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7. Sexual Abuse or Tourette Syndrome?

Author

Comings, David E. and Comings, Brenda G.

Abstract

Notes that sexual abuse of children is common and serious problem and that wide range of behavioral abnormalities have been linked to sexual and physical abuse. Notes that many symptoms also are seen in children with other disorders, including attention deficit hyperactivity disorder and Tourette syndrome. Presents case report of seven-year-old boy with Tourette syndrome. (NB)

Published
1993

22. A multigene test for the risk of sporadic breast carcinoma

Author

Comings, David E., Gade-Andavolu, Radhika, Cone, Lawrence A., Muhleman, Donn, and MacMurray, James P.

Subjects
Oncology, Experimental -- Analysis, Cancer patients -- Health aspects, Cancer patients -- Care and treatment, Cancer patients -- Genetic aspects, Breast cancer -- Health aspects, Breast cancer -- Care and treatment, Breast cancer -- Genetic aspects, Periodic health examinations -- Methods, Periodic health examinations -- Analysis, Physical diagnosis, Genetic screening -- Methods, Genetic screening -- Analysis, Health
Published
2003

26. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders

Author

Comings, David E., Comings, Brenda G., Muhleman, Donn, Dietz, George, Shahbahrami, Bejan, Tast, David, Knell, Ellen, Kocsis, Pat, Baumgarten, Rubin, Kovacs, Bruce W., Levy, Deborah L., Smith, Melissa, Borison, Richard L., Evans, D. Durrell, Klein, Daniel N., MacMurray, James, Tosk, Jeffrey M., Sverd, Jeffrey, Gysin, Reinhard, and Flanagan, Steven D.

Subjects
Mental illness -- Genetic aspects, Genetic screening -- Usage, Alcoholism -- Genetic aspects, Dopamine receptors -- Genetic aspects
Abstract

Dopamine is a chemical substance that plays an important role in the transmission of certain nerve signals. It is thought that abnormalities related to dopamine and its actions could be responsible or partially responsible for some neurological and psychiatric disorders. A few studies have reported an association between alcoholism and the presence of a variation of a gene associated with the expression of the dopamine D2 (DRD2) receptor, labelled the A1 allele. Other studies have not found such an association. These conflicting results could be explainable if the A1 allele is a modifying gene related to alcoholism as opposed to being a gene specifically responsible for alcoholism. To test this hypothesis, the prevalence of the A1 allele in various groups of people was measured. A total of 853 subjects were examined, including 314 healthy control subjects, 147 subjects with Tourette's syndrome (TS), 104 with attention deficit hyperactivity disorder (ADHD), 33 with autism, 104 who were alcoholics, 35 who suffered from posttraumatic stress syndrome, 13 who suffered panic attacks, 17 who had Parkinson's disease, and 10 who were obese. The A1 allele was found in 24.5 percent of the control subjects. It was found in 44.9 percent of subjects with TS, 46.2 percent of subjects with ADHD, 54.4 percent of the autistic patients, and 42.3 percent of the chronic alcoholics The prevalence for all of these groups was significantly greater than that in the control group. The differences in prevalence between the control group and the other groups studied were not statistically different. These results indicate that the A1 allele is related to, but not the direct cause of, a number of neuropsychiatric disorders. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

33. The genetics of addictive behaviors: the role of childhood behavioral disorders

Author

Comings, David E.

Subjects
Alcoholism -- Genetic aspects -- Research, Child psychopathology -- Genetic aspects -- Research, Compulsive behavior -- Genetic aspects -- Research, Brain chemistry -- Research, Alcoholics -- Family -- Research, Health, Psychology and mental health
Abstract

Why do some people become addicts while others do not? Why can some teenagers take a drink of alcohol and not crave more while others know from the instant of [...]

Published
1991

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