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925 results on '"Collet L"'

14. 20P Deciphering tumor microenvironment heterogeneity between primary tumor and metastases in high grade serous ovarian cancer (HGSC) to predict response to immunotherapy (IT): Analyses from the NeoPembrOv/GINECO phase II trial

Author

Collet, L., primary, Ardin, M., additional, Venet, D., additional, Berthet, J., additional, Treilleux, I., additional, Leheurteur, M., additional, Meunier, J., additional, Lefevre, L. Bengrine, additional, Martinez, M., additional, Priou, F., additional, Selle, F., additional, Just, P-A., additional, Bataillon, G., additional, Rothé, F., additional, Sotiriou, C., additional, Dubois, B., additional, Caux, C., additional, Ray-Coquard, I.L., additional, and Le Saux, O., additional

Published
2023
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16. 59P Tumor cells-adipocytes interactions are associated with poor disease outcome in invasive lobular carcinoma

Author

Serra, M., primary, Occelli, N., additional, Rediti, M., additional, Collet, L., additional, Lifrange, F., additional, Wang, X., additional, Vincent, D., additional, Rouas, G., additional, Craciun, L., additional, Larsimont, D., additional, Venet, D., additional, Vikkula, M., additional, Duhoux, F.P., additional, Buisseret, L., additional, Rothé, F., additional, and Sotiriou, C., additional

Published
2023
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17. 34P Investigating morphological heterogeneity in luminal breast cancer integrating artificial intelligence and spatial transcriptomics

Author

Occelli, N., primary, Serra, M., additional, Rediti, M., additional, Collet, L., additional, Lifrange, F., additional, Wang, X., additional, Vincent, D., additional, Rouas, G., additional, Craciun, L., additional, Larsimont, D., additional, Venet, D., additional, Vikkula, M., additional, Duhoux, F.P., additional, Buisseret, L., additional, Rothé, F., additional, and Sotiriou, C., additional

Published
2023
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18. [Mayotte, a malaria-free island at last?]

Author

Lepère, Jf, Collet, L, Idaroussi, Ab, Pradines, Bruno, Centre Hospitalier de Mayotte, Service de lutte antivectorielle, ARS de Mayotte, Centre Kinga, Mamoudzou, Unité de Parasitologie et d’Entomologie [IRBA, Marseille], Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-Département des Maladies Infectieuses, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Centre National de Référence du Paludisme [IRBA, Marseille] (CNRP), and Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA)-Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Elimination, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Mayotte, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Indian Ocean, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Comoros, Malaria, Plasmodium falciparum
Abstract

International audience; Mayotte is a French overseas department and one of the 4 islands of the Comoros archipelago in the Indian Ocean, located between Madagascar and the eastern coast of Africa. Malaria, mainly by Plasmodium falciparum, is endemic to the archipelago and remained a major public health problem until recent years. To control and then eliminate the disease, major strategies have been established in Mayotte since 2001. Preventive measures, diagnostic testing, treatment and disease surveillance were introduced or improved.From 2002 to 2021, 4819 autochthonous cases were reported in Mayotte where the annual incidence decreased from 10.3 per 1,000 population in 2002 (1649 cases) to less than 0.01 per 1,000 population in 2020 (2 cases). The incidence has been below 1 per 1,000 population since 2009. In 2013, WHO classified Mayotte as a territory in malaria elimination phase. In 2021, no locally acquired malaria cases were reported on the island. During this period 2002-2021, 1898 imported cases were observed. They mainly came from the Union of Comoros (85.8%), Madagascar (8.6%) and sub-Saharan Africa (5,6%). Since 2017, the annual number of locally acquired cases was less than 10 and decreased steadily (9 cases in 2017, 5 in 2018, 4 in 2019 and 2 in 2020). The distribution of these rare locally acquired cases both in time and space suggests that they were introduced and not indigenous cases. A study of the genotypic profile of the plasmodial strains of these cases observed from 2017 to 2020 (17 cases analysed out of 20 diagnosed) confirms that these were certainly introduced cases related to imported cases from the neighboring Comoros.Malaria indigenous transmission seems to be eliminated in Mayotte, but the island remains under threat of reintroduction via cases imported from neighbouring countries. It is time to develop a local plan to prevent reintroduction and to implement a proactive policy of regional cooperation in the fight against malaria.

Published
2023

19. 1726P Investigating adipocytes-tumor cells interaction and its effect on disease progression in lobular breast cancer with spatial transcriptomics

Author

Serra, M., primary, Collet, L., additional, Rediti, M., additional, Lifrange, F., additional, Venet, D., additional, Occelli, N., additional, Vincent, D., additional, Rouas, G., additional, Larsimont, D., additional, Craciun, L., additional, Wang, X., additional, Gacquer, D., additional, Vikkula, M., additional, Duhoux, F.P., additional, Rothé, F., additional, and Sotiriou, C., additional

Published
2022
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31. The Analysis of Sequential Behavior in Classrooms and Social Environments: Problems and Proposed Solutions.

Author

Indiana Univ., Bloomington., Collet, L. S., and Semmel, M. I.

