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1. Sublethal necroptosis signaling promotes inflammation and liver cancer

Author

Vucur, Mihael, Ghallab, Ahmed, Schneider, Anne T., Adili, Arlind, Cheng, Mingbo, Castoldi, Mirco, Singer, Michael T., Büttner, Veronika, Keysberg, Leonie S., Küsgens, Lena, Kohlhepp, Marlene, Görg, Boris, Gallage, Suchira, Barragan Avila, Jose Efren, Unger, Kristian, Kordes, Claus, Leblond, Anne-Laure, Albrecht, Wiebke, Loosen, Sven H., Lohr, Carolin, Jördens, Markus S., Babler, Anne, Hayat, Sikander, Schumacher, David, Koenen, Maria T., Govaere, Olivier, Boekschoten, Mark V., Jörs, Simone, Villacorta-Martin, Carlos, Mazzaferro, Vincenzo, Llovet, Josep M., Weiskirchen, Ralf, Kather, Jakob N., Starlinger, Patrick, Trauner, Michael, Luedde, Mark, Heij, Lara R., Neumann, Ulf P., Keitel, Verena, Bode, Johannes G., Schneider, Rebekka K., Tacke, Frank, Levkau, Bodo, Lammers, Twan, Fluegen, Georg, Alexandrov, Theodore, Collins, Amy L., Nelson, Glyn, Oakley, Fiona, Mann, Derek A., Roderburg, Christoph, Longerich, Thomas, Weber, Achim, Villanueva, Augusto, Samson, Andre L., Murphy, James M., Kramann, Rafael, Geisler, Fabian, Costa, Ivan G., Hengstler, Jan G., Heikenwalder, Mathias, and Luedde, Tom

Published
2023
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2. c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Author

Leslie, Jack, Macia, Marina García, Luli, Saimir, Worrell, Julie C., Reilly, William J., Paish, Hannah L., Knox, Amber, Barksby, Ben S., Gee, Lucy M., Zaki, Marco Y. W., Collins, Amy L., Burgoyne, Rachel A., Cameron, Rainie, Bragg, Charlotte, Xu, Xin, Chung, Git W., Brown, Colin D. A., Blanchard, Andrew D., Nanthakumar, Carmel B., Karsdal, Morten, Robinson, Stuart M., Manas, Derek M., Sen, Gourab, French, Jeremy, White, Steven A., Murphy, Sandra, Trost, Matthias, Zakrzewski, Johannes L., Klein, Ulf, Schwabe, Robert F., Mederacke, Ingmar, Nixon, Colin, Bird, Tom, Teuwen, Laure-Anne, Schoonjans, Luc, Carmeliet, Peter, Mann, Jelena, Fisher, Andrew J., Sheerin, Neil S., Borthwick, Lee A., Mann, Derek A., and Oakley, Fiona

Published
2020
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4. Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Author

Leslie, Jack, Macia, Marina García, Luli, Saimir, Worrell, Julie C., Reilly, William J., Paish, Hannah L., Knox, Amber, Barksby, Ben S., Gee, Lucy M., Zaki, Marco Y. W., Collins, Amy L., Burgoyne, Rachel A., Cameron, Rainie, Bragg, Charlotte, Xu, Xin, Chung, Git W., Brown, Colin D. A., Blanchard, Andrew D., Nanthakumar, Carmel B., Karsdal, Morten, Robinson, Stuart M., Manas, Derek M., Sen, Gourab, French, Jeremy, White, Steven A., Murphy, Sandra, Trost, Matthias, Zakrzewski, Johannes L., Klein, Ulf, Schwabe, Robert F., Mederacke, Ingmar, Nixon, Colin, Bird, Tom, Teuwen, Laure-Anne, Schoonjans, Luc, Carmeliet, Peter, Mann, Jelena, Fisher, Andrew J., Sheerin, Neil S., Borthwick, Lee A., Mann, Derek A., and Oakley, Fiona

Published
2021
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8. A Mammalian Target of Rapamycin‐Perilipin 3 (mTORC1‐Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

Author

Garcia‐Macia, Marina, primary, Santos‐Ledo, Adrián, additional, Leslie, Jack, additional, Paish, Hannah L., additional, Collins, Amy L., additional, Scott, Rebecca S., additional, Watson, Abigail, additional, Burgoyne, Rachel A., additional, White, Steve, additional, French, Jeremy, additional, Hammond, John, additional, Borthwick, Lee A., additional, Mann, Jelena, additional, Bolaños, Juan P., additional, Korolchuk, Viktor I., additional, Oakley, Fiona, additional, and Mann, Derek A., additional

