6 results on '"Colunga-Arguelles D"'
Search Results
2. Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry
- Author
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Garcia-Hernandez, FJ, Castillo-Palma, MJ, Tolosa-Vilella, C, Guillen-del Castillo, A, Rubio-Rivas, M, Freire, M, Vargas-Hitos, JA, Todoli-Parra, JA, Rodriguez-Carballeira, M, Espinosa-Garriga, G, Colunga-Arguelles, D, Ortego-Centeno, N, Trapiella-Martinez, L, Rodero-Roldan, MM, Pla-Salas, X, Perales-Fraile, I, del Campo, IPM, Chamorro, AJ, Gimenez, RAFD, Madronero-Vuelta, AB, Ruiz-Munoz, M, Fonollosa-Pla, V, Simeon-Aznar, CP, SSSG, Autoimmune Dis Study Grp GEAS, and Spanish Soc Internal Med SEMI more...
- Subjects
Anti-centromere antibodies ,Systemic sclerosis ,Pulmonary hypertension - Abstract
IntroductionOur objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors.MethodDescriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if 35mmHg. Left heart disease (LHD) and interstitial lung disease (ILD) were identified. When performed, data from right heart catheterisation (RHC) were collected.ResultsesPAP was elevated in 350 of 808 patients (43.3%). One hundred and forty-four patients (17.8%) were considered to have PH (88 via RHC and the rest due to elevated esPAP along with evidence of significant LHD or ILD): PAH 3.7%, secondary to ILD 8.3%, secondary to LHD 2.8% and unclassified 3%. Prevalence of elevated esPAP was greater in diffuse SSc (dSSc) than in limited scleroderma (lSSc) (50.5 vs. 42.2%, p 0.046). In the group with elevated esPAP, a lower prevalence of anti-centromere antibodies (41.9% vs. 52.3%, p 0.006) and a greater prevalence of anti-topoisomerase-1 antibodies (ATA) (25.1% vs. 18.6%, p 0.04) were observed compared to the group with normal esPAP. Patients with elevated esPAP had a lower rate of digital ulcers (50.6% vs. 60.2%, p 0.007) and esophageal involvement (83.6% vs. 88.7%, p 0.07) and higher rate of renal crisis (4.6% vs. 1.8%, p 0.066).ConclusionsPrevalence of PAH was lower than expected (3.7%). Probability of having elevated esPAP was higher among patients with dSSc and among those with ATA. more...
- Published
- 2019
Catalog
3. First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study (vol 37, pg 999, 2018)
- Author
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Rubio-Rivas, M, Corbella, X, Pestana-Fernandez, M, Tolosa-Vilella, C, Guillen-del Castillo, A, Colunga-Arguelles, D, Trapiella-Martinez, L, Iniesta-Arandia, N, Castillo-Palma, MJ, Saez-Comet, L, Egurbide-Arberas, MV, Ortego-Centeno, N, Freire, M, Vargas-Hitos, JA, Rios-Blanco, JJ, Todoli-Parra, JA, Rodriguez-Carballeira, M, Marin-Ballve, A, Segovia-Alonso, P, Pla-Salas, X, Madronero-Vuelta, AB, Ruiz-Munoz, M, Fonollosa-Pla, V, Simeon-Aznar, CP, and RESCLE Investigators more...
- Abstract
When first published, this article inadvertently listed the RESCLE investigators individually within the author list. The names should instead have been listed within the Acknowledgements section only. The corrected author list and the updated Acknowledgements section are presented in this Correction. more...
- Published
- 2018
4. Hepatobiliary involvement in systemic sclerosis and the cutaneous subsets: Characteristics and survival of patients from the Spanish RESCLE Registry
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Mari-Alfonso, B, Pilar Simeon-Aznar, Carmen, Guillen-Del Castillo, A, Rubio-Rivas, M, Trapiella-Martinez, L, Antonio Todoli-Parra, Jose, Rodriguez Carballeira, Monica, Marin-Ballve, A, Iniesta-Arandia, N, Colunga-Arguelles, D, Jesus Castillo-Palma, Maria, Saez-Comet, L, Victoria Egurbide-Arberas, Maria, Ortego-Centeno, N, Freire, M, Vargas Hitos, Jose Antonio, Chamorro, AJ, Belen Madronero-Vuelta, Ana, Perales-Fraile, I, Pla-Salas, X, Fernandez-De-La-Puebla, RA, Fonollosa-Pla, V, Tolosa-Vilella, C, RESCLE Investigators, and Systemic Autoimmune Dis Study Grp more...
