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227 results on '"Comaneshter, D."'

10. Prediction of long-term diabetes remission after rygb, sleeve gastrectomy, and adjustable gastric banding using DiaRem and Advanced-DiaRem scores

Author

Dicker, D., Golan, R., Aron-Wisnewsky, J., Zucker, Jean-Daniel, Sokolowska, N., Comaneshter, D. S., Yahalom, R., Vinker, S., Clement, K., and Rudich, A.

Subjects
Bariatric surgery, Diabetes remission, Prediction score
Abstract

Purpose DiaRem is a clinical scoring system designed to predict diabetes remission (DR) 1-year post-Roux-en-Y gastric bypass (RYGB). We examined long-term (2- and 5-year) postoperative DR prediction by DiaRem and an advanced-DiaRem (Ad-DiaRem) score following RYGB, sleeve gastrectomy (SG), and gastric banding (GB). Methods We accessed data from a computerized database of persons with type 2 diabetes and BMI >= 30 kg/m(2) who underwent RYGB, SG, or GB, and determined DR status 2- and 5-year postoperative according to preoperative DiaRem and the Ad-DiaRem calculated scores. Results Among 1459 patients with 5-year postoperative diabetes status data, 53.6% exhibited DR. For RYGB, Ad-DiaRem trended to exhibit mildly improved predictive capacity 5-year postoperatively compared to DiaRem: Areas under receiver operating characteristic [AUROC] curves were 0.85 (0.76-0.93) and 0.78 (0.69-0.88), respectively. The positive predictive values (PPVs) detecting >80% of those achieving DR (i.e., sensitivity >= 0.8) were 78.2% and 73.2%, respectively, and higher Ad-DiaRem scores more consistently associated with decreased DR rates. Following SG, both scores had an AUROC of 0.82, but Ad-DiaRem still had a higher PPV for predicting >80% of those with 5-year postoperative DR (76.2% and 71.0%). Predictive capacity parameters were comparatively lower, for both scores, when considering DR 5-year post-GB (AUROC: 0.73 for both scores, PPV: 66.3% and 64.3%, respectively). Conclusions Ad-DiaRem provides modest improvement compared to DiaRem in predicting long-term DR 5-years post-RYGB. Both scores similarly provide fair predictive capacity for 5-year postoperative DR after SG.

Published
2019

16. 慢性荨麻疹和骨质疏松

Author

Shalom, G., primary, Kridin, K., additional, Babaev, M., additional, Magen, E., additional, Tiosano, S., additional, Dreiher, J., additional, Horev, A., additional, Khury, R., additional, Comaneshter, D., additional, Agmon‐Levin, N., additional, and Cohen, A.D., additional

Published
2019
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17. Chronic urticaria and osteoporosis

Author

Shalom, G., primary, Kridin, K., additional, Babaev, M., additional, Magen, E., additional, Tiosano, S., additional, Dreiher, J., additional, Horev, A., additional, Khury, R., additional, Comaneshter, D., additional, Agmon‐Levin, N., additional, and Cohen, A.D., additional

Published
2019
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19. The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass

Author

Aron-Wisnewsky, J., Sokolovska, N., Liu, Y. J., Comaneshter, D. S., Vinker, S., Pecht, T., Poitou, C., Oppert, J. M., Bouillot, J. L., Genser, L., Dicker, D., Zucker, Jean-Daniel, Rudich, A., and Clement, K.

Subjects
Bariatric surgery, Type 2 diabetesmellitus, Diabetes remission, Obese
Abstract

Aims/hypothesis Not all people with type 2 diabetes who undergo bariatric surgery achieve diabetes remission. Thus it is critical to develop methods for predicting outcomes that are applicable for clinical practice. The DiaRem score is relevant for predicting diabetes remission post-Roux-en-Y gastric bypass (RYGB), but it is not accurate for all individuals across the entire spectrum of scores. We aimed to develop an improved scoring system for predicting diabetes remission following RYGB (the Advanced-DiaRem [Ad-DiaRem]). Methods We used a retrospective French cohort (n = 1866) that included 352 individuals with type 2 diabetes followed for 1 year post-RYGB. We developed the Ad-DiaRemin a test cohort (n = 213) and examined its accuracy in independent cohorts from France (n = 134) and Israel (n = 99). Results Adding two clinical variables (diabetes duration and number of glucose-lowering agents) to the original DiaRem and modifying the penalties for each category led to improved predictive performance for Ad-DiaRem. Ad-DiaRem displayed improved area under the receiver operating characteristic curve and predictive accuracy compared with DiaRem (0.911 vs 0.856 and 0.841 vs 0.789, respectively; p = 0.03); thus correcting classification for 8% of those initially misclassified with DiaRem. With Ad-DiaRem, there were also fewer misclassifications of individuals with mid-range scores. This improved predictive performance was confirmed in independent cohorts. Conclusions/interpretation We propose the Ad-DiaRem, which includes two additional clinical variables, as an optimised tool with improved accuracy to predict diabetes remission 1 year post-RYGB. This tool might be helpful for personalised management of individuals with diabetes when considering bariatric surgery in routine care, ultimately contributing to precision medicine.

