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3. Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Author

Michelatti, Daniela, Beyes, Sven, Bernardis, Chiara, Negri, Maria Luce, Morelli, Leonardo, Bediaga, Naiara Garcia, Poli, Vittoria, Fagnocchi, Luca, Lago, Sara, D’Annunzio, Sarah, Cona, Nicole, Gaspardo, Ilaria, Bianchi, Aurora, Jovetic, Jovana, Gianesello, Matteo, Turdo, Alice, D’Accardo, Caterina, Gaggianesi, Miriam, Dori, Martina, Forcato, Mattia, Crispatzu, Giuliano, Rada-Iglesias, Alvaro, Sosa, Maria Soledad, Timmers, H. T. Marc, Bicciato, Silvio, Todaro, Matilde, Tiberi, Luca, and Zippo, Alessio

Published
2024
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9. Convergence and data dependence results of the nonlinear Volterra integral equation by the Picard's three step iteration

Author

Lale Cona

Subjects
fixed point, nonlinear volterra integral equations, picard's three step iteration, convergence, data dependency, Mathematics, QA1-939
Abstract

Picard's three step iteration algorithm was one of the iteration algorithms that was recently shown to be faster than some other iterative algorithms in the existing literature. The purpose of this paper was to study using this iteration algorithm for the solution of nonlinear Volterra integral equations. It was investigated that the sequences obtained from this iteration algorithm converged to the solution of nonlinear Volterra integral equations. Moreover, data dependence was obtained for nonlinear Volterra integral equations. An example was given that confirmed the applicability of the newly proven theorems.

Published
2024
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10. Ralstonia insidiosa Bacteremia in Patients with Solid Cancer Treated by Means of a Central Venous Catheter

Author

Lorenzo Ruggieri, Anna Lisa Ridolfo, Sara Giordana Rimoldi, Maria Silvia Cona, Davide Dalu, Pietro Olivieri, Giuliano Rizzardini, Spinello Antinori, Anna Gambaro, Sabrina Ferrario, Cinzia Fasola, Maria Antista, Carmen Giusy Rea, and Nicla La Verde

Subjects
Ralstonia, catheters, bacteremia, cancer, outbreak, Industrial medicine. Industrial hygiene, RC963-969, Industrial hygiene. Industrial welfare, HD7260-7780.8
Abstract

Ralstonia spp. are low-virulent environmental Gram-negative bacteria that can cause serious nosocomial infections in immunocompromised patients. We report the characteristics of a cluster of R. insidiosa bacteremia cases occurring in our oncology day ward in Milan, Italy, between January and March 2022. A case was defined as a cancer patient attending our day ward and whose blood culture (performed because of bacteremia symptoms) led to the isolation of Ralstonia insidiosa. An epidemiological investigation was conducted in order to seek the possible source of infection. Seven adult patients received curative or palliative treatment via infusion through a Port-a-Cath (PAC). All developed symptoms within 24 h of the infusion (three during the infusion itself). Ralstonia insidiosa was isolated in the blood drawn from the PAC in all patients. All of the isolates were susceptible to carbapenems, fluoroquinolones, and piperacillin/tazobactam but resistant to aminoglycosides and cephalosporins. Systemic and/or lock antibiotic therapy led to stable symptom resolution and negative blood cultures in five patients, whereas bacteremia recurred in two patients. An epidemiological investigation suggested that extrinsic contamination of antiseptic solutions was the possible cause of the R. insidiosa infections. Although R. insidiosa is not considered a virulent pathogen, clinicians, microbiologists, and infection control teams should be aware about its potential to cause outbreaks of nosocomial bloodstream infections, especially in immunocompromised patients bearing central venous catheters.

Published
2024
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11. Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Author

Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri, Leonardo Morelli, Naiara Garcia Bediaga, Vittoria Poli, Luca Fagnocchi, Sara Lago, Sarah D’Annunzio, Nicole Cona, Ilaria Gaspardo, Aurora Bianchi, Jovana Jovetic, Matteo Gianesello, Alice Turdo, Caterina D’Accardo, Miriam Gaggianesi, Martina Dori, Mattia Forcato, Giuliano Crispatzu, Alvaro Rada-Iglesias, Maria Soledad Sosa, H. T. Marc Timmers, Silvio Bicciato, Matilde Todaro, Luca Tiberi, and Alessio Zippo

Subjects
Science
Abstract

Abstract Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before giving rise to symptomatic overt metastasis. In this context, DTCs fluctuate between a quiescent and proliferative state in response to systemic and microenvironmental signals including immune-mediated surveillance. Despite its relevance, how intrinsic mechanisms sustain DTCs plasticity has not been addressed. By interrogating the epigenetic state of metastatic cells, we find that tumour progression is coupled with the activation of oncogenic enhancers that are organized in variable interconnected chromatin domains. This spatial chromatin context leads to the activation of a robust transcriptional response upon repeated exposure to retinoic acid (RA). We show that this adaptive mechanism sustains the quiescence of DTCs through the activation of the master regulator SOX9. Finally, we determine that RA-stimulated transcriptional memory increases the fitness of metastatic cells by supporting the escape of quiescent DTCs from NK-mediated immune surveillance. Overall, these findings highlight the contribution of oncogenic enhancers in establishing transcriptional memories as an adaptive mechanism to reinforce cancer dormancy and immune escape, thus amenable for therapeutic intervention.

Published
2024
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14. Donor-derived carbapenem-resistant gram-negative bacterial infections in solid organ transplant recipients: Active surveillance enhances recipient safety

Author

Mularoni, Alessandra, Cona, Andrea, Campanella, Maria, Barbera, Floriana, Medaglia, Alice Annalisa, Cervo, Adriana, Cuscino, Nicola, Di Mento, Giuseppina, Graziano, Elena, El Jalbout, Jana Dib, Alduino, Rossella, Tuzzolino, Fabio, Monaco, Francesco, Cascio, Antonio, Peghin, Maddalena, Gruttadauria, Salvatore, Bertani, Alessandro, Conaldi, Pier Giulio, Mikulska, Malgorzata, and Grossi, Paolo Antonio

Published
2024
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15. Tixagevimab/Cilgavimab as SARS-CoV-2 Pre-Exposure Prophylaxis in Lung Transplant Recipients during the Omicron Wave: A Real-World Monocentric Experience

Author

Andrea Cona, Alessandro Tavelli, Stefano Agrenzano, Neha Hafeez, Giovanni Scianna, Angelo Maria, Francesco Marino, Elizabeth De La Cruz, Maria Di Giorgio, Eglys Osorio, Giuseppe Cucinella, Angelo Luca, Alessio Provenzani, Patrizio Vitulo, Alessandro Bertani, Paolo Antonio Grossi, and Alessandra Mularoni

Subjects
COVID-19, SARS-CoV-2 pre-exposure prophylaxis, tixagevimab/cilgavimab, lung transplantation, Biology (General), QH301-705.5
Abstract

Lung transplant recipients (LTRs) respond poorly to vaccination. SARS-CoV-2 pre-exposure prophylaxis (PrEP) with tixagevimab/cilgavimab (TIX/CIL) reduces the incidence of infection and the evolution to severe COVID-19. In vitro data show decreased activity against Omicron variants. We evaluated the clinical efficacy and safety of TIX/CIL in LTRs during the Omicron wave. A prospective observational cohort study was conducted at ISMETT in Palermo (Italy). In June 2022, SARS-CoV-2 PrEP with TIX/CIL 150/150 mg was offered to LTRs. LTRs who received TIX/CIL were compared to LTRs who did not. Logistic regression analysis (adjusted for prior COVID-19, SARS-CoV-2 vaccination, age, years from transplant, and rejection) was performed. The objective of this study was to compare the following among the two populations: prevalence of SARS-CoV-2, length of SARS-CoV-2 positivity, and COVID-19 disease severity. Among 110 eligible LTRs, 79 (72%) received TIX/CIL and 31 (28%) did not. SARS-CoV-2 infections occurred in 6% (n = 5) of patients who received TIX/CIL and 29% (n = 9) of patients who did not (p < 0.001). In both groups, infections were mild/asymptomatic, and no one was hospitalized or died. At multivariate analysis, TIX/CIL was associated with a lower risk of infection (aOR 0.22; 95%CI 0.06–0.78; p = 0.02). TIX/CIL was safe and effective in reducing the risk of SARS-CoV-2 in LTRs during the Omicron wave.

Published
2024
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16. Efficacy and Safety of Remdesivir in Adult Solid Organ Transplant Recipients: A Scoping Review

Author

Catherine Smith, Maria Eugenia Novara, Andrea Cona, Anna Dolcimascolo, Giulia Cancellieri, Francesca Mortillaro, Enrico Ottavio Giannini, Anna Carollo, Alessandra Mularoni, and Alessio Provenzani

Subjects
COVID-19, SARS-CoV-2, solid organ transplant, remdesivir, efficacy, safety, Medicine, Pharmacy and materia medica, RS1-441
Abstract

The SARS-CoV-2 infection has been associated with important mortality, particularly in immunocompromised patients, including solid organ transplant (SOT) recipients. Remdesivir (RDV) is an antiviral drug that has proven to be effective in reducing the replication of the virus in host cells, by which it may reduce the progression of symptoms and, consequently, the length of hospital stay and mortality. Randomized controlled trials have evaluated its use in the general population but never in SOT recipients. For the first time in this review, the safety and efficacy of RDV is evaluated in this specific population. The literature research was conducted using PubMed/MEDLINE and Scopus databases from 1 January 2020 to 24 November 2023, and 23 studies were analyzed. Although no clinical studies specifically evaluating this population have been conducted yet, RDV is likely safe for SOT patients when compared to the general population, so prescribers should consider utilizing RDV in SOT patients who are at high risk for progression to severe COVID-19. Future research will allow for the confirmation of the observed results and the acquisition of broader and clearer data regarding the safety and efficacy of the drug in this specific setting.

Published
2024
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17. Hospital-Based Influenza and Pneumococcal Vaccination for Cancer Patients on Active Treatment and Their Family Members during the COVID-19 Pandemic in Italy: A Single-Center Experience

Author

Davide Dalu, Anna Lisa Ridolfo, Lorenzo Ruggieri, Maria Silvia Cona, Agostino Riva, Davide De Francesco, Chiara Tricella, Cinzia Fasola, Sabrina Ferrario, Anna Gambaro, Benedetta Lombardi Stocchetti, Valeria Smiroldo, Gaia Rebecchi, Sheila Piva, Giorgia Carrozzo, Spinello Antinori, and Nicla La Verde

Subjects
hospital vaccination, influenza, pneumococcal, cancer, Medicine
Abstract

In patients with cancer, tumor- and treatment-induced immunosuppression are responsible for a four-fold increase in morbidity and mortality caused by influenza and invasive Streptococcus pneumoniae infections compared to the general population. The main oncology societies strongly recommend vaccination in patients with cancer to prevent these infections. However, vaccine hesitancy is a main concern in this population. The aim of this study was to assess the feasibility of in-hospital vaccination for patients under anticancer treatment and their family members (FMs) against influenza and pneumococcal infections during the COVID-19 pandemic in order to increase vaccine coverage. This was a single-center, prospective, observational study conducted at the Department of Oncology of Luigi Sacco University Hospital (Milan, Italy) between October 2020 and April 2021. The main primary outcome was the incidence of influenza-like illness (ILI) and pneumococcal infections. The main secondary outcome was safety. A total of 341 subjects were enrolled, including 194 patients with cancer and 147 FMs. The incidence of ILI was higher among patients than among FMs (9% vs. 2.7%, OR 3.92, p = 0.02). Moreover, two subjects were diagnosed with pneumococcal pneumonia. The most frequent vaccine-related AEs were pain in the injection site (31%) and fatigue (8.7%). In conclusion, this hospital-based vaccination strategy was feasible during the COVID-19 pandemic, representing a potential model to maximize vaccine coverage during a public health emergency.

Published
2024
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22. Clinical efficacy of the first two doses of anti‐SARS‐CoV‐2 mRNA vaccines in solid cancer patients

Author

Maria Silvia Cona, Agostino Riva, Davide Dalu, Arianna Gabrieli, Cinzia Fasola, Giuseppe Lipari, Giacomo Pozza, Eliana Rulli, Francesca Galli, Lorenzo Ruggieri, Elsa Masedu, Gaia Parma, Davide Chizzoniti, Anna Gambaro, Sabrina Ferrario, Maria Antista, Matteo De Monte, Maciej S. Tarkowski, and Nicla La Verde

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction Cancer patients are frail individuals, thus the prevention of SARS‐CoV‐2 infection is essential. To date, vaccination is the most effective tool to prevent COVID‐19. In a previous study, we evaluated the immunogenicity of two doses of mRNA‐based vaccines (BNT162b2 or mRNA‐1273) in solid cancer patients. We found that seroconversion rate in cancer patients without a previous exposure to SARS‐CoV‐2 was lower than in healthy controls (66.7% vs. 95%, p = 0.0020). The present study aimed to evaluate the clinical efficacy of the vaccination in the same population. Methods This is a single‐institution, prospective observational study. Data were collected through a predefined questionnaire through phone call in the period between the second and third vaccine dose. The primary objective was to describe the clinical efficacy of the vaccination, defined as the percentage of vaccinated subjects who did not develop symptomatic COVID‐19 within 6 months after the second dose. The secondary objective was to describe the clinical features of patients who developed COVID‐19. Results From January to June 2021, 195 cancer patients were enrolled. Considering that 7 (3.59%) patients tested positive for SARS‐CoV‐2 and 5 developed symptomatic disease, the clinical efficacy of the vaccination was 97.4%. COVID‐19 disease in most patients was mild and managed at home; only one hospitalization was recorded and no patient required hospitalization in the intensive care unit. Discussion Our study suggests that increasing vaccination coverage, including booster doses, could improve the prevention of infection, hospitalization, serious illness, and death in the frail population of cancer patients.

Published
2023
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23. Happy children! A network of psychological and environmental factors associated with the development of positive affect in 9-13 children.

Author

Tommaso Feraco and Giorgia Cona

Subjects
Medicine, Science
Abstract

To deepen the development of positive affect during early adolescence and shed new light on its predictors, this study adopts an exploratory network approach to first identify the main domains that describe the variability of children's psychological, environmental, and behavioral characteristics, and then use these domains to longitudinally predict positive affect and its development within a latent growth framework. To this aim, we considered 10,904 US participants (9 years old at baseline; 13 years old 42 months later), six measurement occasions of positive affect, and 46 baseline indicators from the ABCD study. Our results not only confirm that positive affect declines between 9 and 13 years old, but also show that among the five domains identified (behavioral dysregulation, cognitive functioning, psychological problems, supportive social environment, and extracurricular activities), only a supportive social environment consistently predicts positive affect. This is crucial for practitioners and policymakers, as it can help them focus on the elements within our complex network of psychological, social, and environmental variability.

Published
2024
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24. Attitudes of women towards intimate partner violence in Guyana: A cross-sectional analytical study.

Author

Gary Joseph, Luis Paulo Vidaletti, Cona Husbands, Lisa Edwards, Michelle K James, Charles C Branas, and Christopher N Morrison

Subjects
Medicine, Science
Abstract

BackgroundTo assess the attitudes of women towards intimate partner violence (IPV) in Guyana.MethodsWe used national data from the publicly available Multiple Indicator Cluster Survey (MICS) conducted in Guyana in 2019 for women aged 15 to 49 years. The prevalence of women who agreed that a husband is justified in beating his wife was analyzed. Respondent reasons included if she: "goes out without telling him", "neglects the children", "argues with him", "refuses sex with him", "burns the food", "has another partner", "stays out late/partying", "refuses to cook or clean", "overspends", and/or "he doesn't have access to her cellphone". Descriptive analyses were carried for all the variables. Logistic regression was used to identify factors associated with these 10 respondent reasons, separately and in combination.ResultsThe overall prevalence of women's attitudes justifying IPV against women if there was a 'yes' response to any of the 10 reasons was 17.9% (95%CI: 16.6-19.3%), and varied from 2.7% if she "goes out without telling him", "burns the food", or "overspends" to 10.0% if she "has another partner". This prevalence ranged from 10.2% in urban areas to 19.3% in rural areas (pConclusionOver one-sixth of the respondents agreed that a husband was justified in committing IPV against women in Guyana. Public health programs focusing on geographic locations, ethnicity, and economic status must be implemented to change attitudes justifying IPV and reduce this significant public health challenge.

