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Full-waveforminversion (FWI) is not yet a mature imaging technology for lithospheric imaging from teleseismic data. Therefore, its promise and pitfalls need to be assessed more accurately according to the specifications of teleseismic experiments. Three important issues are related to (1) the choice of the lithospheric parametrization for optimization and visualization, (2) the initial model and (3) the acquisition design, in particular in terms of receiver spread and sampling. These three issues are investigated with a realistic synthetic example inspired by the CIFALPS experiment in the Western Alps. Isotropic elastic FWI is implemented with an adjoint-state formalism and aims to update three parameter classes byminimization of a classical least-squares difference-based misfit function. Three different subsurface parametrizations, combining density (ρ) with P and S wave speeds (Vp and Vs), P and S impedances (Ip and Is), or elastic moduli (λ and μ) are first discussed based on their radiation patterns before their assessment by FWI. We conclude that the (ρ, λ, μ) parametrization provides the FWI models that best correlate with the true ones after recombining a posteriori the (ρ, λ, μ) optimization parameters into Ip and Is. Owing to the lowfrequency content of teleseismic data, 1-D reference global models as PREM provide sufficiently accurate initial models for FWI after smoothing that is necessary to remove the imprint of the layering. Two kinds of station deployments are assessed: coarse areal geometry versus dense linear one. We unambiguously conclude that a coarse areal geometry should be favoured as it dramatically increases the penetration in depth of the imaging as well as the horizontal resolution. This results because the areal geometry significantly increases local wavenumber coverage, through a broader sampling of the scattering and dip angles, compared to a linear deployment. [ABSTRACT FROM AUTHOR]

ABSTRACT This study presents the main results of the geophysical survey of ancient Epomanduodurum, at Mandeure-Mathay, Eastern France. In northeastern Gaul, Epomanduodurum is a site of a major scientific interest for the understanding of past settlements and territorial formation at the end of the Iron Age and during the Roman period. The site, including a Roman urban centre and two suburbs containing workshops, occupies more than 500 ha inside and beyond a meander of the River Doubs. From the beginning of survey in 2001, several methods (fast electrical imaging automatic resistivity profiling system, ground penetrating radar, magnetic and electromagnetic mapping) have been performed on a large scale in order to precisely identify the vast extent and structure of the Roman town. The interpretation of the geophysical data was carried out using a combination of different data sources, including ancient maps and excavations recently conducted on restricted areas. The overall organization of an artisan quarter of 8 ha was revealed along a main Roman road leading to the left bank of the River Doubs. On the other bank, a river fortification and a vast monumental religious complex were recognized in the southern part of the Roman town. The geophysical imaging shows that the sacred area includes several temples or groups of temples radiating from the theatre. Other new buried structures probably corresponding to annexes, chapels and altars were also detected within this sacred area of 10 ha bound on three sides by a wall enclosure with monumental passages. In a surveyed area of 70 ha, geophysical prospecting techniques provided a clear overall image of the Roman urbanism revealed through a rectangular road network and street system delimiting insulae of variable sizes. The detection along the River Doubs of buildings similar to storehouses attests to fluvial transport and also suggests the likely existence of a port. More generally, the combination on a large scale of geophysical prospecting, aerial photographs and excavations allowed a new plan of the urban structure of the ancient town of Epomanduodurum to be produced for an area of over 300 ha. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background: Independent testing of home blood pressure (BP) measurement (HBPM) devices is often lacking, particularly among older and multi-morbid patients., Methods: We studied the Bpro G2 (using tonometry), Omron HeartGuide (using occlusive oscillometric technology), and Heartisans (using photoplethysmography) wrist watch HBPM devices against a gold standard brachial sphygmomanometer. To test device performance, we used the ISO81060-2 protocol (though this protocol cannot formally validate cuffless devices). We also used linear mixed models to compare adjusted longitudinal BP measurements between devices. Finally, as a surrogate for usability, we recorded instances of device failure where no BP measurement was returned., Results: We enrolled 128 participants (median [Q1-Q3] age 53 [40-65] years, 51% male, 46% on antihypertensive drugs), of whom 100 were suitable for the primary analysis. All three devices had mean BP values within 5 mmHg of sphygmomanometry. However, due to insufficient reliability (e.g., wider than accepted standard deviations of mean BP), none of the three devices passed all criteria required by the ISO81060-2 protocol. In adjusted longitudinal analyses, the Omron device also systematically underestimated systolic and diastolic BP (- 8.46 mmHg; 95% CI 6.07, 10.86; p < 0.001; and - 2.53 mmHg; 95% CI - 4.03, - 1.03; p = 0.001; respectively). Nevertheless, compared to the Omron device, BPro and Heartisans devices had increased odds of failure (BPro: odds ratio [OR] 5.24; p < 0.0001; Heartisans: OR 5.61; p < 0.001)., Conclusions: While we could not formally validate the cuffless devices, our results show that wearable technologies will require improvements to offer reliable BP assessment. This study also highlights the need for validation protocols specifically designed for cuffless BP measurement technologies., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)

Many youth with acute and chronic health conditions require medication to be administered during the school day. This policy statement offers guidance to school physicians, community prescribers, school nurses, other school health professionals, and groups providing oversight to school health activities and ensures patient safety and equity lenses are applied to administration of medications during school and for school-related activities. The American Academy of Pediatrics supports a robust collaborative model that allows all those involved in student health, including the student and family, to communicate, participate in effective medication management, inform delegated medication responsibilities, and promote safe medication storage and administration. School medication administration protocols are developed to help prevent medication administration errors specific to potential risks in the school setting and are responsive to the maturing students' evolving understanding of their health needs, growing autonomy, and responsibility. All protocols involving school nurses, unlicensed assistive personnel, and prescribers must be consistent with state and federal regulations on scope of practice, student privacy laws, and professional nursing organization guidelines. Consistent policies and messaging on safety of the patient and the entire school community enable school health teams to ensure equitable treatment of students prescribed therapeutic agents newly regulated by the US Food and Drug Administration, over-the-counter medications, or products that are currently not regulated by the US Food and Drug Administration., (Copyright © 2024 by the American Academy of Pediatrics.)

