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A qualitative documentary research of software and multimedia artificial intelligences was chosen to enable the ontological understanding of the object of study that aims to explore the potential for learning through Artificial Intelligence (AI). Besides, it is shown how AI, as a novel component within the digital education landscape, contributes to educational technological capital. In light of our research area, the focus is on determining how AI can be harnessed to enhance the development of communicative competence. This entails identifying and categorizing AI tools relevant to language didactics. The sample size for this study is 120 AI applications, sourcing and compiling data on AI tools from specialized websites. This sample serves as a paradigm justifying a mixed-method study capable of combining quantitative and qualitative data. The variables supporting this study consider four characteristics related to the specific typify of the digital tool in the pedagogical context. The first aspect pertains to the classification of generative AI tools with potential educational use. AI tools enriches and enhances the dimensions of learning underscoring the urgent need for literacy in this technology. The second variable was linked to the Pedagogical Competences of Teachers and the areas. The category in language education pertains to educators' ability to create, adapt, and employ digital resources that enhance language teaching and learning. The third and fourth identify the skills related to language learning. In the context of learning environments with AI tools, it is essential to contemplate the role of linguistic competence as subordinate to communicative competence.

The aim of this research was to study the aspects and conditions of physical space which favor or hinder the experience of university mentoring according to the perception of participants. During fieldwork, an ethnographic approach was used, based on direct and indirect observation reflected in research diaries, qualitative interviews, and an ad hoc questionnaire. A sample of 30 individuals was selected, including students and professor-mentors who were users of three spaces with different characteristics designed for individual and group mentoring. The data were collected analysed by identifying verbatim statements obtained from interviews and from accounts from the researchers' journals that were then coded and grouped into thematic categories. The results focus on the importance of factors such as natural light, comfort, accessibility, furnishings, and location; conditions such as privacy and silence; availability of materials and resources; and Internet connectivity. The participants preferred the closed space, with the open space in second place and the semi-open space third. As for other required characteristics, the preferred spaces are multi-functional and versatile, equipped with ICT tools and furniture that facilitates collaborative work and mentorship and close communication between mentor and student, and that provide necessary privacy and silence. Any spaces specifically created for mentorship should thus meet these specific criteria.

A partir de la pandemia COVID-19, el uso de la virtualidad en la educación tomó dimensiones diversas, siendo el modelo pedagógico más empleado para garantizar el derecho a la educación y su permanencia en diversas locaciones geográficas. Empero, el tema de la inclusión sigue siendo un escenario que amerita discusión, en tanto las herramientas digitales y la virtualidad brindan los espacios necesarios para dinamizar el saber, para hacer de los aprendizajes autónomos, para la integración de las tecnologías a las aulas de clase, dando un rol protagónico al alumnado, donde este decide el ritmo de su formación académica. Ahora bien, también se encuentra la otra faceta de esta realidad, donde garantizar el acceso y participación de docentes y estudiantes a la virtualidad es un escenario irresuelto, concatenado a una serie de asimetrías sociales que crean condiciones de vulnerabilidad, exclusión y de nuevas asimetrías sociales. En virtud de lo anterior, el presente ensayo explora el papel de la virtualidad dentro de la educación, en tanto se considera una herramienta paradójica, pero necesaria para el desenvolvimiento de la academia en el siglo XXI.

The research explored the chemical characteristics of essential oils (EOs) extracted from the peels of four citrus fruits grown in northeastern Peru (lime, sweet lemon, mandarin and orange). The essential oils were extracted by hydrodistillation using a green solvent, and subsequently, their physicochemical profile, bioactive, heat capacity, and RAMAN mapping were determined; in addition, the volatile composition was determined by gas chromatography (GC-MS), and the main phenols by liquid chromatography (UHPLC). The results evidenced that sweet lemon and mandarin essential oils had higher antioxidant activity (1592.38 and 1216.13 μmol TE/g) and total phenolic content (680.78 and 420.28 mg GAE/g). In contrast, sweet lemon peel essential oil had the highest total flavonoid content (23.18 mg QE/g). D-limonene was the most abundant aromatic compound in orange (>67 %), mandarin (>70 %), and sweet lemon (>72 %) EOs; however, in the lime, it was the lowest (37 %). The most abundant component was the cyclobutane, 1,2-bis(1-methylethylethylenyl)-, trans- (32 %).

