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1. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Author

Kocatürk, E., Salman, A. (Andaç), Cherrez-Ojeda, I. (Ivan), Ricardo Criado, P. (Paulo), Peter, J. (Jonny), Comert-Ozer, E. (Elif), Abuzakouk, M. (M.), Câmara Agondi, R. (Rosana), Al-Ahmad, M. (Mona), Altrichter, S. (Sabine), Arnaout, R. (Rand), Arruda, L.K. (Luisa Karla), Asero, R. (Riccardo), Bauer, A. (Andrea), Ben-Shoshan, M. (Moshe), Bernstein, J.A. (Jonathan A.), Bizjak, M. (Mojca), Boccon-Gibod, I. (Isabelle), Bonnekoh, H. (Hanna), Bouillet, L. (Laurence), Brzoza, Z. (Zenon), Busse, P. (Paula), Campos, R.A. (Regis A), Carne, E. (Emily), Conlon, N. (Niall), Criado, R.F. (Roberta F.), de Souza Lima, E.M. (Eduardo M.), Demir, S. (Semra), Dissemond, J. (Joachim), Doğan Günaydın, S. (Sibel), Dorofeeva, I. (Irina), Felipe Ensina, L. (Luis), Ertaş, R. (Ragıp), Mariel Ferrucci, S. (Silvia), Figueras-Nart, I. (Ignasi), Fomina, D. (Daria), Franken, S.M. (Sylvie M), Fukunaga, A. (Atsushi), Giménez-Arnau, A., Godse, K., Gonçalo, M. (Margarida), Gotua, M. (M.), Grattan, C., Guillet, C. (Carole), Inomata, N. (Naoko), Jakob, T. (Thilo), Karakaya, G. (Gul), Kasperska-Zając, A. (Alicja), Katelaris, C.H. (Constance H), Košnik, M. (Mitja), Krasowska, D. (Dorota), Kulthanan, K. (Kanokvalai), Sendhil Kumaran, M. (M.), Lang, C. (Claudia), Ignacio Larco-Sousa, J. (José), Lazaridou, E. (Elisavet), Anika Leslie, T. (Tabi), Lippert, U. (Undine), Calderón llosa, O. (Oscar), Makris, M. (Michael), Marsland, A. (Alexander), Medina, I.V. (Iris V.), Meshkova, R. (Raisa), Bastos Palitot, E. (Esther), Parisi, C.A.S. (Claudio A.S.), Pickert, J. (Julia), Ramon, G.D. (German D.), Rodríguez-Gonzalez, M. (Mónica), Rosario, N. (Nelson), Rudenko, M. (Michael), Rutkowski, K. (Krzysztof), Sánchez, J. (Jorge), Schliemann, S. (Sibylle), Sekerel, B.E. (Bulent Enis), Serpa, F.S. (Faradiba S.), Serra-Baldrich, E. (Esther), Song, Z. (Zhiqiang), Soria, A. (Angèle), Staevska, M. (Maria), Staubach, P. (Petra), Tagka, A. (Anna), Takahagi, S. (Shunsuke), Thomsen, S.F. (Simon Francis), Treudler, R. (Regina), Vadasz, Z. (Zahava), Oliveira Rodrigues Valle, S. (Solange), Doorn, M.B.A. (Martijn) van, Vestergaard, C. (C.), Wagner, N. (Nicola), Wang, D. (Dahu), Wang, L. (Liangchun), Wedi, B. (Bettina), Xepapadaki, P. (Paraskevi), Yücel, E. (Esra), Zalewska-Janowska, A. (Anna), Zhao, Z. (Zuotao), Zuberbier, T. (Torsten), Maurer, M. (Marcus), Kocatürk, E., Salman, A. (Andaç), Cherrez-Ojeda, I. (Ivan), Ricardo