Published
2024
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26. Brainhack: Developing a culture of open, inclusive, community-driven neuroscience

Author

Gau, Rémi, Noble, Stephanie, Heuer, Katja, Bottenhorn, Katherine L, Bilgin, Isil P, Yang, Yu-Fang, Huntenburg, Julia M, Bayer, Johanna MM, Bethlehem, Richard AI, Rhoads, Shawn A, Vogelbacher, Christoph, Borghesani, Valentina, Levitis, Elizabeth, Wang, Hao-Ting, Van Den Bossche, Sofie, Kobeleva, Xenia, Legarreta, Jon Haitz, Guay, Samuel, Atay, Selim Melvin, Varoquaux, Gael P, Huijser, Dorien C, Sandström, Malin S, Herholz, Peer, Nastase, Samuel A, Badhwar, AmanPreet, Dumas, Guillaume, Schwab, Simon, Moia, Stefano, Dayan, Michael, Bassil, Yasmine, Brooks, Paula P, Mancini, Matteo, Shine, James M, O’Connor, David, Xie, Xihe, Poggiali, Davide, Friedrich, Patrick, Heinsfeld, Anibal S, Riedl, Lydia, Toro, Roberto, Caballero-Gaudes, César, Eklund, Anders, Garner, Kelly G, Nolan, Christopher R, Demeter, Damion V, Barrios, Fernando A, Merchant, Junaid S, McDevitt, Elizabeth A, Oostenveld, Robert, Craddock, R Cameron, Rokem, Ariel, Doyle, Andrew, Ghosh, Satrajit S, Nikolaidis, Aki, Stanley, Olivia W, Uruñuela, Eneko, Community, The Brainhack, Anousheh, Nasim, Arnatkeviciute, Aurina, Auzias, Guillaume, Bachar, Dipankar, Bannier, Elise, Basanisi, Ruggero, Basavaraj, Arshitha, Bedini, Marco, Bellec, Pierre, Benn, R Austin, Berluti, Kathryn, Bollmann, Steffen, Bollmann, Saskia, Bradley, Claire, Brown, Jesse, Buchweitz, Augusto, Callahan, Patrick, Chan, Micaela Y, Chandio, Bramsh Q, Cheng, Theresa, Chopra, Sidhant, Chung, Ai Wern, Close, Thomas G, Combrisson, Etienne, Cona, Giorgia, Constable, R Todd, Cury, Claire, Dadi, Kamalaker, Damasceno, Pablo F, Das, Samir, De Vico Fallani, Fabrizio, DeStasio, Krista, Dickie, Erin W, Dorfschmidt, Lena, Duff, Eugene P, DuPre, Elizabeth, Dziura, Sarah, Esper, Nathalia B, Esteban, Oscar, Fadnavis, Shreyas, Flandin, Guillaume, Flannery, Jessica E, and Flournoy, John

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Communication, Congresses as Topic, Internet, Practice Guidelines as Topic, Brainhack Community, Brainhack, best practices, collaboration, community building, hackathon, inclusivity, neuroscience, open science, reproducibility, training, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress.

Published
2021

29. Thinking about it: the impact of COVID-19-related stimuli on prospective memory

Author

Stefano Vicentin, Giovanni Cantarella, Giorgia Cona, and Patrizia Bisiacchi

Subjects
Prospective memory, COVID-19, Affective stimuli, Affective priming, Medicine, Biology (General), QH301-705.5
Abstract

Background Since 2020, information regarding COVID-19 has been a constant presence in the news, in our conversations and thoughts. Continuous exposure to this type of stimuli could have an impact on cognitive processes essential for our everyday activities, such as prospective memory (PM). PM is the ability to remember to perform an intention at a specific point in the future, like remembering to take prescribed medicines at a specific time or to turn off the stove after cooking. Do COVID-related stimuli affect our ability to perform a PM task? Methods To answer this question, we proposed a novel version of the classical paradigm used to investigate PM. Namely, this paradigm includes a baseline condition, in which an ongoing task is presented alone, and a PM condition in which the same task is proposed again together with a second (prospective) task. In this study, a short video clip was presented between the baseline and the PM condition. The video clip displayed either neutral, negative, or COVID-related content. Additionally, participants were asked to respond to two questionnaires and a series of questions regarding their well-being and experience with the pandemic. Namely, the DASS-21 scale (evaluating depression, anxiety, and stress), and the COVID-19-PTSD questionnaire (a questionnaire evaluating post-traumatic stress disorder symptoms related to the pandemic experience) were administered. Participants’ performance and responses were analyzed using a linear mixed effect (LME) model approach, and correlation analyses were run to highlight possible correlations between participants’ scores in the DASS-21, the COVID-19-PTSD, and the additional questions on their personal experience with the pandemic. Results The LME models revealed significant effects of the displayed video on performance: in line with previous studies, the clip displaying standard negative contents led to impaired accuracy in the ongoing task in the PM condition, compared to the Baseline. In contrast, participants who saw the COVID-related clip showed improved accuracy in the ongoing task compared to the other participants, selectively in the block performed after the video clip was displayed (PM condition). Furthermore, the explanatory power of the LME model calculated on accuracy to the ongoing trials was enhanced by the inclusion of the scores in the anxiety subscale of the DASS-21, suggesting a detrimental role of anxiety. Altogether, these results indicate a different effect of the exposure to classical negative contents (associated with a cost in terms of accuracy in the ongoing task between the baseline and the PM condition) and the pandemic-related one, which was instead characterized by a higher accuracy to ongoing trials compared to the other video clips. This counterintuitive finding seems to suggest that COVID-related stimuli are processed as “acute stressors” rather than negative stimuli, thus inducing a state of increased alertness and responsivity.

Published
2023
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30. The effectiveness of an immersive virtual reality and telemedicine-based cognitive intervention on prospective memory in Parkinson’s disease patients with mild cognitive impairment and healthy aged individuals: design and preliminary baseline results of a placebo-controlled study

Author

Maria Stefania De Simone, Alberto Costa, Gaetano Tieri, Sara Taglieri, Giorgia Cona, Eleonora Fiorenzato, Giovanni Augusto Carlesimo, Carlo Caltagirone, and Silvia Zabberoni

Subjects
prospective memory, Parkinson’s disease, healthy aging, training, immersive virtual reality, telemedicine, Psychology, BF1-990
Abstract

IntroductionProspective memory (PM) impairments have been extensively documented in individuals with Parkinson’s disease associated with mild cognitive impairment (PD-MCI) and in those with healthy aging. Considering how PM failure decreases individuals’ quality of life and functional independence in the activities of daily living, training to enhance this ability could be a prior target of intervention.ObjectiveHere, we aimed to present the study protocol and preliminary results of a novel immersive virtual reality (IVR) and telemedicine-based (TM) cognitive intervention focused on executive abilities (i.e., planning, shifting, and updating) to improve PM functioning in PD-MCI patients and healthy elderly individuals.MethodsOutcome measures, collected before, immediately after and 2 months after the intervention, included: (1) pre-post training changes in objective cognitive functioning, evaluated with tests assessing executive functions and PM; (2) pre-post training changes in subjective perception of memory functioning, psychiatric symptoms, autonomy in daily living and quality of life, evaluated using the appropriate scales; (3) usability, feasibility and users’ compliance with the proposed IVR and telemedicine program. The efficacy of this intervention compared to an active control condition is currently being evaluated in a randomized, double-blind controlled trial, which will be conducted on 30 eligible PD-MCI patients and 30 older adults.ResultsPreliminary results concerning between-group comparisons of demographic and neuropsychological screening data show a good balance among the intervention groups considered in this study. The results also suggest good levels of usability, feasibility and acceptability, thus supporting the notion that our intervention can be used to promote cognitive functioning, even in people with cognitive decline.ConclusionConsidering the relatively low costs and easy accessibility to this program, it could prove valuable in primary prevention initiatives and early cognitive rehabilitation for dementia risk reduction.

Published
2023
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31. Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries

