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3. Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101

Author

Scholz, Alexander, DeFalco, Jeff, Leung, Yvonne, Aydin, Iraz T., Czupalla, Cathrin J., Cao, Wei, Santos, Daniel, Vad, Nikhil, Lippow, Shaun M., Baia, Gilson, Harbell, Michael, Sapugay, Judevin, Zhang, Danhui, Wu, Dai-Chen, Wechsler, Erin, Ye, Anne Z., Wu, Jenny W., Peng, Xiao, Vivian, John, Kaplan, Hargita, Collins, Rodney, Nguyen, Ngan, Whidden, Mark, Kim, Dongkyoon, Millward, Carl, Benjamin, Jonathan, Greenberg, Norman M., Serafini, Tito A., Emerling, Daniel E., Steinman, Lawrence, Robinson, William H., and Manning-Bog, Amy

Published
2022

7. Data from Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., primary, Seales, Isha T., primary, Satchi-Fainaro, Ronit, primary, Grimmer, Matt, primary, Collins, Rodney, primary, Struett, Chris, primary, Nguyen, Kim N., primary, Kim, Grace, primary, Tihan, Tarik, primary, Bao, Yun, primary, Brekken, Rolf A., primary, Bergers, Gabriele, primary, Folkman, Judah, primary, and Weiss, William A., primary

Published
2023
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8. Supplementary Figure Legends 1-3 from Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., primary, Seales, Isha T., primary, Satchi-Fainaro, Ronit, primary, Grimmer, Matt, primary, Collins, Rodney, primary, Struett, Chris, primary, Nguyen, Kim N., primary, Kim, Grace, primary, Tihan, Tarik, primary, Bao, Yun, primary, Brekken, Rolf A., primary, Bergers, Gabriele, primary, Folkman, Judah, primary, and Weiss, William A., primary

Published
2023
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9. Supplementary Figure 1 from Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., primary, Seales, Isha T., primary, Satchi-Fainaro, Ronit, primary, Grimmer, Matt, primary, Collins, Rodney, primary, Struett, Chris, primary, Nguyen, Kim N., primary, Kim, Grace, primary, Tihan, Tarik, primary, Bao, Yun, primary, Brekken, Rolf A., primary, Bergers, Gabriele, primary, Folkman, Judah, primary, and Weiss, William A., primary

Published
2023
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10. Supplementary Figure 2 from Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., primary, Seales, Isha T., primary, Satchi-Fainaro, Ronit, primary, Grimmer, Matt, primary, Collins, Rodney, primary, Struett, Chris, primary, Nguyen, Kim N., primary, Kim, Grace, primary, Tihan, Tarik, primary, Bao, Yun, primary, Brekken, Rolf A., primary, Bergers, Gabriele, primary, Folkman, Judah, primary, and Weiss, William A., primary

Published
2023
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11. Supplementary Figure 3 from Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., primary, Seales, Isha T., primary, Satchi-Fainaro, Ronit, primary, Grimmer, Matt, primary, Collins, Rodney, primary, Struett, Chris, primary, Nguyen, Kim N., primary, Kim, Grace, primary, Tihan, Tarik, primary, Bao, Yun, primary, Brekken, Rolf A., primary, Bergers, Gabriele, primary, Folkman, Judah, primary, and Weiss, William A., primary

Published
2023
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12. A method for predicting the influence of matric suction changes on CPT tip resistance

Author

Miller Gerald A. and Collins Rodney W.

Subjects
Environmental sciences, GE1-350
Abstract

The Cone Penetration Test (CPT) is a valuable tool for continuous soil profiling and estimating soil properties. A CPT sounding will often pass through the active zone of an unsaturated soil profile, near the ground surface where moisture conditions and matric suction can vary considerably with depth and time. For many projects, the active zone is also significant to the support of shallow foundations and overlying embankments. However, the strength and stiffness of the unsaturated soils in this zone can be significantly affected by variations in the moisture content and matric suction. Likewise, the cone penetration tip resistance and sleeve friction will be influenced by the variations in moisture conditions and suction. Therefore, it is important to consider the soil moisture conditions when CPTs are conducted relative to the moisture conditions assumed for geotechnical design. This paper presents a method for predicting changes in tip resistance as result of changes in matric suction. The method extends the bearing capacity theory to predict changes in cone tip resistance due to changes in matric suction. CPT data collected at test sites, during wet and dry seasons and representing different soil types, are presented to demonstrate the viability of the proposed method.