Criado, P. (Paulo), Peter, J. (Jonny), Comert-Ozer, E. (Elif), Abuzakouk, M. (M.), Câmara Agondi, R. (Rosana), Al-Ahmad, M. (Mona), Altrichter, S. (Sabine), Arnaout, R. (Rand), Arruda, L.K. (Luisa Karla), Asero, R. (Riccardo), Bauer, A. (Andrea), Ben-Shoshan, M. (Moshe), Bernstein, J.A. (Jonathan A.), Bizjak, M. (Mojca), Boccon-Gibod, I. (Isabelle), Bonnekoh, H. (Hanna), Bouillet, L. (Laurence), Brzoza, Z. (Zenon), Busse, P. (Paula), Campos, R.A. (Regis A), Carne, E. (Emily), Conlon, N. (Niall), Criado, R.F. (Roberta F.), de Souza Lima, E.M. (Eduardo M.), Demir, S. (Semra), Dissemond, J. (Joachim), Doğan Günaydın, S. (Sibel), Dorofeeva, I. (Irina), Felipe Ensina, L. (Luis), Ertaş, R. (Ragıp), Mariel Ferrucci, S. (Silvia), Figueras-Nart, I. (Ignasi), Fomina, D. (Daria), Franken, S.M. (Sylvie M), Fukunaga, A. (Atsushi), Giménez-Arnau, A., Godse, K., Gonçalo, M. (Margarida), Gotua, M. (M.), Grattan, C., Guillet, C. (Carole), Inomata, N. (Naoko), Jakob, T. (Thilo), Karakaya, G. (Gul), Kasperska-Zając, A. (Alicja), Katelaris, C.H. (Constance H), Košnik, M. (Mitja), Krasowska, D. (Dorota), Kulthanan, K. (Kanokvalai), Sendhil Kumaran, M. (M.), Lang, C. (Claudia), Ignacio Larco-Sousa, J. (José), Lazaridou, E. (Elisavet), Anika Leslie, T. (Tabi), Lippert, U. (Undine), Calderón llosa, O. (Oscar), Makris, M. (Michael), Marsland, A. (Alexander), Medina, I.V. (Iris V.), Meshkova, R. (Raisa), Bastos Palitot, E. (Esther), Parisi, C.A.S. (Claudio A.S.), Pickert, J. (Julia), Ramon, G.D. (German D.), Rodríguez-Gonzalez, M. (Mónica), Rosario, N. (Nelson), Rudenko, M. (Michael), Rutkowski, K. (Krzysztof), Sánchez, J. (Jorge), Schliemann, S. (Sibylle), Sekerel, B.E. (Bulent Enis), Serpa, F.S. (Faradiba S.), Serra-Baldrich, E. (Esther), Song, Z. (Zhiqiang), Soria, A. (Angèle), Staevska, M. (Maria), Staubach, P. (Petra), Tagka, A. (Anna), Takahagi, S. (Shunsuke), Thomsen, S.F. (Simon Francis), Treudler, R. (Regina), Vadasz, Z. (Zahava), Oliveira Rodrigues Valle, S. (Solange), Doorn, M.B.A. (Martijn) van, Vestergaard, C. (C.), Wagner, N. (Nicola), Wang, D. (Dahu), Wang, L. (Liangchun), Wedi, B. (Bettina), Xepapadaki, P. (Paraskevi), Yücel, E. (Esra), Zalewska-Janowska, A. (Anna), Zhao, Z. (Zuotao), Zuberbier, T. (Torsten), and Maurer, M. (Marcus)