Author

Mwayi Kachapila, Mark Monahan, Adesoji O. Ademuyiwa, Yakubu Momohsani Adinoyi, Bruce M. Biccard, Christina George, Dhruva N. Ghosh, James Glasbey, Dion G. Morton, Osaheni Osayomwanbo, Rupert Pearse, Tracy E. Roberts, Atul Suroy, Saidu Yusuf Yakubu, Raymond Oppong, Aneel Bhangu, Maria Lorena Aguilera, Philip Alexander, Sara W. Al-Saqqa, Giuliano Borda-Luque, Ainhoa Costas-Chavarri, Thomas M. Drake, Faustin Ntirenganya, J. Edward Fitzgerald, Stuart J. Fergusson, J.C. Allen Ingabire, Lawani Ismaïl, Hosni Khairy Salem, Anyomih Theophilus Teddy Kojo, Marie Carmela Lapitan, Richard Lilford, Andre L. Mihaljevic, Dion Morton, Alphonse Zeta Mutabazi, Dmitri Nepogodiev, Adewale O. Adisa, Riinu Ots, Francesco Pata, Thomas Pinkney, Tomas Poškus, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Sarah Rayne, Catherine A. Shaw, Sebastian Shu, Richard Spence, Neil Smart, Stephen Tabiri, Ewen M. Harrison, Azmina Verjee, Emmy Runigamugabo, Chetan Khatri, Midhun Mohan, Zahra Jaffry, Afnan Altamini, Andrew Kirby, Kjetil Søreide, Gustavo Recinos, Jen Cornick, Maria Marta Modolo, Dushyant Iyer, Sebastian King, Tom Arthur, Sayeda Nazmum Nahar, Ade Waterman, Michael Walsh, Arnav Agarwal, Augusto Zani, Mohammed Firdouse, Tyler Rouse, Qinyang Liu, Juan Camilo Correa, Peep Talving, Mengistu Worku, Alexis Arnaud, Vassilis Kalles, Basant Kumar, Sunil Kumar, Radhian Amandito, Roy Quek, Luca Ansaloni, Ahmed Altibi, Donatas Venskutonis, Justas Zilinskas, Tomas Poskus, John Whitaker, Vanessa Msosa, Yong Yong Tew, Alexia Farrugia, Elaine Borg, Zineb Bentounsi, Tanzeela Gala, Ibrahim Al-Slaibi, Haya Tahboub, Osaid H. Alser, Diego Romani, Sebestian Shu, Piotr Major, Aurel Mironescu, Matei Bratu, Amar Kourdouli, Aliyu Ndajiwo, Abdulaziz Altwijri, Mohammed Ubaid Alsaggaf, Ahmad Gudal, Al Faifi Jubran, Sam Seisay, Bettina Lieske, Irene Ortega, Jenifa Jeyakumar, Kithsiri J. Senanayake, Omar Abdulbagi, Yucel Cengiz, Dmitri Raptis, Yuksel Altinel, Chia Kong, Ella Teasdale, Gareth Irwin, Michael Stoddart, Rakan Kabariti, Sukrit Suresh, Katherine Gash, Ragavan Narayanan, Mayaba Maimbo, Besmir Grizhja, Shpetim Ymeri, Gezim Galiqi, Roberto Klappenbach, Diego Antezana, Alvaro Enrique Mendoza Beleño, Cecilia Costa, Belen Sanchez, Susan Aviles, Claudio Gabriel Fermani, Rubén Balmaceda, Santiago Villalobos, Juan Manuel Carmona, Daniel Hamill, Peter Deutschmann, Simone Sandler, Daniel Cox, Ram Nataraja, Claire Sharpin, Damir Ljuhar, Demi Gray, Morgan Haines, Dush Iyer, Nithya Niranjan, Scott D'Amours, Morvarid Ashtari, Helena Franco, Ashrarur Rahman Mitul, Sabbir Karim, Nowrin F. Aman, Mahnuma Mahfuz Estee, Umme Salma, Joyeta Razzaque, Tasnia Hamid Kanta, Sayeeda Aktar Tori, Shadid Alamin, Swapnil Roy, Shadid Al Amin, Rezaul Karim, Muhtarima Haque, Amreen Faruq, Farhana Iftekhar, Margaret O'Shea, Greg Padmore, Ramesh Jonnalagadda, Andrey Litvin, Aliaksandr Filatau, Dzmitry Paulouski, Maryna Shubianok, Tatsiana Shachykava, Dzianis Khokha, Vladimir Khokha, Fernande Djivoh, Francis Dossou, Djifid Morel Seto, Dansou Gaspard Gbessi, Bruno Noukpozounkou, Yacoubou Imorou Souaibou, Kpèmahouton René Keke, Fred Hodonou, Ernest Yemalin Stephane Ahounou, Thierry Alihonou, Max Dénakpo, Germain Ahlonsou, Alemayehu Ginbo Bedada, Carlos Nsengiyumva, Sandrine Kwizera, Venerand Barendegere, Philip Choi, Simon Stock, Luai Jamal, Georges Azzie, Sameer Kushwaha, Tzu-Ling Chen, Chingwan Yip, Irene Montes, Felipe Zapata, Sebastian Sierra, Maria Isabel Villegas Lanau, Maria Clara Mendoza Arango, Ivan Mendoza Restrepo, Ruben Santiago Restrepo Giraldo, Edgar Domini, Robert Karlo, Jakov Mihanovic, Mohamed Youssef, Hossam Elfeki, Waleed Thabet, Aly Sanad, Gehad Tawfik, Ahmed Zaki, Noran Abdel-Hameed, Mohamed Mostafa, Muhammad Fathi Waleed Omar, Ahmed Ghanem, Emad Abdallah, Adel Denewar, Eman Emara, Eman Rashad, Ahmad Sakr, Rehab Elashry, Sameh Emile, Toqa Khafagy, Sara Elhamouly, Arwa Elfarargy, Amna Mamdouh Mohamed, Ghada Saied Nagy, Abeer Esam, Eman Elwy, Aya Hammad, Salwa Khallaf, Eman Ibrahim, Ahmed Saidbadr, Ahmed Moustafa, Amany Eldosouky Mohammed, Mohammed Elgheriany, Eman Abdelmageed, Eman Abd Al Raouf, Esraa Samir Elbanby, Maha Elmasry, Mahitab Morsy Farahat, Eman Yahya Mansor, Eman Magdy Hegazy, Esraa Gamal, Heba Gamal, Hend Kandil, Doaa Maher Abdelrouf, Mohamed Moaty, Dina Gamal, Nada El-Sagheer, Mohamed Salah, Salma Magdy, Asmaa Salah, Ahmed Essam, Ahmed Ali, Mahmoud Badawy, Sara Ahmed, Mazed Mohamed, Abdelrahman Assal, Mohamed Sleem, Mai Ebidy, Aly Abd Elrazek, Diaaaldin Zahran, Nourhan Adam, Mohamed Nazir, Adel B. Hassanein, Ahmed Ismail, Amira Elsawy, Rana Mamdouh, Mohamed Mabrouk, Lopna Ahmed Mohamed Ahmed, Mohamed Hassab Alnaby, Eman Magdy, Manar Abd-Elmawla, Marwan Fahim, Bassant Mowafy, Moustafa Ibrahim Mahmoud, Meran Allam, Muhammad Alkelani, Noran Halim El Gendy, Mariam Saad Aboul-Naga, Reham Alaa El-Din, Alyaa Halim Elgendy, Mohamed Ismail, Mahmoud Shalaby, Aya Adel Elsharkawy, Mahmoud Elsayed Moghazy, Khaled Hesham Elbisomy, Hend Adel Gawad Shakshouk, Mohamed Fouad Hamed, Mai Mohamed Ebidy, Mostafa Abdelkader, Mohamed Karkeet, Hayam Ahmed, Israa Adel, Mohammad Elsayed Omar, Mohamed Ibrahim, Omar Ghoneim, Omar Hesham, Shimaa Gamal, Karim Hilal, Omar Arafa, Sawsan Adel Awad, Menatalla Salem, Fawzia Abdellatif Elsherif, Nourhan Elsabbagh, Moustafa R. Aboelsoud, Ahmed Hossam Eldin Fouad Rida, Amr Hossameldin, Ethar Hany, Yomna Hosny Asar, Nourhan Anwar, Mohamed Gadelkarim, Samar Abdelhady, Eman Mohamed Morshedy, Reham Saad, Nourhan Soliman, Mahmoud Salama, Eslam Ezzat, Arwa Mohamed, Arwa Ibrahim, Alaa Fergany, Sara Mohammed, Aya Reda, Yomna Allam, Hanan Adel Saad, Afnan Abdelfatah, Aya Mohamed Fathy, Ahmed El-Sehily, Esraa Abdalmageed Kasem, Ahmed Tarek Abdelbaset Hassan, Ahmed Rabeih Mohammed, Abdalla Gamal Saad, Yasmin Elfouly, Nesma Elfouly, Arij Ibrahim, Amr Hassaan, Mohammed Mustafa Mohammed, Ghada Elhoseny, Mohamed Magdy, Esraa Abd Elkhalek, Yehia Zakaria, Tarek Ezzat, Ali Abo El Dahab, Mohamed Kelany, Sara Arafa, Osama Mokhtar Mohamed Hassan, Nermin Mohamed Badwi, Ahmad Saber Sleem, Hussien Ahmed, Kholoud Abdelbadeai, Mohamed Abozed Abdullah, Muhammad Amsyar Auni Lokman, Suraya Bahar, Anan Rady Abdelazeam, Abdelrahman Adelshone, Muhammad Bin Hasnan, Athirah Zulkifli, Siti Nur Alia Kamarulzamil, Abdelaziz Elhendawy, Aliang Latif, Ahmad Bin Adnan, Shahadatul Shaharuddin, Aminah Hanum Haji Abdul Majid, Mahmoud Amreia, Dina Al-Marakby, Mahmoud Salma, Mohamad Jeffrey Bin Ismail, Elissa Rifhan Mohd Basir, Citra Dewi, Mohd Ali, Aya Yehia Ata, Maha Nasr, Asmaa Rezq, Ahmed Sheta, Sherif Tariq, Abd Elkhalek Sallam, Abdelrhman K.Z. Darwish, Sohaila Elmihy, Shady Elhadry, Ahmed Farag, Haidar Hajeh, Abdelaziz Abdelaal, Amro Aglan, Ahmed Zohair, Mahitab Essam, Omar Moussa, Esraa El-Gizawy, Mostafa Samy, Safia Ali, Esraa Elhalawany, Ahmed Ata, Mohamed El Halawany, Mohamed Nashat, Samar Soliman, Alaa Elazab, Mostada Samy, Mohamed A. Abdelaziz, Khaled Ibrahim, Ahmed mohamed Ibrahim, Ammar Gado, Usama Hantour, Esraa Alm Eldeen, Mohamed Reda loaloa, Arwa Abouzaid, Mostafa Ahmed Bahaa Eldin, Eman Hashad, Fathy Sroor, Doaa Gamil, Eman Mahmoud Abdulhakeem, Mahmoud Zakaria, Fawzy Mohamed, Marwan Abubakr, Elsayed Ali, Hesham Magdy, Menna Tallah Ramadan, Mohamed Abdelaty Mohamed, Salma Mansour, Hager Abdul Aziz Amin, Ahmed Rabie Mohamed, Mahmoud Saami, Nada Ahmed Reda Elsayed, Adham Tarek, Sabry Mohy Eldeen Mahmoud, Islam Magdy El Sayed, Amira Reda, Martina Yusuf Shawky, Mohammed Mousa Salem, Shahinaz Alaa El-Din, Noha Abdullah Soliman, Muhammed Talaat, Shahinaz Alaael-Dein, Ahmed Abd Elmoen Elhusseiny, Noha Abdullah, Mohammed Elshaar, Aya AbdelFatah Ibraheem, Hager Abdulaziz, Mohammed Kamal Ismail, Mona Hamdy Madkor, Mohamed Abdelaty, Sara Mahmoud Abdel-Kader, Osama Mohamed Salah, Mahmoud Eldafrawy, Ahmed Zaki Eldeeb, Mostafa Mahmoud Eid, Attia Attia, Khalid Salah El-Dien, Ayman Shwky, Mohamed Adel Badenjki, Abdelrahman Soliman, Samaa Mahmoud Al Attar, Farrag Sayed, Fahd Abdel Sabour, Mohammed G. Azizeldine, Muhammad Shawqi, Abdullah Hashim, Ahmed Aamer, Ahmed Mahmoud Abdelraouf, Mahmoud Abdelshakour, Amal Ibrahim, Basma Mahmoud, Mohamed Ali Mahmoud, Mostafa Qenawy, Ahmed M. Rashed, Ahmed Dahy, Marwa Sayed, Ahmed W. Shamsedine, Bakeer Mohamed, Ahmad Hasan, Mahmoud M. Saad, Khalil Abdul Bassit, Nadia Khalid Abd El-Latif, Nada Elzahed, Ahmed El Kashash, Nada Mohamed Bekhet, Sarah Hafez, Ahmed Gad, Mahmoud Elkhadragy Maher, Ahmed Abd Elsameea, Mohamed Hafez, Ahmad Sabe, Ataa Ahmed, Ahmed Shahine, Khaled Dawood, Shireen Gaafar, Reem Husseiny, Omnia Aboelmagd, Ahmed Soliman, Nourhan Mesbah, Hossam Emadeldin, Amgad Al Meligy, Amira Hassan Bekhet, Doaa Hasan, Khaled Alhady, Ahmad Khaled Sabe, Mahmoud A. Elnajjar, Majed Aboelella, Ward Hamsho, Ihab Hassan, Hala Saad, Galaleldin Abdelazim, Hend Mahmoud, Noha Wael, Ahmedali M. Kandil, Ahmed Magdy, Shimaa Said Elkholy, Badr Eldin Adel, Kareem Dabbour, Saged Elsherbiney, Omar Mattar, Abdulshafi Khaled Abdrabou, Mohammed Yahia Mohamed Aly, Abdelrahman Geuoshy, Ahmedglal Elnagar, Saraibrahim Ahmed, Ibrahem Abdelmotaleb, Amr Ahmed Saleh, Manar Saeed, Shady Mahmoud, Badreldin Adel Tawfik, Samar Adel Ismail, Esraay Zakaria, Mariam O. Gad, Mohamed Salah Elhelbawy, Monica Bassem, Noha Maraie, Nourhan Medhat Elhadary, Nourhan Semeda, Shaza Rabie Mohamed, Hesham Mohammed Bakry, A.A. Essam, Dina Tarek, Khlood Ashour, Alaa Elhadad, Abdulrahman Abdel-Aty, Ibrahim Rakha, Sara Mamdouh Matter, Rasha Abdelhamed, Omar Abdelkader, Ayat Hassaan, Yasmin Soliman, Amna Mohamed, Sara Ghanem, Sara Amr Mohamed Farouk, Eman Mohamed Ibrahim, Esraa El-Taher, Merna Mostafa, Mohamed Fawzy Mahrous Badr, Rofida Elsemelawy, Aya El-Sawy, Ahmad Bakr, Ahmad Abdel Razaq Al Rafati, Sten Saar, Arvo Reinsoo, Nebyou Seyoum, Tewodros Worku, Agazi Fitsum, Matti Tolonen, Ari Leppäniemi, Ville Sallinen, Benoît Parmentier, Matthieu Peycelon, Sabine Irtan, Sabrina Dardenne, Elsa Robert, Betty Maillot, Etienne Courboin, Alexis Pierre Arnaud, Juliette Hascoet, Olivier Abbo, Amir Ait Kaci, Thomas Prudhomme, Quentin Ballouhey, Céline Grosos, Laurent Fourcade, Tolg Cecilia, Colombani Jean-Francois, Francois-Coridon Helene, Xavier Delforge, Elodie Haraux, Bertrand Dousset, Roberto Schiavone, Sebastien Gaujoux, Jean-Baptiste Marret, Aurore Haffreingue, Julien Rod, Mariette Renaux-Petel, Jean-François Lecompte, Jean Bréaud, Pauline Gastaldi, Chouikh Taieb, Raquillet Claire, Echaieb Anis, Nasir Bustangi, Manuel Lopezv, Aurelien Scalabre, Maria Giovanna Grella, Aurora Mariani, Guillaume Podevin, Françoise Schmitt, Erik Hervieux, Aline Broch, Cecile Muller, Dickson Bandoh, Francis Abantanga, Martin Kyereh, Hamza Asumah, Eric Kofi Appiah, Paul Wondoh, Adam Gyedu, Charles Dally, Kwabena Agbedinu, Michael Amoah, Abiboye Yifieyeh, Frank Owusu, Mabel Amoako-Boateng, Makafui Dayie, Richmond Hagan, Sam Debrah, Micheal Ohene-Yeboah, Joe-Nat Clegg-Lampety, Victor Etwire, Jonathan Dakubo, Samuel Essoun, William Bonney, Hope Glover-Addy, Samuel Osei-Nketiah, Joachim Amoako, Niiarmah Adu-Aryee, William Appeadu-Mensah, Antoinette Bediako-Bowan, Florence Dedey, Mattew Ekow, Emmanuel Akatibo, Musah Yakubu, Hope Edem Kofi Kordorwu, Kwasi Asare-Bediako, Enoch Tackie, Kenneth Aaniana, Emmanuel Acquah, Richard Opoku-Agyeman, Anthony Avoka, Kwasi Kusi, Kwame Maison, Frank Enoch Gyamfi, Gandau Naa Barnabas, Saiba Abdul-Latif, Philip Taah Amoako, Anthony Davor, Victor Dassah, Enoch Dagoe, Prince Kwakyeafriyie, Elliot Akoto, Eric Ackom, Ekow Mensah, Ebenezer Takyi Atkins, Christian Lari Coompson, Nikolaos Ivros, Christoforos Ferousis, Vasileios Kalles, Christos Agalianos, Ioannis Kyriazanos, Christos Barkolias, Angelos Tselos, Georgios Tzikos, Evangelos Voulgaris, Dimitrios Lytras, Athanasia Bamicha, Kyriakos Psarianos, Anastasios Stefanopoulos, Ioannis Patoulias, Dimitrios Sfougaris, Ioannis Valioulis, Dimitrios Balalis, Dimitrios Korkolis, Dimitrios K. Manatakis, Georgios Kyrou, Georgios Karabelias, Iason-Antonios Papaskarlatos, Kolonia Konstantina, Nikolaos Zampitis, Stylianos Germanos, Aspasia Papailia, Theodosios Theodosopoulos, Georgios Gkiokas, Magdalini Mitroudi, Christina Panteli, Thomas Feidantsis, Konstantinos Farmakis, Dimitrios Kyziridis, Orestis Ioannidis, Styliani Parpoudi, Georgios Gemenetzis, Stavros Parasyris, Christos Anthoulakis, Nikolaos Nikoloudis, Michail Margaritis, Maria-Lorena Aguilera-Arevalo, Otto Coyoy-Gaitan, Javier Rosales, Luis Tale, Rafael Soley, Emmanuel Barrios, Servio Tulio Torres Rodriguez, Carlos Paz Galvez, Danilo Herrera Cruz, Guillermo Sanchez Rosenberg, Alejandro Matheu, David Monterroso Cohen, Marie Paul, Angeline Charles, Justin Chak Yiu Lam, Man Hon Andrew Yeung, Chi Ying Jacquelyn Fok, Ka Hin Gabriel Li, Anthony Chuk-Him Lai, Yuk Hong Eric Cheung, Hong Yee Wong, Ka Wai Leung, Tien Seng Bryan Lee, Wai Him Lam, Weihei Dao, Stephanie Hiu-wai Kwok, Tsz-Yan Katie Chan, Yung Kok Ng, T.W.C. Mak, Chi Chung Foo, James Yang, Ankur Bhatnagar, Vijaid Upadhyaya, Uday Muddebihal, Wasim Dar, K.C. Janardha, Neerav Aruldas, Fidelis Jacklyn Adella, Anthonius Santoso Rulie, Ferdy Iskandar, Jonny Setiawan, Cicilia Viany Evajelista, Hani Natalie, Arlindawati Suyadi, Rudy Gunawan, Herlin Karismaningtyas, Lusi Padma Sulistianingsih Mata, Ferry Fitriya Ayu Andika, Afifatun Hasanah, T. Ariani Widiastini, Nurlaila Ayu Purwaningsih, Annisa Dewi Fitriana Mukin, Dina Faizatur Rahmah, Hazmi Dwinanda Nurqistan, Hasbi Maulana Arsyad, Novia Adhitama, Wifanto Saditya Jeo, Nathania Sutandi, Audrey Clarissa, Phebe Anggita Gultom, Matthew Billy, Andreass Haloho, Nadya Johanna, Felix Lee, Radin Mohd Nurrahman Radin Dorani, Martha Glynn, Mohammad Alherz, Wennweoi Goh, Haaris A. Shiwani, Lorraine Sproule, Kevin C. Conlon, Miklosh Bala, Asaf Kedar, Luca Turati, Federica Bianco, Francesca Steccanella, Gaetano Gallo, Mario Trompetto, Giuseppe Clerico, Matteo Papandrea, Giuseppe Sammarco, Rosario Sacco, Angelo Benevento, Luisa Giavarini, Mariano Cesare Giglio, Luigi Bucci, Gianluca Pagano, Viviana Sollazzo, Roberto Peltrini, Gaetano Luglio, Arianna Birindelli, Salomone Di Saverio, Gregorio Tugnoli, Miguel Angel Paludi, Pietro Mingrone, Domenica Pata, Francesco Selvaggi, Lucio Selvaggi, Gianluca Pellino, Natale Di Martino, Gianluca Curletti, Paolo Aonzo, Raffaele Galleano, Stefano Berti, Elisa Francone, Silvia Boni, Laura Lorenzon, Annalisa lo Conte, Genoveffa Balducci, Gianmaria Confalonieri, Giovanni Pesenti, Laura Gavagna, Giorgio Vasquez, Simone Targa, Savino Occhionorelli, Dario Andreotti, Giacomo Pata, Andrea Armellini, Deborah Chiesa, Fabrizio Aquilino, Nicola Chetta, Arcangelo Picciariello, Mohamed Abdelkhalek, Andrea Belli, Silvia De Franciscis, Annamaria Bigaran, Alessandro Favero, Stefano M.M. Basso, Paola Salusso, Martina Perino, Sylvie Mochet, Diego Sasia, Francesco Riente, Marco Migliore, David Merlini, Silvia Basilicò, Carlo Corbellini, Veronica Lazzari, Yuri Macchitella, Luigi Bonavina, Daniele Angelieri, Diego Coletta, Federica Falaschi, Marco Catani, Claudia Reali, Mariastella Malavenda, Celeste Del Basso, Sergio Ribaldi, Massimo Coletti, Andrea Natili, Norma Depalma, Immacolata Iannone, Angelo Antoniozzi, Davide Rossi, Daniele Gui, Gerardo Perrotta, Matteo Ripa, Francesco Ruben Giardino, Maurizio Foco, Erika Vicario, Federico Coccolini, Gabriela Elisa Nita, Nicoletta Leone, Andrea Bondurri, Anna Maffioli, Andrea Simioni, Davide De Boni, Sandro Pasquali, Elena Goldin, Elena Vendramin, Eleonora Ciccioli, Umberto Tedeschi, Luca Bortolasi, Paola Violi, Tommaso Campagnaro, Simone Conci, Giovanni Lazzari, Calogero Iacono, Alfredo Gulielmi, Serena Manfreda, Anna Rinaldi, Maria Novella Ringressi, Beatrice Brunoni, Giuseppe Salamone, Mirko Mangiapane, Paolino De Marco, Antonella La Brocca, Roberta Tutino, Vania Silvestri, Leo Licari, Tommaso Fontana, Nicolò Falco, Gianfranco Cocorullo, Mostafa Shalaby, Pierpaolo Sileri, Claudio Arcudi, Isam Bsisu, Khaled Aljboor, Lana Abusalem, Aseel Alnusairat, Ahmad Qaissieh, Emad Al-Dakka, Ali Ababneh, Oday Halhouli, Taha Yusufali, Hussein Mohammed, Justus Lando, Robert Parker, Wairimu Ndegwa, Mantas Jokubauskas, Jolanta