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1. Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer

Author

Ferrucci, Veronica, Asadzadeh, Fatemeh, Collina, Francesca, Siciliano, Roberto, Boccia, Angelo, Marrone, Laura, Spano, Daniela, Carotenuto, Marianeve, Chiarolla, Cristina Maria, De Martino, Daniela, De Vita, Gennaro, Macrì, Alessandra, Dassi, Luisa, Vandenbussche, Jonathan, Marino, Natascia, Cantile, Monica, Paolella, Giovanni, D'Andrea, Francesco, di Bonito, Maurizio, Gevaert, Kris, and Zollo, Massimo

Published
2021
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4. Power Capping in High Performance Computing Systems

Author

Borghesi, Andrea, Collina, Francesca, Lombardi, Michele, Milano, Michela, Benini, Luca, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Pesant, Gilles, editor

Published
2015
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5. B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report

Author

Esposito, Emanuela, primary, Varone, Valeria, additional, Siani, Claudio, additional, Di Bonito, Maurizio, additional, Melucci, Maria Teresa, additional, Donzelli, Ivana, additional, di Giacomo, Raimondo, additional, Marone, Ugo, additional, Saponara, Ruggero, additional, Collina, Francesca, additional, Fucito, Alfredo, additional, and Avino, Franca, additional

Published
2023
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6. Concomitant BRAFV600E and NRAS Q61R Mutations in the Same Thyroid Nodule: A Case Study.

Author

Marianna, Brogna, Collina, Francesca, Losito, Simona, Clery, Eduardo, Montone, Angela, Del Sesto, Michele, and Ferrara, Gerardo

Subjects
*THYROID cancer, *THYROID nodules, *PAPILLARY carcinoma, *TOLL-like receptors, *TUMOR growth, *BRAF genes
Abstract

Background: Papillary Thyroid Cancer (PTC) is the most common type of well differentiated endocrine malignancy. Generally thyroid nodules with multiple oncogenic mutations are uncommon with an occurrence which may be related to more aggressive biological behavior of tumors. Rearranged in Transformation/Papillary Thyroid Carcinomas (RET/PTC) rearrangement, RAS and BRAF mutations are considered to be mutually exclusive in PTC. Concomitant RET/PTC, RAS, or BRAF mutations have been documented, although the impact of these mutations for tumor growth and survival is debated. Case presentation: Here, we present a rare case of woman 46 years old with a neck mass and thyroid nodule classified as Toll-Like Receptor 5 (TIR5) on cy-tological examination. We found contemporary BRAF p.(Val600Glu) (p. (V600E); c. 1799T>A) and NRAS p. (Gln61 Arg) (p. (Q61R); c.182A>G) mutations in morphologically different areas within the same lobe (the right one). Two lesions show different morphology. The mutated BRAF lesion showed morphological characteristics compatible with classic papillary carcinoma while the mutant NRAS lesion shows morphological features compatible with follicular variant papillary carcinoma. Results and conclusion: To the best of our knowledge, this is the first time that such mutations, which are normally mutually exclusive, have been detected at the same time. The findings of synchronous mutations are rare occurrence, suggesting for Intratumoral Heterogeneity (ITH) even in PTC. Patients with multiple mutations have a clinical worse prognosis, generally characterized by an aggressive thyroid cancer, which may influence the surgical treatment, chemotherapy, and BRAF V600E mutation-targeting therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Abstract 1353: Immunomodulatory effects of valproic acid in combination with cisplatin and cetuximab in head and neck squamous cell carcinoma

Author

Iannelli, Federica, primary, Zotti, Andrea Ilaria, additional, Roca, Maria Serena, additional, Grumetti, Laura, additional, Moccia, tania, additional, vitagliano, carlo, additional, costantini, susan, additional, capone, francesca, additional, collina, francesca, additional, Gabriele, Lucia, additional, parlato, stefania, additional, Romagnoli, Giulia, additional, Kepp, Oliver, additional, Kroemer, Guido, additional, Di Gennaro, Elena, additional, and Budillon, Alfredo, additional

