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Genomic surveillance of infectious diseases allows monitoring circulating and emerging variants and quantifying their epidemic potential. However, due to the high costs associated with genomic sequencing, only a limited number of samples can be analysed. Thus, it is critical to understand how sampling impacts the information generated. Here, we combine a compartmental model for the spread of COVID-19 (distinguishing several SARS-CoV-2 variants) with different sampling strategies to assess their impact on genomic surveillance. In particular, we compare adaptive sampling, i.e., dynamically reallocating resources between screening at points of entry and inside communities, and constant sampling, i.e., assigning fixed resources to the two locations. We show that adaptive sampling uncovers new variants up to five weeks earlier than constant sampling, significantly reducing detection delays and estimation errors. This advantage is most prominent at low sequencing rates. Although increasing the sequencing rate has a similar effect, the marginal benefits of doing so may not always justify the associated costs. Consequently, it is convenient for countries with comparatively few resources to operate at lower sequencing rates, thereby profiting the most from adaptive sampling. Finally, our methodology can be readily adapted to study undersampling in other dynamical systems.

We consider the optimal arrangement of two diffusion materials in a bounded open set $\Omega\subset \mathbb{R}^N$ in order to maximize the energy. The diffusion problem is modeled by the $p$-Laplacian operator. It is well known that this type of problems has no solution in general and then that it is necessary to work with a relaxed formulation. In the present paper we obtain such relaxed formulation using the homogenization theory, i.e. we replace both materials by microscopic mixtures of them. Then we get some uniqueness results and a system of optimality conditions. As a consequence we prove some regularity properties for the optimal solutions of the relaxed problem. Namely, we show that the flux is in the Sobolev space $H^1(\Omega)^N$ and that the optimal proportion of the materials is derivable in the orthogonal direction to the flux. This will imply that the unrelaxed problem has no solution in general. Our results extend those obtained by the first author for the Laplace operator.

We consider the Robin boundary value problem $\mathrm{div} (A \nabla u) = \mathrm{div} \mathbf{f}+F$ in $\Omega$, $\mathcal{C}^1$ domain, with $(A \nabla u - \mathbf{f})\cdot \mathbf{n} + \alpha u = g$ on $\Gamma$, where the matrix $A$ belongs to $VMO (\mathbb{R}^3) $, and discover the uniform estimates on $\|u\|_{W^{1,p}(\Omega)}$, with $1 < p < \infty$, independent on $\alpha$. At the difference with the case $p = 2,$ which is simpler, we call here the weak reverse H\"older inequality. This estimates show that the solution of Robin problem converges strongly to the solution of Dirichlet (resp. Neumann) problem in corresponding spaces when the parameter $\alpha$ tends to $\infty$ (resp. $0$)., Comment: corrected proof of Theorem 2.3

We study the stationary Stokes and Navier-Stokes equations with non-homogeneous Navier boundary condition in a bounded domain $\Omega\subset\mathbb{R}^{3}$ of class $\mathcal{C}^{1,1}$. We prove existence, uniqueness of weak and strong solutions in $\mathbf{W}^{1,p}(\Omega)$ and $\mathbf{W}^{2,p}(\Omega)$ for all $1

In this paper, we introduce the macroscopic quantity, namely the dispersion tensor or the \textit{Burnett coefficient}s in the class of generalized Hashin-Shtrikman micro-structures \cite[page no. 281]{T}. In the case of two-phase materials associated with the periodic Hashin-Shtrikman structures, we settle the issue that the dispersion tensor has an unique minimizer, which is so called Apollonian-Hashin-Shtrikman micro-structure.

In this paper, we use spectral methods by introducing the Bloch waves to study the homogenization process in the non-periodic class of generalized Hashin-Shtrikman micro-structures \cite[page no. 281]{T}, which incorporates both translation and dilation with a family of scales, including one subclass of laminates. We establish the classical homogenization result with providing the spectral representation of the homogenized coefficients. It offers a new lead towards extending the Bloch spectral analysis in the non-periodic, non-commutative class of micro-structures.

For the parabolic-elliptic Keller-Segel system in R^2 it has been proved that if the initial mass is less than 8\pi/\chi\ global solution exist and in the case that the initial mass is larger than 8\pi/\chi\ blow-up happens. The case of several chemotactic species introduces an additional question: What is the analog for the critical mass obtained for the single species system? We find a threshold curve in the case of two especies case that allows us to determine if the system has blow-up or has a global in time solution., Comment: European Journal of Applied Mathematics, 2013

In this paper, we consider a moving rigid solid immersed in a potential fluid. The fluid-solid system fills the whole two dimensional space and the fluid is assumed to be at rest at infinity. Our aim is to study the inverse problem, initially introduced in [3], that consists in recovering the position and the velocity of the solid assuming that the potential function is known at a given time. We show that this problem is in general ill-posed by providing counterexamples for which the same potential corresponds to different positions and velocities of a same solid. However, it is also possible to find solids having a specific shape, like ellipses for instance, for which the problem of detection admits a unique solution. Using complex analysis, we prove that the well-posedness of the inverse problem is equivalent to the solvability of an infinite set of nonlinear equations. This result allows us to show that when the solid enjoys some symmetry properties, it can be partially detected. Besides, for any solid, the velocity can always be recovered when both the potential function and the position are supposed to be known. Finally, we prove that by performing continuous measurements of the fluid potential over a time interval, we can always track the position of the solid., Comment: 19 pages, 14 figures