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2,798 results on '"Collier R"'

5. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons

Author

Yang, Nicole J., Isensee, Jörg, Neel, Dylan V., Quadros, Andreza U., Zhang, Han-Xiong Bear, Lauzadis, Justas, Liu, Sai Man, Shiers, Stephanie, Belu, Andreea, Palan, Shilpa, Marlin, Sandra, Maignel, Jacquie, Kennedy-Curran, Angela, Tong, Victoria S., Moayeri, Mahtab, Röderer, Pascal, Nitzsche, Anja, Lu, Mike, Pentelute, Bradley L., Brüstle, Oliver, Tripathi, Vineeta, Foster, Keith A., Price, Theodore J., Collier, R. John, Leppla, Stephen H., Puopolo, Michelino, Bean, Bruce P., Cunha, Thiago M., Hucho, Tim, and Chiu, Isaac M.

Published
2022
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7. Atomic structure of anthrax protective antigen pore elucidates toxin translocation

Author

Jiang, Jiansen, Pentelute, Bradley L, Collier, R John, and Zhou, Z Hong

Subjects
Biochemistry and Cell Biology, Chemical Sciences, Physical Sciences, Biological Sciences, Antigens, Bacterial, Bacillus anthracis, Bacterial Toxins, Biocatalysis, Cryoelectron Microscopy, Hydrogen-Ion Concentration, Ion Channels, Models, Molecular, Phenylalanine, Protein Conformation, Protein Transport, Structure-Activity Relationship, General Science & Technology
Abstract

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Protective antigen forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes lethal factor and oedema factor into the cytosol of target cells. Protective antigen is not only a vaccine component and therapeutic target for anthrax infections but also an excellent model system for understanding the mechanism of protein translocation. On the basis of biochemical and electrophysiological results, researchers have proposed that a phi (Φ)-clamp composed of phenylalanine (Phe)427 residues of protective antigen catalyses protein translocation via a charge-state-dependent Brownian ratchet. Although atomic structures of protective antigen prepores are available, how protective antigen senses low pH, converts to active pore, and translocates lethal factor and oedema factor are not well defined without an atomic model of its pore. Here, by cryo-electron microscopy with direct electron counting, we determine the protective antigen pore structure at 2.9-Å resolution. The structure reveals the long-sought-after catalytic Φ-clamp and the membrane-spanning translocation channel, and supports the Brownian ratchet model for protein translocation. Comparisons of four structures reveal conformational changes in prepore to pore conversion that support a multi-step mechanism by which low pH is sensed and the membrane-spanning channel is formed.

Published
2015

9. Cryogenic instrumentation for fast current measurement in a silicon single electron transistor

Author

Ferrus, T., Hasko, D. G., Morrissey, Q. R., Burge, S. R., Freeman, E. J., French, M. J., Lam, A., Creswell, L., Collier, R. J., Williams, D. A., and Briggs, G. A. D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

We present a realisation of high bandwidth instrumentation at cryogenic temperatures and for dilution refrigerator operation that possesses advantages over methods using radio-frequency single electron transistor or transimpedance amplifiers. The ability for the low temperature electronics to carry out faster measurements than with room temperature electronics is investigated by the use of a phosphorous-doped single-electron transistor. A single-shot technique is successfully implemented and used to observe the real time decay of a quantum state. A discussion on various measurement strategies is presented and the consequences on electron heating and noise are analysed., Comment: 18 pages, 6 figures, published in J. Appl. Phys

Published
2009
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10. Single shot measurement of a silicon single electron transistor

Author

Hasko, D. G., Ferrus, T., Morrissey, Q. R., Burge, S. R., Freeman, E. J., French, M. J., Lam, A., Creswell, L., Collier, R. J., Williams, D. A., and Briggs, G. A. D.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Other Condensed Matter
Abstract

We have fabricated a custom cryogenic Complementary Metal-Oxide-Semiconductor (CMOS) integrated circuit that has a higher measurement bandwidth compared with conventional room temperature electronics. This allowed implementing single shot operations and observe the real-time evolution of the current of a phosphorous-doped silicon single electron transistor that was irradiated with a microwave pulse. Relaxation times up to 90 us are observed, suggesting the presence of well isolated electron excitations within the device. It is expected that these are associated with long decoherence time and the device may be suitable for quantum information processing.

Published
2008
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30. Biogeography and Ecological Setting of Indian Ocean Hydrothermal Vents

Author

van Dover, C. L., Humphris, S. E., Fornari, D., Cavanaugh, C. M., Collier, R., Goffredi, S. K., Hashimoto, J., Lilley, M. D., Reysenbach, A. L., Shank, T. M., von Damm, K. L., Banta, A., Gallant, R. M., Götz, D., Green, D., Hall, J., Harmer, T. L., Hurtado, L. A., Johnson, P., McKiness, Z. P., Meredith, C., Olson, E., Pan, I. L., Turnipseed, M., Won, Y., Young, C. R., and Vrijenhoek, R. C.

Published
2001

45. A Middleware for Implicit Interaction

Author

O’Grady, M. J., Ye, J., O’Hare, G. M. P., Dobson, S., Tynan, R., Collier, R., Muldoon, C., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, and Cai, Yang, editor

Published
2011
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