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4. P115A-T High Speed Nanoscale UPLC Separations Combined with Off-Line MALDI MS/MS for Peptide Analysis

Author

Langridge, J., Claude, E., Snel, M., Compson, K., and McKenna, T.

Subjects
Poster Abstracts: Mass Spectrometry
Abstract

MALDI MS/MS is now a standard technique for protein identification and characterisation and this method has been shown to work well with mixtures of low complexity. In the analysis of biological samples considerable sample processing and chromatographic separation is crucial to limit the complexity and dynamic range presented to the MS. A common approach to protein prefractionation is 2D or 1D PAGE. The downside of this approach is that the complexity of the sample is still such that an LC-MALDI experiment is required, prior to analysis. With typical HPLC run times of 45 min to 1 h, the time required to analyze one top level sample can be prohibitive.

Published
2007

6. What effect did the New Zealand COVID-19 lockdown have on computed tomography-head scan utilisation in patients presenting to the emergency department with traumatic head injuries?

Author

Hawkins E, Stewart B, Huggins M, Compson K, Larsen P, and Rogan A

Subjects
Humans, New Zealand epidemiology, Communicable Disease Control, Tomography, X-Ray Computed methods, Emergency Service, Hospital, Retrospective Studies, COVID-19 epidemiology, Craniocerebral Trauma diagnostic imaging, Craniocerebral Trauma epidemiology
Abstract

Objectives: To explore the unique impact the first COVID-19 national lockdown in New Zealand (NZ) had on the utility of computed tomography (CT)-head scanning in patients presenting to the ED with head injuries., Methods: Retrospective observational study of CT-head use in head-injured patients presenting to the ED during the 2020 COVID-19 lockdown compared to the corresponding time period in 2019., Results: During the lockdown period in 2020, the total number of ED presentations reduced by 30.3% (95% confidence interval [CI] 28.8-31.6) from 13 477 to 9403. The total number of head injury presentations also reduced by 32% (95% CI 27-36.7) from 523 to 356. The proportion of head-injured patients remained similar (3.9% [n = 523] in 2019 vs 3.8% [n = 356] in 2020). Of the head injured patients, 185 (51.9%, 95% CI 44.5-59.4) had CT-head scans performed in 2020 compared to 269 (51.4%, 95% CI 45.2-57.5) in 2019; a reduction of 31.2% (95% CI 24.5-37.9). The proportion of patients who had a CT-head scan remained similar (51.4% [95% CI 45.2-57.5] in 2019 vs 51.9% [95% CI 44.5-59.4] in 2020). There were no significant differences in the proportion of CT-head scans with acute traumatic pathology (13.0% [95% CI 8.7-17.3] in 2019 vs 12.4% [95% CI 7.4-17.5] in 2020, P = 0.86)., Conclusions: During the first COVID-19 lockdown in NZ, the total number of patients presenting to the ED decreased by one third. Reassuringly, the proportion of patients who presented with head injuries, had a CT-head scan performed, and had positive CT-head findings remained the same as the previous year., (© 2023 The Authors. Emergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian College for Emergency Medicine.)

Published
2024
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