Conclusions: Seizure frequency and severity remained unchanged in most patients during the lockdown. Mood and sleep disorders were common and associated with seizure worsening. Patients were open to telematic care in the future. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia:A MELD study

Author

Jose Carlos Pariente, Antonio Gambardella, Fernando Cendes, Ane Kloster, Ailsa McLellan, Ben Sinclair, Terry O'Brien, Jonathan O'Muircheartaigh, Gavin P. Winston, Mira Semmelroch, Estefanía Conde-Blanco, Torsten Baldeweg, Zachary Humphreys, Xiaozhen You, Elaine Lui, Nandini Mullatti, Clarissa L. Yasuda, Domenico Tortora, Stephen T. Foldes, Jakob Seidlitz, Martin Tisdall, Yawu Liu, Carmen Barba, Petra E. Vértes, Angelo Labate, Shan Wang, Konrad Wagstyl, Lars H. Pinborg, Jothy Kandasamy, Irene Wang, Mathilde Ripart, Mariasavina Severino, Aswin Chari, Lucy Vivash, Shirin Davies, Carmen Pérez-Enríquez, Nathan T. Cohen, John S. Duncan, Ilaria Lagorio, Maria Eugenia Caligiuri, Drahoslav Sokol, Reetta Kälviäinen, Eugenio Abela, William D. Gaillard, Giske Opheim, Jiajie Mo, Anna Willard, Graeme D. Jackson, Jay Shetty, JH Cross, Marcus Likeman, Renzo Guerrini, Wenhan Hu, Katy Vecchiato, Khalid Hamandi, Sophie Adler, Kai Zhang, Saül Pascual-Diaz, Matteo Lenge, Ignacio Delgado-Martínez, Kirstie Whitaker, Núria Bargalló, Pasquale Striano, Patricia Desmond, Yingying Tang, Sofía González-Ortiz, Armin Raznahan, Wagstyl, Konrad [0000-0003-3439-5808], Cohen, Nathan T [0000-0002-1410-3487], Tang, Yingying [0000-0001-5813-0308], Wang, Shan [0000-0002-6238-2644], Chari, Aswin [0000-0003-0053-147X], Conde-Blanco, Estefanía [0000-0001-7436-987X], Pérez-Enríquez, Carmen [0000-0002-2109-0426], Opheim, Giske [0000-0002-1516-0838], Barba, Carmen [0000-0001-5445-5842], Guerrini, Renzo [0000-0002-7272-7079], Gaillard, William Davis [0000-0001-5709-0033], Wang, Irene [0000-0002-3829-5217], Striano, Pasquale [0000-0002-6065-1476], Gambardella, Antonio [0000-0001-7384-3074], Labate, Angelo [0000-0002-8827-7324], Cendes, Fernando [0000-0001-9336-9568], Baldeweg, Torsten [0000-0002-5724-1679], and Apollo - University of Cambridge Repository

Subjects
Freedom, medicine.medical_specialty, Drug Resistant Epilepsy, lesions, Lesion, Epilepsy, drug-resistant epilepsy, Neuroimaging, Seizures, medicine, Humans, neurosurgery, Child, Retrospective Studies, Errata, business.industry, Retrospective cohort study, Cortical dysplasia, medicine.disease, Magnetic Resonance Imaging, Malformations of Cortical Development, Treatment Outcome, Neurology, Frontal lobe, Neurology (clinical), Radiology, Superior frontal sulcus, medicine.symptom, business, focal cortical dysplasia, MRI
Abstract

Funder: National Institute for Health Research (NIHR) GOSH BRC, OBJECTIVE: Drug-resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unknown. We created a neuroimaging cohort of patients with individually mapped FCDs to determine factors associated with lesion location and predictors of postsurgical outcome. METHODS: The MELD (Multi-centre Epilepsy Lesion Detection) project collated a retrospective cohort of 580 patients with epilepsy attributed to FCD from 20 epilepsy centers worldwide. Magnetic resonance imaging-based maps of individual FCDs with accompanying demographic, clinical, and surgical information were collected. We mapped the distribution of FCDs, examined for associations between clinical factors and lesion location, and developed a predictive model of postsurgical seizure freedom. RESULTS: FCDs were nonuniformly distributed, concentrating in the superior frontal sulcus, frontal pole, and temporal pole. Epilepsy onset was typically before the age of 10 years. Earlier epilepsy onset was associated with lesions in primary sensory areas, whereas later epilepsy onset was associated with lesions in association cortices. Lesions in temporal and occipital lobes tended to be larger than frontal lobe lesions. Seizure freedom rates varied with FCD location, from around 30% in visual, motor, and premotor areas to 75% in superior temporal and frontal gyri. The predictive model of postsurgical seizure freedom had a positive predictive value of 70% and negative predictive value of 61%. SIGNIFICANCE: FCD location is an important determinant of its size, the age at epilepsy onset, and the likelihood of seizure freedom postsurgery. Our atlas of lesion locations can be used to guide the radiological search for subtle lesions in individual patients. Our atlas of regional seizure freedom rates and associated predictive model can be used to estimate individual likelihoods of postsurgical seizure freedom. Data-driven atlases and predictive models are essential for evidence-based, precision medicine and risk counseling in epilepsy.

Published
2022

31. Evaluation of self-stigma in patients with epilepsy: Validation of the self-stigma scale to Spanish (ESSS-S).

Author

Manzanares I, Kuramochi I, Olivera M, Centeno M, Khawaja M, Pintor L, Donaire A, Del Mar Carreño M, and Conde-Blanco E

Abstract

Objective: The Epilepsy Self-Stigma Scale (ESSS) has been developed in Japan for patients with epilepsy (PWE). We aimed to validate the scale in Spanish and examine its validity and reliability., Methods: The transcultural adaptation of the ESSS was conducted using translation and back-translation, along with pilot testing and an expert panel review. An online questionnaire was used to assess construct validity, criterion validity, and internal consistency., Results: A total of 260 out of 628 participants completed the questionnaires. We found a two-factor structure that explained 61.3% of the total variance: factor 1 "self-perceived discrimination" with a Cronbach's alpha of 0.80, and factor 2 "social isolation" with a Cronbach's alpha of 0.75. The reliability of overall ESSS-S 8-item scores was high (Cronbach's alpha = 0.74). Convergent validity was tested and demonstrated a significant correlation. P. Self-perceived discrimination scores were associated with higher anxiety and depression scores (r = 0.53/0.54; p < 0.001), lower self-esteem (-0.53; p < 0.001), and lower quality of life (r = -0.66; p < 0.001). Social isolation scores were associated with higher anxiety and depression scores (r = 0.41/0.33; p < 0.001), lower self-esteem (-0.34; p < 0.001), and lower quality of life (r = -0.35; p < 0.001). Temporal reliability was also tested, showing a test-retest ICC of 0.87. The mean self-stigma score in the Spanish population was 17.68 ± 5.45 out of 32 points. Invariance across gender and age groups indicated that there are no systematic response biases by gender or age, so stratified scores could be related to other constructs., Significance: The Spanish version of ESSS (ESSS-S) is a valid and reliable tool for the assessment of self-stigma in PWE among Spanish speakers., Plain Language Summary: This study aimed to validate the Epilepsy Self-Stigma Scale (ESSS) for Spanish speakers (ESSS-S). We conducted transcultural adaptation of the scale. ESSS-S showed high reliability and strong validity, correlating with higher anxiety and depression, lower self-esteem, and quality of life. ESSS-S is a reliable and valid tool for assessing self-stigma in Spanish-speaking people with epilepsy., (© 2024 The Author(s). Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Published
2024
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