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Aim and Background: Due to the complications caused by overload on the cardiovascular system and the increase of these problems during old age, nowadays, combined exercises are used to reduce these complications. The aim of this study was to investigate the effect of eight weeks of combined exercises on the expression of HIF1, VEGF, UCP1 genes and the body composition of overweight elderly men. Materials and Methods: In this research; 20 elderly men randomly assigned to combined exercise group (10 people) and control group (10 people) with age range 60.70 ± 3.78 (years), weight 91.35 ± 2.66 (kg), height (meters) 1.74 ± 0.337, body mass index (kg/m2) 29.68 ± 1.67, fat mass (percent) 27.61 ± 1.22, muscle mass (kg) 30.03 ± 1.34 and The maximum oxygen consumption (milliliters/kg/minute) was 31.94 ± 2.25, were present. mixed group; They did resistance training for eight weeks and 3 sessions per week. In order to measure HIF1 and VEGF gene expression in white blood cells and PGC1a plasma levels, blood sampling was done 48 hours before the start of the first training session and also 48 hours after the last training session, while all subjects were fasting. Real-time PCR method was used to measure HIF1, VEGF and UCP1 gene expression. In order to analyze the data, independent and dependent t-test was used at a significance level of 0.05, with SPSS version 22 software. Findings: The results of the present study showed that eight weeks of combined exercises caused a significant increase in the expression of HIF1, VEGF, UCP1 genes. There was a significant decrease in fat mass and body mass index (P=0.001). Conclusion: The findings of this research showed that combined exercises with the model described in this research should be used to improve the physiological condition and improve the body composition of elderly people

Background and Objective: Sirtuin1 is one of the important indicators involved in metabolic control, obesity prevention, and homeostasis control. This study aimed to investigate the effect of combined exercises and curcumin consumption on metabolic indices and serum levels of Sirtuin1 in men with metabolic syndrome. Materials and Methods: The present study was conducted as a clinical trial in men with metabolic syndrome in three intervention groups and one control group. The people in the intervention group underwent an exercise program for 8 weeks and three sessions a week, the supplement group took 3 capsules of 500 mg daily. Blood factors were measured before and after the last training session. Data were analyzed by paired t-test, analysis of variance and covariance. Results: A significant difference was observed in the intra-group changes of the studied variables (Sirtuin1, HDL, LDL, TG, FBS, and TC) in all three intervention groups (P≥0.05). The results of analysis of covariance test showed a significant difference between the four groups in the indices (Sirtuin1, HDL, LDL, TG, FBS, and TC) after the test (P

Introduction: Chemerin and pentraxin 3 are involved in age-related metabolic disorders such as type 2 diabetes. The purpose of this study was to investigate the effect of 8 weeks of combined exercises (aerobic and resistance) along with the consumption of mulberry leaf extract supplement on the serum levels of chemerin and pentraxin 3 in elderly men with type 2 diabetes. Methods: In a clinical trial with a single-blind design, 40 elderly men with type 2 diabetes were randomly assigned to five groups: control, placebo, extract, exercise, and extract + exercise (8 people in each group). The exercises were done for eight weeks and three sessions for 90 minutes. 3000 ml of mulberry leaf extract per day was prescribed along with three main meals. Camerin and pentraxin 3 values were measured before the intervention and 48 hours after the last training session. Results: In the exercise, extract and exercise+extract groups, a significant decrease in the levels of chemerin (4/33%) and glucose (12/9%) and a significant increase in pentraxin 3 (4/12%) were observed (P<0/05). The results between groups showed a significant difference in the level of glucose (P=0/001), Chemerin (P=0/001) and Pentraxin 3 (P=0/001) and these changes in the extract + training group compared to the training groups And the extract isbigger. Conclusion: It seems that the administration of a combined program along with the consumption of mulberry leaf extract in diabetic elderly can have a positive effect on the improvement of cardiovascular inflammatory indicators affecting type 2 diabetes. [ABSTRACT FROM AUTHOR]

