Search

Your search keyword '"Colmant, Claire"' showing total 23 results
Start Over Author "Colmant, Claire"
23 results on '"Colmant, Claire"'

1. Idiopathic polyhydramnios and postnatal outcomes of children: The role of exome sequencing.

Author

Grausz, Noémie, Senat, Marie‐Victoire, Colmant, Claire, Boizard, Anne, Benachi, Alexandra, and Bouchghoul, Hanane

Abstract

Objectives: The objective of our study was to evaluate the long‐term outcome of children born from a pregnancy complicated by idiopathic polyhydramnios. The secondary objective was to investigate factors associated with adverse outcomes. Methods: We conducted a retrospective study in two prenatal diagnosis centers between January 1, 2009 and December 31, 2020. Inclusion criteria were pregnancies with a diagnosis of idiopathic polyhydramnios, defined by a deepest pocket greater than 8 cm, no detectable abnormality at ultrasound and a negative amniotic fluid assessment including karyotype, chromosomal microarray, biochemical assays (electrolytes and digestive enzymes), and viruses (parvovirus B19 and cytomegalovirus). One‐year outcomes of these children were collected. The primary endpoint was adverse postnatal outcome, defined by at least one of the following criteria: stillbirth, neonatal death, or serious and incurable condition diagnosed in the first year of life. Results: Of the 245 women referred for isolated polyhydramnios, 73 were diagnosed with idiopathic polyhydramnios after prenatal investigations. The mean age at follow‐up of children was 28 months (95% CI 20−36). An adverse outcome occurred in 25% of cases (18/73), with one stillbirth, two neonatal deaths, and 15 severe conditions diagnosed postnatally, including a rate of monogenic disorders of 8.2% (6/73). Pediatric follow‐up was normal for 75% of the children (55/73), including a rate of 9% (5/55) of curable conditions. Repeated amnioreduction was independently associated with an adverse outcome. Conclusion: Pregnant women with polyhydramnios should be informed of the increased risk of 25% of perinatal mortality and serious conditions diagnosed after birth. Key points: What's already known about this topic? Few retrospective studies have assessed long‐term outcomes and have reported an increased risk of postnatal diagnosis of anomalies in the first years of life in the range of 9%–28%. What does this study add? Idiopathic polyhydramnios, defined by the absence of etiology after prenatal investigations, is associated with a 25% risk of adverse outcomes, including a 21% rate of serious and incurable conditions diagnosed postnatally. When idiopathic polyhydramnios is diagnosed, it may be relevant to consider trio exome sequencing plus consultation with a geneticist in order to increase the diagnostic yield. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Liste des collaborateurs

Author

Abboud, Imad, primary, Aïssou, Linda, additional, Allibert, Rémi, additional, Bazot, Marc, additional, Bellin, Marie-France, additional, Benjoar, Mikhael, additional, Bivol, Silviu, additional, Calvet, David, additional, Colmant, Claire, additional, Cornud, François, additional, Correas, Jean-Michel, additional, Couvidat, Céline, additional, Deklunder, Ghislaine, additional, Domigo, Valérie, additional, Eiss, David, additional, Elmaleh, Annie, additional, Fayet, Patricia, additional, Gautier, Corinne, additional, Giordana, Pascal, additional, Gobin-Metteil, Marie-Pierre, additional, Gouya, Hervé, additional, Guedj, Thierry, additional, Hélénon, Olivier, additional, Kemlin, Delphine, additional, Laaengh-Massoni, Claudine, additional, Lefevre, Arnaud, additional, Legmann, Paul, additional, Lewin, Maïté, additional, Long, Anne, additional, Le Masne de Chermont, Elisabeth, additional, Mellerio, Charles, additional, Meune, Christophe, additional, Azaïs-Noblinski, Béatrice, additional, Pichot, Olivier, additional, and Senat, Marie-Victoire, additional

Published
2015
Full Text
View/download PDF

12. Comparison of crown-rump length discordance and abnormal cord insertions as first-trimester predictors of poor outcome in monochorionic diamniotic twin pregnancies.

