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162 results on '"Colomba, Mariastella"'

1. In vitro anti-inflammatory activity of Malus × domestica var. Mela Rosa Marchigiana pulp callus extract contrasting high glucose conditions

Author

Benayada, Leila, Gubitosa, Federica, Fraternale, Daniele, Carloni, Silvia, Cerioni, Liana, Matacchione, Giulia, Olivieri, Fabiola, Potenza, Lucia, De Bellis, Roberta, Chiarantini, Laura, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Pappagallo, Noemi, Ventura, Natascia, Kass, George E.N., Colomba, Mariastella, and Albertini, Maria Cristina

Published
2024
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2. Long-lasting bioactive compounds production from Malus x domestica Borkh var. Mela Rosa Marchigiana pulp callus culture with antioxidant activity: In vitro, ex vivo and in vivo validation

Author

Gubitosa, Federica, Benayada, Leila, Fraternale, Daniele, De Bellis, Roberta, Carloni, Silvia, Potenza, Lucia, Chiarantini, Laura, Gorassini, Andrea, Verardo, Giancarlo, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Ventura, Natascia, Giannaccini, Francesca, Kass, George E.N., Colomba, Mariastella, and Albertini, Maria Cristina

Published
2024
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9. Molecular analysis of Lepidopleurus cajetanus (Poli, 1791) (Polyplacophora, Leptochitonidae) from the Mediterranean and near Atlantic

Author

Colomba, Mariastella, Sigwart, Julia D., Renda, Walter, Gregorini, Armando, Sosso, Maurizio, and Dell'Angelo, Bruno

Subjects
Lepidopleurus cajetanus, Lepidopleurida, chitons, phylogeny, Biota, Leptochitonidae, Neoloricata, Lepidopleurus, COI, Polyplacophora, standard mitochondrial markers, Mollusca, Animalia, Animal Science and Zoology, 16S rRNA, Lepidopleurina, Ecology, Evolution, Behavior and Systematics
Abstract

In the present paper we used a molecular data set (including mitochondrial partial 16S rRNA and COI gene sequences) to examine the genetic structure ofLepidopleurus cajetanus(Poli, 1791) (Polyplacophora, Leptochitonidae) - a distinctive shallow water chiton and member of the basal branching Lepidopleurida, which is widespread in and adjacent to the Mediterranean. The analyses of the two mt-standard marker fragments resolved two main discrete clusters reported asL. cajetanuss.s. and L. aff. cajetanus, respectively.Lepidopleurus cajetanuss.s. is widespread throughout the area under study, while the second distinct lineage apparently co-occurs on the eastern Spanish mainland coast of the Balearic Sea. This result is discussed comparing our data with those reported, in 2014, by Fernández and colleagues who describedL. cajetanusas exhibiting “a ‘chaotic patchiness’ pattern defined by a high genetic variability with locality-exclusive haplotypes, high genetic divergence, and a lack of geographic structure”. Although genetic data alone are not sufficient to draw any definitive conclusions, nevertheless we believe that present results shed new light onL. cajetanuswhich apparently shows more geographically patterned genetic structure than supposed so far.

Published
2022

17. Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation.

Author

Colomba, Mariastella, Benedetti, Serena, Fraternale, Daniele, Guidarelli, Andrea, Coppari, Sofia, Freschi, Valerio, Crinelli, Rita, Kass, George E. N., Gorassini, Andrea, Verardo, Giancarlo, Roselli, Carla, Meli, Maria Assunta, Di Giacomo, Barbara, and Albertini, Maria Cristina

Abstract

In our previous studies, Prunus spinosa fruit (PSF) ethanol extract was showed to exert antioxidant, antimicrobial, anti-inflammatory and wound healing activities. In the present study, an integrated bioinformatics analysis combined with experimental validation was carried out to investigate the biological mechanism(s) that are responsible for the reported PSF beneficial effects as an antioxidant during a pro-inflammatory TLR4 insult. Bioinformatics analysis using miRNet 2.0 was carried out to address which biological process(es) the extract could be involved in. In addition, Chemprop was employed to identify the key targets of nuclear receptor (NR) signaling and stress response (SR) pathways potentially modulated. The miRNet analysis suggested that the PSF extract mostly activates the biological process of cellular senescence. The Chemprop analysis predicted three possible targets for nine phytochemicals found in the extract: (i) ARE signaling, (ii) mitochondrial membrane potential (MMP) and (iii) p53 SR pathways. The PSF extract antioxidant effect was also experimentally validated in vitro using the human monocyte U937 cell line. Our findings showed that Nrf2 is modulated by the extract with a consequent reduction of the oxidative stress level. This was confirmed by a strong decrease in the amount of reactive oxygen species (ROS) observed in the PSF-treated cells subjected to lipopolysaccharide (LPS) (6 h treatment, 1 µg/mL). No visible effects were observed on p53 and MMP modulation. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Do ancient wheats contain less gluten than modern bread wheat, in favour of better health?