Published
2022
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8. Glyoxalase 1 knockdown induces age‐related β‐cell dysfunction and glucose intolerance in mice

Author

Prevenzano, Immacolata, primary, Leone, Alessia, additional, Longo, Michele, additional, Nicolò, Antonella, additional, Cabaro, Serena, additional, Collina, Francesca, additional, Panarese, Iacopo, additional, Botti, Gerardo, additional, Formisano, Pietro, additional, Napoli, Raffaele, additional, Beguinot, Francesco, additional, Miele, Claudia, additional, and Nigro, Cecilia, additional

Published
2022
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9. Virtual Institute for the Modelling of Industrial Manufacturing Systems : Integration of on-line and ‘face-to-face’ learning in an international platform for teaching and research

Author

Cavalieri, Sergio, Garetti, Marco, Macchi, Marco, Campi, Alessandro, Collina, Francesca, Colorni, Alberto, Locatelli, Ignazio, Longeri, Tiziana, Von Cieminski, Gregor, Lopitzsch, Jens, di Mascolo, Maria, Frein, Yannick, Kadar, Botond, Monostori, Laszlo, Zudor, Elisabeta Ilie, Meroni, Alberto, Santambrogio, Nicoletta, Passey, Don, editor, and Kendall, Mike, editor

Published
2002
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11. Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells

Author

Ambrosio, Maria Rosaria, D'Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, MOSCA, GIUSY, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, Formisano, Pietro, PREVETE, Nella, Ambrosio, Maria Rosaria, D'Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, Mosca, Giusy, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, and Formisano, Pietro

Subjects
0301 basic medicine, medicine.medical_specialty, Adipose tissue, Connective tissue, Estrogen receptor, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, Internal medicine, medicine, connective tissue growth factor, glucose, skin and connective tissue diseases, Cancer prevention, tamoxifen, business.industry, Cancer, medicine.disease, adipose tissue, CTGF, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Oncology, 030220 oncology & carcinogenesis, business, Tamoxifen, medicine.drug, Research Paper
Abstract

// Maria Rosaria Ambrosio 1, * , Vittoria D’Esposito 1, * , Valerio Costa 2 , Domenico Liguoro 1 , Francesca Collina 3 , Monica Cantile 3 , Nella Prevete 1 , Carmela Passaro 1 , Giusy Mosca 1 , Michelino De Laurentiis 4 , Maurizio Di Bonito 3 , Gerardo Botti 3 , Renato Franco 5 , Francesco Beguinot 1 , Alfredo Ciccodicola 2, 6 and Pietro Formisano 1 1 Department of Translational Medicine, University of Naples “Federico II” & URT “Genomic of Diabetes” of Institute of Experimental Endocrinology and Oncology “G. Salvatore”, National Council of Research (CNR), Naples 80131, Italy 2 Institute of Genetic and Biophysics “A. Buzzati-Traverso”, CNR, Naples 80131, Italy 3 Pathology Unit, National Cancer Institute “G. Pascale Foundation”, Naples 80131, Italy 4 Department of Breast Surgery and Cancer Prevention, National Cancer Institute “G. Pascale Foundation”, Naples 80131, Italy 5 Pathology Unit, Universita degli Studi della Campania “Luigi Vanvitelli”, Naples 80138, Italy 6 Department of Science and Technology, University of Naples “Parthenope”, Naples 80131, Italy * These authors have equally contributed to this work Correspondence to: Pietro Formisano, email: fpietro@unina.it Keywords: breast cancer; tamoxifen; glucose; adipose tissue; connective tissue growth factor Received: April 21, 2017 Accepted: July 25, 2017 Published: November 20, 2017 ABSTRACT Type 2 diabetes and obesity are negative prognostic factors in patients with breast cancer (BC). We found that sensitivity to tamoxifen was reduced by 2-fold by 25 mM glucose (High Glucose; HG) compared to 5.5 mM glucose (Low Glucose; LG) in MCF7 BC cells. Shifting from HG to LG ameliorated MCF7 cell responsiveness to tamoxifen. RNA-Sequencing of MCF7 BC cells revealed that cell cycle-related genes were mainly affected by glucose. Connective Tissue Growth Factor (CTGF) was identified as a glucose-induced modulator of cell sensitivity to tamoxifen. Co-culturing MCF7 cells with human adipocytes exposed to HG, enhanced CTGF mRNA levels and reduced tamoxifen responsiveness of BC cells. Inhibition of adipocyte-released IL8 reverted these effects. Interestingly, CTGF immuno-detection in bioptic specimens from women with estrogen receptor positive (ER + ) BC correlated with hormone therapy resistance, distant metastases, reduced overall and disease-free survival. Thus, glucose affects tamoxifen responsiveness directly modulating CTGF in BC cells, and indirectly promoting IL8 release by adipocytes.