Mechanical cues such as stresses and strains are now recognized as essential regulators in many biological processes like cell division, gene expression or morphogenesis. Studying the interplay between these mechanical cues and biological responses requires experimental tools to measure these cues. In the context of large scale tissues, this can be achieved by segmenting individual cells to extract their shapes and deformations which in turn inform on their mechanical environment. Historically, this has been done by segmentation methods which are well known to be time consuming and error prone. In this context however, one doesn't necessarily require a cell-level description and a coarse-grained approach can be more efficient while using tools different from segmentation. The advent of machine learning and deep neural networks has revolutionized the field of image analysis in recent years, including in biomedical research. With the democratization of these techniques, more and more researchers are trying to apply them to their own biological systems. In this paper, we tackle a problem of cell shape measurement thanks to a large annotated dataset. We develop simple Convolutional Neural Networks (CNNs) which we thoroughly optimize in terms of architecture and complexity to question construction rules usually applied. We find that increasing the complexity of the networks rapidly no longer yields improvements in performance and that the number of kernels in each convolutional layer is the most important parameter to achieve good results. In addition, we compare our step-by-step approach with transfer learning and find that our simple, optimized CNNs give better predictions, are faster in training and analysis and don't require more technical knowledge to be implemented. Overall, we offer a roadmap to develop optimized models and argue that we should limit the complexity of such models. We conclude by illustrating this strategy on a similar problem and dataset., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Combe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the literature. This paper aims to present a review of the current literature on the clinical application of OCT-A in optometric practice as well as to analyse and evaluate the quality of the available evidence. This review included 78 articles from a literature search conducted on 26 May 2019 across the following databases: Cochrane Library of Systematic Reviews, Medline, Scopus and Web of Science. Primary ocular pathologies discussed in this review include glaucoma, diabetic retinopathy, age-related macular degeneration, myopia, acquired and congenital macular dystrophies, epiretinal membrane, retinal vein occlusion, retinitis pigmentosa, choroidal melanoma, uveitis, central serous chorioretinopathy, amblyopia and optic neuropathies. Primary outcome variables included vessel density, foveal avascular zone area and diameter, flow velocity and flow index. This review aims to evaluate the evidence available for OCT-A applications in diagnosis and prognosis of ocular conditions in an optometric setting.

The 2015 passage of the Every Student Succeeds Act (ESSA) provides state education agencies with more local control over educational planning, requires development of state accountability plans, and provides opportunities for advocacy surrounding school nursing-sensitive indicators of student success. Federal Title I, II, and IV funds are available for state and local education agency utilization in meeting educational needs of impoverished students and for development of high-quality instructional and support personnel. As Specialized Instructional Support Personnel, school nurses can utilize ESSA Title funding to positively impact chronic absenteeism, school climate, and school nurse staffing. ESSA can be a resource for funding school health services and professional education. This article will assist school nurses in better understanding ESSA and how funding is allocated to states and local education agencies.

This is a retrospective study of all patients presenting to our paediatric unit with status dystonicus (SD) over a period of five years. Anonymous information was collected and a descriptive analysis is made. There were four episodes of SD in three children between 11 and 15 years of age. All children are known to have severe dyskinetic cerebral palsy and presented with an acute or sub-acute deterioration in their symptoms. Symptoms were triggered by infections in three of the four episodes. Early features included frequent and repetitive generalized muscle spasms, poor swallowing, poor sleep, distress and pain. Patients responded to supportive treatment, rehydration, benzodiazepines, baclofen and l-dopa. Intensive care was not necessary in any of the patients and patients made full recovery within 5-14 days. This report shows the value of early recognition and treatment of SD can be successful in preventing serious complications., (Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)

Unlabelled: Refusal of care and support in these patients with Alzheimer's disease and related illnesses at home is a cause of accelerated loss of autonomy and increases the risk of a crisis with early institutionalization. Factors contributing to the denial of care are poorly understood and very few epidemiological data exist., Materials and Methods: we compared age, diagnosis, level of severity of the disease, the type of behavioral, family status of 101 patients living in denial of care and support as seen by a mobile home (group UPEPc) to 136 control patients seen at the memory clinic (group CM). Patients living in denial of care appear to significantly low age [82/80.5, p<0.0001], with more advanced disease [average MMSE 18/22, p<0.0001], the presence family conflicts and behavioral disorders [delirious--hallucination, agitation--aggression, depression, apathy, p<0.05]., Conclusion: the profile of patients refusing home care is specific and it is important to educate GPs conditions that favor an obstacle to medicalization. The advantage of a mobile extramural to analyze risk factors for refusal of care and propose alternatives should be further investigated.