Author

Pandya, Viral M., Colmant, Claire, Stirnemann, Julien, Salomon, Laurent J., and Ville, Yves

Subjects
*MULTIPLE pregnancy, *TWINS, *FETOFETAL transfusion, *HIGH-risk pregnancy, *FETAL growth retardation
Abstract

This is a retrospective study to determine the predictive value and comparison of first trimester (1) crown-rump length discordance and (2) abnormal cord insertion as screening tests for poor outcome in monochorionic diamniotic twin pregnancies. Retrospective data were collected over last 10 years from a single center (2009–2018). A total of 261 patients were a part of this study. CRL discordance or abnormal cord insertions are not accurate predictors of twin-to-twin transfusion syndrome, which corresponds to previously published data on the same subject. Both CRL discordance and abnormal cord insertions are strongly associated with selective fetal growth restriction (sFGR) as defined according to conventional criteria or the newer consensus criteria. A combination of these two markers substantially improves the screening rates, with a positive likelihood ratio of 10.33 for sFGR. However, this combination fails to distinguish the type 1 sFGR cases from the type 2/3, which typically have poorer outcomes. CRL discordance and abnormal cord insertions are strongly associated with the development sFGR in monochorionic pregnancies. A combination of these two markers shows promising potential as a screening test to identify pregnancies at a high risk for development of sFGR. Earlier diagnosis can help plan timely fetal intervention and improve the overall outcomes of these pregnancies. These markers need to be validated in larger studies before being adopted for screening of monochorionic pregnancies. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

13. Spontaneous twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 249 cases

Author

Tollenaar, Lisanne L.S.A., Slaghekke, Femke, Lewi, Liesbeth, Colmant, Claire, Lanna, Mariano, Weingertner, Anne Sophie, Ryan, Greg, Arévalo, Silvia, Klaritsch, Philipp, Tavares de Sousa, Manuela, Khalil, Asma, Papanna, Ramesha, Gardener, Glenn G.J., Bevilacqua, Elisa, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, Lopriore, Enrico, Tollenaar, Lisanne L.S.A., Slaghekke, Femke, Lewi, Liesbeth, Colmant, Claire, Lanna, Mariano, Weingertner, Anne Sophie, Ryan, Greg, Arévalo, Silvia, Klaritsch, Philipp, Tavares de Sousa, Manuela, Khalil, Asma, Papanna, Ramesha, Gardener, Glenn G.J., Bevilacqua, Elisa, Kostyukov, Kirill K.V., Bahtiyar, Mert Ozan, Kilby, Mark M.D., Tiblad, Eleonor, Oepkes, Dick, and Lopriore, Enrico

Abstract

Background: Twin anemia polycythemia sequence is a chronic form of unbalanced fetofetal transfusion through minuscule placental anastomoses in monochorionic twins, leading to anemia in the donor and polycythemia in the recipient. Owing to the low incidence of twin anemia polycythemia sequence, data on diagnosis, management, and outcome are limited. Objective: This study aimed to investigate the diagnosis, management, and outcome in a large international cohort of spontaneous twin anemia polycythemia sequence. Study Design: Data from the international twin anemia polycythemia sequence registry, retrospectively collected between 2014 and 2019, were used for this study. A total of 17 fetal therapy centers contributed to the data collection. The primary outcomes were perinatal mortality and severe neonatal morbidity. Secondary outcomes included a risk factor analysis for perinatal mortality and severe neonatal morbidity. Results: A total of 249 cases of spontaneous twin anemia polycythemia sequence were included in this study, 219 (88%) of which were diagnosed antenatally and 30 (12%) postnatally. Twin anemia polycythemia sequence was diagnosed antenatally at a median gestational age of 23.7 weeks (interquartile range, 9.7–28.8; range, 15.1–35.3). Antenatal management included laser surgery in 39% (86 of 219), expectant management in 23% (51 of 219), delivery in 16% (34 of 219), intrauterine transfusion (with partial exchange transfusion) in 12% (26 of 219), selective feticide in 8% (18 of 219), and termination of pregnancy in 1% (3 of 219) of cases. Perinatal mortality rate was 15% (72 of 493) for the total group, 22% (54 of 243) for donors, and 7% (18 of 242) for recipients (P<.001). Severe neonatal morbidity occurred in 33% (141 of 432) of twins with twin anemia polycythemia sequence and was similar for donors (32%; 63 of 196) and recipients (33%; 75 of 228) (P=.628). Independent risk factors for spontaneous perinatal mortality were donor status (odds ratio, 3.8; 95%, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