- Subjects
integumentary system ,Hepatobiliary involvement ,Survival ,parasitic diseases ,Primary biliary cholangitis ,Systemic sclerosis ,SSc sine scleroderma ,skin and connective tissue diseases ,Autoimmune hepatitis - Abstract
Objective: To assess the prevalence and causes of hepatobiliary involvement (HBI) in systemic sclerosis (SSc), to investigate the clinical characteristics and prognosis of SSc patients with HBI (SSc-HBI) and without HBI (SSc-non-HBI), and to compare both groups according to the cutaneous SSc subsets. Methods: In all, 1572 SSc patients were collected in the RESCLE registry up to January 2015, and all hepatobiliary disturbances were recorded. We investigated the HBI-related characteristics and survival from the entire SSc cohort and according to the following cutaneous subsets: diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc). Results: Out of 1572, 118 (7.5%) patients had HBI. Primary biliary cholangitis (PBC) was largely the main cause (n = 67, 4.3%), followed by autoimmune hepatitis (n = 19, 1.2%), and anti-mitochondrial negative PBC (n = 6, 0.4%). Other causes of HBI were as follows: secondary liver diseases (n = 11, 0.7%), SSc-related HBI (n = 7, 0.4%), nodular regenerative hyperplasia (n = 3, 0.2%), liver cirrhosis (n = 3, 0.2%), and HBI of unknown origin (n = 2, 0.1%). In multivariate analysis, HBI was independently associated to lesser risk of dcSSc (5.1% vs. 24.4%), and higher frequency of calcinosis (26% vs. 18%), left ventricular diastolic dysfunction (46% vs. 27%), sicca syndrome (51% vs. 29%), and anti-centromere antibodies (ACA, 73% vs. 44%). According to the cutaneous subsets, HBI was associated (1) in lcSSc, to longer time from SSc onset to diagnosis (10.8 +/- 12.5 vs. 7.2 +/- 9.3 years), sicca syndrome (54% vs. 33%), and ACA (80% vs. 56%); (2) in ssSSc, to sicca syndrome (44% vs. 19%), and (3) in dcSSc, no associations were found. HBI was the cause of death in 23% patients but the cumulative survival according to the presence or absence of HBI showed no differences. Conclusions: HBI prevalence in SSc is 7.5% and dcSSc is the least involved subset. PBC is the main cause of HBI. Patients with SSc-HBI exhibited specific clinical and immunologic profile. Survival is similar for SSc patients with HBI (C). 2017 Elsevier Inc. All rights reserved. more...
- Published
- 2018
5. Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry
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Tolosa-Vilella, C, Morera-Morales, ML, Simeon-Aznar, CP, Mari-Alfonso, B, Colunga-Arguelles, D, Rubio, JLC, Rubio-Rivas, M, Freire-Dapena, M, Guillen-del Castillo, A, Iniesta-Arandia, N, Castillo-Palma, MJ, Egurbide-Arberas, M, Trapiellla-Martinez, L, Vargas-Hitos, JA, Todoli-Parra, JA, Rodriguez-Carballeira, M, Marin-Ballve, A, Pla-Salas, X, Rios-Blanco, JJ, Fonollosa-Pla, V, and RESCLE Investigators more...
