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5,515 results on '"Colombo, M"'

1. Measurements of Reconfigurable Intelligent Surface in 5G System Within a Reverberation Chamber at mmWave

Author

Bastianelli, L., Diamanti, R., Colella, E., Primiani, V. Mariani, Moglie, F., Toubal, M. A., Odit, M., Gros, J. -B., Nasser, Y., Lerosey, G., Santamaria, L., Allasia, A., Crozzoli, M., Boldi, M., Zimaglia, E., Lieti, V., Colombo, M., and Micheli, D.

Subjects
Physics - Applied Physics
Abstract

In this paper we evaluated the performance of a reconfigurable intelligent surface tested with a fifth generation signal provided by a commercial fifth generation base station. We adopted a reverberation chamber as a real life propagating environment. Tests were conducted at the millimeter wave frequency range. This measurement campaign was carried out under the H2020 European project RISE-6G and a collaboration program between TIM S.p.A., Nokia and Universit\`a Politecnica delle Marche., Comment: Accepted at EuCAP 2024

Published
2023

2. FRC Plates Design in Bending: From the Italian Code to EC2

Author

Pourzarabi, A., Colombo, M., di Prisco, M., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, and Menegotto, Marco, editor

Published
2024
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5. Development of digitally obtainable 10-year risk scores for depression and anxiety in the general population

Author

Morelli, D., Dolezalova, N., Ponzo, S., Colombo, M., and Plans, D.

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

The burden of depression and anxiety in the world is rising. Identification of individuals at increased risk of developing these conditions would help to target them for prevention and ultimately reduce the healthcare burden. We developed a 10-year predictive algorithm for depression and anxiety using the full cohort of over 400,000 UK Biobank (UKB) participants without pre-existing depression or anxiety using digitally obtainable information. From the initial 204 variables selected from UKB, processed into > 520 features, iterative backward elimination using Cox proportional hazards model was performed to select predictors which account for the majority of its predictive capability. Baseline and reduced models were then trained for depression and anxiety using both Cox and DeepSurv, a deep neural network approach to survival analysis. The baseline Cox model achieved concordance of 0.813 and 0.778 on the validation dataset for depression and anxiety, respectively. For the DeepSurv model, respective concordance indices were 0.805 and 0.774. After feature selection, the depression model contained 43 predictors and the concordance index was 0.801 for both Cox and DeepSurv. The reduced anxiety model, with 27 predictors, achieved concordance of 0.770 in both models. The final models showed good discrimination and calibration in the test datasets.We developed predictive risk scores with high discrimination for depression and anxiety using the UKB cohort, incorporating predictors which are easily obtainable via smartphone. If deployed in a digital solution, it would allow individuals to track their risk, as well as provide some pointers to how to decrease it through lifestyle changes., Comment: 13 pages, 2 figures, 2 tables

Published
2021

8. AB1374 DEUCRAVACITINIB IN PLAQUE PSORIASIS: MAINTENANCE OF RESPONSE OVER 3 YEARS

Author

Strober, B., primary, Sofen, H., additional, Imafuku, S., additional, Paul, C., additional, Gooderham, M., additional, Spelman, L., additional, Seo, S. J., additional, Passeron, T., additional, Kisa, R. M., additional, Berger, V., additional, Vritzali, E., additional, Hoyt, K., additional, Colombo, M. J., additional, Banerjee, S., additional, Augustin, M., additional, Stein Gold, L., additional, Alexis, A., additional, Thaçi, D., additional, Blauvelt, A., additional, and Lebwohl, M., additional

Published
2024
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9. POS0543 KINETICS OF MUCOCUTANEOUS AND MUSCULOSKELETAL RESPONSES TO DEUCRAVACITINIB IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) IN THE PHASE 2 PAISLEY TRIAL

Author

Van Vollenhoven, R. F., primary, Merola, J. F., additional, Dao, K. H., additional, Leszczyński, P., additional, Pike, M., additional, Pomponi, S., additional, Hobar, C., additional, Colombo, M. J., additional, Koti, R., additional, Banerjee, S., additional, Wegman, T., additional, and Morand, E., additional

Published
2024
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10. T.02.7: VARIABILITY IN COMPUTER-AIDED DETECTION EFFECT ON ADENOMA DETECTION RATE IN RANDOMIZED CONTROLLED TRIALS: A META-REGRESSION ANALYSIS

Author

Spadaccini, M., primary, Hassan, C., additional, Mori, Y., additional, Facciorusso, A., additional, Rizkala, T., additional, Massimi, D., additional, Maselli, R., additional, Patel, H.K., additional, Khalaf, K., additional, Ramai, D., additional, Rondonotti, E., additional, Radaelli, F., additional, Fugazza, A., additional, Colombo, M., additional, De Marco, A., additional, Franchellucci, G., additional, Rex, D.K., additional, Abdelrahim, M., additional, Bhandari, P., additional, Sharma, P., additional, and Repici, A., additional

Published
2024
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11. BOC.02.5: IMPACT OF EUS-GUIDED BILIARY DRAINAGE ON THE MANAGEMENT OF DIFFICULT BILIARYACCESS IN PATIENTS WITH DISTAL MALIGNANT BILIARY OBSTRUCTION

Author

Spadaccini, M., primary, Colombo, M., additional, Giacchetto, C.M., additional, Andreozzi, M., additional, Carrara, S., additional, De Marco, A., additional, Franchellucci, G., additional, Terrin, M., additional, Binda, C., additional, Mauro, A., additional, Fabbri, C., additional, Anderloni, A., additional, Hassan, C., additional, Repici, A., additional, and Fugazza, A., additional