Gribauskaite, Justas Kuliavas, Audrius Dulskas, Narimantas E. Samalavicius, Kristijonas Jasaitis, Audrius Parseliunas, Viktorija Nevieraite, Margarita Montrimaite, Evelina Slapelyte, Edvinas Dainius, Romualdas Riauka, Zilvinas Dambrauskas, Andrejus Subocius, Linas Venclauskas, Antanas Gulbinas, Saulius Bradulskis, Simona Kasputyte, Deimante Mikuckyte, Mindaugas Kiudelis, Tomas Jankus, Steponas Petrikenas, Matas Pažuskis, Zigmantas Urniežius, Mantas Vilčinskas, Vincas Jonas Banaitis, Vytautas Gaižauskas, Edvard Grisin, Povilas Mazrimas, Rokas Rackauskas, Mantas Drungilas, Karolis Lagunavicius, Vytautas Lipnickas, Dovilè Majauskyté, Valdemaras Jotautas, Tomas Abaliksta, Laimonas Uščinas, Gintaras Simutis, Adomas Ladukas, Donatas Danys, Erikas Laugzemys, Saulius Mikalauskas, Elena Zdanyte Sruogiene, Petras Višinskas, Reda Žilinskienė, Deividas Dragatas, Andrius Burmistrovas, Zygimantas Tverskis, Arturas Vaicius, Ruta Mazelyte, Antanas Zadoroznas, Nerijus Kaselis, Greta Žiubrytė, Finaritra Casimir Fleur Prudence Rahantasoa, Luc Hervé Samison, Fanjandrainy Rasoaherinomenjanahary, Todisoa Emmanuella Christina Tolotra, Cornelius Mukuzunga, Chimwemwe Kwatiwani, Nelson Msiska, Feng Yih Chai, Siti Mohd Desa Asilah, Khuzaimah Zahid Syibrah, Pui Xin Chin, Afizah Salleh, Nur Zulaika Riswan, April Camilla Roslani, Hoong-Yin Chong, Nora Abdul Aziz, Keat-Seong Poh, Chu-Ann Chai, Sandip Kumar, Mustafa Mohammed Taher, Nik Ritza Kosai, Dayang Nita Abdul Aziz, Reynu Rajan, Rokayah Julaihi, Durvesh Lacthman Jethwani, Muhammad Taqiyuddin Yahaya, Nik Azim Nik Abdullah, Susan Wndy Mathew, Kuet Jun Chung, Milaksh Kumar Nirumal, R. Goh Ern Tze, Syed Abdul Wahhab Eusoffee Wan Ali, Yiing Yee Gan, Jesse Ron Swire Ting, Samuel S.Y. Sii, Kean Leong Koay, Yi Koon Tan, Alvin Ee Zhiun Cheah, Chui Yee Wong, Tuan Nur'Azmah Tuan Mat, Crystal Yern Nee Chow, Prisca A.L. Har, Yishan Der, Fitjerald Henry, Xinwei Low, Ya Theng Neo, Hian Ee Heng, Shu Ning Kong, Cheewei Gan, Yi Ting Mok, Yee Wen Tan, Kandasami Palayan, Mahadevan Deva Tata, Yih Jeng Cheong, Kuhaendran Gunaseelan, Wan Nurul 'Ain Wan Mohd Nasir, Pigeneswaren Yoganathan, Eu Xian Lee, Jian Er Saw, Li Jing Yeang, Pei Ying Koh, Shyang Yee Lim, Shuang Yi Teo, Nicole Grech, Daniela Magri, Kristina Cassar, Christine Mizzi, Malcolm Falzon, Nihaal Shaikh, Ruth Scicluna, Stefan Zammit, Sean Mizzi, Svetlana Doris Brincat, Thelma Tembo, Vu Thanh Hien Le, Tara Grima, Keith Sammut, Kurt Carabott, Ciskje Zarb, Andre Navarro, Thea Dimech, Georgette Marie Camilleri, Isaac Bertuello, Jeffrey Dalli, Karl Bonavia, Samantha Corro-Diaz, Marisol Manriquez-Reyes, Amina Abdelhamid, Abdelmalek Hrora, Sarah Benammi, Houda Bachri, Meryem Abbouch, Khaoula Boukhal, Redouane Mammar Bennai, Abdelkader Belkouchi, Mohamed Sobhi Jabal, Chaymae Benyaiche, Maarten Vermaas, Lucia Duinhouwer, Javier Pastora, Greta Wood, Maria Soledad Merlo, Akinlabi Ajao, Omobolaji Ayandipo, Taiwo Lawal, Abdussemiu Abdurrazzaaq, Muslimat Alada, Abdulrasheed Nasir, James Adeniran, Olufemi Habeeb, Ademola Popoola, Ademola Adeyeye, Ademola Adebanjo, Opeoluwa Adesanya, Adewale Adeniyi, Henry Mendel, Bashir Bello, Umar Muktar, Adedapo Osinowo, Thomas Olagboyega Olajide, Oyindamola Oshati, George Ihediwa, Babajide Adenekan, Victor Nwinee, Felix Alakaloko, Adesoji Ademuyiwa, Olumide Elebute, Abdulrazzaq Lawal, Chris Bode, Mojolaoluwa Olugbemi, Alaba Adesina, Olubukola Faturoti, Oluwatomi Odutola, Oluwaseyi Adebola, Clement Onuoha, Ogechukwu Taiwo, Omolara Williams, Fatai Balogun, Olalekan Ajai, Mobolaji Oludara, Iloba Njokanma, Roland Osuoji, Stephen Kache, Jonathan Ajah, Jerry Makama, Ahmed Adamu, Suleiman Baba, Mohammad Aliyu, Shamsudeen Aliyu, Yahaya Ukwenya, Halima Aliyu, Tunde Sholadoye, Muhammad Daniyan, Oluseyi Ogunsua, Lofty-John Anyanwu, Abdurrahaman Sheshe, Aminu Mohammad, Samson Olori, Philip Mshelbwala, Babatunde Odeyemi, Garba Samson, Oyediran Kehinde Timothy, Sani Ali Samuel, Anthony Ajiboye, Isaac Amole, Olajide Abiola, Akin Olaolorun, Torhild Veen, Arezo Kanani, Kristian Styles, Ragnar Herikstad, Johannes Wiik Larsen, Jon Arne Søreide, Elisabeth Jensen, Mads Gran, Eirik Kjus Aahlin, Tina Gaarder, Peter Wiel Monrad-Hansen, Pål Aksel Næss, Giedrius Lauzikas, Joachim Wiborg, Silje Holte, Knut Magne Augestad, Gurpreet Singh Banipal, Michela Monteleone, Thomas Tetens Moe, Johannes Kurt Schultz, Taher Al-Taher, Ayah Hamdan, Ayman Salman, Rana Saadeh, Aseel Musleh, Dana Jaradat, Soha Abushamleh, Sakhaa Hanoun, Amjad Abu Qumbos, Aseel Hamarshi, Ayman, Taher, Israa Qawasmi, Khalid Qurie, Marwa Altarayra, Mohammad Ghannam, Alaa Shaheen, Azher Herebat, Aram Abdelhaq, Ahmad Shalabi, Maram Abu-Toyour, Fatema Asi, Ala Shamasneh, Anwar Atiyeh, Mousa Mustafa, Rula Zaa'treh, Majd Dabboor, Enas Alaloul, Heba Baraka, Jehad Meqbil, Alaa Al-Buhaisi, Mohamedraed Elshami, Samah Afana, Sahar Jaber, Said Alyacoubi, Yousef Abuowda, Tasneem Idress, Eman Abuqwaider, Sara Al-Saqqa, Alaa Bowabsak, Alaa El Jamassi, Doaa Hasanain, Hadeel Al-Farram, Maram Salah, Aya Firwana, Marwa Hamdan, Israa Awad, Ahmad Ashour, Fayez Elian Al Barrawi, Ahmed Al-Khatib, Maha Al-Faqawi, Mohamed Fares, Amjad Elmashala, Mohammad Adawi, Ihdaa Adawi, Reem Khreishi, Rose Khreishi, Ahed Ghaben, Najwa Nadeem, Muhammad Saqlain, Jibran Abbasy, Abdul Rehman Alvi, Noman Shahzad, Kamran Faisal Bhopal, Zainab Iftikhar, Muhammad Talha Butt, Syed Asaat Ul Razi, Asdaq Ahmed, Ali Khan Niazi, Ibrahim Raza, Fatima Baluch, Ahmed Raza, Ahmad Bani-Sadar, Muhammad Adil, Awais Raza, Mahnoor Javaid, Muhammad Waqar, Maryam Ali Khan, Mohammad Mohsin Arshad, Mohammadasim Amjad, Gustavo Miguel Machain Vega, Jorge Torres Cardozo, Marcelo O´Higgins Roche, Gustavo Rodolfo Pertersen Servin, Helmut Alfredo Segovia Lohse, Larissa Ines Páez Lopez, Ramón Augusto Melo Cardozo, Fernando Espinoza, Angel David Pérez Rojas, Diana Sanchez, Camila Sanchez Samaniego, Shalon Guevara Torres, Alexander Canta Calua, Cesar Razuri, Nadia Ortiz, Xianelle Rodriguez, Nahilia Carrasco, Fridiz Saravia, Hector Shibao Miyasato, María Valcarcel-Saldaña, Ysabel Esthefany Alejos Bermúdez, Juan Carpio, Walter Ruiz Panez, Pedro Angel Toribio Orbegozo, Carolina Guzmán Dueñas, Kevin Turpo Espinoza, Ana Maria Sandoval Barrantes, Jorge Armando Chungui Bravo, Lorena Fuentes-Rivera, Carmen Fernández, Bárbara Málaga, Joselyn Ye, Ricardo Velasquez, Jannin Salcedo, Ana Lucia Contreras-Vergara, Angelica Genoveva Vergara Mejia, Maria Soledad Gonzales Montejo, Marilia Del Carmen Escalante Salas, Willy Alcca Ticona, Marvin Vargas, George Christian Manrique Sila, Robinson Mas, Arazzelly del Pilar Paucar, Armando José Román Velásquez, Alina Robledo-Rabanal, Ludwing Alexander Zeta Solis, Kenny Turpo Espinoza, José Luis Hamasaki Hamaguchi, Erick Samuel Florez Farfan, Linda Alvi Madrid Barrientos, Juan Jaime Herrera Matta, John Jemuel V. Mora, Menold Archee P. Redota, Manuel Francisco Roxas, Maria Jesusa B. Maño, Marie Dione Parreno-Sacdalan, Christel Leanne Almanon, Maciej Walędziak, Rafał Roszkowski, Michał Janik, Anna Lasek, Dorota Radkowiak, Mateusz Rubinkiewicz, Cristina Fernandes, Jose Costa-Maia, Renato Melo, Liviu Muntean, Aurel Sandu Mironescu, Lucian Corneliu Vida, Mariuca Popa, Hogea Mircea, Mihaela Vartic, Bogdan Diaconescu, Matei Razvan Bratu, Ionut Negoi, Mircea Beuran, Cezar Ciubotaru, Norbert Uzabumwana, Dieudonne Duhoranenayo, Elio Jovine, Nicola Zanini, Giovanni Landolfo, Murad Aljiffry, Faisal Idris, Mohammed Saleh A. Alghamdi, Ashraf Maghrabi, Abdulmalik Altaf, Aroub Alkaaki, Ahmad Khoja, Abrar Nawawi, Sondos Turkustani, Eyad Khalifah, Adel Albiety, Sarah Sahel, Reham Alshareef, Mohammed Najjar, Ahmed Alzahrani, Ahmed Alghamdi, Wedyan Alhazmi, Ghiath Al Saied, Mohammed Alamoudi, Muhammed Masood Riaz, Mazen Hassanain, Basmah Alhassan, Abdullah Altamimi, Reem Alyahya, Norah Al Subaie, Fatema Al Bastawis, Afnan Altamimi, Thamer Nouh, Roaa Khan, Milan Radojkovic, Ljiljana Jeremic, Milica Nestorovic, Jia Hao Law, Keith Say Kwang Tan, Ryan Choon Kiat Tan, Joel Kin Tan, Lau Wen Liang Joel, Xue Wei Chan, Faith Qi Hui Leong, Choon Seng Chong, Sharon Koh, Kai Yin Lee, Kuok Chung Lee, Kent Pluke, Britta Dedekind, Puyearashid Nashidengo, Mark Ian Hampton, Johanna Joosten, Sanju Sobnach, Liana Roodt, Anthony Sander, James Pape, Niveshni Maistry, Phumudzo Ndwambi, Kamau Kinandu, Myint Tun, Frederick Du Toit, Quinn Ellison, D.C. Grobler, Sule Burger, Lawrence Bongani Khulu, Rachel Moore, Vicky Jennings, Astrid Leusink, Nazmie Kariem, Juan Gouws, Kathryn Chu, Heather Bougard, Fazlin Noor, Angela Dell, Stephanie Van Straten, Arvin Khamajeet, Serge Kapenda Tshisola, Kalangu Kabongo, Victor Kong, Yoshan Moodley, Frank Anderson, Thandinkosi Madiba, Flip du Plooy, Leila Hartford, Gareth Chilton, Parveen Karjiker, Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu, Maria Badicel, Robert Jaich, Jaime Ruiz-Tovar, Luis Garcia-Florez, Jorge L. Otero-Díez, Virginia Ramos Pérez, Nuria Aguado Suárez, Javier Minguez García, Sara Corral Moreno, Maria Vicenta Collado, Virginia Jiménez Carneros, Javier García Septiem, Mariana Gonzalez, Antonio Picardo, Enrique Esteban, Esther Ferrero, Eloy Espin-Basany, Ruth Blanco-Colino, Valeria Andriola, Lorena Solar García, Elisa Contreras, Carmen García Bernardo, Janet Pagnozzi, Sandra Sanz, Alberto Miyar de León, Asnel Dorismé, Joseluis Rodicio, Aida Suarez, Jessica Stuva, Tamara Diaz Vico, Laura Fernandez-Vega, Carla Soldevila-Verdeguer, Fatima Sena-Ruiz, Natalia Pujol-Cano, Paula Diaz-Jover, José Maria Garcia-Perez, Juan Jose Segura-Sampedro, Cristina Pineño-Flores, David Ambrona-Zafra, Andrea Craus-Miguel, Patricia Jimenez-Morillas, Angela Mazzella, A.B. Jayathilake, S.P.B. Thalgaspitiya, L.S. Wijayarathna, P.M.S.N. Wimalge, Hakeem Ayomi Sanni, Ogheneochuko Okenabirhie, Anmar Homeida, Abobaker Younis, Omer Abdelbagi Omer, Mustafa Abdulaziz, Ali Mussad, Ali Adam, Ida Björklund, Sandra Ahlqvist, Anders Thorell, Fredrik Wogensen, Arestis Sokratous, Michaela Breistrand, Hildur Thorarinsdottir, Johanna Sigurdadottir, Maziar Nikberg, Abbas Chabok, Maria Hjertberg, Peter Elbe, Deborah Saraste, Wiktor Rutkowski, Louise Forlin, Karoliina Niska, Malin Sund, Dennis Oswald, Georgios Peros, Rafael Bluelle, Katharina Reinisch, Daniel Frey, Adrian Palma, Dimitri Aristotle Raptis, Lucius Zumbühl, Markus Zuber, Roger Schmid, Gabriela Werder, Antonio Nocito, Alexandra Gerosa, Silke Mahanty, Lukas Werner Widmer, Julia Müller, Alissa Gübeli, Grzegorz Zuk, Osman Bilgin Gulcicek, Talar Vartanoglu, Emin Kose, Servet Rustu Karahan, Mehmet Can Aydin, Nuri Alper Sahbaz, Ilkay Halicioglu, Halil Alis, Ipek Sapci, Can Adıyaman, Ahmet Murat Pektaş, Turgut Bora Cengiz, Ilkan Tansoker, Vedatcan Işler, Muazzez Cevik, Deniz Mutlu, Volkan Ozben, Berk Baris Ozmen, Sefa Bayram, Sinem Yolcu, Berna Buse Kobal, Ömer Faruk Toto, Haluk Cem Çakaloğlu, Kagan Karabulut, Vahit Mutlu, Bahar Busra Ozkan, Saban Celik, Anil Semiz, Selim Bodur, Enisburak Gül, Busra Murutoglu, Reyyan Yildirim, Bahadir Emre Baki, Ekin Arslan, Mehmet Ulusahin, Ali Guner, Nathan Walker, Nikhita Shrimanker, Simon Cole, Ryan Breslin, Ravi Srinivasan, Mohamed Elshaer, Kristina Hunter, Ahmed Al-Bahrani, Ignatius Liew, Nora Grace Mairs, Alistair Rocke, Lachlan Dick, Mobeen Qureshi, Debkumar Chowdhury, Naomi Wright, Clare Skerritt, Dorothy Kufeji, Adrienne Ho, Tharindra Dissanayake, Athula Tennakoon, Wadah Ali, Shujing Jane Lim, Charlene Tan, Stephen O'Neill, Catrin Jones, Stephen Knight, Dima Nassif, Abhishek Sharma, Oliver Warren, Rebecca White, Aia Mehdi, Nathan Post, Eliana Kalakouti, Enkhbat Dashnyam, Frederick Stourton, Ioannis Mykoniatis, Chelise Currow, Francisca Wong, Ashish Gupta, Veeranna Shatkar, Joshua Luck, Suraj Kadiwar, Alexander Smedley, Rebecca Wakefield, Philip Herrod, James Blackwell, Jonathan Lund, Fraser Cohen, Ashwath Bandi, Stefano Giuliani, Giles Bond-Smith, Theodore Pezas, Neda Farhangmehr, Tomas Urbonas, Miklos Perenyei, Philip Ireland, Natalie Blencowe, Kirk Bowling, David Bunting, Lydia Longstaff, Kenneth Keogh, Hyunjin Jeon, Muhammad Rafaih Iqbal, Shivun Khosla, Anna Jeffery, James Perera, Ahmad Aboelkassem Ibrahem, Tariq Alhammali, Yahya Salama, Shaun Oram, Thomas Kidd, Fraser Cullen, Christopher Owen, Michael Wilson, Seehui Chiu, Hannah Sarafilovic, Jennifer Ploski, Elizabeth Evans, Athar Abbas, Sylvia Kamya, Norzawani Ishak, Carly Bisset, Cedar Andress, Ye Ru Chin, Priya Patel, David Evans, Aidan Haslegrave, Adam Boggon, Kirsten Laurie, Katie Connor, Thomas Mann, Anahita Mansuri, Rachel Davies, Ewen Griffiths, Aized Raza Shahbaz, Calvin Eng, Farhat Din, Ariadne L'Heveder, Esther H.G. Park, Ramanish Ravishankar, Kirsten McIntosh, Jih Dar Yau, Luke Chan, Susan McGarvie, Lingshan Tang, Hui Lim, Suhhuey Yap, Jay Park, Zhan Herr Ng, Shahrukh Mirza, Yun Lin Ang, Luke Walls, Chloe Roy, Simon Paterson-Brown, Julian Camilleri-Brennan, Kenneth Mclean, Michelle S. D'Souza, Savva Pronin, David Ewart Henshall, Eunice Zuling Ter, Dina Fouad, Ashish Minocha, William English, Catrin Morgan, Dominic Townsend, Laura Maciejec, Shareef Mahdi, Onyinye Akpenyi, Elisabeth Hall, Hanaan Caydiid, Zakaria Rob, Tom Abbott, Hew D. Torrance, Robin Johnston, Mohammed Akil Gani, Gianpiero Gravante, Shivanchan Rajmohan, Kiran Majid, Shiva Dindyal, Christopher Smith, Madanmohan Palliyil, Sanjay Patel, Luke Nicholson, Neil Harvey, Katie Baillie, Sam Shillito, Suzanne Kershaw, Rebecca Bamford, Peter Orton, Elke Reunis, Robert Tyler, Wai Cheong Soon, Guled M. Jama, Dharminder Dhillon, Khyati Patel, Shayanthan Nanthakumaran, Rachel Heard, Kar Yan Chen, Behrad Barmayehvar, Uttaran Datta, Sivesh K. Kamarajah, Sharad Karandikar, Sobhana Iftekhar Tani, Eimear Monaghan, Philippa Donnelly, Michael Walker, Jehangirshaw Parakh, Sarah Blacker, Anil Kaul, Arjun Paramasivan, Sameh Farag, Ashrafun Nessa, Salwa Awadallah, Jieqi Lim, James Chean Khun Ng, Ravi P. Kiran, Alice Murray, Eric Etchill, Mohini Dasari, Juan Puyana, Nadeem Haddad, Martin Zielinski, Asad Choudhry, Celeste Caliman, Mieshia Beamon, Therese Duane, Mamta Swaroop, Jonathan Myers, Rebecca Deal, Erik Schadde, Mark Hemmila, Lena Napolitano, Kathleen To, Alex Makupe, Joseph Musowoya, Niels Van Der Naald, Dayson Kumwenda, Alex Reece-Smith, Kars Otten, Anna Verbeek, Marloes Prins, Alibeth Andres Baquero Suarez, Ruben Balmaceda, Chelsea Deane, Emilio Dijan, Mahmoud Elfiky, Laura Koskenvuo, Aurore Thollot, Bernard Limoges, Carmen Capito, Challine Alexandre, Henri Kotobi, Julien Leroux, Kalitha Pinnagoda, Nicolas Henric, Olivier Azzis, Olivier Rosello, Poddevin Francois, Sara Etienne, Philippe Buisson, Sophian Hmila, Joe-Nat Clegg-Lamptey, Osman Imoro, Owusu Emmanuel Abem, Dimitrios Papageorgiou, Vasiliki Soulou, Sabrina Asturias, Lenin Peña, Donal B. O’Connor, Alberto Realis Luc, Alfio Alessandro Russo, Andrea Ruzzenente, Antonio Taddei, Camilla Cona, Corrado Bottini, Giovanni Pascale, Giuseppe Rotunno, Leonardo Solaini, Marco Maria Pascale, Margherita Notarnicola, Mario Corbellino, Michele Sacco, Paolo Ubiali, Roberto Cautiero, Tommaso Bocchetti, Elena Muzio, Vania Guglielmo, Eugenio Morandi, Patrizio Mao, Emilia De Luca, Farah Mahmoud Ali, Justas Žilinskas, Kestutis Strupas, Paulius Kondrotas, Robertas Baltrunas, Juozas Kutkevicius, Povilas Ignatavicius, Choy Ling Tan, Jia Yng Siaw, Sir Young Yam, Ling Wilson, Mohamed Rezal Abdul Aziz, John Bondin, Carmina Diaz Zorrilla, Anass Majbar, Danjuma Sale, Lawal Abdullahi, Olabisi Osagie, Omolara Faboya, Adedeji Fatuga, Agboola Taiwo, Emeka Nwabuoku, Marte Bliksøen, Zain Ali Khan, Jazmin Coronel, Cesar Miranda, Idelso Vasquez, Luis M. Helguero-Santin, Jennifer Rickard, Adesina Adedeji, Saleh Alqahtani, Max Rath, Michael Van Niekerk, Modise Zacharia Koto, Roel Matos-Puig, Leif Israelsson, Tobias Schuetz, Mahmut Arif Yuksek, Meric Mericliler, Mehmet Uluşahin, Bernhard Wolf, Cameron Fairfield, Guo Liang Yong, Katharine Whitehurst, Natalie Redgrave, Caroluce K. Musyoka, James Olivier, Kathryn Lee, Michael Cox, Muhamed M.H. Farhan-Alanie, Rory Callan, Chali Chibuye, Tebian Hassanein Ahmed Ali, Syrine Rekhis, Muna Rommaneh, Zi Hao Sam, Thays Brunelli Pugliesi, Gabriel Pardo, and Ruth Blanco