Published
2017

13. Additional file 1 of Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer

Author

Camorani, Simona, Passariello, Margherita, Agnello, Lisa, Esposito, Silvia, Collina, Francesca, Cantile, Monica, Bonito, Maurizio Di, Ulasov, Ilya V., Fedele, Monica, Zannetti, Antonella, Lorenzo, Claudia De, and Cerchia, Laura

Abstract

Additional file 1: Figure S1. PDGFRβ Gint4.T aptamer specifically binds to human and mouse lymphocytes. Cell-ELISA assays on activated human (A) and mouse (B) lymphocytes with 5'-biotinylated PDGFRβ Gint4.T aptamer at the indicated concentrations. The background binding value for 5'-biotinylated Scr aptamer was subtracted from each data point. Data shown are mean ± SD (n=3). Figure S2. Similarity of human and mouse PDGFRβ. (A) The dotplot matrix shows the sequence similarity between human and mouse PDGFRβ protein obtained by using Dotmatcher tool (EMBOSS) with a scoring matrix Blosum 62 and a threshold line of 13. (B) NIH3T3 cells were mock-treated or serum-starved (ss) and then left untreated (-) or stimulated with PDGF-BB, as indicated. Cell lysates were immunoblotted with the indicated antibodies. Molecular weights of indicated proteins are reported. Figure S3. PDGFRβ and PD-L1 immunohistochemical expression. Shown are images from one representative tumor for each treatment group immunostained with anti-PDGFRβ (A) and anti-PDL1 (B) antibodies. Magnification 40 ×, scale bar = 50 μm.

Published
2020
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16. Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer

Author

Camorani, Simona, primary, Passariello, Margherita, additional, Agnello, Lisa, additional, Esposito, Silvia, additional, Collina, Francesca, additional, Cantile, Monica, additional, Bonito, Maurizio Di, additional, Ulasov, Ilya V., additional, Fedele, Monica, additional, Zannetti, Antonella, additional, De Lorenzo, Claudia, additional, and Cerchia, Laura, additional

Published
2020
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20. Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer

Author

Alexandrova, Elena, primary, Lamberti, Jessica, additional, Saggese, Pasquale, additional, Pecoraro, Giovanni, additional, Memoli, Domenico, additional, Mirici Cappa, Valeria, additional, Ravo, Maria, additional, Iorio, Roberta, additional, Tarallo, Roberta, additional, Rizzo, Francesca, additional, Collina, Francesca, additional, Cantile, Monica, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Nassa, Giovanni, additional, Weisz, Alessandro, additional, and Giurato, Giorgio, additional

Published
2020
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21. Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer

Author

Alexandrova, Elena, primary, Giurato, Giorgio, additional, Saggese, Pasquale, additional, Pecoraro, Giovanni, additional, Lamberti, Jessica, additional, Ravo, Maria, additional, Rizzo, Francesca, additional, Rocco, Domenico, additional, Tarallo, Roberta, additional, Nyman, Tuula A., additional, Collina, Francesca, additional, Cantile, Monica, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Nassa, Giovanni, additional, and Weisz, Alessandro, additional

Published
2020
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23. Virtual Institute for the Modelling of Industrial Manufacturing Systems