Background and Aim: High blood pressure and increased lipid profile are risk factors for cardiovascular diseases. To improve cardiovascular health, lifestyle changes should be considered as a guide to reduce people’s inactivity and modify healthy eating patterns. Spirulina is a green alga and has been considered as a food supplement for the treatment of various diseases. This study was conducted with the aim of determining the effect of spirulina supplement and eight weeks of combined exercises on blood pressure and lipid profile in women with high blood pressure. Materials and Methods: The study was conducted as a clinical trial in 40 women with high blood pressure (50-60 years old). People were included in the study in 4 intervention and control groups. The data were collected during two stages of pre-test and post-test in terms of changes in blood pressure and lipid profile. The supplement intervention group consumed 4.2 grams of spirulina supplement daily and had an exercise intervention of 8 weeks of combined aerobic and resistance exercises. Data analysis was conducted using SPSS software (version 23), one-way analysis of variance (ANOVA) and Tukey’s post hoc test at level 0.05. Results: The results of ANOVA showed that there was a significant difference between systolic blood pressure, total cholesterol, and VLDL, after the test, in the study groups (P-value

Background and Aim: High blood pressure and increased lipid profile are risk factors for cardiovascular diseases. To improve cardiovascular health, lifestyle changes should be considered as a guide to reduce people’s inactivity and modify healthy eating patterns. Spirulina is a green alga and has been considered as a food supplement for the treatment of various diseases. This study was conducted with the aim of determining the effect of spirulina supplement and eight weeks of combined exercises on blood pressure and lipid profile in women with high blood pressure. Materials and Methods: The study was conducted as a clinical trial in 40 women with high blood pressure (50-60 years old). People were included in the study in 4 intervention and control groups. The data were collected during two stages of pre-test and post-test in terms of changes in blood pressure and lipid profile. The supplement intervention group consumed 4.2 grams of spirulina supplement daily and had an exercise intervention of 8 weeks of combined aerobic and resistance exercises. Data analysis was conducted using SPSS software (version 23), one-way analysis of variance (ANOVA) and Tukey’s post hoc test at level 0.05. Results: The results of ANOVA showed that there was a significant difference between systolic blood pressure, total cholesterol, and VLDL, after the test, in the study groups (P-value<0.05). The highest mean ± standard deviation (SD) of systolic blood pressure (141.90±9.85), and total cholesterol (213.30±28.93), after the test, was observed in combined exercise group and the mean± SD of VLDL after the test (34.60±6.46) was observed in the control group. Also, the results of Tukey’s post hoc test showed that there was a significant difference between the mean blood pressure in the control groups-spirulina supplement, control-combined exercises, spirulina supplement-spirulina supplement and combined exercises, and combined exercises-spirulina supplement and combined exercises. Also, there was a significant difference between the mean of total cholesterol and VLDL in combined exercises-spirulina supplement, combined exercises, and control-spirulina supplement groups, respectively (P<0.05). Conclusion: It seems that the use of spirulina supplement and eight weeks of combined exercises may have beneficial effects on blood pressure and lipid profile in women with high blood pressure. [ABSTRACT FROM AUTHOR]

The study purpose was to identify the effects of a combination of plyometric exercises in the increasing leg and arm power abilities of volleyball athletes. Materials and methods. Forty students were involved in this study. They were students who were active in practicing volleyball, and then they were divided into four groups of 10 students each, namely (1) Squat thrust jumps and clap push-ups, (2) Squat thrust jumps and lateral push-ups, (3) Rope jumps and clap push-ups; and (4) Rope jumps and lateral push-ups. Then they practiced plyometrics three times a week for eight weeks. Statistical analysis used the t-test and the N-Gain Score using the Statistical Package for Social Science (SPSS) version 26 program. Results. The results of the combination of plyometric exercises stated that it had an effect on the muscle power of both the legs and arms (p<0.05); then, the results showed the combination of squat thrust and lateral push-up exercises was effective in increasing the ability of leg muscle power by 84.43% while the variety of squat thrust jump exercises and clap push-ups provide effectiveness in increasing arm muscle power by 25.23%. Conclusions. The variety of these two types of plyometric exercises was successful in helping volleyball athletes improve their vertical jump abilities. Still, from the results of this study, it was not very effective in increasing the capacity of arm muscle power. [ABSTRACT FROM AUTHOR]