Abstract

Introduction: The COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. Aim: To understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. Materials and Methods: Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. Results: The COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three pat

Published
2020
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2. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Author

Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Salman, A.; Cherrez-Ojeda, I.; Criado, P. R.; Peter, J.; Comert-Ozer, E.; Abuzakouk, M.; Agondi, R. C.; Al-Ahmad, M.; Altrichter, S.; Arnaout, R.; Arruda, L. K.; Asero, R.; Bauer, A.; Ben-Shoshan, M.; Bernstein, J. A.; Bizjak, M.; Boccon-Gibod, I.; Bonnekoh, H.; Bouillet, L.; Brzoza, Z.; Busse, P.; Campos, R. A.; Carne, E.; Conlon, N.; Criado, R. F.; Lima, E. M. D.; Demir, S.; Dissemond, J.; Gunaydin, S. D.; Dorofeeva, I.; Ensina, L. F.; Ertas, R.; Ferrucci, S. M.; Figueras-Nart, I.; Fomina, D.; Franken, S. M.; Fukunaga, A.; Gimenez-Arnau, A. M.; Godse, K.; Goncalo, M.; Gotua, M.; Grattan, C.; Guillet, C.; Inomata, N.; Jakob, T.; Karakaya, G.; Kasperska-Zajac, A.; Katelaris, C. H.; Kosnik, M.; Krasowska, D.; Kulthanan, K.; Kumaran, M. S.; Lang, C.; Larco-Sousa, J. I.; Lazaridou, E.; Leslie, T. A.; Lippert, U.; Llosa, O. C.; Makris, M.; Marsland, A.; Medina, I. V.; Meshkova, R.; Palitot, E. B.; Parisi, C. A. S.; Pickert, J.; Ramon, G. D.; Rodriguez-Gonzalez, M.; Rosario, N.; Rudenko, M.; Rutkowski, K.; Sanchez, J.; Schliemann, S.; Sekerel, B. E.; Serpa, F. S.; Serra-Baldrich, E.; Song, Z. Q.; Soria, A.; Staevska, M.; Staubach, P.; Tagka, A.; Takahagi, S.; Thomsen, S. F.; Treudler, R.; Vadasz, Z.; Valle, S. O. R.; Van Doorn, M. B. A.; Vestergaard, C.; Wagner, N.; Wang, D. H.; Wang, L. C.; Wedi, B.; Xepapadaki, P.; Yücel, E.; Zalewska-Janowska, A.; Zhao, Z. T.; Zuberbier, T.; Maurer, M., School of Medicine, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Salman, A.; Cherrez-Ojeda, I.; Criado, P. R.; Peter, J.; Comert-Ozer, E.; Abuzakouk, M.; Agondi, R. C.; Al-Ahmad, M.; Altrichter, S.; Arnaout, R.; Arruda, L. K.; Asero, R.; Bauer, A.; Ben-Shoshan, M.; Bernstein, J. A.; Bizjak, M.; Boccon-Gibod, I.; Bonnekoh, H.; Bouillet, L.; Brzoza, Z.; Busse, P.; Campos, R. A.; Carne, E.; Conlon, N.; Criado, R. F.; Lima, E. M. D.; Demir, S.; Dissemond, J.; Gunaydin, S. D.; Dorofeeva, I.; Ensina, L. F.; Ertas, R.; Ferrucci, S. M.; Figueras-Nart, I.; Fomina, D.; Franken, S. M.; Fukunaga, A.; Gimenez-Arnau, A. M.; Godse, K.; Goncalo, M.; Gotua, M.; Grattan, C.; Guillet, C.; Inomata, N.; Jakob, T.; Karakaya, G.; Kasperska-Zajac, A.; Katelaris, C. H.; Kosnik, M.; Krasowska, D.; Kulthanan, K.; Kumaran, M. S.; Lang, C.; Larco-Sousa, J. I.; Lazaridou, E.; Leslie, T. A.; Lippert, U.; Llosa, O. C.; Makris, M.; Marsland, A.; Medina, I. V.; Meshkova, R.; Palitot, E. B.; Parisi, C. A. S.; Pickert, J.; Ramon, G. D.; Rodriguez-Gonzalez, M.; Rosario, N.; Rudenko, M.; Rutkowski, K.; Sanchez, J.; Schliemann, S.; Sekerel, B. E.; Serpa, F. S.; Serra-Baldrich, E.; Song, Z. Q.; Soria, A.; Staevska, M.; Staubach, P.; Tagka, A.; Takahagi, S.; Thomsen, S. F.; Treudler, R.; Vadasz, Z.; Valle, S. O. R.; Van Doorn, M. B. A.; Vestergaard, C.; Wagner, N.; Wang, D. H.; Wang, L. C.; Wedi, B.; Xepapadaki, P.; Yücel, E.; Zalewska-Janowska, A.; Zhao, Z. T.; Zuberbier, T.; Maurer, M., and School of Medicine