Author

Cavalieri, Sergio, primary, Garetti, Marco, additional, Macchi, Marco, additional, Campi, Alessandro, additional, Collina, Francesca, additional, Colorni, Alberto, additional, Locatelli, Ignazio, additional, Longeri, Tiziana, additional, Von Cieminski, Gregor, additional, Lopitzsch, Jens, additional, di Mascolo, Maria, additional, Frein, Yannick, additional, Kadar, Botond, additional, Monostori, Laszlo, additional, Zudor, Elisabeta Ilie, additional, Meroni, Alberto, additional, and Santambrogio, Nicoletta, additional

Published
2002
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24. Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution

Author

Collina Francesca, De Chiara Anna, De Renzo Amalia, De Rosa Gaetano, Botti Gerardo, and Franco Renato

Subjects
Chlamydia psittaci, Ocular Adnexa, MALT lymphoma, t(14, 18), bcl10, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Ocular adnexa MALT-lymphomas represent approximatively 5-15% of all extranodal lymphomas. Almost 75% of OAMLs are localized in orbital fat, while 25% of cases involves conjunctive. MALT-lymphomas often recognize specific environmental factors responsible of lymphoma development and progression. In particular as Helicobacter pylori in gastric MALT lymphomas, other bacterial infections have been recognized related to MALT lymphomas in specific site. Recently Chlamydia psittaci has been identified in Ocular Adnexa MALT lymphomas, with variable frequence dependently from geographic areas. Thus bacterial infection is responsible of clonal selection on induced MALT with subsequent lymphoma development. Moreover Chlamydia psittaci could promote chromosomal aberration either through genetic instability as a consequence of induced proliferation and probably through DNA oxidative damage. The most common translocation described in MALT lymphomas affects NF-kB pathway with a substantial antiapoptotic effect. Several therapeutic approaches are now available, but the use of antibiotic-therapy in specific cases, although with conflicting results, could improve the treatment of ocular adnexa MALT lymphomas. In this review we analyse the most relevant features of Ocular adnexa MALT lymphomas, underlining specific biological characteristics mainly related to the potential role of Chlamydia psittaci in lymphomagenesis.

Published
2012
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26. AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer

Author

Collina, Francesca, primary, La Sala, Lucia, additional, Liotti, Federica, additional, Prevete, Nella, additional, La Mantia, Elvira, additional, Chiofalo, Maria Grazia, additional, Aquino, Gabriella, additional, Arenare, Laura, additional, Cantile, Monica, additional, Liguori, Giuseppina, additional, Di Gennaro, Francesca, additional, Pezzullo, Luciano, additional, Losito, Nunzia Simona, additional, Vecchio, Giancarlo, additional, Botti, Gerardo, additional, Melillo, Rosa Marina, additional, and Franco, Renato, additional

Published
2019
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32. Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers

Author

Di Mauro, Concetta, primary, Rosa, Roberta, additional, D'Amato, Valentina, additional, Ciciola, Paola, additional, Servetto, Alberto, additional, Marciano, Roberta, additional, Orsini, Roberta Clara, additional, Formisano, Luigi, additional, De Falco, Sandro, additional, Cicatiello, Valeria, additional, Di Bonito, Maurizio, additional, Cantile, Monica, additional, Collina, Francesca, additional, Chambery, Angela, additional, Veneziani, Bianca Maria, additional, De Placido, Sabino, additional, and Bianco, Roberto, additional

Published
2017
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33. Programmed Death Ligand 1 (PD-L1) Tumor Expression Is Associated with a Better Prognosis and Diabetic Disease in Triple Negative Breast Cancer Patients

Author

Botti, Gerardo, primary, Collina, Francesca, additional, Scognamiglio, Giosuè, additional, Rao, Federica, additional, Peluso, Valentina, additional, De Cecio, Rossella, additional, Piezzo, Michela, additional, Landi, Gabriella, additional, De Laurentiis, Michelino, additional, Cantile, Monica, additional, and Di Bonito, Maurizio, additional

Published
2017
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34. HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer

Author

Franco, Renato, Collina, Francesca, Di Bonito, Maurizio, Botti, Gerardo, Montanaro, Donatella, Di Maio, Luigi, Vincenz, Bruno, Landi, Gabriella, D’Aiuto, Massimiliano, Caraglia, Michele, and Baldi, Alfonso