Published
2021
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10. A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

Author

Newcastle University, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Fundación BBVA, Fundación Ramón Areces, Biotechnology and Biological Sciences Research Council (UK), García-Macia, Marina, Santos-Ledo, Adrián, Leslie, Jack, Paish, Hannah L., Collins, Amy L., Scott, Rebecca S., Watson, Abigail, Burgoyne, Rachel A., White, Steven A., French, Jeremy, Hammond, John, Borthwick, Lee A., Mann, Jelena, Bolaños, Juan P., Korolchuk, Viktor I., Oakley, Fiona, Mann, Derek A., Newcastle University, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Fundación BBVA, Fundación Ramón Areces, Biotechnology and Biological Sciences Research Council (UK), García-Macia, Marina, Santos-Ledo, Adrián, Leslie, Jack, Paish, Hannah L., Collins, Amy L., Scott, Rebecca S., Watson, Abigail, Burgoyne, Rachel A., White, Steven A., French, Jeremy, Hammond, John, Borthwick, Lee A., Mann, Jelena, Bolaños, Juan P., Korolchuk, Viktor I., Oakley, Fiona, and Mann, Derek A.

Abstract

[Background and Aims] NAFLD is the most common hepatic pathology in western countries and no treatment is currently available. NAFLD is characterized by the aberrant hepatocellular accumulation of fatty acids in the form of lipid droplets (LDs). Recently, it was shown that liver LD degradation occurs through a process termed lipophagy, a form of autophagy. However, the molecular mechanisms governing liver lipophagy are elusive. Here, we aimed to ascertain the key molecular players that regulate hepatic lipophagy and their importance in NAFLD., [Approach and Results] We analyzed the formation and degradation of LD in vitro (fibroblasts and primary mouse hepatocytes), in vivo and ex vivo (mouse and human liver slices) and focused on the role of the autophagy master regulator mammalian target of rapamycin complex (mTORC) 1 and the LD coating protein perilipin (Plin) 3 in these processes. We show that the autophagy machinery is recruited to the LD on hepatic overload of oleic acid in all experimental settings. This led to activation of lipophagy, a process that was abolished by Plin3 knockdown using RNA interference. Furthermore, Plin3 directly interacted with the autophagy proteins focal adhesion interaction protein 200 KDa and autophagy-related 16L, suggesting that Plin3 functions as a docking protein or is involved in autophagosome formation to activate lipophagy. Finally, we show that mTORC1 phosphorylated Plin3 to promote LD degradation., [Conclusions] These results reveal that mTORC1 regulates liver lipophagy through a mechanism dependent on Plin3 phosphorylation. We propose that stimulating this pathway can enhance lipophagy in hepatocytes to help protect the liver from lipid-mediated toxicity, thus offering a therapeutic strategy in NAFLD.

Published
2021

12. Change in Loneliness Experienced by Older Men and Women Living Alone and With Others at the Onset of the COVID-19 Pandemic.

Author

Wilson-Genderson, Maureen, Heid, Allison R., Cartwright, Francine, Collins, Amy L., and Pruchno, Rachel

Subjects
SOCIAL support, AGE distribution, HEALTH status indicators, SOCIAL isolation, SEX distribution, INCOME, INDEPENDENT living, LONELINESS, RESIDENTIAL patterns, MARITAL status, COVID-19 pandemic, EDUCATIONAL attainment, OLD age
Abstract

Building on theory suggesting that loneliness is distinct from living arrangements, social isolation, and perceived social support, we examined change in loneliness for older people at the onset of the COVID-19 pandemic. Analyzing 14-years of data with multilevel mixed-effects models, we found higher levels of loneliness among people living alone, people more socially isolated, and people with less perceived support. Gender affected changes in loneliness, controlling for social isolation, perceived support, living arrangements, age, education, income, health, and marital status. Women, whether living alone or with others, experienced increases in loneliness; women living alone reported the greatest increase in loneliness. Men living alone reported high levels of loneliness prior to the pandemic, but only a slight increase over time. These analyses, which demonstrate that loneliness changed at the onset of the pandemic as a function of gender and living arrangement identify older people most likely to benefit from intervention. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Author