Abstract

Introduction: the COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. Aim: to understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. Materials and methods: our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. Results: the COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three patients, with higher rates in patients with severe COVID-19. Conclusions: the COVID-19 pandemic brings major changes and challenges for CU patients and their physicians. The long-term consequences of these changes, especially the increased use of remote consultations, require careful evaluation., Novartis; Sanofi; Menarini Universidad Espiritu Santo; Takeda; Allakos; AstraZeneca; CSL Behring; Genentech; Pharming; GSK; Shire/Takada; BioCryst; ResTORbio; Pearl Therapeutics, CVS Health; Law offices of Levin; Riback; Adelman; Flangel; Vedder Price; Fresenius; Taiho; Kyowa Kirin; Tanabe; Korin; Uriach Pharma; Instituto Carlos III FEDER; Menarini; Amgen; Thermo Fisher; Avene; ALK‐Abello; Bencard/Allergy Therapeutics; Celgene; Allergopharma; Faes Farma; AbbVie; Janssen; Leo Pharma; Lilly; Roche; Genesis; Menlo Therapeutics; UCB; Pfizer; Almirall; Galderma; Allergika; Beiersdorf; Biocryst; Biogen Idec; BMS; Boehringer‐Ingelheim; Eli‐Lilly; Galderma; Hexal; Klosterfrau; LEO‐Pharma; LETI‐Pharma; L´Oreal; Medice; Octapharma; Pflüger; Pharming; Regeneron; Shire; ALK‐Abello; Fraunhofer‐IZI Leipzig; Hautnetz Leipzig/Westsachsen; MSD; HAL‐Allergy; Bencard; Nestle; Nutricia; Bayer Health Care; FAES; Henkel; Allakos; Argenx; Genentech Menarini; Moxie; Aralez; Celldex