Published
2024
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12. Palliation of Gastric Outflow Obstruction in Case of Biliary Obstruction Previously Treated with EUS-Guided-Choledochoduodenostomy. A Retrospective, Multicenter Study: The B-GOOD Study

Author

Fugazza, A., additional, Andreozzi, M., additional, Binda, C., additional, Lisotti, A., additional, Tarantino, I., additional, Vila, J. J., additional, Robles-Medranda, C., additional, Amato, A., additional, Larghi, A., additional, Perez-Cuadrado Robles, E., additional, Di Matteo, F., additional, Badas, R., additional, Aragona, G., additional, Barbera, C., additional, Mangiavillano, B., additional, Crinò, S. F., additional, Colombo, M., additional, Spadaccini, M., additional, Fabbri, C., additional, Facciorusso, A., additional, Anderloni, A., additional, and Repici, A., additional

Published
2024
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13. BD-IPMN surveillance: a real-life experience from an Italian level III center

Author

Terrin, M., additional, Poletti, V., additional, Mercurio, M., additional, Minini, F., additional, Spertino, M., additional, Cataldo, D. P., additional, Bonifacio, C., additional, Spadaccini, M., additional, Colombo, M., additional, Spaggiari, P., additional, Sollai, M., additional, Andreozzi, M., additional, Rossi, R. E., additional, Bozzarelli, S., additional, Fugazza, A., additional, Repici, A., additional, Zerbi, A., additional, and Carrara, S., additional

Published
2024
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14. Variability in Computer-Aided Detection effect on Adenoma Detection Rate in randomized controlled trials: a meta-regression analysis

Author

Spadaccini, M., additional, Yuichi, M., additional, Hassan, C., additional, Antonio, F., additional, Rizkala, T., additional, Massimi, D., additional, Roberta, M., additional, Patel, H., additional, Kareem, K., additional, Ramai, D., additional, Emanuele, R., additional, Radaelli, F., additional, Fugazza, A., additional, Colombo, M., additional, Alessandro, D. M., additional, franchellucci, G., additional, Rex, D. K., additional, Abdelrahim, M., additional, Pradeep, B., additional, Prateek, S., additional, and Repici, A., additional

Published
2024
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15. OC.10.5: PALLIATION OF GASTRIC OUTFLOW OBSTRUCTION IN CASE OF BILIARY OBSTRUCTION. A RETROSPECTIVE, MULTICENTER STUDY: THE B-GOOD STUDY

Author

Fugazza, A., primary, Andreozzi, M., additional, Binda, C., additional, Lisotti, A., additional, Tarantino, I., additional, J Vila, J., additional, Medranda, C.R., additional, Amato, A., additional, Larghi, A., additional, Enrique Perez, C.R., additional, Di Matteo, F.M., additional, Badas, R., additional, Aragona, G., additional, Barbera, C., additional, Mangiavillano, B., additional, Crinò, S.F., additional, Colombo, M., additional, Spadaccini, M., additional, Fabbri, C., additional, Facciorusso, A., additional, Anderloni, A., additional, and Repici, A., additional

Published
2024
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16. OC.17.9: PIECEMEAL LIFTING + COLD SNARING EMR FOR LARGE PROXIMAL COLONIC ADENOMAS: A SINGLE CENTER PRELIMINARY RESULTS

Author

Maselli, R., primary, Fiacca, M., additional, Massimi, D., additional, Capogreco, A., additional, De Sire, R., additional, Alfarone, L., additional, De Blasio, F., additional, Galtieri, P.A., additional, Spadaccini, M., additional, Fugazza, A., additional, Colombo, M., additional, Hassan, C., additional, and Repici, A., additional

Published
2024
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17. A New Pre-Sealing Technique Reduces the Use of Coagulation Forceps in Third-Space Endoscopy: One-Stop Shopping

Author

Capogreco, A., additional, De Blasio, F., additional, Massimi, D., additional, de Sire, R., additional, Alfarone, L., additional, Galtieri, A., additional, Fiacca, M., additional, Spadaccini, M., additional, Alessandro, F., additional, Carrara, S., additional, Colombo, M., additional, Antonio, F., additional, Maselli, R., additional, Hassan, C., additional, and Repici, A., additional

Published
2024
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18. Impact of EUS-guided biliary drainage on the management of difficult biliary cannulation in patients with distal malignant biliary obstruction

Author

Spadaccini, M., additional, Giacchetto, M. C., additional, Colombo, M., additional, Andreozzi, M., additional, Carrara, S., additional, Alessandro, D. M., additional, franchellucci, G., additional, Terrin, M., additional, Binda, C., additional, Mauro, A., additional, Massimi, D., additional, Roberta, M., additional, Capogreco, A., additional, Galtieri, A., additional, Pellegatta, G., additional, Fabbri, C., additional, Anderloni, A., additional, Hassan, C., additional, Repici, A., additional, and Fugazza, A., additional

Published
2024
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19. T.09.1: A NEW PRE-SEALING TECHNIQUE REDUCES THE USE OF COAGULATION FORCEPS IN THIRD SPACE ENDOSCOPY: ONE-STOP SHOPPING

Author

Capogreco, A., primary, De Blasio, F., additional, Massimi, D., additional, De Sire, R., additional, Alfarone, L., additional, Galtieri, P.A., additional, Fiacca, M., additional, Spadaccini, M., additional, Fugazza, A., additional, Carrara, S., additional, Colombo, M., additional, Facciorusso, A., additional, Maselli, R., additional, Hassan, C., additional, and Repici, A., additional

Published
2024
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22. PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study

Author

Willacker, L., Raiser, T. M., Bassi, M., Bender, A., Comanducci, A., Rosanova, M., Sobel, N., Arzi, A., Belloli, L., Casarotto, S., Colombo, M., Derchi, C. C., Fló Rama, E., Grill, E., Hohl, M., Kuehlmeyer, K., Manasova, D., Rosenfelder, M. J., Valota, C., and Sitt, J. D.