Subjects
abdominal surgery, cost-effectiveness analysis, global surgery, high fraction of inspired oxygen, low-and middle-income countries, surgical site infection, Anesthesiology, RD78.3-87.3
Abstract

Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results: High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was $216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with $195 for low FiO2 leading to a −$11 (95% CI: −$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was $1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this.

Published
2023
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34. Rising incidence of late stage breast cancer after COVID-19 outbreak. Real-world data from the Italian COVID-DELAY study

Author

Giulia Mentrasti, Luca Cantini, Patrizia Vici, Nicola D'Ostilio, Nicla La Verde, Rita Chiari, Vittorio Paolucci, Sonia Crocetti, Chiara De Filippis, Federica Pecci, Francesca Sofia Di Lisa, Donatella Traisci, Maria Silvia Cona, Linda Nicolardi, Laura Pizzuti, Simona Gildetti, Simone Oldani, Arianna Della Mora, Marco Luigi Bruno Rocchi, and Rossana Berardi

Subjects
Breast cancer, COVID-19, Diagnostic delay, Therapeutic delay, Multidisciplinary discussions, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: Breast cancer (BC) patients’ (pts) management was affected by a global reorganization after Coronavirus disease 2019 (COVID-19). Our multicenter study aimed to assess the impact of COVID-19 on access to diagnosis, staging and treatment for BC pts compared to pre-pandemic. Methods: Medical records of all consecutive newly diagnosed BC pts referred to 6 Italian Institutions between March and December 2020 were assessed. Monthly access rate and temporal intervals between date of symptoms onset, radiological, cytohistological diagnosis and treatment start were analyzed and compared with 2019. Results: A reduction (25%) in newly diagnosed BC was observed compared to 2019 (666 vs 890). New BC pts in 2020 were less likely to be diagnosed with early stage BC (77% vs 83%, p 0 in 2020 vs 16.5% in 2019, p

Published
2022
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36. Donor‐derived mold infections in lung transplant recipients: The importance of active surveillance

Author

Mularoni, Alessandra, primary, Cona, Andrea, additional, Coniglione, Giulia, additional, Barbera, Floriana, additional, Di Martino, Giuseppina, additional, Mulè, Giovanni, additional, Campanella, Maria, additional, Di Mento, Giuseppina, additional, Nunnari, Giuseppe, additional, Grossi, Paolo Antonio, additional, Sanguinetti, Maurizio, additional, Mikulska, Malgorzata, additional, De Carolis, Elena, additional, and Bertani, Alessandro, additional

Published
2024
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38. Use of Telemedicine for Postdischarge Assessment of the Surgical Wound: International Cohort Study, and Systematic Review With Meta-analysis