Published
2017

37. Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study.

Author

Kridin, K., Zelber-Sagi, S., Comaneshter, D., and Cohen, A. D.

Subjects
SCHIZOPHRENIA, AUTOIMMUNE diseases, PEMPHIGUS, UNIVARIATE analysis, MEDICAL care, T-test (Statistics)
Abstract

Aims.: Immunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database. Methods.: This study was conducted as a cross-sectional study utilising the database of Clalit Health Services. The proportion of schizophrenia was compared between patients diagnosed with pemphigus and age-, gender- and ethnicity-matched control subjects. Univariate analysis was performed using χ 2 and Student's t -test and a multivariate analysis was performed using a logistic regression model. Results.: A total of 1985 pemphigus patients and 9874 controls were included in the study. The prevalence of schizophrenia was greater in patients with pemphigus as compared to the control group (2.0% v. 1.3%, respectively; p = 0.019). In a multivariate analysis, pemphigus was significantly associated with schizophrenia (OR, 1.5; 95% CI, 1.1–2.2). The association was more prominent among females, patients older than 60 years, and Jews. Conclusions.: Pemphigus is significantly associated with schizophrenia. Physicians treating patients with pemphigus should be aware of this possible association. Patients with pemphigus should be carefully assessed for comorbid schizophrenia and be treated appropriately. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Musculoskeletal Manifestations of Cat Scratch Disease

Author

Maman, E., primary, Bickels, J., additional, Ephros, M., additional, Paran, D., additional, Comaneshter, D., additional, Metzkor-Cotter, E., additional, Avidor, B., additional, Varon-Graidy, M., additional, Wientroub, S., additional, and Giladi, M., additional

Published
2007
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48. Vaccination against influenza in patients with rheumatoid arthritis: the effect of rituximab on the humoral response

Author

Oren, S., primary, Mandelboim, M., additional, Braun-Moscovici, Y., additional, Paran, D., additional, Ablin, J., additional, Litinsky, I., additional, Comaneshter, D., additional, Levartovsky, D., additional, Mendelson, E., additional, Azar, R., additional, Wigler, I., additional, Balbir-Gurman, A., additional, Caspi, D., additional, and Elkayam, O., additional

Published
2007
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49. Cat-scratch disease-associated arthropathy.

Author

Giladi M, Maman E, Paran D, Bickels J, Comaneshter D, Avidor B, Varon-Graidy M, Ephros M, and Wientroub S

Abstract

OBJECTIVE: To characterize the articular manifestations of cat-scratch disease (CSD) and to evaluate the long-term clinical outcome of those manifestations. METHODS: A community- and hospital-based surveillance study of CSD was conducted in Israel between 1991 and 2002. CSD was defined as present in a patient when a compatible clinical syndrome and a positive confirmatory finding of Bartonella henselae (by serology and/or polymerase chain reaction) were identified. CSD patients with arthropathy (arthritis/arthralgia) that limited or precluded usual activities of daily living constituted the study group. Patients were followed up until > or =6 weeks after resolution of symptoms, or if symptoms persisted, for >/=12 months. CSD patients without arthropathy served as controls. RESULTS: Among 841 CSD patients, 24 (2.9%) had rheumatoid factor-negative arthropathy that was often severe and disabling. Both univariate and multivariate analyses identified female sex (67% of arthropathy patients versus 40% of controls; relative risk [RR] 2.5, P = 0.047), age older than 20 years (100% of arthropathy patients versus 43% of controls; RR 4.9, P = 0.001), and erythema nodosum (21% of arthropathy patients versus 2% of controls; RR 7.9, P = 0.001) as variables significantly associated with arthropathy. Knee, wrist, ankle, and elbow joints were most frequently affected. Ten patients (42%) had severe arthropathy in the weight-bearing joints, which substantially limited their ability to walk, and 4 of these patients were hospitalized. All of the patients had regional lymphadenopathy, 37.5% had nocturnal joint pain, and 25% had morning stiffness. Nineteen patients (79.2%) recovered after a median duration of 6 weeks (range 1-24 weeks), whereas 5 patients (20.8%) developed chronic disease persisting 16-53 months (median 30 months) after the onset of arthropathy. CONCLUSION: This is the first comprehensive study of arthropathy in CSD. CSD-associated arthropathy is an uncommon syndrome affecting mostly young and middle-age women. It is often severe and disabling, and may take a chronic course. [ABSTRACT FROM AUTHOR]

Published
2005
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