Author

Brouns, Fred, primary, Geisslitz, Sabrina, additional, Guzman, Carlos, additional, Ikeda, Tatsuya M., additional, Arzani, Ahmad, additional, Latella, Giovanni, additional, Simsek, Senay, additional, Colomba, Mariastella, additional, Gregorini, Armando, additional, Zevallos, Victor, additional, Lullien‐Pellerin, Valerie, additional, Jonkers, Daisy, additional, and Shewry, Peter R., additional

Published
2022
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21. Figure 2 from: Colomba M, Sigwart JD, Renda W, Gregorini A, Sosso M, Dell’Angelo B (2022) Molecular analysis of Lepidopleurus cajetanus (Poli, 1791) (Polyplacophora, Leptochitonidae) from the Mediterranean and near Atlantic. ZooKeys 1099: 29-40. https://doi.org/10.3897/zookeys.1099.75837

Author

Colomba, Mariastella, primary, Sigwart, Julia D., additional, Renda, Walter, additional, Gregorini, Armando, additional, Sosso, Maurizio, additional, and Dell’Angelo, Bruno, additional

Published
2022
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22. Figure 1 from: Colomba M, Sigwart JD, Renda W, Gregorini A, Sosso M, Dell’Angelo B (2022) Molecular analysis of Lepidopleurus cajetanus (Poli, 1791) (Polyplacophora, Leptochitonidae) from the Mediterranean and near Atlantic. ZooKeys 1099: 29-40. https://doi.org/10.3897/zookeys.1099.75837

Author

Colomba, Mariastella, primary, Sigwart, Julia D., additional, Renda, Walter, additional, Gregorini, Armando, additional, Sosso, Maurizio, additional, and Dell’Angelo, Bruno, additional

Published
2022
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26. Molecular and biometric data on Carabus (Macrothorax) morbillosus Fabricius, 1792 (Coleoptera, Carabidae) from Mid Mediterranean areas.

Author

Colomba, Mariastella, Lo Verde, Gabriella, Liberto, Fabio, Gregorini, Armando, and Sparacio, Ignazio

Subjects
*BIOMETRIC identification, *BEETLES, *CYTOCHROME oxidase, *BAYESIAN analysis, *GROUND beetles, *SUBSPECIES, *BIOMETRY
Abstract

The present study was carried out using molecular and biometric data of Carabus (Macrothorax) morbillosus from mid-Mediterranean areas to determine additional information on basal relationships among its representative subspecies. To this aim, two different kinds of approach were employed, including a morphometric analysis of four morphological parameters (i.e., elytra length, elytra width, pronotum length, pronotum width) of 128 specimens, and a Bayesian genetic analysis of 44 cytochrome oxidase subunit I (COI) partial sequences (i.e., 38 examined for the first time and six retrieved from GenBank database). Representative populations of C. (M.) morbillosus were sampled in four countries, namely Italy, Malta, Spain, and Tunisia. The present findings support the validity of four C. (M.) morbillosus subspecies, specifically C. (M.) m. alternans, C. (M.) m. bruttianus, C. (M.) m. constantinus, and C. (M.) m. macilentus, and redefine these subspecies' distributions. Notably, within the C. (M.) m. constantinus clade, two (i.e., Sardinia/Tuscany and Lampedusa) out of the three subgroups appear as homogeneous geographical groupings. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy

Author

Coppari, Sofia, primary, Colomba, Mariastella, additional, Fraternale, Daniele, additional, Brinkmann, Vanessa, additional, Romeo, Margherita, additional, Rocchi, Marco Bruno Luigi, additional, Di Giacomo, Barbara, additional, Mari, Michele, additional, Guidi, Loretta, additional, Ramakrishna, Seeram, additional, Ventura, Natascia, additional, and Albertini, Maria Cristina, additional

Published
2021
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31. Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract

Author

Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Sabatini, Luigia, Fraternale, Daniele, Di Giacomo, Barbara, Mari, Michele, Albertini, María Cristina, Gordillo Arrobas, Belén, Rocchi, Marco Bruno Luigi, Sisti, Davide, Coppari, Sofia, Colomba, Mariastella, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Sabatini, Luigia, Fraternale, Daniele, Di Giacomo, Barbara, Mari, Michele, Albertini, María Cristina, Gordillo Arrobas, Belén, Rocchi, Marco Bruno Luigi, Sisti, Davide, Coppari, Sofia, and Colomba, Mariastella