Author

Glasbey, James, Trout, Issi, Adeyeye, Victoria, Ademuyiwa, Adesoji, Adisa, Adewale, Bhatt, Alisha, Biccard, Bruce, Brocklehurst, Peter, Chakrabortee, Sohini, Allen Ingabire, Jean De La Croix, Dossou, Francis Moïse, Durán, Irani, Dutta, Rohini, Ghosh, Dhruva, Gyamfi, Frank, Hardy, Pollyanna, Hyman, Gabriella, Jain, Ritu, Kadir, Bryar, Knight, Stephen, Ladipo-Ajayi, Oluwaseun, Lawani, Ismail, Lawani, Souliath, Lillywhite, Rachel, Macefield, Rhiannon, Magill, Laura, Martin, Janet, Mathers, Jonathan, McLean, Kenneth, Mistry, Unam, Mittal, Rohin, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Ofori, Emmanuel, Pearse, Rupert, Peón, Alberto, Pinkney, Thomas, Medina, Antonio Ramos de la, Ronald, Tubasiime, Roman, David, Simoes, Joana, Slade, Anita, Tabiri, Stephen, Smith, Donna, Harrison, Ewen, Bhangu, Aneel, Glasbey, James, Trout, Issi, Bhangu, Aneel, Runigamugabo, Azmina Verjee Emmy, Ademuyiwa, Adesoji O, Adisa, Adewale O, Aguilera, Maria Lorena, Altamini, Afnan, Alexander, Philip, Al-Saqqa, Sara W, Borda-Luque, Giuliano, Cornick, Jen, Costas-Chavarri, Ainhoa, Drake, Thomas M, Fergusson, Stuart J, Fitzgerald, J Edward, Glasbey, James, Ingabire, J.C Allen, Ismaïl, Lawani, Jaffry, Zahra, Salem, Hosni Khairy, Khatri, Chetan, Kirby, Andrew, Kojo, Anyomih Theophilus Teddy, Lapitan, Marie Carmela, Lilford, Richard, Mihaljevic, Andre L, Mohan, Midhun, Morton, Dion, Mutabazi, Alphonse Zeta, Nepogodiev, Dmitri, Ntirenganya, Faustin, Ots, Riinu, Pata, Francesco, Pinkney, Thomas, Poškus, Tomas, Qureshi, Ahmad Uzair, la Medina, Antonio Ramos-De, Rayne, Sarah, Recinos, Gustavo, Søreide, Kjetil, Shaw, Catherine A, Shu, Sebastian, Spence, Richard, Smart, Neil, Tabiri, Stephen, Lilford, Richard, Morton, Dion, Harrison, Ewen M, Bhangu, Aneel, Modolo, Maria Marta, Iyer, Dushyant, King, Sebastian, Arthur, Tom, Nahar, Sayeda Nazmum, Waterman, Ade, Ismaïl, Lawani, Walsh, Michael, Agarwal, Arnav, Zani, Augusto, Firdouse, Mohammed, Rouse, Tyler, Liu, Qinyang, Correa, Juan Camilo, Salem, Hosni Khairy, Talving, Peep, Worku, Mengistu, Arnaud, Alexis, Tabiri, Stephen, Kalles, Vassilis, Aguilera, Maria Lorena, Recinos, Gustavo, Kumar, Basant, Kumar, Sunil, Amandito, Radhian, Quek, Roy, Pata, Francesco, Ansaloni, Luca, Altibi, Ahmed, Venskutonis, Donatas, Zilinskas, Justas, Poskus, Tomas, Whitaker, John, Msosa, Vanessa, Tew, Yong Yong, Farrugia, Alexia, Borg, Elaine, la Medina, Antonio Ramos-De, Bentounsi, Zineb, Ademuyiwa, Adesoji O, Søreide, Kjetil, Gala, Tanzeela, Al-Slaibi, Ibrahim, Tahboub, Haya, Alser, Osaid H., Romani, Diego, Shu, Sebestian, Major, Piotr, Mironescu, Aurel, Bratu, Matei, Kourdouli, Amar, Ndajiwo, Aliyu, Altwijri, Abdulaziz, Alsaggaf, Mohammed Ubaid, Gudal, Ahmad, Jubran, Al Faifi, Seisay, Sam, Lieske, Bettina, Rayne, Sarah, Spence, Richard, Ortega, Irene, Jeyakumar, Jenifa, Senanayake, Kithsiri J., Abdulbagi, Omar, Cengiz, Yucel, Raptis, Dmitri, Altinel, Yuksel, Kong, Chia, Teasdale, Ella, Irwin, Gareth, Stoddart, Michael, Kabariti, Rakan, Suresh, Sukrit, Gash, Katherine, Narayanan, Ragavan, Maimbo, Mayaba, Grizhja, Besmir, Ymeri, Shpetim, Galiqi, Gezim, Klappenbach, Roberto, Antezana, Diego, Beleño, Alvaro Enrique Mendoza, Costa, Cecilia, Sanchez, Belen, Marta Modolo, Susan Aviles Maria, Fermani, Claudio Gabriel, Balmaceda, Rubén, Villalobos, Santiago, Carmona, Juan Manuel, Hamill, Daniel, Deutschmann, Peter, Sandler, Simone, Cox, Daniel, Nataraja, Ram, Sharpin, Claire, Ljuhar, Damir, Gray, Demi, Iyer, Morgan Haines Dush, Niranjan, Nithya, D’Amours, Scott, Ashtari, Morvarid, Franco, Helena, Mitul, Ashrarur Rahman, Karim, Sabbir, Aman, Nowrin F., Umme Salma, Mahnuma Mahfuz Estee, Razzaque, Joyeta, Kanta, Tasnia Hamid, Tori, Sayeeda Aktar, Alamin, Shadid, Roy, Swapnil, Amin, Shadid Al, Haque, Rezaul Karim Muhtarima, Faruq, Amreen, Iftekhar, Farhana, O’Shea, Margaret, Padmore, Greg, Litvin, Ramesh Jonnalagadda Andrey, Filatau, Aliaksandr, Paulouski, Dzmitry, Shubianok, Maryna, Shachykava, Tatsiana, Khokha, Dzianis, Djivoh, Vladimir Khokha Fernande, Ismaïl, Lawani, Morel Seto, Francis Dossou Djifid, Gbessi, Dansou Gaspard, Noukpozounkou, Bruno, Souaibou, Yacoubou Imorou, Keke, Kpèmahouton René, Stephane Ahounou, Fred Hodonou Ernest Yemalin, Bedada, Thierry Alihonou Alemayehu Ginbo, Nsengiyumva, Carlos, Kwizera, Sandrine, Choi, Venerand Barendegere Philip, Stock, Simon, Jamal, Luai, Firdouse, Mohammed, Zani, Augusto, Azzie, Georges, Kushwaha, Sameer, Agarwal, Arnav, Chen, Tzu-Ling, Yip, Chingwan, Montes, Irene, Zapata, Felipe, Sierra, Sebastian, Lanau, Maria Isabel Villegas, Arango, Maria Clara Mendoza, Restrepo, Ivan Mendoza, Sierra, Sebastian, Giraldo, Ruben Santiago Restrepo, Arango, Maria Clara Mendoza, Domini, Edgar, Karlo, Robert, Mihanovic, Jakov, Youssef, Mohamed, Elfeki, Hossam, Thabet, Waleed, Sanad, Aly, Tawfik, Gehad, Zaki, Ahmed, Abdel-Hameed, Noran, Mostafa, Mohamed, Omar, Muhammad Fathi Waleed, Ghanem, Ahmed, Abdallah, Emad, Denewar, Adel, Emara, Eman, Rashad, Eman, Sakr, Ahmad, Elashry, Rehab, Emile, Sameh, Khafagy, Toqa, Elhamouly, Sara, Elfarargy, Arwa, Mohamed, Amna Mamdouh, Nagy, Ghada Saied, Esam, Abeer, Elwy, Eman, Hammad, Aya, Khallaf, Salwa, Ibrahim, Eman, Saidbadr, Ahmed, Moustafa, Ahmed, Mohammed, Amany Eldosouky, Elgheriany, Mohammed, Abdelmageed, Eman, Raouf, Eman Abd Al, Elbanby, Esraa Samir, Elmasry, Maha, Farahat, Mahitab Morsy, Mansor, Eman Yahya, Hegazy, Eman Magdy, Gamal, Esraa, Gamal, Heba, Kandil, Hend, Abdelrouf, Doaa Maher, Moaty, Mohamed, Gamal, Dina, El-Sagheer, Nada, Salah, Mohamed, Magdy, Salma, Salah, Asmaa, Essam, Ahmed, Ali, Ahmed, Badawy, Mahmoud, Ahmed, Sara, Mohamed, Mazed, Assal, Abdelrahman, Sleem, Mohamed, Ebidy, Mai, Elrazek, Aly Abd, Zahran, Diaaaldin, Adam, Nourhan, Nazir, Mohamed, Hassanein, Adel B, Ismail, Ahmed, Elsawy, Amira, Mamdouh, Rana, Mabrouk, Mohamed, Ahmed, Lopna Ahmed Mohamed, Alnaby, Mohamed Hassab, Magdy, Eman, Abd-Elmawla, Manar, Fahim, Marwan, Mowafy, Bassant, Mahmoud, Moustafa Ibrahim, Allam, Meran, Alkelani, Muhammad, El Gendy, Noran Halim, Aboul-Naga, Mariam Saad, El-Din, Reham Alaa, Elgendy, Alyaa Halim, Ismail, Mohamed, Shalaby, Mahmoud, Elsharkawy, Aya Adel, Moghazy, Mahmoud Elsayed, Elbisomy, Khaled Hesham, Shakshouk, Hend Adel Gawad, Hamed, Mohamed Fouad, Ebidy, Mai Mohamed, Abdelkader, Mostafa, Ahmed, Mohamed Karkeet Hayam, Adel, Israa, Omar, Mohammad Elsayed, Ibrahim, Mohamed, Ghoneim, Omar, Hesham, Omar, Gamal, Shimaa, Hilal, Karim, Arafa, Omar, Awad, Sawsan Adel, Salem, Menatalla, Elsherif, Fawzia Abdellatif, Elsabbagh, Nourhan, Aboelsoud, Moustafa R., Rida, Ahmed Hossam Eldin Fouad, Hossameldin, Amr, Hany, Ethar, Asar, Yomna Hosny, Anwar, Nourhan, Gadelkarim, Mohamed, Abdelhady, Samar, Morshedy, Eman Mohamed, Saad, Reham, Soliman, Nourhan, Ezzat, Mahmoud Salama Eslam, Mohamed, Arwa, Ibrahim, Arwa, Fergany, Alaa, Mohammed, Sara, Reda, Aya, Allam, Yomna, Saad, Hanan Adel, Abdelfatah, Afnan, Fathy, Aya Mohamed, El-Sehily, Ahmed, Kasem, Esraa Abdalmageed, Hassan, Ahmed Tarek Abdelbaset, Mohammed, Ahmed Rabeih, Saad, Abdalla Gamal, Elfouly, Yasmin, Elfouly, Nesma, Ibrahim, Arij, Hassaan, Amr, Mohammed, Mohammed Mustafa, Elhoseny, Ghada, Magdy, Mohamed, Elkhalek, Esraa Abd, Zakaria, Yehia, Ezzat, Tarek, El Dahab, Ali Abo, Kelany, Mohamed, Arafa, Sara, Hassan, Osama Mokhtar Mohamed, Badwi, Nermin Mohamed, Sleem, Ahmad Saber, Ahmed, Hussien, Abdelbadeai, Kholoud, Abdullah, Mohamed Abozed, Lokman, Muhammad Amsyar Auni, Bahar, Suraya, Abdelazeam, Anan Rady, Adelshone, Abdelrahman, Bin Hasnan, Muhammad, Zulkifli, Athirah, Kamarulzamil, Siti Nur Alia, Elhendawy, Abdelaziz, Latif, Aliang, Bin Adnan, Ahmad, Shaharuddin, Shahadatul, Abdul Majid, Aminah Hanum Haji, Amreia, Mahmoud, Al-Marakby, Dina, Salma, Mahmoud, Bin Ismail, Mohamad Jeffrey, Basir, Elissa Rifhan Mohd, Ali, Citra Dewi Mohd, Maha Nasr, Aya Yehia Ata, Rezq, Asmaa, Sheta, Ahmed, Tariq, Sherif, Sallam, Abd Elkhalek, Darwish, Abdelrhman KZ, Elmihy, Sohaila, Elhadry, Shady, Farag, Ahmed, Hajeh, Haidar, Abdelaal, Abdelaziz, Aglan, Amro, Zohair, Ahmed, Essam, Mahitab, Moussa, Omar, El-Gizawy, Esraa, Samy, Mostafa, Ali, Safia, Elhalawany, Esraa, Ata, Ahmed, El Halawany, Mohamed, Nashat, Mohamed, Soliman, Samar, Elazab, Alaa, Samy, Mostada, Abdelaziz, Mohamed A, Ibrahim, Khaled, Ibrahim, Ahmed mohamed, Gado, Ammar, Alm Eldeen, Usama Hantour Esraa, loaloa, Mohamed Reda, Abouzaid, Arwa, Eldin, Mostafa Ahmed Bahaa, Hashad, Eman, Sroor, Fathy, Gamil, Doaa, Abdulhakeem, Eman Mahmoud, Zakaria, Mahmoud, Mohamed, Fawzy, Abubakr, Marwan, Ali, Elsayed, Magdy, Hesham, Ramadan, Menna Tallah, Mohamed, Mohamed Abdelaty, Mansour, Salma, Amin, Hager Abdul Aziz, Mohamed, Ahmed Rabie, Saami, Mahmoud, Elsayed, Nada Ahmed Reda, Tarek, Adham, Mahmoud, Sabry Mohy Eldeen, El Sayed, Islam Magdy, Reda, Amira, Shawky, Martina Yusuf, Salem, Mohammed Mousa, El-Din, Shahinaz Alaa, Soliman, Noha Abdullah, Talaat, Muhammed, Alaael-Dein, Shahinaz, Elhusseiny, Ahmed Abd Elmoen, Abdullah, Noha, Elshaar, Mohammed, Ibraheem, Aya AbdelFatah, Abdulaziz, Hager, Ismail, Mohammed Kamal, Madkor, Mona Hamdy, Abdelaty, Mohamed, Abdel-Kader, Sara Mahmoud, Salah, Osama Mohamed, Eldafrawy, Mahmoud, Eldeeb, Ahmed Zaki, Attia, Mostafa Mahmoud Eid Attia, El-Dien, Khalid Salah, Shwky, Ayman, Badenjki, Mohamed Adel, Soliman, Abdelrahman, Attar, Samaa Mahmoud Al, Sayed, Farrag, Sabour, Fahd Abdel, Azizeldine, Mohammed G., Shawqi, Muhammad, Hashim, Abdullah, Aamer, Ahmed, Abdelraouf, Ahmed Mahmoud, Abdelshakour, Mahmoud, Ibrahim, Amal, Mahmoud, Basma, Mahmoud, Mohamed Ali, Qenawy, Mostafa, Rashed, Ahmed M., Dahy, Ahmed, Sayed, Marwa, Shamsedine, Ahmed W., Mohamed, Bakeer, Hasan, Ahmad, Saad, Mahmoud M., Khalid Abd El-Latif, Khalil Abdul Bassit Nadia, Elzahed, Nada, El Kashash, Ahmed, Bekhet, Nada Mohamed, Hafez, Sarah, Gad, Ahmed, Maher, Mahmoud Elkhadragy, Elsameea, Ahmed Abd, Hafez, Mohamed, Sabe, Ahmad, Ahmed, Ataa, Shahine, Ahmed, Dawood, Khaled, Gaafar, Shireen, Husseiny, Reem, Aboelmagd, Omnia, Soliman, Ahmed, Mesbah, Nourhan, Emadeldin, Hossam, Meligy, Amgad Al, Bekhet, Amira Hassan, Hasan, Doaa, Alhady, Khaled, Sabe, Ahmad Khaled, Elnajjar, Mahmoud A., Aboelella, Majed, Hamsho, Ward, Hassan, Ihab, Saad, Hala, Abdelazim, Galaleldin, Mahmoud, Hend, Wael, Noha, Kandil, Ahmedali M, Magdy, Ahmed, Elkholy, Shimaa Said, Adel, Badr Eldin, Dabbour, Kareem, Elsherbiney, Saged, Mattar, Omar, Abdrabou, Abdulshafi Khaled, Aly, Mohammed Yahia Mohamed, Geuoshy, Abdelrahman, Elnagar, Ahmedglal, Ahmed, Saraibrahim, Abdelmotaleb, Ibrahem, Saleh, Amr Ahmed, Saeed, Manar, Mahmoud, Shady, Tawfik, Badreldin Adel, Ismail, Samar Adel, Zakaria, Esraay, Gad, Mariam O., Elhelbawy, Mohamed Salah, Bassem, Monica, Maraie, Noha, Elhadary, Nourhan Medhat, Semeda, Nourhan, Mohamed, Shaza Rabie, Bakry, Hesham Mohammed, Essam, AA, Tarek, Dina, Ashour, Khlood, Elhadad, Alaa, Abdel-Aty, Abdulrahman, Rakha, Ibrahim, Matter, Sara Mamdouh, Abdelhamed, Rasha, Abdelkader, Omar, Hassaan, Ayat, Soliman, Yasmin, Mohamed, Amna, Ghanem, Sara, Farouk, Sara Amr Mohamed, Ibrahim, Eman Mohamed, Mostafa, Esraa El-Taher Merna, Badr, Mohamed Fawzy Mahrous, Elsemelawy, Rofida, El-Sawy, Aya, Bakr, Ahmad, Al Rafati, Ahmad Abdel Razaq, Saar, Sten, Reinsoo, Arvo, Talving, Peep, Seyoum, Nebyou, Worku, Tewodros, Fitsum, Agazi, Tolonen, Matti, Leppäniemi, Ari, Sallinen, Ville, Parmentier, Benoît, Peycelon, Matthieu, Irtan, Sabine, Dardenne, Sabrina, Robert, Elsa, Maillot, Betty, Courboin, Etienne, Arnaud, Alexis Pierre, Hascoet, Juliette, Abbo, Olivier, Kaci, Amir Ait, Prudhomme, Thomas, Ballouhey, Quentin, Grosos, Céline, Fourcade, Laurent, Cecilia, Tolg, Jean-Francois, Colombani, Delforge, Francois-Coridon Helene Xavier, Haraux, Elodie, Dousset, Bertrand, Schiavone, Roberto, Gaujoux, Sebastien, Marret, Jean-Baptiste, Haffreingue, Aurore, Rod, Julien, Jean-François Lecompte, Mariette Renaux-Petel, Bréaud, Jean, Gastaldi, Pauline, Taieb, Chouikh, Claire, Raquillet, Anis, Echaieb, Bustangi, Nasir, Lopez, Manuel, Scalabre, Aurelien, Grella, Maria Giovanna, Mariani, Aurora, Podevin, Guillaume, Schmitt, Françoise, Hervieux, Erik, Broch, Aline, Muller, Cecile, Tabiri, Stephen, Kojo, Anyomih Theophilus Teddy, Bandoh, Dickson, Abantanga, Francis, Kyereh, Martin, Asumah, Hamza, Appiah, Eric Kofi, Wondoh, Paul, Gyedu, Adam, Dally, Charles, Agbedinu, Kwabena, Amoah, Michael, Yifieyeh, Abiboye, Owusu, Frank, Amoako-Boateng, Mabel, Dayie, Makafui, Hagan, Richmond, Debrah, Sam, Ohene-Yeboah, Micheal, Clegg-Lampety, Joe-Nat, Etwire, Victor, Dakubo, Jonathan, Essoun, Samuel, Bonney, William, Glover-Addy, Hope, Osei-Nketiah, Samuel, Amoako, Joachim, Adu-Aryee, Niiarmah, Appeadu-Mensah, William, Bediako-Bowan, Antoinette, Dedey, Florence, Ekow, Mattew, Akatibo, Emmanuel, Yakubu, Musah, Kordorwu, Hope Edem Kofi, Asare-Bediako, Kwasi, Tackie, Enoch, Aaniana, Kenneth, Acquah, Emmanuel, Opoku-Agyeman, Richard, Avoka, Anthony, Kusi, Kwasi, Maison, Kwame, Gyamfi, Frank Enoch, Barnabas, Gandau Naa, Amoako, Saiba Abdul-Latif Philip Taah, Davor, Anthony, Dassah, Victor, Dagoe, Enoch, Kwakyeafriyie, Prince, Akoto, Elliot, Ackom, Eric, Mensah, Ekow, Atkins, Ebenezer Takyi, Coompson, Christian Lari, Ivros, Nikolaos, Ferousis, Christoforos, Kalles, Vasileios, Agalianos, Christos, Kyriazanos, Ioannis, Barkolias, Christos, Tselos, Angelos, Tzikos, Georgios, Lytras, Evangelos Voulgaris Dimitrios, Bamicha, Athanasia, Psarianos, Kyriakos, Stefanopoulos, Anastasios, Patoulias, Ioannis, Sfougaris, Dimitrios, Valioulis, Ioannis, Balalis, Dimitrios, Korkolis, Dimitrios, Manatakis, Dimitrios K, Kyrou, Georgios, Karabelias, Georgios, Konstantina, Iason-Antonios Papaskarlatos Kolonia, Zampitis, Nikolaos, Papailia, Stylianos Germanos Aspasia, Theodosopoulos, Theodosios, Gkiokas, Georgios, Mitroudi, Magdalini, Panteli, Christina, Feidantsis, Thomas, Farmakis, Konstantinos, Kyziridis, Dimitrios, Ioannidis, Orestis, Gemenetzis, Styliani Parpoudi Georgios, Parasyris, Stavros, Anthoulakis, Christos, Nikoloudis, Nikolaos, Aguilera-Arevalo, Michail Margaritis Maria-Lorena, Coyoy-Gaitan, Otto, Tale, Javier Rosales Luis, Soley, Rafael, Rodriguez, Emmanuel Barrios Servio Tulio Torres, Galvez, Carlos Paz, Cruz, Danilo Herrera, Rosenberg, Guillermo Sanchez, Matheu, Alejandro, Cohen, David Monterroso, Paul, Marie, Charles, Angeline, Lam, Justin Chak Yiu, Yeung, Man Hon Andrew, Fok, Chi Ying Jacquelyn, Li, Ka Hin Gabriel, Lai, Anthony Chuk-Him, Cheung, Yuk Hong Eric, Wong, Hong Yee, Leung, Ka Wai, Lee, Tien Seng Bryan, Lam, Wai Him, Dao, Weihei, Kwok, Stephanie Hiu-wai, Chan, Tsz-Yan Katie, Ng, Yung Kok, Liu, TWC Mak Qinyang, Foo, Chi Chung, Yang, James, Kumar, Basant, Bhatnagar, Ankur, Upadhyaya, Vijaid, Muddebihal, Sunil Kumar Uday, Dar, Wasim, Alexander, KC Janardha Philip, Aruldas, Neerav, Adella, Fidelis Jacklyn, Rulie, Anthonius Santoso, Iskandar, Ferdy, Setiawan, Jonny, Evajelista, Cicilia Viany, Natalie, Hani, Suyadi, Arlindawati, Gunawan, Rudy, Karismaningtyas, Herlin, Mata, Lusi Padma Sulistianingsih, Andika, Ferry Fitriya Ayu, Hasanah, Afifatun, Widiastini, T Ariani, Purwaningsih, Nurlaila Ayu, Mukin, Annisa Dewi Fitriana, Rahmah, Dina Faizatur, Nurqistan, Hazmi Dwinanda, Arsyad, Hasbi Maulana, Adhitama, Novia, Jeo, Wifanto Saditya, Sutandi, Nathania, Clarissa, Audrey, Gultom, Phebe Anggita, Billy, Matthew, Haloho, Andreass, Amandito, Radhian, Johanna, Nadya, Lee, Felix, Radin Dorani, Radin Mohd Nurrahman, Glynn, Martha, Alherz, Mohammad, Goh, Wennweoi, Shiwani, Haaris A., Sproule, Lorraine, Conlon, Kevin C., Bala, Miklosh, Turati, Asaf Kedar Luca, Bianco, Federica, Steccanella, Francesca, Gallo, Gaetano, Trompetto, Mario, Papandrea, Giuseppe Clerico Matteo, Sammarco, Giuseppe, Sacco, Rosario, Benevento, Angelo, Pata, Francesco, Giavarini, Luisa, Giglio, Mariano Cesare, Bucci, Luigi, Pagano, Gianluca, Sollazzo, Viviana, Peltrini, Roberto, Birindelli, Gaetano Luglio Arianna, Di Saverio, Salomone, Tugnoli, Gregorio, Paludi, Miguel Angel, Mingrone, Pietro, Pata, Domenica, Selvaggi, Francesco, Selvaggi, Lucio, Pellino, Gianluca, Curletti, Natale Di Martino Gianluca, Aonzo, Paolo, Galleano, Raffaele, Berti, Stefano, Francone, Elisa, Boni, Silvia, Lorenzon, Laura, Conte, Annalisa lo, Balducci, Genoveffa, Confalonieri, Gianmaria, Laura Gavagna, Giovanni Pesenti, Vasquez, Giorgio, Targa, Simone, Occhionorelli, Savino, Pata, Dario Andreotti Giacomo, Armellini, Andrea, Aquilino, Deborah Chiesa Fabrizio, Chetta, Nicola, Abdelkhalek, Arcangelo Picciariello Mohamed, Belli, Andrea, Bigaran, Silvia De Franciscis Annamaria, Favero, Alessandro, Salusso, Stefano M.M Basso Paola, Perino, Martina, Mochet, Sylvie, Sasia, Diego, Riente, Francesco, Merlini, Marco Migliore David, Basilicò, Silvia, Lazzari, Carlo Corbellini Veronica, Macchitella, Yuri, Angelieri, Luigi Bonavina Daniele, Coletta, Diego, Falaschi, Federica, Catani, Marco, Reali, Claudia, Malavenda, Mariastella, Basso, Celeste Del, Ribaldi, Sergio, Coletti, Massimo, Natili, Andrea, Depalma, Norma, Iannone, Immacolata, Antoniozzi, Angelo, Gui, Davide Rossi Daniele, Perrotta, Gerardo, Ripa, Matteo, Giardino, Francesco Ruben, Foco, Maurizio, Vicario, Erika, Coccolini, Federico, Ansaloni, Luca, Nita, Gabriela Elisa, Leone, Nicoletta, Bondurri, Andrea, Simioni, Anna Maffioli Andrea, De Boni, Davide, Goldin, Sandro Pasquali Elena, Vendramin, Elena, Tedeschi, Eleonora Ciccioli Umberto, Bortolasi, Luca, Violi, Paola, Campagnaro, Tommaso, Conci, Simone, Lazzari, Giovanni, Iacono, Calogero, Gulielmi, Alfredo, Rinaldi, Serena Manfreda Anna, Ringressi, Maria Novella, Salamone, Beatrice Brunoni Giuseppe, Mangiapane, Mirko, Marco, Paolino De, Brocca, Antonella La, Tutino, Roberta, Silvestri, Vania, Licari, Leo, Fontana, Tommaso, Falco, Nicolò, Cocorullo, Gianfranco, Shalaby, Mostafa, Sileri, Pierpaolo, Bsisu, Claudio Arcudi Isam, Aljboor, Khaled, Abusalem, Lana, Alnusairat, Aseel, Qaissieh, Ahmad, Al-Dakka, Emad, Ababneh, Ali, Yusufali, Oday Halhouli Taha, Lando, Hussein Mohammed Justus, Parker, Robert, Ndegwa, Wairimu, Jokubauskas, Mantas, Gribauskaite, Jolanta, Kuliavas, Donatas Venskutonis Justas, Dulskas, Audrius, Samalavicius, Narimantas E., Jasaitis, Kristijonas, Parseliunas, Audrius, Nevieraite, Viktorija, Montrimaite, Margarita, Slapelyte, Evelina, Dainius, Edvinas, Riauka, Romualdas, Dambrauskas, Zilvinas, Subocius, Andrejus, Venclauskas, Linas, Gulbinas, Antanas, Bradulskis, Saulius, Kasputyte, Simona, Mikuckyte, Deimante, Kiudelis, Mindaugas, Zilinskas, Justas, Jankus, Tomas, Pažuskis, Steponas Petrikenas Matas, Urniežius, Zigmantas, Vilčinskas, Mantas, Banaitis, Vincas Jonas, Gaižauskas, Vytautas, Grisin, Edvard, Mazrimas, Povilas, Rackauskas, Rokas, Drungilas, Mantas, Lagunavicius, Karolis, Lipnickas, Vytautas, Majauskyté, Dovilè, Jotautas, Valdemaras, Abaliksta, Tomas, Uščinas, Laimonas, Simutis, Gintaras, Ladukas, Adomas, Danys, Donatas, Laugzemys, Erikas, Mikalauskas, Saulius, Poskus, Tomas, Sruogiene, Elena Zdanyte, Višinskas, Petras, Žilinskienė, Reda, Vaicius, Deividas Dragatas Arturas, Mazelyte, Ruta, Kaselis, Antanas Zadoroznas Nerijus, Žiubrytė, Greta, Rahantasoa, Finaritra Casimir Fleur Prudence, Samison, Luc Hervé, Rasoaherinomenjanahary, Fanjandrainy, Tolotra, Todisoa Emmanuella Christina, Mukuzunga, Cornelius, Msosa, Vanessa, Kwatiwani, Chimwemwe, Chai, Nelson Msiska Feng Yih, Asilah, Siti Mohd Desa, Pui Xin Chin, Khuzaimah Zahid Syibrah, Salleh, Afizah, Roslani, Nur Zulaika Riswan April Camilla, Chong, Hoong-Yin, Aziz, Nora Abdul, Poh, Keat-Seong, Chai, Chu-Ann, Kumar, Sandip, Taher, Mustafa Mohammed, Kosai, Nik Ritza, Aziz, Dayang Nita Abdul, Julaihi, Reynu Rajan Rokayah, Jethwani, Durvesh Lacthman, Yahaya, Muhammad Taqiyuddin, Abdullah, Nik Azim Nik, Mathew, Susan Wndy, Chung, Kuet Jun, Nirumal, Milaksh Kumar, Tze, R. 