Subjects
Tissue MicroArray, HTRA1, Breast Cancer, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Tumor suppressor, eye diseases
Abstract

Aim: HtrA1, a member of the High Temperature Requirement Factor A family of oxidative stress-response proteases seems to play a role as a tumor suppressor, being down-regulated in a series of human cancers during their progression. Particularly, low HtrA1 mRNA levels have been observed in breast cancer patients with more aggressive clinical features. These have been shown to relate to a longer disease free and overall survival, with more pronounced effects in axillary nodes positive patients. Subjects and Methods: We have analyzed for immunohistochemical HtrA1 expression a series of 66 sentinel node positive breast cancers through Tissue Micro Array technology. Results: HtrA1 was absent to low in 29 cases, medium in 19 cases and high in 18 cases. Our data revealed a positive significant relation between HtrA1 expression level and estrogen (p=0,002) and progestinic receptor expression (p=0.003) and a negative correlation with histological grading (p=0.028), proliferation index (p=0.05), common BC histotypes (p=0.040), luminal A and B subtypes (p=0.001), metastasis development (p

Published
2015

35. Noncoding RNAs within the HOX gene network in tumor pathogenesis and progression.

Author

Botti, Gerardo, De Chiara, Anna, Di Bonito, Maurizio, Cerrone, Margherita, Malzone, Maria Gabriella, Collina, Francesca, and Cantile, Monica

Subjects
NON-coding RNA, CELL proliferation, MOLECULAR genetics, HOMEOBOX genes, CANCER cells
Abstract

HOX genes are involved with normal development, cell identity, cell differentiation, cell metabolism, apoptosis, autophagy as well as with diseases such as tumor pathogenesis and progression. In particular, the genes belonging to HOX paralogous 13 seem to carry out a relevant role in both tumor development and disease progression. In recent years, several noncoding RNAs (ncRNA) sequences have been identified in HOX loci, including long noncoding RNA (lncRNA) and microRNA (miRNA), highly conserved during evolution. Many studies have shown that specific intergenic ncRNAs in HOX loci could directly modulate HOX genes expression in normal and pathological conditions. In the present review we attempt to describe the role of these ncRNAs, through the regulation of the HOX gene network, in normal cell biology, and, with particular emphasis, in diseases such as in cancer pathogenesis and progression. Specific intergenic noncoding RNAs (ncRNAs) in HOX loci directly modulate HOX genes expression in normal and pathological conditions. NcRNAs within the HOX loci are strongly involved in tumor progression and in mechanisms of resistance to anticancer drugs. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5

Author

D'Esposito, Vittoria, primary, Liguoro, Domenico, additional, Ambrosio, Maria Rosaria, additional, Collina, Francesca, additional, Cantile, Monica, additional, Spinelli, Rosa, additional, Raciti, Gregory Alexander, additional, Miele, Claudia, additional, Valentino, Rossella, additional, Campiglia, Pietro, additional, De Laurentiis, Michelino, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Franco, Renato, additional, Beguinot, Francesco, additional, and Formisano, Pietro, additional

Published
2016
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40. Interleukin-8, but not the Related Chemokine CXCL1, Sustains an Autocrine Circuit Necessary for the Properties and Functions of Thyroid Cancer Stem Cells.

Author

Liotti, Federica, Collina, Francesca, Pone, Emanuela, La Sala, Lucia, Franco, Renato, Prevete, Nella, and Melillo, Rosa Marina

