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Early in the Covid-19 pandemic, Salim S. Abdool Karim was catapulted into a prominent position in the media and on television as the face of South African science in the country's response to the pandemic. Up to that point, his groundbreaking research on AIDS had garnered many awards, leading to his recognition as one of the world's leading epidemiologists, making him ideally positioned to take the scientific lead in the Covid-19 response.Standing Up for Science is Abdool Karim's personal, behind-the-scenes account of the first three years of the Covid-19 pandemic. It is inspiring and informative, shedding light on the difficulties in providing scientific advice, on the international co-operation that was integral to responding to the pandemic, as well as giving insight to some of the controversies in the science-to-policy process, and drawing lessons from Covid-19 to prepare for future pandemics. Beyond the recent events in which the story is grounded, the book is an ode to the value of science and its power to help us tackle some of the world's biggest problems.

A pacy, real-life page-turner by award-winning health reporter Sets out the world's 100-days mission to catch the next virus outbreak Inside access to decision-makers (including global Coalition for Epidemic Preparedness, CEPI) Foreword by Sir Tony Blair, former British Prime Minister

Current textbooks provide a strong bio-medical view on epidemics. In this textbook, the bio-medical view will be extended to a human view including insights from humanities, social sciences. This extension challenges us all the more to combine the requirement of scientific objectivity with the subjectivity inherent to human life. In addition, the bio-medical view is deepened using knowledge of botanical epidemiology with respect to ‘evolutionary dynamics of pathogens'and ‘epidemic spread of pathogens'. Bio-medical oriented students and senior scientists are invited to reflect on the multi-dimensional, subjective, character of epidemics. Reflections that may enable appropriate, human, management of epidemics.

Infectious Disease Epidemiology: An Introduction is a foundational textbook for public health and related health science degrees. It provides a comprehensive public health strategy for understanding and managing the spread of infectious diseases. This unique book offers an integrated approach that covers the important methods underlying the discipline of infectious disease epidemiology, while also illustrating key social and environmental factors critical for understanding disease spread and its effect on population health. The book is divided into four parts that cover the entire scope of infectious disease origin, spread, and management. It breaks down factors leading to disease emergence and modes of transmission, the social, behavioral, cultural, and environmental dimensions that contribute to communicable spread and severity, as well as the tools used for disease detection, surveillance, control, and eradication. It discusses the latest knowledge and technologies in the field—including specific coverage on the role of big data and digital disease detection, the impact and challenges of vaccines, and much more. Core epidemiologic principles are explored through rich real-world examples, utilizing a combination of case studies, popular media examples, and didactic exercises. Each chapter has an engaging narrative and includes key terms and definitions, insightful vignettes, visually compelling illustrations, thought questions, and discussion questions to foster critical thinking and spark further investigation. Infectious Disease Epidemiology: An Introduction is an essential resource for students of public health and other health professionals in developing a nuanced and comprehensive understanding of this growing and dynamic field. Key Features: Provides students with an integrated approach illustrating important epidemiologic methods and tools in the context of current and historic real-world examples Uses multidisciplinary approaches to contextualize broader socio-behavioral factors and disparities in infectious disease Illustrates how novel methodological and technological advances support progress in infectious disease epidemiology Poses engaging discussion questions in each chapter that help guide in-class discussions and group work

Infectious diseases have been a threat since the beginning of civilization, leading the world to constantly adapt and advance medical knowledge in order to survive. The way society responds to these diseases has changed significantly throughout the years due to an influx of new technology, information, and research. In order to ensure society is equipped to handle future battles with infectious diseases, it is essential to understand past outbreaks and how they were handled. Historical and Epidemiological Analyses on the Impact of Infectious Disease on Society considers the history of infectious disease from the dawn of man to the present and discusses the scope and impact they have had on society and humanity. This book also examines how nation-state conflicts have interwoven with microscopic conflicts. Covering a range of critical topics such as plague, lethality, and technology, this reference work is ideal for medical professionals, historians, researchers, scholars, practitioners, academicians, instructors, and students.