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Y., Koay, Kean Leong, Tan, Yi Koon, Cheah, Alvin Ee Zhiun, Wong, Chui Yee, Mat, Tuan Nur’Azmah Tuan, Chow, Crystal Yern Nee, Har, Prisca A.L., Der, Yishan, Tew, Yong Yong, Henry, Fitjerald, Low, Xinwei, Neo, Ya Theng, Heng, Hian Ee, Kong, Shu Ning, Gan, Cheewei, Mok, Yi Ting, Tan, Yee Wen, Palayan, Kandasami, Tata, Mahadevan Deva, Cheong, Yih Jeng, Gunaseelan, Kuhaendran, Nasir, Wan Nurul ‘Ain Wan Mohd, Yoganathan, Pigeneswaren, Lee, Eu Xian, Saw, Jian Er, Yeang, Li Jing, Koh, Pei Ying, Lim, Shyang Yee, Teo, Shuang Yi, Grech, Nicole, Magri, Daniela, Cassar, Kristina, Mizzi, Christine, Falzon, Malcolm, Shaikh, Nihaal, Scicluna, Ruth, Zammit, Stefan, Borg, Elaine, Mizzi, Sean, Brincat, Svetlana Doris, Tembo, Thelma, Le, Vu Thanh Hien, Grima, Tara, Sammut, Keith, Carabott, Kurt, Farrugia, Alexia, Zarb, Ciskje, Navarro, Andre, Dimech, Thea, Camilleri, Georgette Marie, Bertuello, Isaac, Dalli, Jeffrey, Bonavia, Karl, Corro-Diaz, Samantha, Manriquez-Reyes, Marisol, Abdelhamid, Antonio Ramos-De la Medina Amina, Hrora, Abdelmalek, Benammi, Sarah, Bachri, Houda, Abbouch, Meryem, Boukhal, Khaoula, Bennai, Redouane Mammar, Belkouchi, Abdelkader, Jabal, Mohamed Sobhi, Vermaas, Chaymae Benyaiche Maarten, Duinhouwer, Lucia, Pastora, Javier, Wood, Greta, Merlo, Maria Soledad, Ajao, Akinlabi, Ayandipo, Omobolaji, Lawal, Taiwo, Abdurrazzaaq, Abdussemiu, Alada, Muslimat, Nasir, Abdulrasheed, Adeniran, James, Habeeb, Olufemi, Popoola, Ademola, Adeyeye, Ademola, Adebanjo, Ademola, Adesanya, Opeoluwa, Mendel, Adewale Adeniyi Henry, Bello, Bashir, Osinowo, Umar Muktar Adedapo, Olajide, Thomas Olagboyega, Oshati, Oyindamola, Ihediwa, George, Adenekan, Babajide, Nwinee, Victor, Alakaloko, Felix, Ademuyiwa, Adesoji, Elebute, Olumide, Lawal, Abdulrazzaq, Bode, Chris, Olugbemi, Mojolaoluwa, Adesina, Alaba, Faturoti, Olubukola, Odutola, Oluwatomi, Adebola, Oluwaseyi, Onuoha, Clement, Taiwo, Ogechukwu, Williams, Omolara, Balogun, Fatai, Ajai, Olalekan, Oludara, Mobolaji, Njokanma, Iloba, Osuoji, Roland, Kache, Stephen, Ajah, Jonathan, Makama, Jerry, Adamu, Ahmed, Baba, Suleiman, Aliyu, Mohammad, Aliyu, Shamsudeen, Ukwenya, Yahaya, Aliyu, Halima, Sholadoye, Tunde, Daniyan, Muhammad, Ogunsua, Oluseyi, Anyanwu, Lofty-John, Sheshe, Abdurrahaman, Olori, Aminu Mohammad Samson, Mshelbwala, Philip, Odeyemi, Babatunde, Samson, Garba, Timothy, Oyediran Kehinde, Samuel, Sani Ali, Ajiboye, Anthony, Adeyeye, Ademola, Amole, Isaac, Abiola, Olajide, Olaolorun, Akin, Søreide, Kjetil, Veen, Torhild, Kanani, Arezo, Styles, Kristian, Herikstad, Ragnar, Larsen, Johannes Wiik, Søreide, Jon Arne, Jensen, Elisabeth, Gran, Mads, Gaarder, Eirik Kjus Aahlin Tina, Monrad-Hansen, Peter Wiel, Næss, Pål Aksel, Lauzikas, Giedrius, Wiborg, Joachim, Augestad, Silje Holte Knut Magne, Banipal, Gurpreet Singh, Monteleone, Michela, Moe, Thomas Tetens, Schultz, Johannes Kurt, Al-taher, Taher, Hamdan, Ayah, Salman, Ayman, Saadeh, Rana, Musleh, Aseel, Jaradat, Dana, Abushamleh, Soha, Hanoun, Sakhaa, Qumbos, Amjad Abu, Hamarshi, Aseel, Taher, Ayman And, Qawasmi, Israa, Qurie, Khalid, Altarayra, Marwa, Ghannam, Mohammad, Shaheen, Alaa, Abdelhaq, Azher Herebat Aram, Shalabi, Ahmad, Abu-toyour, Maram, Asi, Fatema, Shamasneh, Ala, Atiyeh, Anwar, Mustafa, Mousa, Zaa’treh, Rula, Dabboor, Majd, Alaloul, Enas, Baraka, Heba, Meqbil, Jehad, Al-Buhaisi, Alaa, Elshami, Mohamedraed, Afana, Samah, Jaber, Sahar, Alyacoubi, Said, Idress, Yousef Abuowda Tasneem, Al-saqqa, Eman Abuqwaider Sara, Bowabsak, Alaa, El Jamassi, Alaa, Hasanain, Doaa, Al-farram, Hadeel, Salah, Maram, Firwana, Aya, Hamdan, Marwa, Ashour, Israa Awad Ahmad, Al-khatib, Fayez Elian Al Barrawi Ahmed, Al-faqawi, Maha, Fares, Mohamed, Elmashala, Amjad, Adawi, Mohammad, Adawi, Ihdaa, Khreishi, Reem, Khreishi, Rose, ashour, Ahmad, Nadeem, Ahed Ghaben Najwa, Abbasy, Muhammad Saqlain Jibran, Alvi, Abdul Rehman, Gala, Tanzeela, Bhopal, Noman Shahzad Kamran Faisal, Iftikhar, Zainab, Butt, Muhammad Talha, ul Razi, Syed Asaat, Ahmed, Asdaq, Raza, Ali Khan Niazi Ibrahim, Baluch, Fatima, Raza, Ahmed, Bani-Sadar, Ahmad, Qureshi, Ahmad Uzair, Adil, Muhammad, Raza, Awais, Javaid, Mahnoor, Waqar, Muhammad, Khan, Maryam Ali, Arshad, Mohammad Mohsin, Vega, Mohammadasim Amjad Gustavo Miguel Machain, Cardozo, Jorge Torres, O´Higgins Roche, Marcelo, Servin, Gustavo Rodolfo Pertersen, Lohse, Helmut Alfredo Segovia, Lopez, Larissa Ines Páez, Espinoza, Ramón Augusto Melo Cardozo Fernando, Rojas, Angel David Pérez, Sanchez, Diana, Samaniego, Camila Sanchez, Torres, Shalon Guevara, Calua, Alexander Canta, Razuri, Cesar, Ortiz, Nadia, Rodriguez, Xianelle, Carrasco, Nahilia, Saravia, Fridiz, Miyasato, Hector Shibao, Valcarcel-Saldaña, María, Bermúdez, Ysabel Esthefany Alejos, Carpio, Juan, Panez, Walter Ruiz, Orbegozo, Pedro Angel Toribio, Dueñas, Carolina Guzmán, Espinoza, Kevin Turpo, Barrantes, Ana Maria Sandoval, Bravo, Jorge Armando Chungui, Shu, Sebastian, Fuentes-Rivera, Lorena, Fernández, Carmen, Romani, Diego, Málaga, Bárbara, Ye, Joselyn, Velasquez, Ricardo, Salcedo, Jannin, Contreras-Vergara, Ana Lucia, Mejia, Angelica Genoveva Vergara, Montejo, Maria Soledad Gonzales, Salas, Marilia Del Carmen Escalante, Ticona, Willy Alcca, Vargas, Marvin, Sila, George Christian Manrique, Mas, Robinson, Paucar, Arazzelly del Pilar, Velásquez, Armando José Román, Robledo-Rabanal, Alina, Solis, Ludwing Alexander Zeta, Espinoza, Kenny Turpo, Hamaguchi, José Luis Hamasaki, Farfan, Erick Samuel Florez, Barrientos, Linda Alvi Madrid, Matta, Juan Jaime Herrera, Mora, John Jemuel V., Redota, Menold Archee P., Roxas, Manuel Francisco, Maño, Maria Jesusa B., Parreno-Sacdalan, Marie Dione, Lapitan, Marie Carmela, Walędziak, Christel Leanne Almanon Maciej, Roszkowski, Rafał, Janik, Michał, Lasek, Anna, Major, Piotr, Radkowiak, Dorota, Rubinkiewicz, Mateusz, Fernandes, Cristina, Costa-Maia, Jose, Melo, Renato, Muntean, Liviu, Mironescu, Aurel Sandu, Vida, Lucian Corneliu, Kourdouli, Amar, Mircea, Mariuca Popa Hogea, Vartic, Mihaela, Diaconescu, Bogdan, Bratu, Matei Razvan, Negoi, Ionut, Beuran, Mircea, Ciubotaru, Cezar, Ingabire, J.C Allen, Mutabazi, Alphonse Zeta, Uzabumwana, Norbert, Jovine, Dieudonne Duhoranenayo Elio, Zanini, Nicola, Aljiffry, Giovanni Landolfo Murad, Idris, Faisal, Alghamdi, Mohammed Saleh A., Maghrabi, Ashraf, Altaf, Abdulmalik, Alkaaki, Aroub, Khoja, Ahmad, Nawawi, Abrar, Turkustani, Sondos, Khalifah, Eyad, Gudal, Ahmad, Albiety, Adel, Sahel, Sarah, Alshareef, Reham, Alzahrani, Mohammed Najjar Ahmed, Alghamdi, Ahmed, Alhazmi, Wedyan, Saied, Ghiath Al, Alamoudi, Mohammed, Riaz, Muhammed Masood, Hassanain, Mazen, Alhassan, Basmah, Altamimi, Abdullah, Alyahya, Reem, Subaie, Norah Al, Bastawis, Fatema Al, Altamimi, Afnan, Nouh, Thamer, Khan, Roaa, Radojkovic, Milan, Jeremic, Ljiljana, Nestorovic, Milica, Law, Jia Hao, Tan, Keith Say Kwang, Tan, Ryan Choon Kiat, Tan, Joel Kin, Joel, Lau Wen Liang, Lieske, Bettina, Chan, Xue Wei, Leong, Faith Qi Hui, Chong, Choon Seng, Koh, Sharon, Lee, Kai Yin, Pluke, Kuok Chung Lee Kent, Dedekind, Britta, Nashidengo, Puyearashid, Hampton, Mark Ian, Joosten, Johanna, Sobnach, Sanju, Roodt, Liana, Sander, Anthony, Pape, James, Spence, Richard, Maistry, Niveshni, Ndwambi, Phumudzo, Kinandu, Kamau, Tun, Myint, Toit, Frederick Du, Ellison, Quinn, Burger, Sule, Grobler, DC, Khulu, Lawrence Bongani, Moore, Rachel, Jennings, Vicky, Leusink, Astrid, Kariem, Nazmie, Gouws, Juan, Chu, Kathryn, Bougard, Heather, Noor, Fazlin, Dell, Angela, Rayne, Sarah, Van Straten, Stephanie, Khamajeet, Arvin, Tshisola, Serge Kapenda, Kabongo, Kalangu, Kong, Victor, Moodley, Yoshan, Anderson, Frank, Madiba, Thandinkosi, du Plooy, Flip, Hartford, Leila, Chilton, Gareth, Mabitsela, Parveen Karjiker Matlou Ernest, Ndlovu, Sibongile Ruth, Badicel, Maria, Jaich, Robert, Garcia-Florez, Jaime Ruiz-Tovar Luis, Otero-Díez, Jorge L., Pérez, Virginia Ramos, García, Nuria Aguado Suárez Javier Minguez, Moreno, Sara Corral, Collado, Maria Vicenta, Carneros, Virginia Jiménez, Gonzalez, Javier García Septiem Mariana, Picardo, Antonio, Esteban, Enrique, Ferrero, Esther, Ortega, Irene, Espin-Basany, Eloy, Blanco-Colino, Ruth, Andriola, Valeria, García, Lorena Solar, Contreras, Elisa, Bernardo, Carmen García, Pagnozzi, Janet, Sanz, Sandra, de León, Alberto Miyar, Dorismé, Asnel, Rodicio, Joseluis, Suarez, Aida, Stuva, Jessica, Fernandez-Vega, Tamara Diaz Vico Laura, Soldevila-Verdeguer, Carla, Sena-Ruiz, Fatima, Pujol-Cano, Natalia, Diaz-Jover, Paula, Garcia-Perez, José Maria, Segura-Sampedro, Juan Jose, Pineño-Flores, Cristina, Ambrona-Zafra, David, Craus-Miguel, Andrea, Jimenez-Morillas, Patricia, Jayathilake, Angela Mazzella A.B, Thalgaspitiya, S.P.B, Wijayarathna, L.S., Sanni, P.M.S.N. Wimalge Hakeem Ayomi, Ndajiwo, Aliyu, Okenabirhie, Ogheneochuko, Homeida, Anmar, Younis, Abobaker, Omer, Omer Abdelbagi, Abdulaziz, Mustafa, Mussad, Ali, Adam, Ali, Cengiz, Yucel, Björklund, Ida, Ahlqvist, Sandra, Ahlqvist, Sandra, Thorell, Anders, Sokratous, Fredrik Wogensen Arestis, Sigurdadottir, Michaela Breistrand Hildur Thorarinsdottir Johanna, Nikberg, Maziar, Elbe, Abbas Chabok Maria Hjertberg Peter, Saraste, Deborah, Rutkowski, Wiktor, Niska, Louise Forlin Karoliina, Oswald, Malin Sund Dennis, Peros, Georgios, Bluelle, Rafael, Reinisch, Katharina, Frey, Daniel, Raptis, Adrian Palma Dimitri Aristotle, Zumbühl, Lucius, Schmid, Markus Zuber Roger, Nocito, Gabriela Werder Antonio, Gerosa, Alexandra, Widmer, Silke Mahanty Lukas Werner, Müller, Julia, Zuk, Alissa Gübeli Grzegorz, Gulcicek, Osman Bilgin, Altinel, Yuksel, Vartanoglu, Talar, Kose, Emin, Karahan, Servet Rustu, Aydin, Mehmet Can, Sahbaz, Nuri Alper, Halicioglu, Ilkay, Sapci, Halil Alis Ipek, Adıyaman, Can, Pektaş, Ahmet Murat, Cengiz, Turgut Bora, Tansoker, Ilkan, Işler, Vedatcan, Cevik, Muazzez, Mutlu, Deniz, Ozben, Volkan, Ozmen, Berk Baris, Bayram, Sefa, Yolcu, Sinem, Kobal, Berna Buse, Toto, Ömer Faruk, Karabulut, Haluk Cem Çakaloğlu Kagan, Mutlu, Vahit, Ozkan, Bahar Busra, Celik, Saban, Semiz, Anil, Bodur, Selim, Gül, Enisburak, Murutoglu, Busra, Yildirim, Reyyan, Baki, Bahadir Emre, Arslan, Ekin, Ulusahin, Mehmet, Walker, Ali Guner Nathan, Shrimanker, Nikhita, Stoddart, Michael, Cole, Simon, Breslin, Ryan, Srinivasan, Ravi, Elshaer, Mohamed, Hunter, Kristina, Liew, Ahmed Al-Bahrani Ignatius, Mairs, Nora Grace, Rocke, Alistair, Dick, Lachlan, Chowdhury, Mobeen Qureshi Debkumar, Wright, Naomi, Skerritt, Clare, Kufeji, Dorothy, Ho, Adrienne, Dissanayake, Tharindra, Tennakoon, Athula, Ali, Wadah, Lim, Shujing Jane, Tan, Charlene, O’Neill, Stephen, Jones, Catrin, Knight, Stephen, Nassif, Dima, Sharma, Abhishek, Warren, Oliver, White, Rebecca, Mehdi, Aia, Post, Nathan, Kalakouti, Eliana, Dashnyam, Enkhbat, Stourton, Frederick, Mykoniatis, Ioannis, Currow, Chelise, Wong, Francisca, Gupta, Ashish, Shatkar, Veeranna, Luck, Joshua, Kadiwar, Suraj, Smedley, Alexander, Wakefield, Rebecca, Herrod, Philip, Blackwell, James, Lund, Jonathan, Cohen, Fraser, Bandi, Ashwath, Bond-Smith, Stefano Giuliani Giles, Pezas, Theodore, Farhangmehr, Neda, Urbonas, Tomas, Perenyei, Miklos, Ireland, Philip, Blencowe, Natalie, Bowling, Kirk, Bunting, David, Longstaff, Lydia, Smart, Neil, Keogh, Kenneth, Jeon, Hyunjin, Iqbal, Muhammad Rafaih, Khosla, Shivun, Jeffery, Anna, Perera, James, Teasdale, Ella, Ibrahem, Ahmad Aboelkassem, Alhammali, Tariq, Salama, Yahya, Kabariti, Rakan, Oram, Shaun, Kidd, Thomas, Cullen, Fraser, Owen, Christopher, Wilson, Michael, Chiu, Seehui, Sarafilovic, Hannah, Ploski, Jennifer, Evans, Elizabeth, Abbas, Athar, Kamya, Sylvia, Ishak, Norzawani, Bisset, Carly, Andress, Cedar, Chin, Ye Ru, Patel, Priya, Evans, David, Jeffery, Anna, Perera, James, Haslegrave, Aidan, Boggon, Adam, Laurie, Kirsten, Connor, Katie, Mann, Thomas, Nepogodiev, Dmitri, Mansuri, Anahita, Davies, Rachel, Griffiths, Ewen, Shahbaz, Aized Raza, Eng, Calvin, Din, Farhat, L’Heveder, Ariadne, Park, Esther H.G., Ravishankar, Ramanish, McIntosh, Kirsten, Yau, Jih Dar, Chan, Luke, McGarvie, Susan, Tang, Lingshan, Lim, Hui, Yap, Suhhuey, Park, Jay, Ng, Zhan Herr, Mirza, Shahrukh, Ang, Yun Lin, Walls, Luke, Teasdale, Ella, Roy, Chloe, Paterson-Brown, Simon, Camilleri-Brennan, Julian, Mclean, Kenneth, D’Souza, Michelle S, Pronin, Savva, Henshall, David Ewart, Ter, Eunice Zuling, Fouad, Dina, Minocha, Ashish, English, William, Morgan, Catrin, Townsend, Dominic, Maciejec, Laura, Mahdi, Shareef, Akpenyi, Onyinye, Hall, Elisabeth, Caydiid, Hanaan, Rob, Zakaria, Abbott, Tom, Torrance, Hew D, Irwin, Gareth, Johnston, Robin, Gani, Mohammed Akil, Gravante, Gianpiero, Rajmohan, Shivanchan, Majid, Kiran, Dindyal, Shiva, Smith, Christopher, Palliyil, Madanmohan, Patel, Sanjay, Nicholson, Luke, Harvey, Neil, Baillie, Katie, Shillito, Sam, Kershaw, Suzanne, Bamford, Rebecca, Orton, Peter, Reunis, Elke, Tyler, Robert, Soon, Wai Cheong, Jama, Guled M., Dhillon, Dharminder, Patel, Khyati, Nanthakumaran, Shayanthan, Heard, Rachel, Chen, Kar Yan, Barmayehvar, Behrad, Datta, Uttaran, Kamarajah, Sivesh K, Karandikar, Sharad, Tani, Sobhana Iftekhar, Monaghan, Eimear, Donnelly, Philippa, Walker, Michael, Parakh, Jehangirshaw, Blacker, Sarah, Kaul, Anil, Paramasivan, Arjun, Farag, Sameh, Nessa, Ashrafun, Awadallah, Salwa, Lim, Jieqi, Ng, James Chean Khun, Gash, Katherine, Kiran, Ravi P., Murray, Alice, Etchill, Eric, Dasari, Mohini, Puyana, Juan, Haddad, Nadeem, Zielinski, Martin, Caliman, Asad Choudhry Celeste, Beamon, Mieshia, Duane, Therese, Narayanan, Ragavan, Swaroop, Mamta, Myers, Jonathan, Deal, Rebecca, Schadde, Erik, Hemmila, Mark, Napolitano, Lena, To, Kathleen, Makupe, Alex, Musowoya, Joseph, Maimbo, Mayaba, Van Der Naald, Niels, Kumwenda, Dayson, Reece-Smith, Alex, Otten, Kars, Verbeek, Anna, Prins, Marloes, Suarez, Alibeth Andres Baquero, Balmaceda, Ruben, Deane, Chelsea, Dijan, Emilio, Elfiky, Mahmoud, Koskenvuo, Laura, Thollot, Aurore, Limoges, Bernard, Capito, Carmen, Alexandre, Challine, Kotobi, Henri, Leroux, Julien, Rod, Julien, Pinnagoda, Kalitha, Henric, Nicolas, Azzis, Olivier, Rosello, Olivier, Francois, Poddevin, Etienne, Sara, Buisson, Philippe, Hmila, Sophian, Clegg-Lamptey, Joe-Nat, Imoro, Osman, Abem, Owusu Emmanuel, Wondoh, Paul, Papageorgiou, Dimitrios, Soulou, Vasiliki, Asturias, Sabrina, Peña, Lenin, Kumar, Basant, O’Connor, Donal B, Luc, Alberto Realis, Russo, Alfio Alessandro, Ruzzenente, Andrea, Taddei, Antonio, Cona, Camilla, Bottini, Corrado, Pascale, Giovanni, Rotunno, Giuseppe, Solaini, Leonardo, Pascale, Marco Maria, Notarnicola, Margherita, Corbellino, Mario, Sacco, Michele, Ubiali, Paolo, Cautiero, Roberto, Bocchetti, Tommaso, Muzio, Elena, Guglielmo, Vania, Morandi, Eugenio, Mao, Patrizio, De Luca, Emilia, Notarnicola, Margherita, Ali, Farah Mahmoud, Žilinskas, Justas, Strupas, Kestutis, Kondrotas, Paulius, Baltrunas, Robertas, Kutkevicius, Juozas, Ignatavicius, Povilas, Tan, Choy Ling, Siaw, Jia Yng, Yam, Sir Young, Wilson, Ling, Aziz, Mohamed Rezal Abdul, Bondin, John, Zorrilla, Carmina Diaz, Majbar, Anass, Sale, Danjuma, Abdullahi, Lawal, Osagie, Olabisi, Faboya, Omolara, Fatuga, Adedeji, Taiwo, Agboola, Nwabuoku, Emeka, Bliksøen, Marte, Khan, Zain Ali, Coronel, Jazmin, Miranda, Cesar, Vasquez, Idelso, Helguero-Santin, Luis M., Rickard, Jennifer, Mironescu, Aurel, Adedeji, Adesina, Alqahtani, Saleh, Rath, Max, Van Niekerk, Michael, Koto, Modise Zacharia, Matos-Puig, Roel, Israelsson, Leif, Schuetz, Tobias, Yuksek, Mahmut Arif, Mericliler, Meric, Uluşahin, Mehmet, Wolf, Bernhard, Fairfield, Cameron, Yong, Guo Liang, Whitehurst, Katharine, Wilson, Michael, Redgrave, Natalie, Musyoka, Caroluce K, Olivier, James, Lee, Kathryn, Cox, Michael, Farhan-Alanie, Muhamed M H, Callan, Rory, Chibuye, Chali, Ali, Tebian Hassanein Ahmed, Rekhis, Syrine, Rommaneh, Muna, Halhouli, Oday, Sam, Zi Hao, Chen, Jacky Hong Chieh, Roi, Dylan, Ismaïl, Lawani, Kalles, Vasileios, Pata, Francesco, Nita, Gabriela Elisa, Coccolini, Federico, Ansaloni, Luca, Pugliesi, Thays Brunelli, Pardo, Gabriel, Blanco, Ruth, and Escobar, Eugenio Grasset