14. Spontaneous twin anemia polycythemia sequence: diagnosis, management, and outcome in an international cohort of 249 cases

Author

Tollenaar, Lisanne S.A., primary, Slaghekke, Femke, additional, Lewi, Liesbeth, additional, Colmant, Claire, additional, Lanna, Mariano, additional, Weingertner, Anne Sophie, additional, Ryan, Greg, additional, Arévalo, Silvia, additional, Klaritsch, Philipp, additional, Tavares de Sousa, Manuela, additional, Khalil, Asma, additional, Papanna, Ramesha, additional, Gardener, Glenn J., additional, Bevilacqua, Elisa, additional, Kostyukov, Kirill V., additional, Bahtiyar, Mert O., additional, Kilby, Mark D., additional, Tiblad, Eleonor, additional, Oepkes, Dick, additional, and Lopriore, Enrico, additional

Published
2021
Full Text
View/download PDF

21. Is Intrapartum Intravenous Zidovudine for Prevention of Mother-to-Child HIV-1 Transmission Still Useful in the Combination Antiretroviral Therapy Era?

Author

Briand, Nelly, primary, Warszawski, Josiane, additional, Mandelbrot, Laurent, additional, Dollfus, Catherine, additional, Pannier, Emmanuelle, additional, Cravello, Ludovic, additional, Nguyen, Rose, additional, Matheron, Isabelle, additional, Winer, Norbert, additional, Tubiana, Roland, additional, Rouzioux, Christine, additional, Faye, Albert, additional, Blanche, Stéphane, additional, Meier, Françoise, additional, Duro, Dominique, additional, Joras, Marine, additional, Mortier, Emmanuel, additional, Crenn-Hebert, Catherine, additional, Floch-Tudal, Corinne, additional, Mazy, Fabienne, additional, Bensalah, Mariam, additional, Villemant-Uludag, Agnès, additional, Lefort, Agnès, additional, Zarrouk, Virginie, additional, Ceccaldi, Pierre-François, additional, Philip, Gisèle, additional, Hittinger, Gilles, additional, Malet, Martine, additional, Bachelard, Bruno, additional, Medus, Marie, additional, Dendale-Nguyen, Joëlle, additional, Brossier, Jean-Pierre, additional, Aubry, Olivier, additional, Esnault, Jean-Luc, additional, Leautez, Sophie, additional, Perré, Philippe, additional, Suaud, Isabelle, additional, Martha, Sandrine-Anne, additional, Rouha, Mahfoud, additional, Perfezou, Pascale, additional, Blondin, Gilles, additional, Bellot, Charles, additional, Ansart, Séverine, additional, Le Moine, Philippe, additional, Bages-Jaffuel, Karine, additional, Duthé, Jean-Charles, additional, Garré, Michel, additional, Jaffuel, Sylvain, additional, Daniel, Corinne, additional, Calvez, Christian, additional, Beuscart, Claude, additional, Boutaric, Emmanuelle, additional, Rohan, Jennifer, additional, Lemoal, Sylvie, additional, Lassel, Linda, additional, Cotten, Ghislaine, additional, Dupré, Christelle, additional, Beauville, Esther, additional, Arvieux, Cédric, additional, Dos Santos, Anabèle, additional, Cudeville, Corinne, additional, Poinsignon, Yves, additional, Mouton-Rioux, Virginie, additional, Mousset, Gaétane, additional, Grellier, Anne, additional, Moreau, Philippe, additional, Tillaut, Philippe, additional, Luycx-Vaillant, Odile, additional, de Morel, Philippe, additional, Le