Son muchas las comunidades rurales que se enfrentan a un nuevo contexto marcado por la despoblación, hasta el punto de situarlas al borde de su abandono. Otras, por razones diferentes, también afrontan un proceso de desestructuración. Este es el caso del medio rural vasco, sometido a las tensiones producidas por un medio urbano próximo. Para hacer frente a este problema, el País Vasco aprueba una nueva ley de desarrollo rural, potenciando un modelo de intervención que pretende ser más agil. Para ello, zonificar el espacio rural como medio para señalar los territorios que mayor problemática y menos opciones de intervención tienen es fundamental. El trabajo desarrolla una propuesta sustentada en una combinación de variables geográficas, económicas, demográficas y sociales reunidas a partir de indicadores compuestos y en una zonificación planteada en diferentes pasos, desde la delimitación de todo su medio rural hasta la graduación de la intervención en función de objetivos y microunidades territoriales, coincidentes con las entidades singulares de población. El conocimiento del territorio y el contraste de los resultados con los agentes rurales, desde los regionales a los locales, identifican un modelo caracterizado por tratar de definir el grado de incidencia de la ciudad en el espacio rural.

This study was conducted to determine the histopathological features of the small intestines and to quantify lactic acid bacterial population in the ceca of broiler chickens supplemented with varying doses of plectasin, an antimicrobial peptide with gut health- promoting potentials. This research was done by supplementing broiler chickens with varying doses (150 ppm, 300 ppm and 450 ppm) of plectasin alongside negative and positive control groups. Small intestinal samples showed decreased occurrence and severity of histopathological lesions from the duodenum to the ileum. The occurrence of duodenal lesions such villi necrosis, de-epithelization of villi, haemorrhage and inflammation, observed in the duodenum decreased with supplementation of plectasin, which demonstrated its potential in promoting the structural integrity of the small intestines. On the other hand, microbial enumeration resulted in lower total lactic acid bacteria count in treatment groups supplemented with plectasin, demonstrating its inability to enhance beneficial microbiota, but may be suggestive of improved intestinal absorptive capacity based on the concept of competitive exclusion.

Background: Few studies have been conducted to investigate the socioeconomic profiles of patients with ankylosing spondylitis (AS) and their associations with disease severity and disability. Objectives: The objectives of this study were to identify clusters of patients with AS according to their socioeconomic characteristics and to evaluate the associations between these clusters and the severity of the disease and permanent disability. Design: This was a cross-sectional and multicentre study. Methods: Patients with AS from the REGISPONSER study were included in this analysis. A cluster analysis was conducted using information on sociodemographic (age, sex, race, marital status, education) and socioeconomic (employment, profession, housing conditions and social level) characteristics. Disease burden and permanent disability were compared between the different clusters using logistic regression adjusted for disease duration and disease activity. Results: A total of 866 patients with AS were included. Two clusters were identified according to socioeconomic characteristics: Cluster 1 ( n = 476), with a predominantly low socioeconomic profile, and Cluster 2 ( n = 390), with a predominantly high socioeconomic profile. After adjusting for disease duration, patients in Cluster 1 had a longer diagnosis delay, greater body mass index and greater structural damage than those in Cluster 2. Access to biologic disease-modifying anti-rheumatic drugs (bDMARDs) was similar for both groups. However, patients in Cluster 1 had a greater prevalence of permanent disability than those in Cluster 2 after adjusting for disease duration and disease activity (30.8% vs 13.2%, odds ratio 2.58 (95% confidence interval 1.76–3.83)). Conclusion: This study suggests that the socioeconomic status of patients with AS may have implications for disease severity and permanent disability, despite the similar use of bDMARDs.

Abstract Background Bovine genital campylobacteriosis (BGC) is caused by Campylobacter fetus subsp. venerealis (Cfv) including its biovar intermedius (Cfvi). This sexually transmitted disease induces early reproductive failure causing considerable economic losses in the cattle industry. Using a collection of well-characterized isolates (n = 13), C. fetus field isolates (n = 64) and saprophytic isolates resembling Campylobacter (n = 75) obtained from smegma samples of breeding bulls, this study evaluated the concordance of the most used phenotypic (H2S production in cysteine medium and 1% glycine tolerance) and molecular (PCR) methods for the diagnosis of BGC and assessed possible cross-reactions in the molecular diagnostic methods. Results Characterization at the subspecies level (fetus vs. venerealis) of C. fetus isolated from bull preputial samples using phenotypic and molecular (PCR targeting nahE and ISCfe1) methods showed moderate concordance (κ = 0.462; CI: 0.256–0.669). No cross-reactions were observed with other saprophytic microaerophilic species or with other Campylobacter species that can be present in preputial samples. Whole genome sequencing (WGS) of discrepant isolates showed 100% agreement with PCR identification. For the differentiation of Cfv biovars, comparison of the H2S test (at 72 h and 5 days of incubation) and a PCR targeting the L-cysteine transporter genes showed higher concordance when H2S production was assessed after 5 days (72 h; κ = 0.553, 0.329–0.778 CI vs. 5 days; κ = 0.881, 0.631–1 CI), evidencing the efficacy of a longer incubation time. Conclusions This study confirmed the limitations of biochemical tests to correctly identify C. fetus subspecies and biovars. However, in the case of biovars, when extended incubation times for the H2S test (5 days) were used, phenotypic identification results were significantly improved, although PCR-based methods produced more accurate results. Perfect agreement of WGS with the PCR results and absence of cross-reactions with non-C. fetus saprophytic bacteria from the smegma demonstrated the usefulness of these methods. Nevertheless, the identification of new C. fetus subspecies-specific genes would help to improve BGC diagnosis.