Published
2022
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23. Real-Life Clinical Data of Lenvatinib versus Sorafenib for Unresectable Hepatocellular Carcinoma in Italy

Author

Burgio V, Iavarone M, Di Costanzo GG, Marra F, Lonardi S, Tamburini E, Piscaglia F, Masi G, Celsa C, Foschi FG, Silletta M, Amoruso DC, Rimini M, Bruccoleri M, Tortora R, Campani C, Soldà C, Viola MG, Forgione A, Conti F, Salani F, Catanese S, Giacchetto CM, Fulgenzi C, Coppola C, Lampertico P, Pellino A, Rancatore G, Cabibbo G, Ratti F, Pedica F, Della Corte A, Colombo M, De Cobelli F, Aldrighetti L, Cascinu S, and Casadei-Gardini A

Subjects
hepatocarcinoma, sorafenib, lenvatinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Valentina Burgio,1 Massimo Iavarone,2 Giovanni Giuseppe Di Costanzo,3 Fabio Marra,4 Sara Lonardi,5,6 Emiliano Tamburini,7 Fabio Piscaglia,8 Gianluca Masi,9,10 Ciro Celsa,11 Francesco Giuseppe Foschi,12 Marianna Silletta,13 Daniela Caterina Amoruso,14 Margherita Rimini,15 Mariangela Bruccoleri,2 Raffaella Tortora,3 Claudia Campani,4 Caterina Soldà,6 Massimo Giuseppe Viola,16 Antonella Forgione,8 Fabio Conti,12 Francesca Salani,9,10 Silvia Catanese,9,10 Carmelo Marco Giacchetto,17 Claudia Fulgenzi,13 Carmine Coppola,14 Pietro Lampertico,18 Antonio Pellino,6,19 Gabriele Rancatore,17 Giuseppe Cabibbo,17 Francesca Ratti,20 Federica Pedica,21 Angelo Della Corte,22 Massimo Colombo,18 Francesco De Cobelli,23 Luca Aldrighetti,20 Stefano Cascinu,1,23 Andrea Casadei-Gardini1,23 1Department of Medical Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 2Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, Milan, Italy; 3Department of Hepatology, Naples, 80131, Italy; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Firenze, Italy; 5Early Phase Clinical Trial Unit, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy; 6Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy; 7Department of Oncology and Palliative Care, Cardinale Hospital, Naples, Italy; 8Division of Internal Medicine, Hepatobiliary and Immunoallergic Disease, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 9Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; 10Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; 11Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, 90127, Italy; 12Internal Medicine, Infermi Hospital, Faenza (AUSL ROMAGNA), Ravenna, Italy; 13Department of Oncology, Campus Bio Medico, Roma, Italy; 14Hepatology Unit, Internal Medicine, Area Stabiese Hospital, Naples, Italy; 15Department of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, Modena, 4121, Italy; 16Department of General Surgery and Emergency Surgery, Cardinale Hospital, Tricase, Italy; 17Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, 90127, Italy; 18Liver Center, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 19Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; 20Hepatobiliary Surgery Division, Liver Center, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 21Department of Experimental Oncology, Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 22Department of Radiology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 23School of Medicine, Vita-Salute San Raffaele University, Milan, 20132, ItalyCorrespondence: Andrea Casadei-GardiniDepartment of Medical Oncology, IRCCS San Raffaele Hospital, Via Olgettina n. 60, Milan, ItalyEmail casadeigardini@gmail.comBackground: Lenvatinib has been approved in Italy since October 2019 as a first-line therapy for advanced hepatocellular carcinoma (HCC) and to date data on effectiveness and safety of lenvatinib are not available in our region. To fill this gap, we performed a multicentric analysis of the real-world treatment outcomes with the propensity score matching in a cohort of Italian patients with unresectable HCC who were treated with either sorafenib or lenvatinib.Aims and Methods: To evaluate the effectiveness of sorafenib and lenvatinib as primary treatment of advanced HCC in clinical practice we performed a multicentric analysis of the treatment outcomes of 288 such patients recruited in 11 centers in Italy. A propensity score was used to mitigate confounding due to referral biases in the assessment of mortality and progression-free survival.Results: Over a follow-up period of 11 months the Cox regression model showed 48% reduction of death risk for patients treated with lenvatinib (95% CI: 0.34– 0.81; p = 0.0034), compared with those treated with sorafenib. The median PFS was 9.0 and 4.9 months for lenvatinib and sorafenib arm, respectively. Patients treated with lenvatinib showed a higher percentage of response rate (29.4% vs 2.8%; p < 0.00001) compared with patients treated with sorafenib. Sorafenib was shown to be correlated with more HFSR, diarrhea and fatigue, while lenvatinib with more hypertension and fatigue.Conclusion: Our study highlighted for the first time the efficacy and safety of lenvatinib in an Italian cohort of patients.Keywords: hepatocarcinoma, sorafenib, lenvatinib