Coz, Marie-Françoise, additional, Belzic, Isabelle, additional, Niault, Mathilde, additional, Vandenbergh, Anne, additional, Janssen, Cécile, additional, Braig, Susanne, additional, Vitrat, Virginie, additional, Gaillat, Jacques, additional, Clavere, Gaëlle, additional, Bru, Jean-Pierre, additional, Peyret, Blandine, additional, Mullard, Catherine, additional, Echard, Marie, additional, Talon, Philippe, additional, Dehlinger, Marion, additional, Winter, Cécile, additional, Heller-Roussin, Brigitte, additional, Launay, Odile, additional, Fouchet, Maria, additional, Firtion, Ghislaine, additional, Goupil, Isabelle, additional, Boudjoudi, Nora, additional, Bourgeois-Moine, Agnès, additional, Bodard, Marylène, additional, Vivier, Valérie, additional, Rajguru, Mandovi, additional, Huri, Virginie, additional, Azria, Elie, additional, Matheron, Sophie, additional, Elaoun, Neila, additional, Faucher, Philippe, additional, Garrait, Valérie, additional, Komme, Christiane, additional, Hau, Isabelle, additional, Richier, Laurent, additional, Touboul, Claudine, additional, Thoirain, Valérie, additional, Cotte, Laurent, additional, Tariel, Olivier, additional, Koffi, Joseph, additional, Labaune, Jean-Marc, additional, Brochier, Corinne, additional, Roux, Denis, additional, Elleau, Christophe, additional, Runel, Camille, additional, Bataille, Henri, additional, Sow, Marie-Thérèse, additional, Samar, Ketty, additional, Muanza, Blandine, additional, Duval, Marc, additional, Kingue-Ekollo, Clarisse, additional, Carpentier, Bénédicte, additional, Ronda, Isabelle, additional, Chamouilli, Jean-Marc, additional, Entz-Werle, Natacha, additional, Seaume, Hervé, additional, Ducrocq, Sarah, additional, Bailly-Salin, Philippe, additional, Lemercier, Yvon, additional, Tricoire, Joëlle, additional, Berrebi, Alain, additional, Antras, Michèle, additional, Armand, Evelyne, additional, Cayla, Claudine, additional, Bonnal, François, additional, Chabanier, Catherine, additional, Chacé, Anne, additional, Couderc, Sophie, additional, Boutemy, Anne, additional, Dallot, Marie-Christelle, additional, Al-Issa, Alain, additional, Routier, Corinne, additional, Zakaria, Ahmed, additional, Favret, Véronique, additional, Gerbe, Juliette, additional, Questiaux, Elisabeth, additional, Partisani, MariaLuisa, additional, Rey, David, additional, Cheneau, Christine, additional, Allisy, Christine, additional, Brault, Dominique, additional, Hervé, François, additional, Lebrette, Marie-Gisèle, additional, Selleret, Lise, additional, Ekoukou, Dieudonné, additional, Bolot, Pascal, additional, Khuong-Josses, Marie-Aude, additional, Allemon, Marie-Christine, additional, Ghibaudo, Nelly, additional, Frange, Pierre, additional, Veber, Florence, additional, Lemercier, Delphine, additional, Mourey, Marie-Christine, additional, Blasquez, Gilles, additional, Granier, Michèle, additional, Touahri, Houda, additional, Devidas, Alain, additional, Nisand, Israël, additional, Weil, Michèle, additional, Vayssière, Christophe, additional, Berger, Jean-Luc, additional, Munzer, Martine, additional, Graesslin, Olivier, additional, Naime-Alix, Anne-Florence, additional, Quetin, Frédérique, additional, Laubies, Anne, additional, Bonmarchand, Manuela, additional, Sommer, Jennifer, additional, Bourse, Patricia, additional, Coursol, Anne, additional, Youssef, Michel, additional, Laurent, Juliette, additional, Raho, Mariem, additional, Chambrin, Véronique, additional, Labrune, Philippe, additional, Clech, Laure, additional, Benachi, Alexandra, additional, Le