Communicable diseases have been an important part of human history. Epidemics afflicted populations, causing many deaths before gradually fading away and emerging again years after. Epidemics of infectious diseases are occurring more often, and spreading faster and further than ever, in many different regions of the world. The scientific community, in addition to its accelerated efforts to develop an effective treatment and vaccination, is also playing an important role in advising policymakers on possible non-pharmacological approaches to limit the catastrophic impact of epidemics using mathematical and machine learning models. Controlling Epidemics With Mathematical and Machine Learning Models provides mathematical and machine learning models for epidemical diseases, with special attention given to the COVID-19 pandemic. It gives mathematical proof of the stability and size of diseases. Covering topics such as compartmental models, reproduction number, and SIR model simulation, this premier reference source is an essential resource for statisticians, government officials, health professionals, epidemiologists, sociologists, students and educators of higher education, librarians, researchers, and academicians.

Infectious Diseases of Haiti is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature.Chapters are arranged alphabetically, by disease name. Each chapter is divided into three sections:1. Descriptive epidemiology2. Status of the disease in Haiti3. ReferencesA chapter outlining the routine vaccination schedule of Haiti follows the diseases chapters.There are 361 generic infectious diseases in the world today. 212 of these are endemic, or potentially endemic, to Haiti. A number of other diseases are not relevant to Haiti and have not been included in this book.In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Haiti are included.

Information on, and investigation of, the epidemiology and methods of vector-borne diseases is usually incorporated only sparsely into books about the epidemiology of infectious diseases. The most generally accessible sources are the WHO's annual malaria guidelines and annual World Malaria Reports. In contrast, the details and findings of research are found in specialist journals, and explain the minute details of a particular situation.This book is designed for people who need to investigate the sources of disease, and report their findings. Although it references hundreds of peer-reviewed studies, it presents the procedures that can be used by vector control and epidemiologists in straightforward language. It also makes mention of, and references, new and novel techniques that are currently being developed for investigations. The book begins with an explanation of what is required to conduct vector-borne disease epidemiology, and why the focus of prevention is the biting insects and arthropods. It also shows how the environment is the main unit of investigation in this regard, and explains techniques for developing a comprehensive and linked surveillance system and for detecting a disease prior to the infection of a human index case.

The urban built environment is a prime setting for microbial transmission, because just as cities serve as hubs for migration and international travel, components of the urban built environment serve as hubs that drive the transmission of infectious disease pathogens. The risk of infectious diseases for many people living in slums is further compounded by their poverty and their surrounding physical and social environment, which is often overcrowded, is prone to physical hazards, and lacks adequate or secure housing and basic infrastructure, including water, sanitation, or hygiene services. To examine the role of the urban built environment in the emergence and reemergence of infectious diseases that affect human health, the National Academies of Sciences, Engineering, and Medicine planned a public workshop. This publication summarizes the presentations and discussions from the workshop.

Infectious Diseases of Taiwan is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into three sections: 1. Descriptive epidemiology 2. Status of the disease in Taiwan 3. References A chapter outlining the routine vaccination schedule of Taiwan follows the diseases chapters. There are 357 generic infectious diseases in the world today. 221 of these are endemic, or potentially endemic, to Taiwan. A number of other diseases are not relevant to Taiwan and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Taiwan are included.

Pandemics, epidemics and food borne diseases are a major global challenge. Focusing on the food and farming sector, and mobilising social theory as well as empirical enquiry, Pathological Lives investigates current approaches to biosecurity and ask how pathological lives can be successfully ‘regulated'without making life more dangerous as a result. Uses empirical and social theoretical resources developed in the course of a 40-month research project entitled ‘Biosecurity borderlands'Focuses on the food and farming sector, where the generation and subsequent transmission of disease has the ability to reach pandemic proportions Demonstrates the importance of a geographical and spatial analysis, drawing together social, material and biological approaches, as well as national and international examples The book makes three main conceptual contributions, reconceptualising disease as situated matters, the spatial or topological analysis of situations and a reformulation of biopolitics Uniquely brings together conceptual development with empirically and politically informed work on infectious and zoonotic disease, to produce a timely and important contribution to both social science and to policy debate

This volume presents infectious diseases modeled mathematically, taking seasonality and changes in population behavior into account, using a switched and hybrid systems framework. The scope of coverage includes background on mathematical epidemiology, including classical formulations and results; a motivation for seasonal effects and changes in population behavior, an investigation into term-time forced epidemic models with switching parameters, and a detailed account of several different control strategies. The main goal is to study these models theoretically and to establish conditions under which eradication or persistence of the disease is guaranteed. In doing so, the long-term behavior of the models is determined through mathematical techniques from switched systems theory. Numerical simulations are also given to augment and illustrate the theoretical results and to help study the efficacy of the control schemes.