Published
2021

24. Surgical and new generation imaging tips and tricks to maximize robotic radical prostatectomy outcomes

Author

Piramide, F., primary, Amparore, D., additional, Checcucci, E., additional, De Cillis, S., additional, Piana, A., additional, Volpi, G., additional, Sica, M., additional, Verri, P., additional, Burgio, M., additional, Meziere, J., additional, Busacca, G., additional, Cisero, E., additional, Marsero, L., additional, Quarà, A., additional, Colombo, M., additional, Mandaletti, M., additional, Garzena, V., additional, Ribolzi, B., additional, Manfredi, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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26. Use of TYTOCARE device for home telemonitoring in patients undergoing radical cystectomy: Comparative analysis of early post-operative outcomes

Author

Amparore, D., primary, Quarà, A., additional, De Cillis, S., additional, Colombo, M., additional, Garzena, V., additional, Verri, P., additional, Poggio, M., additional, Checcucci, E., additional, Piana, A., additional, Piramide, F., additional, Volpi, G., additional, Sica, M., additional, Burgio, M., additional, Meziere, J., additional, Marsero, L., additional, Sterrantino, A., additional, Ziani, N., additional, Turcan, A., additional, Manfredi, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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27. Robotic assisted partial nephrectomy with metaverse based surgical planning: A single center preliminary experience

Author

Piramide, F., primary, De Cillis, S.T., additional, Amparore, D., additional, Checcucci, E., additional, Piana, A., additional, Volpi, G., additional, Sica, M., additional, Verri, P., additional, Burgio, M., additional, Meziere, J., additional, Quarà, A., additional, Cisero, E., additional, Busacca, G., additional, Marsero, L., additional, Colombo, M., additional, Mandaletti, M., additional, Mesterca, A.G., additional, Ortenzi, M., additional, Ribolzi, B.S., additional, Di Dio, M., additional, Manfredi, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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28. 3D augmented reality robot-assisted segmental ureterectomy with buccal mucosa graft repair: Technique description and short-term outcomes

Author

Piramide, F., primary, Piana, A., additional, Amparore, D., additional, Manfredi, M., additional, Checcucci, E., additional, Alessio, P., additional, De Cillis, S.T., additional, Volpi, G., additional, Sica, M., additional, Verri, P., additional, Burgio, M., additional, Meziere, J., additional, Quara’, A., additional, Cisero, E., additional, Busacca, G., additional, Marsero, L., additional, Colombo, M., additional, Mesterca, A.G., additional, Sterrantino, A., additional, Ribolzi, B.S., additional, Di Dio, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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29. The ILY® robotic system for flexible ureteroscopy: First Italian case series in a single center

Author

Cossu, M., primary, Quarà, A., additional, Poggio, M., additional, De Cillis, S., additional, Amparore, D., additional, Checcucci, E., additional, Piana, A., additional, Piramide, F., additional, Volpi, G., additional, Verri, P., additional, Sica, M., additional, Burgio, M., additional, Cisero, E., additional, Colombo, M., additional, Ferrando, L., additional, Rosi, F., additional, Manfredi, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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30. Functional and endoscopic outcomes after aquablation procedure for BPH-related LUTS: Results after 2 years of follow-up in a prospective cohort

Author

De Cillis, S.T., primary, De Luca, S., additional, Amparore, D., additional, Quarà, A., additional, Sica, M., additional, Ortenzi, M., additional, Burgio, M., additional, Cisero, E., additional, Colombo, M., additional, Verri, P., additional, Ferrando, L., additional, Trapella, G., additional, Ziani, N., additional, Piramide, F., additional, Manfredi, M., additional, Poggio, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2024
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34. Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study