Lorier, Bertrand, additional, Pauly-Ravelly, Isolde, additional, Allouche, Claude, additional, Johnson, Ama, additional, Benoist, Laurence, additional, Delannoy, Catherine, additional, Lachassine, Eric, additional, Bolie, Stéphanie, additional, Gaudelus, Joël, additional, Jeantils, Vincent, additional, Benabara, Amelie, additional, Karaoui, Leïla, additional, Lefèvre, Véronique, additional, Bongain, André, additional, Galiba, Eliane, additional, Deville, Anne, additional, Monpoux, Fabrice, additional, Durant, Jacques, additional, Aufrant, Christian, additional, Furioli, Jean, additional, Salomon, Jean-Louis, additional, Granier, Françoise, additional, Doumet, Antoine, additional, Douadi, Youssef, additional, Gondry, Jean, additional, Schmit, Jean-Luc, additional, Pautard, Brigitte, additional, Gamerre, Marc, additional, Thuret, Isabelle, additional, Neimann, Laurence, additional, Hubert, Claire, additional, Carbonne, Bruno, additional, Vaudre, Geneviève, additional, Tabone, Marie-Dominique, additional, Pinquier, Didier, additional, Pinto Cardoso, Gaëlle, additional, Clavier, Brigitte, additional, Borsa-Lebas, Françoise, additional, De Lauzanne, Agathe, additional, Borie, Constance, additional, Leveillé, Sandrine, additional, Bellaton, Erianna, additional, Garion, Dominique, additional, Levine, Martine, additional, Colmant, Claire, additional, Goujard, Cécile, additional, Tardieu, Marc, additional, Fuchs, Florent, additional, Jrad, Ikram, additional, Peretti, Delphine, additional, Bourdic, Katia, additional, Fourcade, Corinne, additional, Chirouze, Catherine, additional, Estavoyer, Jean-Marie, additional, Maillet, Robert, additional, Reliquet, Véronique, additional, Brunet, Cécile, additional, Reynaud, Isabelle, additional, Briandet, Claire, additional, Brouard, Jacques, additional, Beucher, Gaël, additional, Goubin, Pascale, additional, Lanty, Cécile, additional, Froguel, Eric, additional, Gourdel, Béatrice, additional, Chalvon Demersay, Arnaud, additional, Algava, Gilbert, additional, Hentgen, Véronique, additional, Messaoudi, Fabienne, additional, Nau, Pascale, additional, Besnier, Jean-Marc, additional, Potin, Jérôme, additional, Taché, Nadine, additional, Bertrand, Yves, additional, Kebaïli, Kamila, additional, Ronat, Véronique, additional, Fresard, Anne, additional, Billiemaz, Kareen, additional, Abrudan, Ramona, additional, Fournié, Alain, additional, Chennebault, Jean-Marie, additional, Arsac, Philippe, additional, Ciraru-Vigneron, Nicole, additional, Mouchnino, Geneviève, additional, Ayral, Dominique, additional, Guigue, Nelly, additional, Lalande, Muriel, additional, Benos, Paul, additional, De Gennes, Christiane, additional, Chanzy, Sonia, additional, Isart, Valérie, additional, Cazassus, François, additional, Walter, Véronique, additional, Bissuel, François, additional, Hammou, Yamina, additional, d'Angelo, Sophie, additional, Ajana, Faïza, additional, Mazingue, Françoise, additional, Mezin, Raymond, additional, Hatchuel, Yves, additional, Cabié, André, additional, and Elenga, Narcisse, additional

