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22 results on '"Compagnoni, Chiara"'

4. MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression

Author

Compagnoni, Chiara, primary, Capelli, Roberta, additional, Zelli, Veronica, additional, Corrente, Alessandra, additional, Vecchiotti, Davide, additional, Flati, Irene, additional, Di Vito Nolfi, Mauro, additional, Angelucci, Adriano, additional, Alesse, Edoardo, additional, Zazzeroni, Francesca, additional, and Tessitore, Alessandra, additional

Published
2023
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6. Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status

Author

Irelli, Azzurra, primary, Parisi, Alessandro, additional, D’Orazio, Carla, additional, Sidoni, Tina, additional, Rotondaro, Silvia, additional, Patruno, Leonardo, additional, Pavese, Francesco, additional, Bafile, Alberto, additional, Resta, Valter, additional, Pizzorno, Laura, additional, Ciuffetelli, Virginia, additional, Dalmas, Antonella, additional, Calvisi, Giuseppe, additional, Di Sibio, Alessandra, additional, Marzullo, Anna, additional, Zelli, Veronica, additional, Compagnoni, Chiara, additional, Tessitore, Alessandra, additional, Alesse, Edoardo, additional, Ficorella, Corrado, additional, Cortellini, Alessio, additional, and Cannita, Katia, additional

Published
2022
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8. MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway

Author

Compagnoni, Chiara, primary, Zelli, Veronica, additional, Bianchi, Andrea, additional, Di Marco, Antinisca, additional, Capelli, Roberta, additional, Vecchiotti, Davide, additional, Brandolini, Laura, additional, Cimini, Anna Maria, additional, Zazzeroni, Francesca, additional, Allegretti, Marcello, additional, Alesse, Edoardo, additional, and Tessitore, Alessandra, additional

Published
2022
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9. Role of exosomal microRNAs in cancer therapy and drug resistance mechanisms: focus on hepatocellular carcinoma

Author

Zelli, Veronica, Compagnoni, Chiara, Capelli, Roberta, Corrente, Alessandra, Di Vito Nolfi, Mauro, Zazzeroni, Francesca, Alesse, Edoardo, and Tessitore, Alessandra

Subjects
Cancer Research, therapy, drug resistance, Oncology, exosomes, hepatocellular carcinoma, miRNAs
Abstract

Extracellular vesicles (EVs), defined as intercellular messengers that carry their cargos between cells, are involved in several physiological and pathological processes. These small membranous vesicles are released by most cells and contain biological molecules, including nucleic acids, proteins and lipids, which can modulate signaling pathways of nearby or distant recipient cells. Exosomes, one the most characterized classes of EVs, include, among others, microRNAs (miRNAs), small non-coding RNAs able to regulate the expression of several genes at post-transcriptional level. In cancer, exosomal miRNAs have been shown to influence tumor behavior and reshape tumor microenvironment. Furthermore, their possible involvement in drug resistance mechanisms has become evident in recent years. Hepatocellular carcinoma (HCC) is the major type of liver cancer, accounting for 75-85% of all liver tumors. Although the improvement in HCC treatment approaches, low therapeutic efficacy in patients with intermediate-advanced HCC is mainly related to the development of tumor metastases, high risk of recurrence and drug resistance. Exosomes have been shown to be involved in pathogenesis and progression of HCC, as well as in drug resistance, by regulating processes such as cell proliferation, epithelial-mesenchymal transition and immune response. Herein, we summarize the current knowledge about the involvement of exosomal miRNAs in HCC therapy, highlighting their role as modulators of therapeutic response, particularly chemotherapy and immunotherapy, as well as possible therapeutic tools.

Published
2022

10. Concurrent RAS and RAS/BRAF V600E variants in colorectal cancer: more frequent than expected?

Author

Zelli, Veronica, Parisi, Alessandro, Patruno, LEONARDO VALERIO, Katia, Cannita, Ficorella, Corrado, Luzi, Carla, Compagnoni, Chiara, Zazzeroni, Francesca, Alesse, Edoardo, and Tessitore, Alessandra

Subjects
concurrent RAS/BRAF variants, colorectal cancer, concurrent RAS/BRAF variants, case report, mutation frequency, Q9 clinical–pathological features, Q9 clinical–pathological features, case report, colorectal cancer, mutation frequency
Published
2022