Lagnado, Anthony, primary, Leslie, Jack, additional, Ruchaud‐Sparagano, Marie‐Helene, additional, Victorelli, Stella, additional, Hirsova, Petra, additional, Ogrodnik, Mikolaj, additional, Collins, Amy L, additional, Vizioli, Maria Grazia, additional, Habiballa, Leena, additional, Saretzki, Gabriele, additional, Evans, Shane A, additional, Salmonowicz, Hanna, additional, Hruby, Adam, additional, Geh, Daniel, additional, Pavelko, Kevin D, additional, Dolan, David, additional, Reeves, Helen L, additional, Grellscheid, Sushma, additional, Wilson, Colin H, additional, Pandanaboyana, Sanjay, additional, Doolittle, Madison, additional, von Zglinicki, Thomas, additional, Oakley, Fiona, additional, Gallage, Suchira, additional, Wilson, Caroline L, additional, Birch, Jodie, additional, Carroll, Bernadette, additional, Chapman, James, additional, Heikenwalder, Mathias, additional, Neretti, Nicola, additional, Khosla, Sundeep, additional, Masuda, Claudio Akio, additional, Tchkonia, Tamar, additional, Kirkland, James L, additional, Jurk, Diana, additional, Mann, Derek A, additional, and Passos, João F, additional

Published
2021
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14. Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Author

Leslie, Jack, primary, Macia, Marina García, additional, Luli, Saimir, additional, Worrell, Julie C., additional, Reilly, William J., additional, Paish, Hannah L., additional, Knox, Amber, additional, Barksby, Ben S., additional, Gee, Lucy M., additional, Zaki, Marco Y. W., additional, Collins, Amy L., additional, Burgoyne, Rachel A., additional, Cameron, Rainie, additional, Bragg, Charlotte, additional, Xu, Xin, additional, Chung, Git W., additional, Brown, Colin D. A., additional, Blanchard, Andrew D., additional, Nanthakumar, Carmel B., additional, Karsdal, Morten, additional, Robinson, Stuart M., additional, Manas, Derek M., additional, Sen, Gourab, additional, French, Jeremy, additional, White, Steven A., additional, Murphy, Sandra, additional, Trost, Matthias, additional, Zakrzewski, Johannes L., additional, Klein, Ulf, additional, Schwabe, Robert F., additional, Mederacke, Ingmar, additional, Nixon, Colin, additional, Bird, Tom, additional, Teuwen, Laure-Anne, additional, Schoonjans, Luc, additional, Carmeliet, Peter, additional, Mann, Jelena, additional, Fisher, Andrew J., additional, Sheerin, Neil S., additional, Borthwick, Lee A., additional, Mann, Derek A., additional, and Oakley, Fiona, additional

Published
2020
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18. Positive affective tone and team performance: The moderating role of collective emotional skills.

Author

Collins, Amy L., Jordan, Peter J., Lawrence, Sandra A., and Troth, Ashlea C.

Subjects
*COLLECTIVE behavior, *EMOTIONS, *PERFORMANCE evaluation, *GROUP theory, *PSYCHOLOGICAL research
Abstract

Research on affect as a group-level phenomenon has shown that over time, individual members within a group become highly similar in their affect (i.e., members experience and display similar emotions and moods), and often become similar enough that the aggregation of individuals’ affect can meaningfully represent the “affective tone” of the group. It is generally assumed that a more positive affective tone will lead to better team performance. We challenge the conclusion that positive affective tone is always good for team performance, suggesting that the relationship between positive affective tone and team performance is subject to moderating influences. Across two studies, we demonstrate that the self-reported collective emotional skills of team members play a crucial role in determining whether positive affective tone is beneficial or detrimental to team performance. Implications for theory and practice are discussed. [ABSTRACT FROM PUBLISHER]

Published
2016
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21. Construct validity of Wechsler factor scores

Author

Livingston, Ronald B, Gray, Robert M., Broquie, Jo Ann P., Dickson, Terri L., Collins, Amy L., and Spence, Shannon

Subjects
Verbal learning -- Evaluation, Children -- Language, Neurophysiology -- Research, Health, Psychology and mental health
Abstract

The construct validity of the Verbal Comprehension, Perceptual Organization, and Freedom from Distractibility factor scores was examined in a sample of school-aged referred children. Examination of correlations between factor scores and neuropsychological and achievement tests generally supported the construct validity of the factors. The Verbal Comprehension factor was associated with verbal, quantitative, and concept-formation abilities. The Perceptual Organization factor was related to nonverbal concept formation, tactual performance, and visual attention. The Freedom from Distractibility factor demonstrated a complex pattern of correlations and appeared to reflect a range of abilities including quantitative, language, attentional, and concept formation.

Published
2001

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