Published
2013
Full Text
View/download PDF

22. Effect of gestational age at laser therapy on perinatal outcome in monochorionic diamniotic pregnancies affected by twin-to-twin transfusion syndrome.

Author

Bartin R, Colmant C, Bourgon N, Ville Y, and Stirnemann J

Subjects
Female, Fetal Membranes, Premature Rupture, Fetoscopy methods, Gestational Age, Humans, Infant, Newborn, Laser Coagulation methods, Placenta, Pregnancy, Pregnancy Outcome epidemiology, Pregnancy, Twin, Retrospective Studies, Fetofetal Transfusion surgery, Laser Therapy, Premature Birth epidemiology, Premature Birth surgery
Abstract

Objective: To evaluate the effect of gestational age at laser therapy for twin-to-twin transfusion syndrome (TTTS) on perinatal outcome., Design and Settings: Single retrospective observational cohort., Population: All consecutive pregnancies affected by TTTS and referred to our department between January 2013 and August 2020., Methods: Gestational age was modelled both as a categorical and as a continuous variable. Log-binomial regression was used to estimate the odds ratios (crude and adjusted for placental location, Quintero stage and cervical length) as well as the adjusted predicted probability of survival and fetal loss according to gestational age at laser therapy., Main Outcomes: Fetal and neonatal survival, preterm prelabour rupture of membranes (PPROM)., Results: Of the 503 pregnancies referred for TTTS, 431 were treated by laser therapy. Gestational age at laser therapy was positively and significantly associated with the overall survival at birth and at discharge (adjusted odds ratio [aOR] 1.12, 95% CI 1.05-1.19), as with a reduction in double fetal loss (aOR 0.81, 95% CI 0.71-0.92). Conversely, the rate of PPROM before 24 weeks was significantly higher in early cases (32% of PPROM <24 weeks when laser therapy was performed before 17 weeks versus 1.5% after 22 weeks, p < 0.001, aOR 0.60, 95% CI 0.48-0.72). Among the survivors, preterm birth before 28 weeks was significantly related to the gestational age at laser (OR 0.91, 95% CI 0.84-0.99), resulting in a significant impact on neonatal morbidity (OR 0.91, 95% CI 0.85-0.97)., Conclusion: Our results suggest a significant and independent impact of the gestational age at laser surgery on perinatal survival, PPROM and neonatal morbidity., (© 2022 John Wiley & Sons Ltd.)

Published
2022
Full Text
View/download PDF

23. Non-invasive prenatal testing for fetal sex determination: is ultrasound still relevant?

Author

Colmant C, Morin-Surroca M, Fuchs F, Fernandez H, and Senat MV

Subjects
Adrenal Hyperplasia, Congenital diagnosis, Adult, Chorionic Villi Sampling adverse effects, DNA blood, Female, Genetic Diseases, X-Linked diagnosis, Humans, Male, Pregnancy, Pregnancy Trimester, First, SOXB1 Transcription Factors genetics, Sensitivity and Specificity, Ultrasonography, Prenatal, Prenatal Diagnosis methods, Sex Determination Analysis methods
Abstract

Early prenatal diagnosis of fetal sex is necessary to optimize pregnancy management in families known to be at risk of some heritable disorders. The demonstration of cell-free fetal DNA (cffDNA) in the mother's blood has made it possible to identify Y chromosome sequences in maternal blood and to determine fetal sex noninvasively, during the first trimester. This procedure can significantly reduce the number of invasive procedures for women with fetuses at risk of sex-linked diseases and optimize the management of these pregnancies. Fetal sex can be diagnosed by ultrasound with the same sensitivity and specificity, but later in pregnancy. We performed a review of the published literature evaluating the use of cffDNA and ultrasound for prenatal determination of fetal sex during the first trimester of pregnancy. We present the feasibility of the two methods and their impact on clinical practice. We applied a sensitive search of multiple bibliographic databases including Pubmed (MEDLINE), EMBASE, the Cochrane Library and Web of science between 1998 and 2013. Sixteen reports of the determination of fetal sex in maternal blood and 13 reports of the determination by ultrasound met our inclusion criteria. We found a sensitivity and specificity of nearly 100% from 8 weeks of gestation for cffDNA and from 13 weeks of gestation for ultrasound respectively. Based on this review, we conclude that fetal sex can be determined with a high level of accuracy by analyzing cffDNA and at an earlier gestation than ultrasound. Ten years after the first feasibility study, the French National Authority for Health (HAS) released a technological assessment report on the determination of fetal sex in maternal blood, which has resulted in validating this test for reimbursement by the national health insurance fund for the following indications: X-linked recessive disease and congenital adrenal hyperplasia., (Copyright © 2013. Published by Elsevier Ireland Ltd.)

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results