- Subjects
Anti-centromere antibodies ,integumentary system ,Survival ,Anti-topoisomerase I antibodies ,Nailfold capillaroscopy ,Systemic sclerosis ,Limited cutaneous SSc ,SSc sine scleroderma ,Digital ulcers ,skin and connective tissue diseases ,Diffuse cutaneous SSc - Abstract
Objective: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc. Methods: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Demographics, organ involvement, autoimmunity features, nailfold capillary pattern, survival time, and causes of death were analyzed to identify DU related characteristics and survival of the entire series and according to the following cutaneous subsets diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc). Results: Out of 1326, 552 patients enrolled in the RESCLE registry had prior or current DU, 88% were women, the mean age was 50 +/- 16 years, and the mean disease duration from first SSc symptom was 7.6 +/- 9.6 years. Many significant differences were observed in the univariate analysis between patients with and without prior/current DU. Multivariate analysis identified that history of prior/current DU in patients with SSc was independently associated to younger age at SSc diagnosis, diffuse cutaneous SSc, peripheral vascular manifestations such Raynaud's phenomenon, telangiectasia, and acro-osteolysis but no other vascular features such as pulmonary arterial hypertension or scleroderma renal crisis. DU was also associated to calcinosis cutis, interstitial lung disease, as well as worse survival. Multivariate analysis performed in the cutaneous subsets showed that prior/current DU were independently associated: (1) in dcSSc, to younger age at SSc diagnosis, presence of telangiectasia and calcinosis and rarely a non-SSc pattern on nailfold capillaroscopy; (2) in lcSSc, to younger age at SSc diagnosis, presence of Raynaud's phenomenon as well as calcinosis cutis, interstitial lung disease, and higher incidence of death from all causes; and (3) in ssSSc, to younger age at first SSc symptom and greater incidence of death from all causes. Conclusions: Digital ulcers develop in patients with SSc younger at diagnosis, mainly in patients with dcSSc and IcSSc, and they are associated to other peripheral vascular manifestations such as Raynaud's phenomenon, telangiectasia, and acro-osteolysis but also to calcinosis, and interstitial lung disease. History of DU in SSc leads to worse survival, also noticeable for lcSSc and ssSSc subsets but not for dcSSc patients. (C) 2016 Elsevier Inc. All rights reserved. more...
- Published
- 2016
6. Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.
- Author
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Tolosa-Vilella C, Morera-Morales ML, Simeón-Aznar CP, Marí-Alfonso B, Colunga-Arguelles D, Callejas Rubio JL, Rubio-Rivas M, Freire-Dapena M, Guillén-Del Castillo A, Iniesta-Arandia N, Castillo-Palma MJ, Egurbide-Arberas M, Trapiellla-Martínez L, Vargas-Hitos JA, Todolí-Parra JA, Rodriguez-Carballeira M, Marin-Ballvé A, Pla-Salas X, Rios-Blanco JJ, and Fonollosa-Pla V more...
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Microscopic Angioscopy, Middle Aged, Registries, Scleroderma, Systemic mortality, Scleroderma, Systemic physiopathology, Skin Ulcer mortality, Skin Ulcer physiopathology, Spain epidemiology, Survival Rate, Scleroderma, Systemic complications, Skin Ulcer etiology
- Abstract
Objective: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc., Methods: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Demographics, organ involvement, autoimmunity features, nailfold capillary pattern, survival time, and causes of death were analyzed to identify DU related characteristics and survival of the entire series and according to the following cutaneous subsets-diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc)., Results: Out of 1326, 552 patients enrolled in the RESCLE registry had prior or current DU, 88% were women, the mean age was 50 ± 16 years, and the mean disease duration from first SSc symptom was 7.6 ± 9.6 years. Many significant differences were observed in the univariate analysis between patients with and without prior/current DU. Multivariate analysis identified that history of prior/current DU in patients with SSc was independently associated to younger age at SSc diagnosis, diffuse cutaneous SSc, peripheral vascular manifestations such Raynaud's phenomenon, telangiectasia, and acro-osteolysis but no other vascular features such as pulmonary arterial hypertension or scleroderma renal crisis. DU was also associated to calcinosis cutis, interstitial lung disease, as well as worse survival. Multivariate analysis performed in the cutaneous subsets showed that prior/current DU were independently associated: (1) in dcSSc, to younger age at SSc diagnosis, presence of telangiectasia and calcinosis and rarely a non-SSc pattern on nailfold capillaroscopy; (2) in lcSSc, to younger age at SSc diagnosis, presence of Raynaud's phenomenon as well as calcinosis cutis, interstitial lung disease, and higher incidence of death from all causes; and (3) in ssSSc, to younger age at first SSc symptom and greater incidence of death from all causes., Conclusions: Digital ulcers develop in patients with SSc younger at diagnosis, mainly in patients with dcSSc and lcSSc, and they are associated to other peripheral vascular manifestations such as Raynaud's phenomenon, telangiectasia, and acro-osteolysis but also to calcinosis, and interstitial lung disease. History of DU in SSc leads to worse survival, also noticeable for lcSSc and ssSSc subsets but not for dcSSc patients., (Copyright © 2016 Elsevier Inc. All rights reserved.) more...
- Published
- 2016
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