Published
2019
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25. Parent-embryo acoustic communication: a specialised heat vocalisation allowing embryonic eavesdropping

Author

Mariette, Mylene, Pessato, Anais, Buttemer, William A., McKechnie, Andrew E., Udino, Eve, Collins, Rodney, Meillere, Alizee, Bennett, Andrew, Buchanan, Katherine, Mariette, Mylene, Pessato, Anais, Buttemer, William A., McKechnie, Andrew E., Udino, Eve, Collins, Rodney, Meillere, Alizee, Bennett, Andrew, and Buchanan, Katherine

Abstract

Sound is arguably the external cue most accessible to embryos of many species, and as such may constitute an unrivalled source of early information. Recent evidence shows that prenatal sounds, similarly to maternal effects, may shape developmental trajectories. Establishing whether parental vocalisations are signals directed at embryos, or parental cues on which embryos eavesdrop, can elucidate whether parents or embryos control developmental outcomes. Prenatal exposure to a characteristic heat-related parental call was recently shown to alter zebra finch growth and fitness. Here, we test the ecological context of this behaviour in the wild, and assess the information value and specificity of this vocalisation for an embryonic audience. We show that wild zebra finches also produce this characteristic call, only at high temperatures. In addition, in the lab, we demonstrate experimentally that calling is specifically triggered by high air temperatures, can occur without an embryonic audience, and importantly, is predicted by individuals' body mass. Overall, our findings reveal a specialised heat vocalisation that enables embryonic eavesdropping, by indicating high ambient temperatures, and parents' capacity to cope with such conditions. This challenges the traditional view of embryos as passive agents of their development, and opens exciting research avenues on avian adaptation to extreme heat.

Published
2018

26. Parent-embryo acoustic communication: a specialised heat vocalisation allowing embryonic eavesdropping

Author

Mariette, Mylene M, Pessato, Anais, Buttemer, William A, McKechnie, Andrew, Udino, Eve, Collins, Rodney, Meillere, Alizee, Bennett, Andrew, Buchanan, Katherine, Mariette, Mylene M, Pessato, Anais, Buttemer, William A, McKechnie, Andrew, Udino, Eve, Collins, Rodney, Meillere, Alizee, Bennett, Andrew, and Buchanan, Katherine

Abstract

Sound is arguably the external cue most accessible to embryos of many species, and as such may constitute an unrivalled source of early information. Recent evidence shows that prenatal sounds, similarly to maternal effects, may shape developmental trajectories. Establishing whether parental vocalisations are signals directed at embryos, or parental cues on which embryos eavesdrop, can elucidate whether parents or embryos control developmental outcomes. Prenatal exposure to a characteristic heat-related parental call was recently shown to alter zebra finch growth and fitness. Here, we test the ecological context of this behaviour in the wild, and assess the information value and specificity of this vocalisation for an embryonic audience. We show that wild zebra finches also produce this characteristic call, only at high temperatures. In addition, in the lab, we demonstrate experimentally that calling is specifically triggered by high air temperatures, can occur without an embryonic audience, and importantly, is predicted by individuals' body mass. Overall, our findings reveal a specialised heat vocalisation that enables embryonic eavesdropping, by indicating high ambient temperatures, and parents' capacity to cope with such conditions. This challenges the traditional view of embryos as passive agents of their development, and opens exciting research avenues on avian adaptation to extreme heat.

Published
2018

27. Pleiotropic role for MYCN in medulloblastoma

Author

Fredrik J. Swartling, Matthew R. Grimmer, Hackett, Christopher S., Northcott, Paul A., Qi-Wen Fan, Goldenberg, David D., Jasmine Lau, Masic, Selma, Kim Nguyen, Yakovenko, Slava, Xiao-Ning Zhe, Flynn Gilmer, Heather C., Collins, Rodney, Nagaoka, Mai, Phillips, Joanna J., Jenkins, Robert B., Tihan, Tarik, Vandenberg, Scott R., James, C. David, Tanaka, Kohichi, Taylor, Michael D., Weiss, William A., and Chesler, Louis

Subjects
Bioluminescence -- Analysis, Metastasis -- Research, Cerebellum -- Genetic aspects, Cerebellum -- Physiological aspects, Genetic regulation -- Analysis, Medulloblastoma -- Genetic aspects, Messenger RNA -- Research, Biological sciences
Published
2010