Abstract

Problems in the analysis of sequential behavior are discussed in relation to observation-coding procedures. A set of heuristic constructs are presented toward the development of a solution strategy for the analysis of chains of interactive behaviors. A proposed analytic computer program is briefly outlined and discussed. (Author)

Published
1971

40. Biological and clinical features of triple negative Invasive Lobular Carcinomas of the breast. Clinical outcome and actionable molecular alterations

Author

Conforti, F, Pala, L, Pagan, E, Rocco, E, Bagnardi, V, Montagna, E, Peruzzotti, G, De Pas, T, Fumagalli, C, Pileggi, S, Pesenti, C, Marchini, S, Corso, G, Marchio’, C, Sapino, A, Graffeo, R, Collet, L, Aftimos, P, Sotiriou, C, Piccart, M, Gelber, R, Viale, G, Colleoni, M, Goldhirsch, A, Conforti, Fabio, Pala, Laura, Pagan, Eleonora, Rocco, Elena Guerini, Bagnardi, Vincenzo, Montagna, Emilia, Peruzzotti, Giulia, De Pas, Tommaso, Fumagalli, Caterina, Pileggi, Silvana, Pesenti, Chiara, Marchini, Sergio, Corso, Giovanni, Marchio’, Caterina, Sapino, Anna, Graffeo, Rossella, Collet, Laetitia, Aftimos, Philippe, Sotiriou, Christos, Piccart, Martine, Gelber, Richard D., Viale, Giuseppe, Colleoni, Marco, Goldhirsch, Aron, Conforti, F, Pala, L, Pagan, E, Rocco, E, Bagnardi, V, Montagna, E, Peruzzotti, G, De Pas, T, Fumagalli, C, Pileggi, S, Pesenti, C, Marchini, S, Corso, G, Marchio’, C, Sapino, A, Graffeo, R, Collet, L, Aftimos, P, Sotiriou, C, Piccart, M, Gelber, R, Viale, G, Colleoni, M, Goldhirsch, A, Conforti, Fabio, Pala, Laura, Pagan, Eleonora, Rocco, Elena Guerini, Bagnardi, Vincenzo, Montagna, Emilia, Peruzzotti, Giulia, De Pas, Tommaso, Fumagalli, Caterina, Pileggi, Silvana, Pesenti, Chiara, Marchini, Sergio, Corso, Giovanni, Marchio’, Caterina, Sapino, Anna, Graffeo, Rossella, Collet, Laetitia, Aftimos, Philippe, Sotiriou, Christos, Piccart, Martine, Gelber, Richard D., Viale, Giuseppe, Colleoni, Marco, and Goldhirsch, Aron

Abstract

Background: We report here for the first time, a comprehensive characterization of biological and clinical features of early-stage triple negative Invasive Lobular Carcinomas(TN-ILCs) Methods: We analyzed all consecutive patients with early-stage TN-ILC operated at two reference cancer-centers between 1994 and 2012. Primary objective was to assess the invasive disease-free survival(iDFS). Co-primary objective was to assess biological features of TN-ILCs, including molecular intrinsic subtypes based on PAM-50 assay, expression of androgen receptor (AR) and mutational status of ERBB2-gene. Additionally, DNA mutational status of an independent cohort of 45 TN-ILCs from three databases were analyzed, to confirm mutations in ERBB2-gene and to identify other recurrently mutated genes. Results: Among 4152 ILCs, 74(1.8%) were TN and were analyzed. The iDFS at 5 and 10 years of FUP were 50.4%(95%CI,38.0–61.6) and 37.2%(95%CI,25.5–48.8), respectively. The molecular subtype was defined through PAM50-classifier for 31 out of 74 TN-ILCs: 48% were Luminal-A(15/31), 3% luminal-B(1/31), 32% HER2-enriched (10/31), and only 16% basal-like(5/31). Luminal tumors expressed AR more frequently than non-luminal tumors (AR≥1% in 94% of luminal tumors versus 53% in non-luminal tumors; p-value = 0.001). 20% of TN-ILCs analyzed(7/35), harbored a pathogenetic and actionable mutation in the ERBB2-gene. Analysis of the independent cohort of 45 TN-ILCs from three different databases, confirmed similar percentage of pathogenetic and actionable mutations in ERBB2-gene(20%; 9/45). Among the top 10 molecular pathways significantly enriched for recurrently mutated genes in TN-ILCs(FDR<0.05), there were ErbB-signaling and DNA-damage-response pathways. Conclusions: TN-ILCs are rare tumors with poor prognosis. Their specific biological features require newly defined targeted therapeutic strategies.

Published
2021

48. Effects of heterogeneous Al and supply on root growth and screening of maize cultivars differing in Al resistance

Author

Collet, L., Horst, W. J., Horst, W. J., editor, Schenk, M. K., editor, Bürkert, A., editor, Claassen, N., editor, Flessa, H., editor, Frommer, W. B., editor, Goldbach, H., editor, Olfs, H. -W., editor, Römheld, V., editor, Sattelmacher, B., editor, Schmidhalter, U., editor, Schubert, S., editor, v. Wirén, N., editor, and Wittenmayer, L., editor

Published
2001
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49. Characterisation of maize cultivars in their adaptation to acid soils on the single plant level

Author

Collet, L., Horst, W. J., Horst, W. J., editor, Schenk, M. K., editor, Bürkert, A., editor, Claassen, N., editor, Flessa, H., editor, Frommer, W. B., editor, Goldbach, H., editor, Olfs, H. -W., editor, Römheld, V., editor, Sattelmacher, B., editor, Schmidhalter, U., editor, Schubert, S., editor, v. Wirén, N., editor, and Wittenmayer, L., editor

Published
2001
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