Published
2020

3. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Author

Kocatürk, Emek, Salman, Andaç, Cherrez-Ojeda, Ivan, Criado, Paulo Ricardo, Peter, Jonny, Comert-Ozer, Elif, Abuzakouk, Mohamed, Câmara Agondi, Rosana, Al-Ahmad, Mona, Altrichter, Sabine, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Bauer, Andrea, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bizjak, Mojca, Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Busse, Paula, Campos, Regis A., Carne, Emily, Conlon, Niall, Criado, Roberta Fachini Jardim, De Souza Lima, Eduardo Magalhães, Demir, Semra, Dissemond, Joachim, Doğan Günaydın, Sibel, Dorofeeva, Irina, Ensina, Luis Felipe, Ertaş, Ragip, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fomina, Daria, Franken, Sylvie M., Fukunaga, Atsushi, Giménez Arnau, Ana M, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Guillet, Carole, Inomata, Naoko, Jakob, Thilo, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Košnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M.Sendhil, Lang, Claudia, Larco-Sousa, José Ignacio, Lazaridou, Elisavet, Leslie, Tabi Anika, Lippert, Undine, Calderón llosa, Oscar, Makris, Michael, Marsland, Alexander, Medina, Iris V., Meshkova, Raisa, Bastos Palitot, Esther, Parisi, Claudio A.S., Pickert, Julia, Ramon, Germán D., Rodríguez-Gonzalez, Mónica, Rosario, Nelson, Rudenko, Michael, Rutkowski, Krzysztof, Sánchez Caraballo, Jorge Mario, Schliemann, Sibylle, Sekerel, Bulent Enis, Serpa, Faradiba S., Serra-Baldrich, E, Song, Zhiqiang, Soria, Angèle, Staevska, Maria, Staubach, Petra, Tagka, Anna, Takahagi, Shunsuke, Thomsen, Simon Francis, Treudler, Regina, Vadasz, Zahava, Rodrigues Valle, Solange Oliveira, Van Doorn, Martijn B.A., Vestergaard, Christian, Wagner, Nicola, Wang, Dahu, Wang, Liangchun, Wedi, Bettina, Xepapadaki, Paraskevi, Yücel, Esra, Zalewska-Janowska, Anna, Zhao, Zuotao, Zuberbier, Torsten, Maurer, Marcus, Universitat Autònoma de Barcelona, Dermatology, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Salman, A., Cherrez-Ojeda, I., Criado, P. R., Peter, J., Comert-Ozer, E., Abuzakouk, M., Agondi, R. C., Al-Ahmad, M., Altrichter, S., Arnaout, R., Arruda, L. K., Asero, R., Bauer, A., Ben-Shoshan, M., Bernstein, J. A., Bizjak, M., Boccon-Gibod, I., Bonnekoh, H., Bouillet, L., Brzoza, Z., Busse, P., Campos, R. A., Carne, E., Conlon, N., Criado, R. F., Lima, E. M. D., Demir, S., Dissemond, J., Gunaydin, S. D., Dorofeeva, I., Ensina, L. F., Ertas, R., Ferrucci, S. M., Figueras-Nart, I., Fomina, D., Franken, S. M., Fukunaga, A., Gimenez-Arnau, A. M., Godse, K., Goncalo, M., Gotua, M., Grattan, C., Guillet, C., Inomata, N., Jakob, T., Karakaya, G., Kasperska-Zajac, A., Katelaris, C. H., Kosnik, M., Krasowska, D., Kulthanan, K., Kumaran, M. S., Lang, C., Larco-Sousa, J. I., Lazaridou, E., Leslie, T. A., Lippert, U., Llosa, O. C., Makris, M., Marsland, A., Medina, I. V., Meshkova, R., Palitot, E. B., Parisi, C. A. S., Pickert, J., Ramon, G. D., Rodriguez-Gonzalez, M., Rosario, N., Rudenko, M., Rutkowski, K., Sanchez, J., Schliemann, S., Sekerel, B. E., Serpa, F. S., Serra-Baldrich, E., Song, Z. Q., Soria, A., Staevska, M., Staubach, P., Tagka, A., Takahagi, S., Thomsen, S. F., Treudler, R., Vadasz, Z., Valle, S. O. R., Van Doorn, M. B. A., Vestergaard, C., Wagner, N., Wang, D. H., Wang, L. C., Wedi, B., Xepapadaki, P., Yücel, E., Zalewska-Janowska, A., Zhao, Z. T., Zuberbier, T., Maurer, M., School of Medicine, AII - Infectious diseases, Kocaturk, Emek, Salman, Andac, Cherrez-Ojeda, Ivan, Criado, Paulo Ricardo, Peter, Jonny, Comert-Ozer, Elif, Abuzakouk, Mohamed, Agondi, Rosana Camara, Al-Ahmad, Mona, Altrichter, Sabine, Arnaout, Rand, Arruda, Luisa Karla, Asero, Riccardo, Bauer, Andrea, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bizjak, Mojca, Boccon-Gibod, Isabelle, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Busse, Paula, Campos, Regis A., Carne, Emily, Conlon, Niall, Criado, Roberta F., de Souza Lima, Eduardo M., Demir, Semra, Dissemond, Joachim, Gunaydin, Sibel Dogan, Dorofeeva, Irina, Ensina, Luis Felipe, Ertas, Ragip, Ferrucci, Silvia Mariel, Figueras-Nart, Ignasi, Fomina, Daria, Franken, Sylvie M., Fukunaga, Atsushi, Gimenez-Arnau, Ana M., Godse, Kiran, Goncalo, Margarida, Gotua, Maia, Grattan, Clive, Guillet, Carole, Inomata, Naoko, Jakob, Thilo, Karakaya, Gul, Kasperska-Zajac, Alicja, Katelaris, Constance H., Kosnik, Mitja, Krasowska, Dorota, Kulthanan, Kanokvalai, Kumaran, M. Sendhil, Lang, Claudia, Ignacio Larco-Sousa, Jose, Lazaridou, Elisavet, Leslie, Tabi Anika, Lippert, Undine, Llosa, Oscar Calderon, Makris, Michael, Marsland, Alexander, Medina, Iris, V, Meshkova, Raisa, Palitot, Esther Bastos, Parisi, Claudio A. S., Pickert, Julia, Ramon, German D., Rodriguez-Gonzalez, Monica, Rosario, Nelson, Rudenko, Michael, Rutkowski, Krzysztof, Sanchez, Jorge, Schliemann, Sibylle, Sekerel, Bulent Enis, Serpa, Faradiba S., Serra-Baldrich, Esther, Song, Zhiqiang, Soria, Angele, Staevska, Maria, Staubach, Petra, Tagka, Anna, Takahagi, Shunsuke, Thomsen, Simon Francis, Treudler, Regina, Vadasz, Zahava, Rodrigues Valle, Solange Oliveira, Van Doorn, Martijn B. A., Vestergaard, Christian, Wagner, Nicola, Wang, Dahu, Wang, Liangchun, Wedi, Bettina, Xepapadaki, Paraskevi, Yucel, Esra, Zalewska-Janowska, Anna, Zhao, Zuotao, Zuberbier, Torsten, and Maurer, Marcus