Author

Tarasconi, A., Sella, M., Auriemma, S., Paternò, G., Faggian, G., Lucarelli, C., De Grazia, N., Alberto, C., Margola, A., Porcella, L., Nardiello, I., Chimenti, E., Zeni, M., Giani, A., Famularo, S., Romairone, E., Minaglia, C., Ceccotti, C., Guerra, G., Mantovani, G., Monacelli, F., Candiani, T., Ballestrero, A., Santolini, F., Rosso, M., Bono, V., Sibilla, S., Dal Santo, P., Ceci, M., Barone, P., Schirinzi, T., Formenti, A., Nastasi, G., Isaia, G., Gonella, D., Battuello, A., Casson, S., Calvani, D., Boni, F., Ciaccio, A., Rosa, R., Sanna, G., Manfredini, S., Cortese, L., Rizzo, M., Prestano, R., Greco, A., Lauriola, M., Gelosa, G., Piras, V., Arena, M., Cosenza, D., Bellomo, A., LaMontagna, M., Gabbani, L., Lambertucci, L., Perego, S., Parati, G., Basile, G., Gallina, V., Pilone, G., Giudice, C., De, F., Pietrogrande, L., De, B., Mosca, M., Corazzin, I., Rossi, P., Nunziata, V., D'Amico, F., Grippa, A., Giardini, S., Barucci, R., Cossu, A., Fiorin, L., Distefano, M., Lunardelli, M., Brunori, M., Ruffini, I., Abraham, E., Varutti, A., Fabbro, E., Catalano, A., Martino, G., Leotta, D., Marchet, A., Dell'Aquila, G., Scrimieri, A., Davoli, M., Casella, M., Cartei, A., Polidori, G., Brischetto, D., Motta, S., Saponara, R., Perrone, P., Russo, G., Del, D., Car, C., Pirina, T., Franzoni, S., Cotroneo, A., Ghiggia, F., Volpi, G., Menichetti, C., Bo, M., Panico, A., Calogero, P., Corvalli, G., Mauri, M., Lupia, E., Manfredini, R., Fabbian, F., March, A., Pedrotti, M., Veronesi, M., Strocchi, E., Borghi, C., Bianchetti, A., Crucitti, A., DiFrancesco, V., Fontana, G., Bonanni, L., Barbone, F., Serrati, C., Ballardini, G., Simoncelli, M., Ceschia, G., Scarpa, C., Brugiolo, R., Fusco, S., Ciarambino, T., Biagini, C., Tonon, E., Porta, M., Venuti, D., DelSette, M., Poeta, M., Barbagallo, G., Trovato, G., Delitala, A., Arosio, P., Reggiani, F., Zuliani, G., Ortolani, B., Mussio, E., Girardi, A., Coin, A., Ruotolo, G., Castagna, A., Masina, M., Cimino, R., Pinciaroli, A., Tripodi, G., Cannistrà, U., Cassadonte, F., Vatrano, M., Scaglione, L., Fogliacco, P., Muzzuilini, C., Romano, F., Padovani, A., Rozzini, L., Cagnin, A., Fragiacomo, F., Desideri, G., Liberatore, E., Bruni, A., Orsitto, G., Franco, M., Bonfrate, L., Bonetto, M., Pizio, N., Magnani, G., Cecchetti, G., Longo, A., Bubba, V., Marinan, L., Cotelli, M., Turla, M., Sessa, M., Abruzzi, L., Castoldi, G., LoVetere, D., Musacchio, C., Novello, M., Cavarape, A., Bini, A., Leonardi, A., Seneci, F., Grimaldi, W., Fimognari, F., Bambara, V., Saitta, A., Corica, F., Braga, M., Ettorre, E., Camellini, C., Bellelli, G., Annoni, G., Marengoni, A., Crescenzo, A., Noro, G., Turco, R., Ponzetto, M., Giuseppe, L., Mazzei, B., Maiuri, G., Costaggiu, D., Damato, R., Formilan, M., Patrizia, G., Gallucci, M., Paragona, M., Bini, P., Modica, D., Abati, C., Clerici, M., Barbera, I., NigroImperiale, F., Manni, A., Votino, C., Castiglioni, C., Di, M., Degl'Innocenti, M., Moscatelli, G., Guerini, S., Casini, C., Dini, D., D'Imporzano, E., DeNotariis, S., Bonometti, F., Paolillo, C., Riccardi, A., Tiozzo, A., DiBari, M., Vanni, S., Scarpa, A., Zara, D., Ranieri, P., Alessandro, M., Di, F., Pezzoni, D., Platto, C., D'Ambrosio, V., Ivaldi, C., Milia, P., DeSalvo, F., Solaro, C., Strazzacappa, M., Cazzadori, M., Confente, S., Grasso, M., Troisi, E., Guerini, V., Bernardini, B., Corsini, C., Boffelli, S., Filippi, A., Delpin, K., Faraci, B., Bertoletti, E., Vannucci, M., Tesi, F., Crippa, P., Malighetti, A., Bettini, D., Maltese, F., Abruzzese, G., Cosimo, D., Azzini, M., Colombo, M., Procino, G., Fascendini, S., Barocco, F., Del, P., Mazzone, A., Riva, E., Dell'Acqua, D., Cottino, M., Vezzadini, G., Avanzi, S., Brambilla, C., Orini, S., Sgrilli, F., Mello, A., Lombardi, L., Muti, E., Dijk, B., Fenu, S., Pes, C., Gareri, P., Passamonte, M., Rigo, R., Locusta, L., Caser, L., Rosso, G., Cesarini, S., Cozzi, R., Santini, C., Carbone, P., Cazzaniga, I., Lovati, R., Cantoni, A., Ranzani, P., Barra, D., Pompilio, G., Dimori, S., Cernesi, S., Riccò, C., Piazzolla, F., Capittini, E., Rota, C., Gottardi, F., Merla, L., Barelli, A., Millul, A., De, G., Morrone, G., Bigolari, M., Macchi, M., Zambon, F., Pizzorni, C., DiCasaleto, G., Menculini, G., Marcacci, M., Catanese, G., Sprini, D., DiCasalet, T., Bocci, M., Borga, S., Caironi, P., Cat, C., Cingolani, E., Avalli, L., Greco, G., Citerio, G., Gandini, L., Cornara, G., Lerda, R., Brazzi, L., Simeone, F., Caciorgna, M., Alampi, D., Francesconi, S., Beck, E., Antonini, B., Vettoretto, K., Meggiolaro, M., Garofalo, E., Notaro, S., Varutti, R., Bassi, F., Mistraletti, G., Marino, A., Rona, R., Rondelli, E., Riva, I., Scapigliati, A., Cortegiani, A., Vitale, F., Pistidda, L., D'Andrea, R., Querci, L., Gnesin, P., Todeschini, M., Lugano, M., Castelli, G., Ortolani, M., Cotoia, A., Maggiore, S., DiTizio, L., Graziani, R., Testa, I., Ferretti, E., Castioni, C., Lombardi, F., Caserta, R., Pasqua, M., Simoncini, S., Baccarini, F., Rispoli, M., Grossi, F., Cancelliere, L., Carnelli, M., Puccini, F., Biancofiore, G., Siniscalchi, A., Laici, C., Mossello, E., Torrini, M., Pasetti, G., Palmese, S., Oggioni, R., Mangani, V., Pini, S., Martelli, M., Rigo, E., Zuccalà, F., Cherri, A., Spina, R., Calamai, I., Petrucci, N., Caicedo, A., Ferri, F., Gritti, P., Brienza, N., Fonnesu, R., Dessena, M., Fullin, G., Saggioro, D., Morandi, Alessandro, Inzitari, Marco, Udina, Cristina, Gual, Neus, Mota, Miriam, Tassistro, Elena, Andreano, Anita, Cherubini, Antonio, Gentile, Simona, Mossello, Enrico, Marengoni, Alessandra, Olivé, Anna, Riba, Francesc, Ruiz, Domingo, de Jaime, Elisabet, and Bellelli, Giuseppe