Introduction The aim of this research was to investigate the changes of some growth factors following twelve weeks of combined exercises with and without blood flow restriction in young women. Material and Method The statistical population of this research was the inactive young women of Mashhad. Among them, 45 people were randomly divided into three groups of combined exercise + with blood flow restriction (15 people), combined exercise group + without blood flow restriction (15 people) and control group (15 people). The current research methodology was semi-experimental with a pre-test-post-test design. The combined training group did three resistance and aerobic training sessions per week. These exercises were done on consecutive days. The combined training group with blood flow restriction performed resistance training by closing the cuff and training intensity 20% of one maximum repetition at the beginning of the training and aerobic exercise with 45% maximum heart rate, and the combined training group without blood flow restriction, only resistance training with 80% 1RM and training They did aerobic exercise with 45% HRmax. The data were analyzed using t-correlated test, one-way analysis of variance test and Bonferroni's post hoc test at a significance level of P≥0.05 and SPSS software version 21. Results Statistical results show that twelve weeks of combined exercises with blood flow restriction and without blood flow restriction increases the levels of insulin-like factor 1, follistatin, platelet-derived factor and decreases myostatin in young women. Conclusion combined exercises with blood flow restriction can improve the physical condition and improve the physiological conditions of young women by making some changes affecting the growth factors. [ABSTRACT FROM AUTHOR]

Exercise not only regulates neurotransmitters and synapse formation but also enhances the function of multiple brain regions, beyond cortical activation. Prolonged aerobic or resistance exercise modality has been widely applied to reveal the beneficial effects on the brain, but few studies have investigated the direct effects of different exercise modalities and variations in exercise intensity on the neuroinflammatory response in the brain and overall health. Therefore, in this study, we investigated changes in brain cells and the immune environment of the brain according to exercise modalities. This study was conducted to confirm whether different exercise modalities affect the location and function of dopaminergic neurons, which are responsible for regulating voluntary movement, before utilizing animal models of disease. The results showed that high-intensity interval exercise (HIE) increased the activity of A2-reactive astrocytes in the striatum (STR), which is directly involved in movement control, resulting in neuroprotective effects. Both HIE and combined exercises (CE) increased the expression of dopamine transporter (DAT) in the STR without damaging dopamine neurons in the ventral midbrain (VM). This means that exercise training can help improve and maintain exercise capacity. In conclusion, specific exercise modalities or intensity of exercise may contribute to preventing neurodegenerative diseases such as Parkinson's disease or enhancing therapeutic effects when combined with medication for patients with neurodegenerative diseases. • Exercise activates neuroprotective glial cells in the striatum and ventral midbrain. • Exercise is involved in the activation of dopaminergic neurons in the striatum. • Parkinson's disease patients can improve their movement ability through exercise. [ABSTRACT FROM AUTHOR]

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Objective: Regular physical activity and the use of portulaca oleracea may be effective in treating liver disease. The purpose of this study was to assess the response of liver enzymes to both exercise and supplementation with Portulaca oleracea in obese postmenopausal women with Non-Alcoholic Fatty Liver Disease (NAFLD). Methods: Forty obese women with NAFLD were randomly divided into four groups of supplementation (n=10), combined exercise (n=10), placebo (n=10), and supplementation + exercise (n=10) after signing an informed consent form. Portulaca oleracea supplementation was taken as a 500 mg capsule daily before lunch and dinner. Combined exercise was performed for 12 weeks, 3 sessions per week each for 90 minutes. Liver enzymes were measured before and after the intervention. For statistical analysis, paired t-test and ANCOVA were used with a significance level set at P

Introduction: Metabolic syndrome is defined as a cluster of metabolic disorders, which may lead to type II diabetes and cardiovascular diseases. Promotion of healthy lifestyle and use of herbal supplements with anthocyanin and phenols are recommended for the treatment of metabolic syndrome. The present study aimed to investigate the effects of eight weeks of combined aerobic and resistance exercises and pomegranate concentrate consumption on the levels of HbA1c and C-peptide in women with metabolic syndrome. Methods: This study was conducted on 30 middle-aged­ women with metabolic syndrome, who were randomly assigned to two groups of exercise (E; n=15) and exercise with pomegranate concentrate (EPC; n=15). The exercise protocol was conducted at 60-80% intensity of the maximal heart rate and 60-80% of one-repetition maximum. Data analysis was performed in SPSS version 20 at the significance level of P≤0.05. Results: HbA1C levels significantly reduced in the EPC group (P0.05). In addition, the within-group comparison indicated no significant changes in the C-peptide levels in the E and EPC groups (P>0.05). Conclusion: According to the results, regular physical exercises along with the consumption of pomegranate concentrate could be effective in reducing HBA1c. Improving a number of metabolic syndrome indices (e.g., insulin resistance) could prevent the complications of metabolic syndrome in middle-aged women.