Infectious diseases are continuing to threaten humankind. While some diseases have been controlled, new diseases are constantly appearing. Others are now reappearing in forms that are resistant to drug treatments. A capacity for continual re-adaptation furnishes pathogens with the power to escape our control efforts through evolution. This makes it imperative to understand the complex selection pressures that are shaping and reshaping diseases. Modern models of evolutionary epidemiology provide powerful tools for creating, expressing, and testing such understanding. Bringing together international leaders in the field, this volume offers a panoramic tour of topical developments in understanding the mechanisms of disease evolution. The volume's first part elucidates the general concepts underlying models of disease evolution. Methodological challenges addressed include those posed by spatial structure, stochastic dynamics, disease phases and classes, single- and multi-drug resistance, the heterogeneity of host populations and tissues, and the intricate coupling of disease evolution with between-host and within-host dynamics. The book's second part shows how these methods are utilized for investigating the dynamics and evolution of specific diseases, including HIV/AIDS, tuberculosis, SARS, malaria, and human rhinovirus infections. This volume is particularly suited for introducing young scientists and established researchers with backgrounds in mathematics, computer science, or biology to the current techniques and challenges of mathematical evolutionary epidemiology.

Essential resource for the fight against emerging infectious diseases Incidences such as the 2014 Ebola epidemic in West Africa and the 2015 appearance of Zika in Brazil provide dramatic evidence of the continued ability of microbes to emerge, spread, adapt, and threaten global health. The challenge facing infectious disease specialists and public health professionals is to improve and find new diagnostic, therapeutic, and prevention strategies. The editors of the 10th installment of the Emerging Infections series have compiled the perspectives of leading infectious disease experts into 22 chapters that provide important updates on a broad range of emerging and reemerging bacterial, viral, parasitic, and fungal infectious diseases in the United States and globally. In addition to focusing on MERS, Ebola virus disease, chikungunya, and Zika virus disease, Emerging Infections 10 explores the global threat of antimicrobial resistance in reviews on carbapenem-resistant Enterobacteriaceae, multiply-resistant gonococcal infections, non-typhoidal Salmonella infections, and artemisinin-resistant Plasmodium falciparum malaria. Topics include both recently- and long-recognized diseases that pose challenges for the clinical, laboratory, research, public health, and animal health communities. Emerging Infections 10 presents new and emerging strategies to prevent, control, and eradicate infectious diseases and guides readers to the primary literature where they can explore individual topics in greater depth. This book is a valuable reference for professionals in microbiology, epidemiology, public health, and clinical and veterinary medicine.

With the amount of data in the world exploding, big data could generate significant value in the field of infectious disease. The increased use of social media provides an opportunity to improve public health surveillance systems and to develop predictive models. Advances in machine learning and crowdsourcing may also offer the possibility to gather information about disease dynamics, such as contact patterns and the impact of the social environment. New, rapid, point-of-care diagnostics may make it possible to capture not only diagnostic information but also other potentially epidemiologically relevant information in real time. With a wide range of data available for analysis, decision-making and policy-making processes could be improved. While there are many opportunities for big data to be used for infectious disease research, operations, and policy, many challenges remain before it is possible to capture the full potential of big data. In order to explore some of the opportunities and issues associated with the scientific, policy, and operational aspects of big data in relation to microbial threats and public health, the National Academies of Sciences, Engineering, and Medicine convened a workshop in May 2016. Participants discussed a range of topics including preventing, detecting, and responding to infectious disease threats using big data and related analytics; varieties of data (including demographic, geospatial, behavioral, syndromic, and laboratory) and their broader applications; means to improve their collection, processing, utility, and validation; and approaches that can be learned from other sectors to inform big data strategies for infectious disease research, operations, and policy. This publication summarizes the presentations and discussions from the workshop.