11. Ultrasound-Based Method for the Identification of Novel MicroRNA Biomarkers in Prostate Cancer

Author

Cornice, Jessica, primary, Capece, Daria, additional, Di Vito Nolfi, Mauro, additional, Di Padova, Monica, additional, Compagnoni, Chiara, additional, Verzella, Daniela, additional, Di Francesco, Barbara, additional, Vecchiotti, Davide, additional, Flati, Irene, additional, Tessitore, Alessandra, additional, Alesse, Edoardo, additional, Barbato, Gaetano, additional, and Zazzeroni, Francesca, additional

Published
2021
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13. Aryl hydrocarbon receptor Interacting Protein (AIP) status in a functional adrenal adenoma occurring in a patient with a germline AIP mutation

Author

Feola, Tiziana, primary, Capelli, Roberta, additional, Gianno, Francesca, additional, Compagnoni, Chiara, additional, Letizia, Claudio, additional, Toma, Giorgio De, additional, Ciardi, Antonio, additional, Vincentis, Giuseppe De, additional, Giangaspero, Felice, additional, Tessitore, Alessandra, additional, and Marie-Lise, Jaffrain-Rea, additional

Published
2021
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15. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease

Author

Calì, Elisa, Lin, Sheng-Jia, Rocca, Clarissa, Sahin, Yavuz, Al Shamsi, Aisha, El Chehadeh, Salima, Chaabouni, Myriam, Mankad, Kshitij, Galanaki, Evangelia, Efthymiou, Stephanie, Sudhakar, Sniya, Athanasiou-Fragkouli, Alkyoni, Çelik, Tamer, Narlı, Nejat, Bianca, Sebastiano, Murphy, David, De Carvalho Moreira, Francisco Martins, Hannah, Michael G., Bugiardini, Enrico, Kriouile, Yamna, El Khorassani, Mohamed, Aguennouz, Mhammed, Groppa, Stanislav, Karashova, Blagovesta Marinova, Di Rosa, Gabriella, Goraya, Jatinder S., Sultan, Tipu, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Banu, Selina, Veggiotti, Pierangelo, Verrotti, Alberto, Savasta, Salvatore, Ruiz, Alfons Macaya, Garavaglia, Barbara, Borgione, Eugenia, Papacostas, Savvas, Compagnoni, Chiara, Piccirilli, Alessandra, Vikelis, Michail, Chelban, Viorica, Kaiyrzhanov, Rauan, Cortese, Andrea, Sullivan, Roisin, Papanicolaou, Eleni Zamba, Dardiotis, Efthymios, Maqbool, Shazia, Ibrahim, Shahnaz, Kirmani, Salman, Rana, Nuzhat Noureen, Atawneh, Osama, Lim, Shen-Yang, Shaikh, Farooq, Scardamaglia, Annarita, Koutsis, George, Mangano, Salvatore, Scuderi, Carmela, Borgione, Eugenia, Morello, Giovanna, Zollo, Massimo, Heimer, Gali, Striano, Pasquale, Al-Khawaja, Issam, Al-Mutairi, Fuad, Alkuraya, Fowzan S., Rizig, Mie, Shashkin, Chingiz, Zharkynbekova, Nazira, Koneyev, Kairgali, Manizha, Ganieva, Isrofilov, Maksud, Guliyeva, Ulviyya, Salayev, Kamran, Khachatryan, Samson, Xiromerisiou, Georgia, Spanaki, Cleanthe, Tucci, Arianna, Fiorillo, Chiara, Rissotto, Federico, Munell, Francina, Gagliano, Antonella, Jan, Farida, Chimenz, Roberto, Gitto, Eloisa, Cuppari, Caterina, Romeo, Carmelo, Magrinelli, Francesca, Gupta, Neerja, Kabra, Madhulika, Benrhouma, Hanene, Tazir, Meriem, Zagaroli, Luca, Caloisi, Claudia, Fabiano, Cecilia, Bottone, Gabriella, Farello, Giovanni, Di Fabio, Sandra, Obeid, Makram, Bakhtadze, Sophia, Saadi, Nebal W., Zaki, Maha S., Triki, Chahnez C., Kara, Majdi, Belcastro, Vincenzo, Specchio, Nicola, Karimiani, Ehsan G., Salih, Ahmed M., Ramenghi, Luca A., David, Emanuele, Curró, Riccardo, Iezzi, Maria Laura, Iapadre, Giulia, Nanni, Giuliana, Scorrano, Giovanna, Fiorile, Maria F., Brancati, Francesco, Di Falco, Giovanna, Mandarà, Luana, Barrano, Giuseppe, Elia, Maurizio, Terrone, Gaetano, Operto, Francesca F., Valenzise, Mariella, Della Rocca, Ylenia, Zazzeroni, Francesca, Alesse, Edoardo, Manti, Filippo, Galosi, Serena, Nardecchia, Francesca, Leuzzi, Vincenzo, Pironti, Erica, Amore, Greta, Ceravolo, Giorgia, Zafar, Faisal, Ullah, Ehsan, Afzal, Erum, Javed, Iram, Rahman, Fatima, Ahmed, Muhammad Mehboob, Parisi, Pasquale, Borgia, Paola, Mangano, Giuseppe D., Chiarelli, Francesco, Genomics, Queen Square, Accogli, Andrea, Petree, Cassidy, Huang, Kevin, Monastiri, Kamel, Edizadeh, Masoud, Nardello, Rosaria, Ognibene, Marzia, De Marco, Patrizia, Ruggieri, Martino, Zara, Federico, Striano, Pasquale, Şahin, Yavuz, Al-Gazali, Lihadh, Abi Warde, Marie Therese, Gerard, Benedicte, Zifarelli, Giovanni, Beetz, Christian, Fortuna, Sara, Soler, Miguel, Valente, Enza Maria, Varshney, Gaurav, Maroofian, Reza, Salpietro, Vincenzo, and Houlden, Henry