Published
2021
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35. 99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Treatment of HER2-Positive Breast Cancer

Author

Rainone P, De Palma A, Sudati F, Roffia V, Rigamonti V, Salvioni L, Colombo M, Ripamonti M, Spinelli AE, Mazza D, Mauri P, Moresco RM, Prosperi D, and Belloli S

Subjects
her2-positive bc, targeted silica nanoparticles, tz-half chain conjugation, 99mtc-radiolabeling, spect imaging, doxorubicin-loaded nanoparticles, Medicine (General), R5-920
Abstract

Paolo Rainone,1– 3 Antonella De Palma,4 Francesco Sudati,5 Valentina Roffia,4 Valentina Rigamonti,6 Lucia Salvioni,6 Miriam Colombo,6 Marilena Ripamonti,2 Antonello Enrico Spinelli,7 Davide Mazza,7 Pierluigi Mauri,4 Rosa Maria Moresco,1,2,7 Davide Prosperi,6 Sara Belloli2,7 1Department of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy; 2Institute of Molecular Bioimaging and Physiology of CNR, Segrate, 20090, Italy; 3Doctorate School of Molecular and Translational Medicine, University of Milan, Milan, Italy; 4Institute of Biomedical Technologies of CNR, Segrate, 20090, Italy; 5PET and Nuclear Medicine Unit, San Raffaele Scientific Institute, Milan, 20132, Italy; 6NanoBioLab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, 20126, Italy; 7Experimental Imaging Center, San Raffaele Scientific Institute, Milan, 20132, ItalyCorrespondence: Sara BelloliInstitute of Molecular Bioimaging and Physiology of CNR, Via Fratelli Cervi 93, Segrate, 20090, ItalyTel +39 02 26433640Fax +39 02 26432717Email belloli.sara@hsr.itIntroduction: The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. Functionalized silica-based nanocarriers (SiNPs) can be labeled for in vivo imaging applications and loaded with chemotherapy drugs, making possible the simultaneous noninvasive diagnosis and treatment (theranostic) for HER2-positive BC.Methods: Firstly, FITC-filled SiNPs, were engineered with two different amounts of Hc-TZ (trastuzumab half-chain) per single nanoparticle (1:2 and 1:8, SiNPs to Hc-TZ ratio), which was 99mTc-radiolabeled at histidine residues for ex vivo and in vivo biodistribution evaluations. Secondly, nanoparticles were loaded with DOX and their in vitro and ex vivo/in vivo delivery was assessed, in comparison with liposomal Doxorubicin (Caelyx). Finally, the treatment efficacy of DOX-SiNPs-TZ (1:8 Hc-TZ) was evaluated in vivo by PET and supported by MS-based proteomics profiling of tumors.Results: SiNPs-TZ (1:8 Hc-TZ) tumor uptake was significantly greater than that of SiNPs-TZ (1:2 Hc-TZ) at 6 hours post-injection (p.i.) in ex vivo biodistribution experiment. At 24 h p.i., radioactivity values remained steady. Fluorescence microscopy, confirmed the presence of radiolabeled SiNPs-TZ (1:8 Hc-TZ) within tumor even at later times. SiNPs-TZ (1:8 Hc-TZ) nanoparticles loaded with Doxorubicin (DOX-SiNPs-TZ) showed a similar DOX delivery capability than Caelyx (at 6 h p.i.), in in vitro and ex vivo assays. Nevertheless, at the end of treatment, tumor volume was significantly reduced by DOX-SiNPs-TZ (1:8 Hc-TZ), compared to Caelyx and DOX-SiNPs treatment. Proteomics study identified 88 high stringent differentially expressed proteins comparing the three treatment groups with controls.Conclusion: These findings demonstrated a promising detection specificity and treatment efficacy for our system (SiNPs-TZ, 1:8 Hc-TZ), encouraging its potential use as a new theranostic agent for HER2-positive BC lesions. In addition, proteomic profile confirmed that a set of proteins, related to tumor aggressiveness, were positively affected by targeted nanoparticles.Keywords: HER2-positive BC, targeted silica nanoparticles, TZ-half chain conjugation, 99mTc-radiolabeling, SPECT imaging, doxorubicin-loaded nanoparticles

Published
2021

36. Anti-MAdCAM-1-Conjugated Nanocarriers Delivering Quantum Dots Enable Specific Imaging of Inflammatory Bowel Disease

Author

Truffi M, Sevieri M, Morelli L, Monieri M, Mazzucchelli S, Sorrentino L, Allevi R, Bonizzi A, Zerbi P, Marchini B, Longhi E, Sampietro GM, Colombo F, Prosperi D, Colombo M, and Corsi F

Subjects
polymeric nanoparticles, adhesion molecule, targeted imaging, Medicine (General), R5-920
Abstract