Infectious Disease Epidemiology is a concise reference guide which provides trainees and practicing epidemiologists with the information that they need to understand the basic concepts necessary for working in this specialist area. Divided into two sections, part one comprehensively covers the basic principles and methods relevant to the study of infectious disease epidemiology. It is organised in order of increasing complexity, ranging from a general introduction to subjects such as mathematical modelling and sero-epidemiology. Part two examines key major infectious diseases that are of global significance. Grouped by their route of transmission for ease of reference, they include diseases that present a particular burden or a high potential for causing mortality. This practical guide will be essential reading for postgraduate students in infectious disease epidemiology, health protection trainees, and practicing epidemiologists.

This book develops a new multimodal theoretical model of contagion for interdisciplinary scholars, featuring contributions from influential scholars spanning the fields of medical humanities, philosophy, political science, media studies, technoculture, literature, and bioethics. Exploring the nexus of contagion's metaphorical and material aspects, this volume contends that contagiousness in its digital, metaphorical, and biological forms is a pervasively endemic condition in our contemporary moment. The chapters explore both endemicity itself and how epidemic discourse has become endemic to processes of social construction. Designed to simultaneously prime those new to the discourse of humanistic perspectives of contagion, complicate issues of interest to seasoned scholars of science and technology studies, and add new topics for debate and inquiry in the field of bioethics, Endemic will be of wide interest for researchers and educators.

Authored by two professionals in the medical and science fields, Ebola: An Emerging Infectious Disease Case Study analyzes the recent outbreak of the virus from a variety of angles and provides context for our understanding of emerging infectious diseases, how they are treated, and how agencies and governments respond to them.

Infectious Diseases of Argentina is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections:1. Descriptive epidemiology2. Summary of clinical features3. Status of the disease in Argentina4. References A chapter outlining the routine vaccination schedule of Argentina follows the diseases chapters. There are 353 generic infectious diseases in the world today. 225 of these are endemic, or potentially endemic, to Argentina. A number of other diseases are not relevant to Argentina and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Argentina are included.

Only a few decades ago, we were ready to declare victory over infectious diseases. Today, infectious diseases are responsible for significant morbidity and mortality throughout the world. This book examines the epidemiology and social impact of past and present infectious disease epidemics in the developing and developed world. In the introduction, the authors define global health as a discipline, justify its critical importance in the modern era, and introduce the Millennium Development Goals, which have become critical targets for most of the developing world. The first half of the volume provides an epidemiological overview, exploring early and contemporary perspectives on disease and disease control. An analysis of nutrition, water, and sanitation anchors the discussion of basic human needs. Specific diseases representing both “loud” and “silent” emergencies are investigated within broader structures of ecological and biological health such as economics, education, state infrastructure, culture, and personal liberty. The authors also examine antibiotic resistance, AIDS, malaria, tuberculosis, and pandemic influenza, and offer an epilogue on diseases of affluence, which now threaten citizens of countries both rich and poor. A readable guide to specific diseases, richly contextualized in environment and geography, this book will be used by health professionals in all disciplines interested in global health and its history and as a textbook in university courses on global health.

Infectious Diseases of Haiti is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections:1. Descriptive epidemiology2. Summary of clinical features3. Status of the disease in Haiti4. References A chapter outlining the routine vaccination schedule of Haiti follows the diseases chapters. There are 351 generic infectious diseases in the world today. 202 of these are endemic, or potentially endemic, to Haiti. A number of other diseases are not relevant to Haiti and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Haiti are included.

