1. Clinical risk factors and Risk assessment model for Anastomotic leakage after Rectal cancer resection
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Ding, Rui, He, Ming, Cen, Hong, Chen, Zheng, and Su, Yonghui
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Oncology, Experimental -- Health aspects ,Obesity -- Health aspects ,Metronidazole -- Health aspects ,Colorectal cancer -- Health aspects ,Risk assessment -- Health aspects ,Cancer -- Research ,Surgery -- Health aspects ,Health - Abstract
Background: Anastomotic leakage (AL) is the most serious complication after rectal cancer surgery. Risk factors associated with AL have been documented in previous studies; however, the consensus is still lacking. In this retrospective study, we aimed to identify risk factors for AL after rectal cancer resection and to create an accurate and effective tool for predicting the risk of this complication. Methods: The study cohort comprised of 276 patients with rectal cancer who had undergone anterior resection between 2015 and 2020. Twenty-four selected variables were assessed by univariate and multivariate logistic regression analyses to identify independent risk factors of AL. A risk assessment model for predicting the risk of AL was established on the basis of the regression coefficients of each identified independent risk factor. Results: Anastomotic leakage occurred in 20 patients (7.2%, 20/276). Multivariate analysis identified the following variables as independent risk or protective factors of AL: perioperative ileus (P < 0.001, odds ratio [OR] = 14.699), tumor size ≥5 cm (P = 0.025, OR = 3.925), distance between tumor and anal verge Conclusions: Our risk assessment model accurately and effectively identified patients at high risk of AL and could be useful in aiding decision-making aimed at minimizing adverse outcomes associated with leakage. Keywords: Anastomotic leakage, rectal cancer, risk assessment model, Author(s): Rui Ding [1]; Ming He [1]; Hong Cen [1]; Zheng Chen [1]; Yonghui Su (corresponding author) [1] Introduction Colorectal cancer is one of the commonest malignant tumors, ranking third [...]
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- 2024
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