Marta Truffi,1 Marta Sevieri,2 Lucia Morelli,3 Matteo Monieri,2 Serena Mazzucchelli,2 Luca Sorrentino,2 Raffaele Allevi,2 Arianna Bonizzi,2 Pietro Zerbi,2 Beatrice Marchini,2 Erika Longhi,2 Gianluca Matteo Sampietro,4 Francesco Colombo,4 Davide Prosperi,3 Miriam Colombo,3 Fabio Corsi2,5 1Nanomedicine and Molecular Imaging Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia 27100, Italy; 2Department of Biomedical and Clinical Sciences “Luigi Sacco, Università degli studi di Milano, Milano, 20157, Italy; 3NanoBioLab, Department of Biotechnology and Biosciences, Università degli studi di Milano-Bicocca, Milano, 20126, Italy; 4IBD Surgery Unit, ASST Fatebenefratelli Sacco - Ospedale “Luigi Sacco” Polo Universitario, Milano, 20157, Italy; 5Surgery Department, Breast Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, 27100, ItalyCorrespondence: Fabio CorsiSurgery Department, Breast Unit, Istituti Clinici Scientifici Maugeri IRCCS, via Maugeri 4, Pavia 27100, ItalyTel +39 02 5031 9850Fax +39 02 5031 9846Email fabio.corsi@icsmaugeri.itPurpose: Assessment of inflammatory bowel disease (IBD) currently relies on aspecific clinical signs of bowel inflammation. Specific imaging of the diseased bowel regions is still lacking. Here, we investigate mucosal addressin cell adhesion molecule 1 (MAdCAM-1) as a reliable and specific endothelial target for engineered nanoparticles delivering imaging agents to obtain an exact mapping of diseased bowel foci.Materials and Methods: We generated a nanodevice composed of PLGA-PEG coupled with anti-MAdCAM-1 antibody half-chains and loaded with quantum dots (P@QD-MdC NPs). Bowel localization and systemic biodistribution of the nanoconjugate were analyzed upon injection in a murine model of chronic IBD obtained through repeated administration of dextran sulfate sodium salt. Specificity for diseased bowel regions was also assessed ex vivo in human specimens from patients with IBD. Potential for development as contrast agent in magnetic resonance imaging was assessed by preliminary study on animal model.Results: Synthesized nanoparticles revealed good stability and monodispersity. Molecular targeting properties were analyzed in vitro in a cell culture model. Upon intravenous injection, P@QD-MdC NPs were localized in the bowel of colitic mice, with enhanced accumulation at 24 h post-injection compared to untargeted nanoparticles (p< 0.05). Nanoparticles injection did not induce histologic lesions in non-target organs. Ex vivo exposure of human bowel specimens to P@QD-MdC NPs revealed specific recognition of the diseased regions vs uninvolved tracts (p< 0.0001). After loading with appropriate contrast agent, the nanoparticles enabled localized contrast enhancement of bowel mucosa in the rectum of treated mice.Conclusion: P@QD-MdC NPs efficiently detected bowel inflammation foci, accurately following the expression pattern of MAdCAM-1. Fine-tuning of this nanoconjugate with appropriate imaging agents offers a promising non-invasive tool for specific IBD diagnosis.Keywords: polymeric nanoparticles, inflamed bowel, adhesion molecule, targeted imaging

Published
2020

45. A tertiary care center experience in salvage robotic-assisted radical prostatectomy after High-Intensity Focused Ultrasound (HIFU)

Author

Piana, A., primary, De Cillis, S., additional, De Luca, S., additional, Checcucci, E., additional, Amparore, D., additional, Piramide, F., additional, Volpi, G., additional, Sica, M., additional, Zamengo, D., additional, Cisero, E., additional, Colombo, M., additional, Gatti, C., additional, Sterrantino, A., additional, Mesterca, A.G., additional, Rosi, F., additional, Garino, D., additional, Venezia, A., additional, Manfredi, M., additional, Fiori, C., additional, and Porpiglia, F., additional

Published
2023
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46. Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study

Author

Cova E, Pandolfi L, Colombo M, Frangipane V, Inghilleri S, Morosini M, Mrakic-Sposta S, Moretti S, Monti M, Pignochino Y, Benvenuti S, Prosperi D, Stella G, Morbini P, and Meloni F

Subjects
Gold nanoparticles, nano-drug delivery, mesothelioma, pemetrexed, intrapleural delivery, Medicine (General), R5-920
Abstract