Abstract

The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11(c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families.

Published
2022
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20. Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy

Author

Bottoni, Carlo, primary, Marcoccia, Francesca, additional, Compagnoni, Chiara, additional, Colapietro, Martina, additional, Sabatini, Alessia, additional, Celenza, Giuseppe, additional, Segatore, Bernardetta, additional, Maturo, Maria Giovanna, additional, Amicosante, Gianfranco, additional, and Perilli, Mariagrazia, additional

Published
2015
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21. Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veroniiand Aeromonas hydrophilaIsolates from Municipal Sewage in Central Italy

Author

Bottoni, Carlo, Marcoccia, Francesca, Compagnoni, Chiara, Colapietro, Martina, Sabatini, Alessia, Celenza, Giuseppe, Segatore, Bernardetta, Maturo, Maria Giovanna, Amicosante, Gianfranco, and Perilli, Mariagrazia

Abstract

ABSTRACTTwo new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems only. CphA5 showed kcatvalues about 40-, 12-, and 97-fold higher than those observed for CphA4 versus imipenem, ertapenem, and biapenem, respectively.

Published
2015
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22. Role of Circulating microRNAs in Liver Disease and HCC: Focus on miR-122.

Author

Colaianni F, Zelli V, Compagnoni C, Miscione MS, Rossi M, Vecchiotti D, Di Padova M, Alesse E, Zazzeroni F, and Tessitore A

Subjects
Humans, Liver Diseases blood, Liver Diseases genetics, Biomarkers, Tumor blood, Biomarkers, Tumor genetics, MicroRNAs blood, MicroRNAs genetics, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular virology, Liver Neoplasms genetics, Liver Neoplasms blood, Circulating MicroRNA blood, Circulating MicroRNA genetics
Abstract

miR-122 is the most abundant microRNA (miRNA) in the liver; it regulates several genes mainly involved in cell metabolism and inflammation. Host factors, diet, metabolic disorders and viral infection promote the development of liver diseases, including hepatocellular carcinoma (HCC). The downregulation of miR-122 in tissue is a common feature of the progression of liver injury. In addition, the release of miR-122 in the bloodstream seems to be very promising for the early diagnosis of both viral and non-viral liver disease. Although controversial data are available on the role of circulating miR-122 as a single biomarker, high diagnostic accuracy has been observed using miR-122 in combination with other circulating miRNAs and/or proteins. This review is focused on comprehensively summarizing the most recent literature on the potential role of circulating miR-122, and related molecules, as biomarker(s) of metabolic liver diseases, hepatitis and HCC.

Published
2024
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