Abstract

Interleukin-8 (IL-8/CXCL8) mediates its biological effects through two receptors, CXCR1 and CXCR2. While CXCR1 recognizes IL-8 and granulocyte chemotactic protein-2, CXCR2 binds to multiple chemokines including IL-8, CXCL1, 2 and 3. Both IL-8 and CXCL1 have been implicated in the neoplastic features of thyroid cancer (TC). Here, we assessed the role of the autocrine circuits sustained by IL-8 and CXCL1 in determining TC stem cell (TC SC) features. Using immunohistochemistry, we found that thyroid epithelial cancerous, but not normal, cells stained positive for IL-8, whose levels correlated with lymph-nodal metastases. We assessed the expression of endogenous IL-8 and CXCL1, by ELISA assays, and of their receptors CXCR1 and CXCR2, by flow cytometry, in a panel of TC cell lines. These molecules were expressed in TC cell lines grown in adherence, and at higher levels also in thyrospheres enriched in stem-like cells. RNA interference demonstrated that IL-8/CXCR1, but not CXCL1/CXCR2, is crucial for the sphere-forming, self-renewal and tumor-initiating ability of TC cells. Accordingly, treatment of TC cells with IL-8, but not with CXCL1, potentiated cell stemness. We identified CD34 as an IL-8-induced gene and as a TC SC marker, since it was overexpressed in thyrospheres compared to adherent cells. Moreover, CD34 is required for the efficient sphere-forming ability and tumorigenicity of TC cells. Our data indicate that IL-8, but not the CXCL1 circuit, is critical for the regulation of TC SCs, and unveils novel potential targets for the therapy of as yet untreatable forms of TC. S tem C ells 2017;35:135-146 [ABSTRACT FROM AUTHOR]

Published
2017
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45. PP072

Author

Aquino, Gabriella, primary, Sabatino, Rocco, additional, Collina, Francesca, additional, Longo, Francesco, additional, Gigantino, Vincenzo, additional, Madonna, Colomba, additional, Ionna, Franco, additional, Botti, Gerardo, additional, Pannone, Giuseppe, additional, and Franco, Renato, additional

Published
2013
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46. Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen

Author

Aquino, Gabriella, primary, Sabatino, Rocco, additional, Cantile, Monica, additional, Aversa, Corrado, additional, Ionna, Franco, additional, Botti, Gerardo, additional, La Mantia, Elvira, additional, Collina, Francesca, additional, Malzone, Gabriella, additional, Pannone, Giuseppe, additional, Losito, Nunzia Simona, additional, Franco, Renato, additional, and Longo, Francesco, additional

Published
2013
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47. Erratum to: Aberrant Expression of Cancer Stem Cells Marker Prominin-1 in Low-Grade Tubulobular Breast Carcinoma: A Correlative Study between qRT-PCR, Flow-Cytometric and Immunohistochemistry Analysis

Author

Di Bonito, Maurizio, primary, Collina, Francesca, additional, Cantile, Monica, additional, Camerlingo, Rosalba, additional, Cerrone, Margherita, additional, Marra, Laura, additional, Liguori, Giuseppina, additional, Pirozzi, Giuseppe, additional, and Botti, Gerardo, additional

Published
2013
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48. Aberrant Expression of Cancer Stem Cells Marker Prominin-1 in Low-Grade Tubulobular Breast Carcinoma: A Correlative Study between qRT-PCR, Flow-Cytometric and Immunohistochemistry Analysis

Author

Di Bonito, Maurizio, primary, Collina, Francesca, additional, Cantile, Monica, additional, Camerlingo, Rosalba, additional, Cerrone, Margherita, additional, Marra, Laura, additional, Liguori, Giuseppina, additional, Pirozzi, Giuseppe, additional, and Botti, Gerardo, additional

Published
2012
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50. Coexistence of Granular Cell Tumor and Invasive Ductal Breast Cancer in Contralateral Breasts: A Case Report.

Author

Bonito, Maurizio Di, Cantile, Monica, Collina, Francesca, Cecio, Rossella De, Petrosino, Teresa, and Botti, Gerardo

Subjects
BREAST cancer, MAMMOGRAMS, DUCTAL carcinoma, IMMUNOPHENOTYPING, GENETIC markers
Abstract

Granular cell tumor (GCT) is a benign tumor of the breast that can mimic, on breast imaging, invasive carcinomas. Biological evolution of mammary GCT is unknown, especially if it is associated with an invasive carcinoma in the same or contralateral breast. This report details the morphological features of these synchronous lesions highlighting their biological characteristics and suggesting an appropriate follow up. [ABSTRACT FROM AUTHOR]

Published
2014
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