Emanuela Cova,1 Laura Pandolfi,1 Miriam Colombo,2 Vanessa Frangipane,1 Simona Inghilleri,1 Monica Morosini,1 Simona Mrakic-Sposta,3 Sarah Moretti,3 Manuela Monti,4 Ymera Pignochino,5 Silvia Benvenuti,5 Davide Prosperi,2,6 Giulia Stella,1 Patrizia Morbini,7 Federica Meloni8 1Clinic of Lung Diseases, IRCCS Foundation Policlinico San Matteo, Pavia, Italy; 2Deparment of Biotechnology and Bioscience, University of Milano - Bicocca, Milan, Italy; 3National Council of Research, Institute of Bioimaging and Molecular Physiology, Segrate, Milan, Italy; 4Laboratory of Biotechnology, Research Center of Rigenerative Medicine, IRCCS Foundation Policlinico San Matteo, Pavia, Italy; 5Experimental Clinical Molecular Oncology, IRCCS Candiolo Cancer Institute-FPO, Candiolo, Turin, Italy; 6Laboratory of Nanomedicine, Clinical Institute of Maugeri, S.p.A., Pavia, Italy; 7Department of Molecular Medicine, Pathology Unit, IRCCS Foundation Policlinico San Matteo, Pavia, Italy; 8Department of Internal Medicine, Pneumology Unit, University of Pavia, Pavia, Italy Purpose: Malignant pleural mesothelioma (MPM) is an aggressive tumor characterized by poor prognosis. Its incidence is steadily increasing due to widespread asbestos exposure. There is still no effective therapy for MPM. Pemetrexed (Pe) is one of the few chemotherapeutic agents approved for advanced-stage disease, although the objective response to the drug is limited. The use of gold nanoparticles (GNPs) as a drug delivery system promises several advantages, including specific targeting of malignant cells, with increased intracellular drug accumulation and reduced systemic toxicity, and, in the case of MPM, direct treatment administration into the pleural space. This study aims at exploring CD146 as a potential MPM cell-specific target for engineered Pe-loaded GNPs and to assess their effectiveness in inhibiting MPM cell line growth.Methods: MPM cell lines and primary cultures obtained by pleural effusions from MPM patients were assayed for CD146 expression by flow cytometry. Internalization by MPM cell lines of fluorescent dye-marked GNPs decorated with a monoclonal anti CD146 coated GNPs (GNP-HC) was proven by confocal microscopy. The effects of anti CD146 coated GNPs loaded with Pe (GNP-HCPe) on MPM cell lines were evaluated by cell cycle (flow cytometry), viability (MTT test), clonogenic capacity (soft agar assay), ROS production (electric paramagnetic resonance), motility (wound healing assay), and apoptosis (flow cytometry).Results: GNP-HC were selectively uptaken by MPM cells within 1 hour. MPM cell lines were blocked in the S cell cycle phase in the presence of GNP-HCPe. Both cell viability and motility were significantly affected by nanoparticle treatment compared to Pe. Apoptotic rate and ROS production were significantly higher in the presence of nanoparticles. Clonogenic capacity was completely inhibited following nanoparticle internalization.Conclusion: GNP-HCPe treatment displays in vitro antineoplastic action and is more effective than Pe alone in inhibiting MPM cell line malignant phenotype. The innovative use of specifically targeted GNPs opens the perspective of local intrapleural administration to avoid normal cell toxicity and enhance chemotherapy efficacy. Keywords: gold nanoparticles, nanodrug delivery, mesothelioma, pemetrexed, intrapleural delivery

Published
2019

48. List of contributors

Author

Arney, David, primary, Barna, Judit, additional, Campanile, Giuseppe, additional, Cánovas, Sebastián, additional, Cibelli, Jose, additional, Clotaire, Daguia Zambe John, additional, Colombo, M., additional, Coy, Pilar, additional, Crichton, Elizabeth G., additional, De Rosa, Giuseppe, additional, Farías, J., additional, Figueroa, E., additional, Formato, Giovanni, additional, Gadea, Joaquín, additional, Gard, Julie, additional, Garrels, Wiebke, additional, Gasparrini, Bianca, additional, Herrid, Muren, additional, Hua, Jinlian, additional, Izquierdo, Dolors, additional, Kaneko, Takehito, additional, Ledda, S., additional, Liptói, Krisztina, additional, Luvoni, G.C., additional, Malo, Clara M., additional, Mastromonaco, Gabriela F., additional, Matás, Carmen, additional, Merino, O., additional, Morselli, M.G., additional, Moškrič, Ajda, additional, Mota-Rojas, Daniel, additional, Naitana, S., additional, Napolitano, Fabio, additional, Neglia, Gianluca, additional, Paramio, Maria-Teresa, additional, Patakiné Várkonyi, Eszter, additional, Prešern, Janez, additional, Presicce, Giorgio A., additional, Pursley, J. Richard, additional, Risopatrón, J., additional, Romar, Raquel, additional, Salzano, Angela, additional, Sandoval, L., additional, Sansinena, Marina, additional, Skidmore, Julian A., additional, Smodiš Škerl, Maja Ivana, additional, Songsasen, Nucharin, additional, Soto-Heras, Sandra, additional, Valdebenito, I., additional, Vaughan, Jane L., additional, Végi, Barbara, additional, Wani, Nisar A., additional, Wei, Yudong, additional, Yang, Shihua, additional, and Zicarelli, Luigi, additional

Published
2020
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49. Prevalence and features of delirium in older patients admitted to rehabilitation facilities

Author

Sidoli, Chiara, Zambon, Antonella, Tassistro, Elena, Rossi, Emanuela, Mossello, Enrico, Inzitari, Marco, Cherubini, Antonio, Marengoni, Alessandra, Morandi, Alessandro, Bellelli, Giuseppe, Tarasconi, A, Sella, M, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D’Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell’Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Null, Ettorre, E, Camellini Bellelli, C G, Annoni, G, Marengoni, A, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl’Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D’Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L E, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Riccò, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D’Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Mossello, E, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccalà, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, 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Saggioro, D

Subjects
Aging, Disability, Rehabilitation, Delirium, Dementia, Physical restraint, Cross-Sectional Studies, Activities of Daily Living, mental disorders, Prevalence, Humans, Geriatrics and Gerontology, Aged
Abstract

Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.

Published
2022

50. Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma

Author

Abou-Alfa, G.K., Qin, S., Ryoo, B.-Y., Lu, S.-N., Yen, C.-J., Feng, Y.-H., Lim, H.Y., Izzo, F., Colombo, M., Sarker, D., Bolondi, L., Vaccaro, G., Harris, W.P., Chen, Z., Hubner, R.A., Meyer, T., Sun, W., Harding, J.J., Hollywood, E.M., Ma, J., Wan, P.J., Ly, M., Bomalaski, J., Johnston, A., Lin, C.-C., Chao, Y., and Chen, L.-T.

Published
2018
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