El artículo tiene por objetivo analizar el tratamiento jurídico referido al derecho a heredar en parejas LGBTIQ+, bajo el régimen de unión de hecho en el contexto peruano. Para lograr tal fin, el artículo considera los siguientes aspectos: 1. Los criterios socio-jurídicos para su reconocimiento, la problemática implícita en la administración pública sobre el conviviente supérstite y las posibles propuestas de solución. 2. Los pronunciamientos por parte del Ministerio de Justicia y Derechos Humanos, así como de la Defensoría del Pueblo, organismos que han emitido posiciones conjuntas, con el fin de garantizar el reconocimiento a este derecho. 3. Los derechos específicos que guardan concordancia con la Constitución Política y el Código Civil, siendo imprescindible delimitar conceptualmente los derechos por la connotación, no sólo a la pareja, sino también a sus familiares y terceros. El estudio se basa en una propuesta analítica-descriptiva. Se concluye en la relevancia del reconocimiento de los derechos sucesorios en las uniones LGBTIQ+ por parte del Estado peruano, como medio de garantizar la protección de los derechos humanos y las libertades civiles de los individuos.

As for many other organisms, CRISPR-Cas9 mediated genetic modification has gained increasing importance for the identification of vaccine candidates and drug targets in Neospora caninum, an apicomplexan parasite causing abortion in cattle and neuromuscular disease in dogs. A widely used approach for generating knock-out (KO) strains devoid of virulence factors is the integration of a drug selectable marker such as mutated dihydrofolate reductase-thymidylate synthase (mdhfr-ts) into the target gene, thus preventing the synthesis of respective protein and mediating resistance to pyrimethamine. However, CRISPR-Cas9 mutagenesis is not free of off-target effects, which can lead to integration of multiple mdhfr-ts copies into other sites of the genome. To determine the number of integrated mdhfr-ts in N. caninum, a duplex quantitative TaqMan PCR was developed. For this purpose, primers were designed that amplifies a 106 bp fragment from wild-type (WT) parasites corresponding to the single copy wtdhfrs-ts gene, as well as the mutated mdhfrs-ts present in KO parasites that confers resistance and were used simultaneously with primers amplifying the diagnostic NC5 gene. Thus, the dhfr-ts to NC5 ratio should be approximately 1 in WT parasites, while in KO parasites with a single integrated mdhrf-ts gene this ratio is doubled, and in case of multiple integration events even higher. This approach was applied to the Neospora KO strains NcΔGRA7 and NcΔROP40. For NcΔGRA7, the number of tachyzoites determined by dhfr-ts quantification was twice the number of tachyzoites determined by NC5 quantification, thus indicating that only one mdhfr-ts copy was integrated. The results obtained with the NcΔROP40 strain, however, showed that the number of dhfr-ts copies per genome was substantially higher, indicating that at least three copies of the selectable mdhfr-ts marker were integrated into the genomic DNA during gene editing by CRISPR-Cas9. This duplex TaqMan-qPCR provides a reliable and easy-to-use tool for assessing CRISPR-Cas9 mediated mutagenesis in WT N. caninum strains.

The cone geometry has a great significant for heat transmission in many industrial processes due to its ability to induce turbulence, enable directional flow, promote uniform temperature distribution, and offer versatility in applications. The current study aims to investigate the heat transport process of an inclined magnetized cross hybrid nanofluid over a heated porous cone under the influence of Hall and Ion slip consequences. Additionally, porous medium the flow is past under the effect of inclined uniform magnetic field and porosity of the medium is used to enhance heat transfer. The framed set of governing equations took the form of dimension free structure through appropriate transformations and then finally solved by an effective spectral relaxation method. Thermal impacts and heat transport mechanism associated with the hybrid flow is seen through different values of emerging parameters. Heat transport is seen higher with higher radiation parameters, as radiation and rising temperature are similar. Augmented values of Fr causes pressure drop in fluids which reduces the fluid motion and brings depreciation in velocity field. Eckert number also boosts the temperature of the fluid stirring via a porous rotating cone.