Striking changes have occurred in the world since the publication of the last edition of Viral Infections of Humans. The global population is rapidly approaching 8 billion; climate change is leading to the introduction of new hosts, vectors and virus diseases heretofore never seen in many parts of the world; technological advances have revolutionized the ability to recognize and characterize viruses new and old; vaccines are altering the epidemiological landscape of the diseases they target, in some cases raising the hope of their eradication and remarkably powerful computational tools are enabling not only detection of outbreaks of disease much sooner than in the past but also, through complex mathematical modeling, more accurate prediction of their potential impact.The new Fifth Edition of Viral Infections of Humans captures the both the excitement and frustration of the dynamic struggle between humankind and the viruses that continue to cause immense suffering. It presents the latest concepts, methods and technologies in epidemiology, detection, investigation, modeling and intervention. Updated and entirely new chapters by dozens of experts across the field provide analytic summaries of current knowledge of viruses and prions causing acute syndromes, chronic illnesses and/or malignancies. In sum, this ambitiously expanded volume offers a uniquely comprehensive perspective on viruses in humans, from agents of classic diseases (e.g., hepatitis, measles, polio, rabies and yellow fever), to those with greatest pandemic impact (e.g., influenza and human immunodeficiency virus), to those discovered relatively recently (e.g., henipavirus, metapneumovirus and norovirus).The new Fifth Edition of Viral Infections of Humans is an invaluable reference for students, fellows and established professionals in the fields of microbiology, public health and infectious disease epidemiology, medicine and health policy.

Examines the ongoing, worldwide epidemiological transition from acute infectious diseases to chronic diseases as the predominant causes of death, presenting a new theory on how chronic diseases have developed.Since the eighteenth century, chronic diseases have superseded acute infectious diseases as the predominant cause of morbidity and mortality; age at death has shifted from childhood to older adult ages; and life expectancy, population, and the proportion of older people continue to increase. This transition constitutes a fundamental change in the human condition, and thus an understanding of the historical process behind it is of major importance. This book is the first to document this ongoing, worldwide epidemiological transition in a single country, drawing on records of cause-specific mortality since the eighteenth century in England and comparative data from other Westerncountries. Alexander Mercer discusses possible causes of specific disease trends, reassessing the relative importance of'health interventions'and'standard of living'as determinants of increased life expectancy, and presents anew theory of how chronic diseases have developed. Showing that specific microorganisms are causal agents in some chronic diseases, the study suggests that a new conceptualization of the epidemiological transition is required, one that takes into account interrelationships between infectious diseases, between infections and chronic diseases, and between disorders underlying different chronic diseases. Alexander Mercer is an independent researcher.

Infectious Diseases of Pitcairn Island is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections: 1. Descriptive epidemiology 2. Summary of clinical features 3. Status of the disease in Pitcairn Island 4. References There are 351 generic infectious diseases in the world today. 181 of these are endemic, or potentially endemic, to Pitcairn Island. A number of other diseases are not relevant to Pitcairn Island and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Pitcairn Island are included.

Infectious Diseases of Paraguay is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections: 1. Descriptive epidemiology 2. Summary of clinical features 3. Status of the disease in Paraguay 4. References There are 351 generic infectious diseases in the world today. 208 of these are endemic, or potentially endemic, to Paraguay. A number of other diseases are not relevant to Paraguay and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Paraguay are included.

Infectious Diseases of Kyrgyzstan is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each chapter is divided into four sections: 1. Descriptive epidemiology 2. Summary of clinical features 3. Status of the disease in Kyrgyzstan 4. References There are 351 generic infectious diseases in the world today. 207 of these are endemic, or potentially endemic, to Kyrgyzstan. A number of other diseases are not relevant to Kyrgyzstan and have not been included in this book. In addition to endemic diseases, all published data regarding imported diseases and infection among expatriates from Kyrgyzstan are included.

Sarcocystosis: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status including distribution map 4. Status of the disease in a specific country 5. References

Acanthocephalan worms: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status including distribution map 4. Status of the disease in a specific country 5. References

This next volume in the series will provide up to date Information and discussion on future approach to control several challenging Infectious Disease worldwide. The past decade has been highlighted by numerous advances in research of medical scientific knowledge. medical technology and the biological and diagnostic techniques-but somewhat less dramatic changes or improvement in management of medical conditions. This volume will address some of the emerging issues, challenges, and controversies in Infectious Diseases.

Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.