28. Pleiotropic role for MYCN in medulloblastoma

Author

Swartling, Fredrik J., Grimmer, Matthew R., Hackett, Christopher S., Northcott, Paul A., Qi-Wen Fan, Goldenberg, David D., Lau, Jasmine, Masic, Selma, Kim Nguyen, Yakovenko, Slava, Xiao-Ning Zhe, Flynn Gilmer, Heather C., Collins, Rodney, Nagaoka, Mai, Phillips, Joanna J., Jenkins, Robert B., Tihan, Tarik, Vandenberg, Scott R., James, C. David, Tanaka, Kohichi, Taylor, Michael D., Weiss, William A., and Chesler, Louis

Subjects
Cerebellum -- Genetic aspects, Cerebellum -- Physiological aspects, Cancer in children -- Genetic aspects, Gene expression -- Analysis, Medulloblastoma -- Genetic aspects, Medulloblastoma -- Physiological aspects, Oncogenes -- Research, Biological sciences
Published
2010

32. Pleiotropic role for MYCN in medulloblastoma

Author

Swartling, Fredrik Johansson, Grimmer, Matthew R, Hackett, Christopher S, Northcott, Paul A, Fan, Qi-Wen, Goldenberg, David D, Lau, Jasmine, Masic, Selma, Nguyen, Kim, Yakovenko, Slava, Zhe, Xiao-Ning, Gilmer, Heather C Flynn, Collins, Rodney, Nagaoka, Mai, Phillips, Joanna J, Jenkins, Robert B, Tihan, Tarik, Vandenberg, Scott R, James, C David, Tanaka, Kohichi, Taylor, Michael D, Weiss, William A, Chesler, Louis, Swartling, Fredrik Johansson, Grimmer, Matthew R, Hackett, Christopher S, Northcott, Paul A, Fan, Qi-Wen, Goldenberg, David D, Lau, Jasmine, Masic, Selma, Nguyen, Kim, Yakovenko, Slava, Zhe, Xiao-Ning, Gilmer, Heather C Flynn, Collins, Rodney, Nagaoka, Mai, Phillips, Joanna J, Jenkins, Robert B, Tihan, Tarik, Vandenberg, Scott R, James, C David, Tanaka, Kohichi, Taylor, Michael D, Weiss, William A, and Chesler, Louis

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Sonic Hedgehog (SHH) signaling drives a minority of MB, correlating with desmoplastic pathology and favorable outcome. The majority, however, arises independently of SHH and displays classic or large cell anaplastic (LCA) pathology and poor prognosis. To identify common signaling abnormalities, we profiled mRNA, demonstrating misexpression of MYCN in the majority of human MB and negligible expression in normal cerebella. We clarified a role in pathogenesis by targeting MYCN (and luciferase) to cerebella of transgenic mice. MYCN-driven MB showed either classic or LCA pathologies, with Shh signaling activated in approximately 5% of tumors, demonstrating that MYCN can drive MB independently of Shh. MB arose at high penetrance, consistent with a role for MYCN in initiation. Tumor burden correlated with bioluminescence, with rare metastatic spread to the leptomeninges, suggesting roles for MYCN in both progression and metastasis. Transient pharmacological down-regulation of MYCN led to both clearance and senescence of tumor cells, and improved survival. Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis.

Published
2010
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38. Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

Author

Chesler, Louis, primary, Goldenberg, David D., additional, Seales, Isha T., additional, Satchi-Fainaro, Ronit, additional, Grimmer, Matt, additional, Collins, Rodney, additional, Struett, Chris, additional, Nguyen, Kim N., additional, Kim, Grace, additional, Tihan, Tarik, additional, Bao, Yun, additional, Brekken, Rolf A., additional, Bergers, Gabriele, additional, Folkman, Judah, additional, and Weiss, William A., additional

Published
2007
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41. Peace, love and politics

Author

Danforth, John C., Collins, Rodney C., and Sponauer, John R.

Subjects
Public opinion
Abstract

I READ THE ARTICLE 'HOW HE GOT HIS Groove' in your Special Election Report on President Clinton (NATIONAL AFFAIRS, Sept. 2) with utter disgust and amazement. Sixty-one percent of the [...]