Published
2023
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39. Distinct role of AtCuAOβ- and RBOHD-driven H2O2 production in wound-induced local and systemic leaf-to-leaf and root-to-leaf stomatal closure

Author

Ilaria Fraudentali, Chiara Pedalino, Riccardo D’Incà, Paraskevi Tavladoraki, Riccardo Angelini, and Alessandra Cona

Subjects
CuAO, RBOH, polyamines, ROS, hydrogen peroxide, wounding, Plant culture, SB1-1110
Abstract

Polyamines (PAs) are ubiquitous low-molecular-weight aliphatic compounds present in all living organisms and essential for cell growth and differentiation. The developmentally regulated and stress-induced copper amine oxidases (CuAOs) oxidize PAs to aminoaldehydes producing hydrogen peroxide (H2O2) and ammonia. The Arabidopsis thaliana CuAOβ (AtCuAOβ) was previously reported to be involved in stomatal closure and early root protoxylem differentiation induced by the wound-signal MeJA via apoplastic H2O2 production, suggesting a role of this enzyme in water balance, by modulating xylem-dependent water supply and stomata-dependent water loss under stress conditions. Furthermore, AtCuAOβ has been shown to mediate early differentiation of root protoxylem induced by leaf wounding, which suggests a whole-plant systemic coordination of water supply and loss through stress-induced stomatal responses and root protoxylem phenotypic plasticity. Among apoplastic ROS generators, the D isoform of the respiratory burst oxidase homolog (RBOH) has been shown to be involved in stress-mediated modulation of stomatal closure as well. In the present study, the specific role of AtCuAOβ and RBOHD in local and systemic perception of leaf and root wounding that triggers stomatal closure was investigated at both injury and distal sites exploiting Atcuaoβ and rbohd insertional mutants. Data evidenced that AtCuAOβ-driven H2O2 production mediates both local and systemic leaf-to-leaf and root-to-leaf responses in relation to stomatal movement, Atcuaoβ mutants being completely unresponsive to leaf or root wounding. Instead, RBOHD-driven ROS production contributes only to systemic leaf-to-leaf and root-to-leaf stomatal closure, with rbohd mutants showing partial unresponsiveness in distal, but not local, responses. Overall, data herein reported allow us to hypothesize that RBOHD may act downstream of and cooperate with AtCuAOβ in inducing the oxidative burst that leads to systemic wound-triggered stomatal closure.

Published
2023
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41. The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen

Author

Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, and Tetsu Akiyama

Subjects
apoptosis, DHX38, ovarian cancer, PRP16, splicing factor, tumorigenesis, Biology (General), QH301-705.5
Abstract

Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies. In order to identify novel genes critical to OCCC growth, we carried out a comprehensive CRISPR‐Cas9 knockout screen against cell growth using an OCCC cell line and a normal ovarian surface epithelium cell line. We identified the gene encoding DHX38/PRP16, an ATP‐dependent RNA helicase involved in splicing, as critical for the growth and tumorigenesis of OCCC. DHX38/PRP16 knockdown in OCCC cells, but not normal cells, induces apoptosis and impairs OCCC tumorigenesis in a mouse model. Our results suggest that DHX38/PRP16 may play a role in OCCC tumorigenesis and could potentially be a promising therapeutic target.

Published
2022
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42. Evaluation of COVID-19 impact on DELAYing diagnostic-therapeutic pathways of lung cancer patients in Italy (COVID-DELAY study): fewer cases and higher stages from a real-world scenario

Author

Cantini, L., Mentrasti, G., Russo, G.L., Signorelli, D., Pasello, G., Rijavec, E., Russano, M., Antonuzzo, L., Rocco, D., Giusti, R., Adamo, V., Genova, C., Tuzi, A., Morabito, A., Gori, S., Verde, N. La, Chiari, R., Cortellini, A., Cognigni, V., Pecci, F., Indini, A., De Toma, A., Zattarin, E., Oresti, S., Pizzutilo, E.G., Frega, S., Erbetta, E., Galletti, A., Citarella, F., Fancelli, S., Caliman, E., Della Gravara, L., Malapelle, U., Filetti, M., Piras, M., Toscano, G., Zullo, L., De Tursi, M., Di Marino, P., D’Emilio, V., Cona, M.S., Guida, A., Caglio, A., Salerno, F., Spinelli, G., Bennati, C., Morgillo, F., Russo, A., Dellepiane, C., Vallini, I., Sforza, V., Inno, A., Rastelli, F., Tassi, V., Nicolardi, L., Pensieri, V., Emili, R., Roca, E., Migliore, A., Galassi, T., Rocchi, M. L. Bruno, and Berardi, R.

Published
2022
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43. Treatment With Kiwi Peel Extract Delays Browning in Ready‐to‐Eat Lettuce.

Author

Fraudentali, Ilaria, Pedalino, Chiara, Furlani, Adriana, Secchiero, Andrea, Rogers, Hilary J., Gallo, Valentina, Antonini, Giovanni, Angelini, Riccardo, Cona, Alessandra, and Gutiérrez-Grijalva, Erick

Abstract

Browning reactions caused by oxidative stress occurring during postharvest procedures significantly compromise the quality of ready‐to‐eat (RTE) vegetables, negatively affecting their market value. Polyphenol oxidase (PPO) and peroxidase (POD) are two major enzymes involved in this phenomenon, as they oxidize phenolic compounds to quinones, which in turn polymerize to brown pigments. Recently, there has been an increasing interest in developing antibrowning treatments using food by‐products. Herein, the efficiency of a kiwi peel extract in reducing enzymatic browning of minimally processed lettuce (Lactuca sativa) has been investigated. PPO and POD activities showed an opposite spatial distribution within the leaf, with a higher POD activity in the midvein (MV) and in the inner lamina tissues, and a prevalence of PPO activity in the mesophyll. Considering that MV lignified tissues are those mainly affected by browning, the temporal trend of POD activity over a 20‐day storage period at 4°C was investigated. Data showed that treatment with a kiwi peel extract hinders both the increasing trend of POD activity and browning development compared to control leaves. These results could be potentially useful for the industry as they confirm that natural extracts, such as kiwi peel extract, can be valuable for extending the shelf‐life of RTE products. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Sezgisel Bulanık Normlu Uzaylarda Sezgisel f ve ψ Bulanık Daralma Dönüşüm Sınıfları için Yaklaşık Sabit Nokta Özelliği.

Author

CONA, Lale and GÜZEL TAN, Gizem

Subjects
METRIC spaces, DEFINITIONS
Abstract

Copyright of Afyon Kocatepe University Journal of Science & Engineering / Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi is the property of Afyon Kocatepe University, Faculty of Science & Literature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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45. Happy children! A network of psychological and environmental factors associated with the development of positive affect in 9–13 children.

Author

Feraco, Tommaso and Cona, Giorgia

Subjects
*AFFECT (Psychology), *PSYCHOLOGICAL factors, *COGNITIVE ability, *SOCIAL context, *STUDENT activities
Abstract

To deepen the development of positive affect during early adolescence and shed new light on its predictors, this study adopts an exploratory network approach to first identify the main domains that describe the variability of children's psychological, environmental, and behavioral characteristics, and then use these domains to longitudinally predict positive affect and its development within a latent growth framework. To this aim, we considered 10,904 US participants (9 years old at baseline; 13 years old 42 months later), six measurement occasions of positive affect, and 46 baseline indicators from the ABCD study. Our results not only confirm that positive affect declines between 9 and 13 years old, but also show that among the five domains identified (behavioral dysregulation, cognitive functioning, psychological problems, supportive social environment, and extracurricular activities), only a supportive social environment consistently predicts positive affect. This is crucial for practitioners and policymakers, as it can help them focus on the elements within our complex network of psychological, social, and environmental variability. [ABSTRACT FROM AUTHOR]

Published
2024
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