Abstract

Prunus spinosa L. (from Italy) fruit ethanol extract (40 µg/mL) was assessed by evaluating the antioxidant, anti-inflammatory and antimicrobial activities against five bacterial and two fungi ATCC strains. Moreover, the phenolic profile was also investigated and results are indicative of an intense anthocyanin accumulation which may be responsible for the antioxidant properties revealed by the DPPH assay. MIC and MBC/MFC values (4.36–8.72 mg/mL; 8.72–17.44 mg/mL, respectively) revealed a wide antibacterial activity and yeast inhibition. No specific inhibitory action was observed against the tested Gram-negative or Gram-positive bacteria. Preliminary data on the effect on both miR-126 and miR-146a expression levels suggested a very interesting anti-inflammatory activity of the extract. A possible mechanism underpinning the observed effects was hypothesized and discussed. Finally, P. spinosa fruit extract could be used as supplementary source of functional additives and might be a promising antimicrobial compound of natural origin to be employed to fight microbial resistance.

Published
2020

32. Prunus spinosa Extract Loaded in Biomimetic Nanoparticles Evokes In Vitro Anti-Inflammatory and Wound Healing Activities

Author

Tiboni, Mattia, primary, Coppari, Sofia, additional, Casettari, Luca, additional, Guescini, Michele, additional, Colomba, Mariastella, additional, Fraternale, Daniele, additional, Gorassini, Andrea, additional, Verardo, Giancarlo, additional, Ramakrishna, Seeram, additional, Guidi, Loretta, additional, Di Giacomo, Barbara, additional, Mari, Michele, additional, Molinaro, Roberto, additional, and Albertini, Maria Cristina, additional

Published
2020
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38. Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa)

Author

Albertini, Maria Cristina, primary, Fraternale, Daniele, additional, Semprucci, Federica, additional, Cecchini, Silvio, additional, Colomba, Mariastella, additional, Rocchi, Marco B.L., additional, Sisti, Davide, additional, Di Giacomo, Barbara, additional, Mari, Michele, additional, Sabatini, Luigia, additional, Cesaroni, Lucia, additional, Balsamo, Maria, additional, and Guidi, Loretta, additional

Published
2019
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40. Sex-Biased Dispersal Obscures Species Boundaries in Integrative Species Delimitation Approaches

Author

Eberle, Jonas, primary, Bazzato, Erika, additional, Fabrizi, Silvia, additional, Rossini, Michele, additional, Colomba, Mariastella, additional, Cillo, Davide, additional, Uliana, Marco, additional, Sparacio, Ignazio, additional, Sabatinelli, Guido, additional, Warnock, Rachel C M, additional, Carpaneto, Giuseppe, additional, and Ahrens, Dirk, additional

Published
2018
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41. Bio-genetic theories of ageing

Author

Gregorini, Armando and Colomba, Mariastella

Subjects
Ageing, Lifespan, Genetic theories, Neuroendocrine theory, Immunological theory, Free radical/Oxidative stress theory, Caloric restriction, Glication theory, Membrane theory, Prions
Published
2016

43. La ‘pet therapy’ nella malattia di Alzheimer

Author

Gregorini, Armando, Di Canio, Angela, and Colomba, Mariastella

Abstract

Le stime più recenti indicano come su scala mondiale, ogni anno, il numero di individui colpiti da Demenza oscilli tra un minimo di 3,5 (in Africa) ad un massimo di 10 (nel nord America) ogni 1.000 (incidenza media = 7,5‰; prevalenza media = 3,5‰). Ogni 7 secondi una nuova persona viene colpita da Demenza: entro il 2040 si prevede che gli affetti saranno circa 81 milioni, con un terzo dei casi (circa 26 milioni) in Cina che, a causa della numerosità della sua popolazione, sarà il Paese più esposto. Lungi dall’essere sinonimo di pazzia come sostenuto in passato, oggi le demenze sono considerate espressione di una malattia organica cerebrale, su basi fisiopatologiche, di tipo degenerativo vascolare o misto, cui si correlano sintomi cognitivi e conseguenze funzionali e comportamentali. La demenza è quindi considerata una sindrome, ovvero un insieme di sintomi e segni tra loro associati e responsabili del quadro clinico. In generale, la demenza viene distinta in due categorie: 1) demenza primaria (60% dei casi), di cui resta sconosciuta la causa; 2) demenza secondaria (40% dei casi), quando invece è possibile risalire all’origine. [... segue nel testo ...] Presentato dal Dipartimento di Psicologia e del Territorio e dal Dipartimento di Scienze della Terra, della Vita e dell’Ambiente., Studi Urbinati, B - Scienze umane e sociali, V. 81 (2011)

Published
2013
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