Published
1996

42. Stabilization of Horseshoe Lake Road using Geofibers and Soil-Sement®

Author

Alaska. Department of Transportation. Research, Development, and Technology Transfer, Alaska. Department of Transportation and Public Facilities, United States. Federal Highway Administration, Connor, Billy, Collins, Rodney, Alaska University Transportation Center, Alaska. Department of Transportation. Research, Development, and Technology Transfer, Alaska. Department of Transportation and Public Facilities, United States. Federal Highway Administration, Connor, Billy, Collins, Rodney, and Alaska University Transportation Center

Abstract

G00005806-334659-68102, DTFH70-09-E-00020, S12609, One solution to reducing the cost of importing gravel in areas where available soils are predominately silts and, sands is to stabilize the local soils with geofibers and synthetic fluids. There have been several studies which, have evaluated improvements in soil strength using geofibers. Laboratory work at the Alaska University, Transportation Center has shown that the use of geofibers in combination with synthetic fluids has the potential, to stabilize silts and sands, making them usable for roadway and airport construction. A test 500 foot test section, was constructed on Horseshoe Lake Road, near Wasilla, Alaska. The test section was comprised of 250 feet, using six inches of geofiber and Soil-Sement® and 250 feet using twelve inches of geofiber and Soil-Sement®., The test section was monitored over 16 months for performance and soil strength. Overall the test section has, performed well.

43. In Situ Testing and its Application to Foundation Analysis in Fine-Grained Unsaturated Soils

Author

Collins, Rodney

Subjects
Geotechnical Engineering, Unsaturated Soils, Foundation Engineering
Abstract

The in situ test is an important part of a geotechnical engineer’s arsenal. Currently, there are no established methods for interpreting results of in situ tests in unsaturated soils. The difficulty in interpreting in situ tests in unsaturated soil comes from the presence of suction, which is often unknown and directly influences a soil’s stress state. Unsaturated soils are also subject to fluctuating soil moisture conditions and therefore, fluctuating suction and stress states. For such soils, it is important to establish a methodology to estimate the influence of variable moisture conditions on the interpreted results of in situ tests. This is particularly true when those in situ tests are used as a basis for analysis and design in geotechnical projects. The doctoral study outlined in this dissertation is an important step toward the development of a comprehensive methodology for interpreting in situ tests considering possible variations in soil suction resulting from changes in moisture content. In addition, this study goes one step further by including a laboratory scale investigation of foundation response to loading in unsaturated soil at different moisture conditions that has been also been tested using the pre-bored pressuremeter. The goal is to observe the influence of suction on the results of an in situ test and foundation performance, simultaneously. In this way, the methods of analysis developed for interpreting in situ tests in unsaturated soil can be calibrated and validated against observed foundation performance. The primary objectives of the research work described in this dissertation include collection of data that describes the influence of matric suction on in situ test results including the pressuremeter (PMT), cone penetration test (CPT), and standard penetration test (SPT). In situ test and suction data was analyzed and recommendations for interpreting results of aforementioned in situ tests when soil moisture conditions fluctuate were made. Finally, a method was developed through which bearing capacity and settlement of shallow foundations on unsaturated fine-grained soils can be predicted based on pressuremeter results. To achieve the objectives of this project the following tasks were completed: 1) a detailed literature search was performed to gather information regarding in situ tests in unsaturated soil, model bearing capacity tests on unsaturated soils, and predicting shallow foundation behavior in unsaturated soil with the pressuremeter. 2) Established two field test sites to perform field tests including the pressuremeter, cone penetration test, and standard penetration while monitoring weather conditions and soil volumetric moisture content. Performed in situ tests, collected soil samples, and observe field sites over a two-year period. 3) Performed soil tests to identify engineering properties of the soil for both field sites and developed soil water characteristic curves for soils involved in the research to establish the relationship between the soil moisture content and suction. 4) Conducted extensive analysis of the results of in situ tests to establish empirical relationships. 5) Conducted extensive theoretical analysis of the pressuremeter and CPT data using cavity expansion theory for unsaturated soils. 6) Constructed a testing chamber and load frame such that model bearing capacity tests on unsaturated soils could be performed. Constructed a miniature pressuremeter for testing soil in the chamber. 7) Performed pressuremeter and model bearing capacity tests on unsaturated soil and conducted extensive analysis of the data. The major contributions of this research include: 1) a unique and valuable dataset including the results of PMTs at two fine-grained soil sites, with accompanying measurements of soil moisture content determinations, total suction determinations, and other supporting laboratory test data was developed. Similar datasets were developed for CPTs and SPTs. 2) Empirical relationships between matric suction and pressuremeter parameters including: limit pressure, pressuremeter modulus, and unload-reload modulus were developed for different soil types encountered at the test sites. In addition, relationships including the limited data that could be extracted from the literature, were developed, which expand the knowledge gained through the current study. 3) Empirical relationships between matric suction and CPT parameters including: tip resistance, and sleeve friction, were also developed for different soil types encountered at the test sites. Further empirical relationships between matric suction and standard penetration test N-value and N1(60) were also developed. 4) The use of unsaturated cylindrical cavity expansion theory for prediction of limit pressures under fluctuating soil moisture conditions was further investigated. This involved developing a theoretically based approach to estimating limit pressure as a function of changing suction. In a similar manner to the PMT, a method to apply unsaturated spherical cavity expansion theory for prediction of tip resistance under fluctuating soil moisture conditions was provided. 5) A unique and incredibly valuable dataset was obtained by conducting model scale footing tests and miniature pressuremeter tests in unsaturated soil prepared to different moisture conditions. The dataset includes load-displacement curves from five footing tests, pressuremeter test curves from all five test beds, water content and total suction data from test beds as well as other supporting laboratory data. Observations from this testing were extremely valuable in providing insight into the use of PMT for shallow foundation analysis in unsaturated soil.