Introdution: The purpose of this study was to investigate the effect of twelve weeks of combined exercise with two patterns (aerobic-resistance and resistance-aerobic) on GLP-1 and insulin resistance in women with type 2 diabetes. Methods: In this practical and semi-experimental study, 42 women with type 2 diabetes were divided into three groups: aerobic-resistance group (n=15), resistance-aerobic group (n=15) and control group (n=15). Then, they were practiced three sessions a week for 12 weeks. The exercise protocol for both groups was the same and the only difference was in the sequence of exercises. The aerobic exercise protocol was 10×1 minutes active with one minute active rest between the sets with using a treadmill. Resistance exercises included movements such as leg press, bench press, seated leg extension, lat pulldown, and lying leg curl, seated shoulder press, which included the main muscles of the lower trunk and upper trunk and was done by the machine. Blood samples were prepared in the pre-test and 48 hours after the last exercise session in the post-test. The data were analyzed through SPSS version.16 (Inc., Chicago, IL); the results of analysis of variance and dependent t-Student were analyzed at the significance level (P0.05). Conclusion The results of this research show that combined exercises with increased levels of GLP-1 play an important role in the improving the status of insulin resistance in women with type 2 diabetes. However, more research is needed about different patterns of combined exercises.

Background and Aim: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities that insulin resistance and obesity are among its main causes. The purpose of this study was to investigate the effect of chronic aerobic and resistive exercises along with supplementation of cinnamon on insulin resistance in women with polycystic ovary syndrome in Ahwaz in 2017. Materials and Methods: In this semi-experimental study, 40 women with aged 18 to 30 years (BMI ≤24) were randomly divided into 4 groups. The intervention group performed 6 weeks, 3 sessions per week with intensity 50 to 75% of maximum heart rate for 50 to 85 minutes of exercise aerobic-resistance. Serum levels of insulin, glucose, and body composition indexes were evaluated. The t-test was correlated and ANCOVA was used. Ethical Considerations: This study with research ethics code EE/ 96.24.3.77886/Scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz, Iran. Findings: Data analysis showed that body mass index, fat percentage and insulin resistance were decreased in exercise and supplementation exercises (p≤0.05). Cinnamon was also effective in combination with combined exercises in body composition and insulin resistance index (p≤0.05). Changes in fat free mass were not significant in any of the groups (p≤0.05). Conclusion: It seems that this decrease in the difference in insulin resistance is more due to the combined exercise, and given the positive effect of cinnamon on reducing BMI, its use may be effective in the long term on insulin resistance.

Background: Betatrophin is a β-cell proliferation marker produced as a result of irisin expression. It is regarded as a therapeutic indicator of diabetes due to elevated insulin secretion. Objectives: The purpose of this study was to compare the effects of 2 different intensities of combined training on the levels of irisin, betatrophin, and insulin in women with type 2 diabetes. Methods: In this study, 26 female patients with type 2 diabetes were divided into 3 groups of combined high-intensity training, combined moderate-intensity training, and control. The training groups participated in combined training at high or moderate intensities for 8 weeks. The variance analysis test and the Duncan post-hoc test were applied to analyze the data (P > 0.05). Results: Combined training at 2 intensities of moderate and vigorous led to a rise in the levels of irisin, betatrophin, and insulin. Exercise intensity was a determining factor for these elevated levels insofar as combined high-intensity training resulted in higher levels of these hormones than combined moderate-intensity training. Conclusions: It appears that participating in relatively high-intensity training programs may be beneficial for diabetic patients inasmuch as they increase the levels of irisin, betatrophin, and then, insulin. [ABSTRACT FROM AUTHOR]

Introduction: Metabolic syndrome is defined as a cluster of metabolic disorders, which may lead to type II diabetes and cardiovascular diseases. Promotion of healthy lifestyle and use of herbal supplements with anthocyanin and phenols are recommended for the treatment of metabolic syndrome. The present study aimed to investigate the effects of eight weeks of combined aerobic and resistance exercises and pomegranate concentrate consumption on the levels of HbA1c and Cpeptide in women with metabolic syndrome. Methods: This study was conducted on 30 middle-aged women with metabolic syndrome, who were randomly assigned to two groups of exercise (E; n=15) and exercise with pomegranate concentrate (EPC; n=15). The exercise protocol was conducted at 60-80% intensity of the maximal heart rate and 60-80% of one-repetition maximum. Data analysis was performed in SPSS version 20 at the significance level of P=0.05. Results: HbA1C levels significantly reduced in the EPC group (P<0.05), while no significant difference was observed between the groups in terms of the C-peptide and HbA1C levels (P>0.05). In addition, the within-group comparison indicated no significant changes in the C-peptide levels in the E and EPC groups (P>0.05). Conclusion: According to the results, regular physical exercises along with the consumption of pomegranate concentrate could be effective in reducing HBA1c. Improving a number of metabolic syndrome indices (e.g., insulin resistance) could prevent the complications of metabolic syndrome in middle-aged women. [ABSTRACT FROM AUTHOR]