Subjects
Male, 0301 basic medicine, STRESS, Exacerbation, UCARE, pandemije, Medizin, Omalizumab, SERUM, chronic urticaria, 0302 clinical medicine, Pandemic, Health care, Immunology and Allergy, Chronic Urticaria, treatment, Chronic urticaria, COVID-19, Cyclosporine, SARS-CoV-2, Treatment, zdravljenje, ASSOCIATION, Middle Aged, cyclosporine, omalizumab, pandemic, kronična urtikarija, INFECTIONS, GA(2)LEN, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), Immunology, udc:616-097, pandemics, ciklosporin, Young Adult, 03 medical and health sciences, Patient referral, medicine, Humans, In patient, Patient Reported Outcome Measures, Aged, Internet, business.industry, DEFINITION, Medicine, Allergy, Cross-Sectional Studies, 030104 developmental biology, 030228 respiratory system, Emergency medicine, business
Abstract

Introduction: the COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. Aim: to understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. Materials and methods: our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. Results: the COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three patients, with higher rates in patients with severe COVID-19. Conclusions: the COVID-19 pandemic brings major changes and challenges for CU patients and their physicians. The long-term consequences of these changes, especially the increased use of remote consultations, require careful evaluation., Novartis; Sanofi; Menarini Universidad Espiritu Santo; Takeda; Allakos; AstraZeneca; CSL Behring; Genentech; Pharming; GSK; Shire/Takada; BioCryst; ResTORbio; Pearl Therapeutics, CVS Health; Law offices of Levin; Riback; Adelman; Flangel; Vedder Price; Fresenius; Taiho; Kyowa Kirin; Tanabe; Korin; Uriach Pharma; Instituto Carlos III FEDER; Menarini; Amgen; Thermo Fisher; Avene; ALK‐Abello; Bencard/Allergy Therapeutics; Celgene; Allergopharma; Faes Farma; AbbVie; Janssen; Leo Pharma; Lilly; Roche; Genesis; Menlo Therapeutics; UCB; Pfizer; Almirall; Galderma; Allergika; Beiersdorf; Biocryst; Biogen Idec; BMS; Boehringer‐Ingelheim; Eli‐Lilly; Galderma; Hexal; Klosterfrau; LEO‐Pharma; LETI‐Pharma; L´Oreal; Medice; Octapharma; Pflüger; Pharming; Regeneron; Shire; ALK‐Abello; Fraunhofer‐IZI Leipzig; Hautnetz Leipzig/Westsachsen; MSD; HAL‐Allergy; Bencard; Nestle; Nutricia; Bayer Health Care; FAES; Henkel; Allakos; Argenx; Genentech Menarini; Moxie; Aralez; Celldex

Published
2021
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4. Netherton syndrome: Temporary response to dupilumab.

Author

Aktas M, Salman A, Apti Sengun O, Comert Ozer E, Hosgoren Tekin S, Akin Cakici O, Demir G, and Ergun T

Subjects
Antibodies, Monoclonal, Humanized, Humans, Hair Diseases, Ichthyosiform Erythroderma, Congenital, Netherton Syndrome diagnosis, Netherton Syndrome drug therapy, Netherton Syndrome genetics
Abstract

Netherton syndrome (NS) is an orphan disease characterized by congenital ichthyosis, hair abnormalities, and atopy, with limited treatment options. We achieved temporary improvement only during the initial 6 weeks of treatment with dupilumab, which differs from the sustained improvement observed in 2 other recently published cases. Although the clinical presentation of atopy and increased pre-allergic cytokines in NS patients suggest that dupilumab may be beneficial, larger studies are required., (© 2020 Wiley Periodicals LLC.)

Published
2020
Full Text
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