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4. Exotic Hormones

Author

Comhaire, F., Mahmoud, A., Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, and Hargreave, Timothy B., editor

Published
2006
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9. Endocrine Regulation

Author

Comhaire, F., Mahmoud, A., Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, and Hargreave, Timothy B., editor

Published
2006
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11. Cause: Varicocele

Author

Comhaire, F., Mahmoud, A., Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, and Hargreave, Timothy B., editor

Published
2006
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15. Immunological Causes

Author

Mahmoud, A., Comhaire, F., Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, and Hargreave, Timothy B., editor

Published
2006
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18. The exceptional case of a large extra-uterine, so-called parasitic leiomyoma in a post-menopausal woman with Hashimoto’s thyroiditis

Author

Decleer, W, Debeuckelaere, A, and Comhaire, F

Subjects
extra-uterine, Case Report, Hashimoto’s thyroiditis, post-menopausal, Parasitic leiomyoma
Abstract

A large tumour mass was detected in a 65-year-old patient during a routine gynaecological examination. This patient had been treated for over 10 years with levothyroxine for Hashimoto’s thyroiditis and was also given transdermal oestrogen replacement therapy. Before the operation, detailed imaging by CT scan and MRI was performed. A tumour weighing 1.056 grams and measuring 23x12x7 cm was successfully removed through laparotomy. Histopathology revealed the diagnosis of an extra-uterine, so-called parasitic leiomyoma. Post-surgery recovery was uneventful, but Tibolone treatment was indicated due to disturbing menopausal complaints.

Published
2021

20. Preconception nutraceutical food supplementation can prevent oxidative and epigenetic DNA alterations induced by ovarian stimulation for IVF and increases pregnancy rates

Author

Decleer, W., Comhaire, F., Declerck, Ken, Vanden Berghe, Wim, Devriendt, G., and Osmanagaoglu, K.

Subjects
nutraceuticals, Original Paper, Epigenetics, Human medicine, 8-hydroxy-2-deoxyguanosine, hTERT promoter, in vitro fertilisation, infertility
Abstract

Background: It is hypothesized that oxidative and epigenetic alterations to DNA induced by ovarian stimulation for in vitro fertilization (IVF) may be associated with an increased risk of diseases and cancer in the offspring and could possibly be attenuated by preconception food supplementation. Methods: In a prospective randomised open-label trial, 62 patients were randomly assigned to either 30 days of preconception treatment with the nutraceutical Fertility woman (R) duo (Nutriphyt, Beernem, Belgium) (group 1), this nutraceutical complemented with selenomethionine (group 2), or folic acid only (group 3). Biochemical and epigenetic effects and pregnancy rates were assessed. Results: In all 3 groups the level of DNA oxidative damage, estimated by the concentration of 8-hydroxy-2-deoxyguanosine over creatinine in early morning urine, and the concentration of homocysteine in the blood decreased after treatment. In group 2, the degree of methylation of the cancer-associated CpG2 dinucleotide of the human Telomerase Reverse Transcriptase (hTERT) promoter region, assessed by pyrosequence in follicular cells obtained at oocyte pick-up, was 18% lower than that of group 3. The pregnancy rate, including the transfer of fresh and frozen embryos, was significantly higher in group 2 (50%) than in group 3 (6%) with the result in group 1 being intermediate (30%). Conclusion: The results suggest that preconception food supplementation using a specific nutraceutical significantly reduces oxidative and epigenetic DNA changes to follicular cells of women treated by IVF, and may optimize gene expression in the oocytes, thus increasing the pregnancy rate per cycle of ovarian stimulation.

Published
2020

34. Outils diagnostiques

Author

Hargreave, T. B., primary, Comhaire, F., additional, Mahmoud, A., additional, Haidl, G., additional, Schuppe, H. -C., additional, Schiefer, H. G., additional, von Graevenitz, A., additional, Klingmüller, D., additional, Bliesener, N., additional, Bracke, M. E., additional, Nijs, E. L. F., additional, Oyen, R. H., additional, Gat, Y., additional, Gornish, M., additional, Bergmann, M., additional, Elliott, D. J., additional, Tatarov, O., additional, and Kirk, D., additional

Published
2008
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49. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines

Author

Delmulle, L., Bellahcene, A., Dhooge, W., Comhaire, F., Roelens, F., Huvaere, K., Heyerick, A., Castronovo, V., and De Keukeleire, D.

Subjects
Hops -- Health aspects -- Research, Bioflavonoids -- Health aspects -- Research, Flavones -- Health aspects -- Research, Prostate cancer -- Drug therapy -- Research, Flavonoids -- Health aspects -- Research, Biological sciences, Health, Science and technology
Abstract

Abstract Chalcones xanthohumol (X) and desmethylxanthohumol (DMX), present in hops (Humulus lupulus L.), and the corresponding flavanones isoxanthohumol (IX, from X), 8-prenylnaringenin (8-PN, from DMX), and 6-prenylnaringenin (6-PN, from DMX), [...]

Published
2006

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