Published
2016

44. Letters.

Author

Darnell, John, Hammond, Terry, McGrath, Chris, and Collins, Rodney

Published
2018

45. Letters.

Author

Perry, Russ, Rhind, Charles, Anon, Booth, Peter, and Collins, Rodney

Published
2017

46. LETTERS.

Author

Conti, Greg, Fearn, Antony, Collins, Rodney, and Mai, Anders Schelde

Subjects
LETTERS to the editor, CYCLISTS, SPORTS spectators, OLYMPIC Games
Abstract

Several letters to the editor are presented including one criticizing the Olympic Test Event for frustrating spectators, one writing in support of Alberto Contador, and another responding to a reader's reaction to "The Wedding Spinner" in the August 4, 2011 issue.

Published
2011

47. LETTERS.

Author

Cookson, David, Stout, Bryan, and Collins, Rodney

Subjects
LETTERS to the editor, CYCLING, CYCLING accidents, BICYCLE racing
Abstract

Several letters to the editor are presented in response to articles and topics in previous issues including a sender's recollection of a cycling experience with his wife, "Take a Brain Check," by Rob Sledge in the September 16, 2010 issue, and the 115th edition of the Catford hill-climb classic held on October 10, 2010.

Published
2010

48. LETTERS.

Author

Collins, Rodney, Noton, Jonny, and McNamara, Ian

Subjects
LETTERS to the editor, CYCLISTS, APOLOGIZING, CYCLING
Abstract

Several letters to the editor are presented, including a reaction to Union Cycliste Internationale's (UCI) ruling on one athlete per country per event rule, an apology offered by a driver to a cyclist for a near-collision accident, and a comment on Discover Rutland Sportive's 4,000 feet of climbing on an empty stomach.

Published
2010

49. LETTERS.

Author

Gray, Michael, Swann, David, Collins, Rodney, West, Brian, Harrison, Dave, Webb, Neville, and McLean, Michael

Subjects
LETTERS to the editor, TRAFFIC accidents, DIVING injuries, CYCLING equipment, BICYCLE design
Abstract

Several letters to the editor are presented in response to articles in previous issues including the conclusions of Andrew Osborne about his injury in a high-speed collision with a car in the April 8, 2010 issue, "All the gear," in the April 8, 2010 and the banning of certain track bike design by the University of California, Irvine in the April 1, 2010 issue.

Published
2010

50. LETTERS.

Author

Caldbeck, Terry, Collins, Rodney, Reeds, Ian, Bosley, John, Oxborough, Tom, and Ramsay, Allan

Subjects
LETTERS to the editor, CYCLING competitions, SPORTS events, AIRLINE rates
Abstract

Several letters to the editor are presented in response to issues including one on Manchester Velodrome for Revolution 28, one on organizing a time trial with 2,000 to 3,000 riders, and one on the unfair fares of Ryanair Holdings PLC for bicycles.

Published
2010

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