Background and Aim: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities that insulin resistance and obesity are among its main causes. The purpose of this study was to investigate the effect of chronic aerobic and resistive exercises along with supplementation of cinnamon on insulin resistance in women with polycystic ovary syndrome in Ahwaz in 2017. Materials and Methods: In this semi-experimental study, 40 women with aged 18 to 30 years (BMI ≤24) were randomly divided into 4 groups. The intervention group performed 6 weeks, 3 sessions per week with intensity 50 to 75% of maximum heart rate for 50 to 85 minutes of exercise aerobicresistance. Serum levels of insulin, glucose, and body composition indexes were evaluated. The t-test was correlated and ANCOVA was used. Ethical Considerations: This study with research ethics code EE/ 96.24.3.77886/Scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz, Iran. Findings: Data analysis showed that body mass index, fat percentage and insulin resistance were decreased in exercise and supplementation exercises (p≤0.05). Cinnamon was also effective in combination with combined exercises in body composition and insulin resistance index (p≤0.05). Changes in fat free mass were not significant in any of the groups (p≤0.05). Conclusion: It seems that this decrease in the difference in insulin resistance is more due to the combined exercise, and given the positive effect of cinnamon on reducing BMI, its use may be effective in the long term on insulin resistance. [ABSTRACT FROM AUTHOR]

Introduction: Irisin is a myokine released from a membrane protein FNDC5 and has positive effects on carbohydrate metabolism. The aim of this study was to compare the effect of two different intensities of combined training on serum irisin, FBS, HbA1c and insulin resistance. Materials and Methods: 26 patients with type 2 diabetes mellitus were divided into 3 groups, intense and moderate combined exercise and control group. The training groups participated in combination exercises with high or moderate intensity for 8 weeks. Exercise aerobic moderate intensity performed with 70 to 89% of HRmax, 75 minutes per week. Addition 2 day strength training with elastic band. Moderate exercise aerobic exercises were performed at 55-69% of HRmax, 150 minutes per week. and resistance training two days a week with elastic band. Blood samples were taken before exercise and 48 hours after the last session. Results: Combined exercise leading to increased irisin, decrease fasting blood glucose, HbA1c, and decreased insulin resistance in both experimental groups (P<0.05). Although the increase irisin hormone in intense training group was more than moderate group, but there was no significant difference in fasting blood glucose, HbA1c and insulin resistance between the two groups (P<0.05). Conclusion: Combined exercises are beneficial for increasing the level of irisin, reducing fasting blood glucose, HbA1c and decreasing insulin resistance, and therefore controlling diabetes. Moderate combination exercises can be used to improve glycemic conditions as an efficient method. [ABSTRACT FROM AUTHOR]

Background and Objectives: Several studies have showed that high levels of CRP and homocysteine increase the risk of coronary artery diseases. This study was aimed to investigate the effects of combined exercises on homocysteine, CRP and lipid profile in middle-aged inactive men. Materials and Methods: In this semi-empirical study, 24 subjects were selected by convenience sampling method. The cases were randomly assigned into two groups [experimental (n=12) and control (n=12)]. The aerobic training method included: 3 times a week, 20 minutes per session, with intensity of 60-70 percent of heart rate reserve. Also the resistance training program conducted by intensity of 70% one repetition maximum. Results: The levels of serum homocysteine and CRP after combined exercises were decreased significantly (P=0.001 and P=0.003, respectively). Although, TC, TG, HDL-C and LDL-C levels between both groups did not differed significantly. As well as, maximum oxygen consumption has increased significantly (P=0.008). Conclusion: It seems that combined exercise (aerobic and resistance) with reduction of homocysteine and CRP levels can used as a non-pharmacological methods to prevent the development of atherosclerosis. [ABSTRACT FROM AUTHOR]