This study examined information integration cognitive mechanisms underlying the test anxiety judgments of 474 engineering students. The experimental design considered the orthogonal combination of three factors (teaching style, exam type, and test mode), resulting in 12 experimental scenarios. During the experiments, participants were provided one scenario at a time and were asked to rate their anticipated anxiety level in the described situation. Subsequent analyses failed to reveal statistically significant differences in the anxiety levels reported by females and males. However, the factor selection and valuation female students adopted to make their anxiety judgments differed from those employed by their male peers. Cluster analysis identified three groups based on the anxiety level (low, medium, and high). The most relevant factor for all clusters was test mode, and only the medium anxiety group considered a second factor (exam type) to make their anxiety judgments, which was integrated through an additive cognitive rule. These findings suggest that participants place a higher weight on the examination context than its type when making their test anxiety judgments. Identifying these cognitive mechanisms underlying test anxiety could help regulate conditions that undermine the students' ability to cope with test anxiety.

Abstract Campylobacter fetus comprises two closely related mammal-associated subspecies: Campylobacter fetus subsp. fetus (Cff) and Campylobacter fetus subsp. venerealis (Cfv). The latter causes bovine genital campylobacteriosis, a sexually-transmitted disease endemic in Spain that results in significant economic losses in the cattle industry. Here, 33 C. fetus Spanish isolates were whole-genome sequenced and compared with 62 publicly available C. fetus genomes from other countries. Genome-based taxonomic identification revealed high concordance with in silico PCR, confirming Spanish isolates as Cff (n = 4), Cfv (n = 9) and Cfv biovar intermedius (Cfvi, n = 20). MLST analysis assigned the Spanish isolates to 6 STs, including three novel: ST-76 and ST-77 for Cfv and ST-78 for Cff. Core genome SNP phylogenetic analysis of the 95 genomes identified multiple clusters, revealing associations at subspecies and biovar level between genomes with the same ST and separating the Cfvi genomes from Spain and other countries. A genome-wide association study identified pqqL as a Cfv-specific gene and a potential candidate for more accurate identification methods. Functionality analysis revealed variations in the accessory genome of C. fetus subspecies and biovars that deserve further studies. These results provide valuable information about the regional variants of C. fetus present in Spain and the genetic diversity and predicted functionality of the different subspecies.

RESUMEN El taller tiene como objetivo compartir la lectura de microrrelatos escritos por mujeres. Los participantes (n=63) corresponden a distintos grupos de Educación Secundaria Obligatoria y Bachillerato de la provincia de Cádiz (España). El método se basa en la selección de un corpus de textos con una temática desde una perspectiva de género, la tertulia y la escritura creativa. Los resultados indican la necesidad de apostar por proyectos literarios desde una perspectiva de género, así como la incentivación de la escritura creativa en el alumnado como medio de expresión compartido.

Introduction: Activation of the focal adhesion kinase (FAK) in podocytes is involved in the pathogenesis of minimal change disease (MCD), but the pathway leading to its activation in this disease is unknown. Here, we tested whether podocyte β1 integrin is the upstream modulator of FAK activation and podocyte injury in experimental models of MCD-like injury. Methods: We used lipopolysaccharide (LPS) and MCD sera to induce MCD-like changes in vivo and in cultured human podocytes, respectively. We performed functional studies using specific β1 integrin inhibitors in vivo and in vitro, and integrated histological analysis, western blotting, and immunofluorescence to assess for morphological and molecular changes in podocytes. By ELISA, we measured serum LPS levels in 35 children with MCD or presumed MCD (idiopathic nephrotic syndrome [INS]) and in 18 healthy controls. Results: LPS-injected mice showed morphological (foot process effacement, and normal appearing glomeruli on light microscopy) and molecular features (synaptopodin loss, nephrin mislocalization, FAK phosphorylation) characteristic of human MCD. Administration of a β1 integrin inhibitor to mice abrogated FAK phosphorylation, and ameliorated proteinuria and podocyte injury following LPS. Children with MCD/INS in relapse had higher serum LPS levels than controls. In cultured human podocytes, β1 integrin blockade prevented cytoskeletal rearrangements following exposure to MCD sera in relapse. Conclusions: Podocyte β1 integrin activation is an upstream mediator of FAK phosphorylation and podocyte injury in models of MCD-like injury. Resumen: Antecedentes: La activación de la quinasa de adhesión focal (FAK) en podocitos juega un papel en la patogénesis de la enfermedad de cambios mínimos (ECM), pero su mecanismo de activación en dicha enfermedad es desconocido. En este estudio investigamos si la integrina β1 de los podocitos modula la activación de FAK y del daño podocitario en modelos experimentales de la ECM. Métodos: Utilizamos lipopolisacárido (LPS) y suero de pacientes con ECM para inducir daño podocitario in vivo e in vitro, respectivamente. Realizamos estudios funcionales usando inhibidores específicos de la integrina β1 in vivo e in vitro, así como estudios histológicos, western blots y técnicas de inmunofluorescencia para evaluar cambios morfológicos y moleculares en podocitos. Usando ELISA medimos los niveles séricos de LPS en 35 niños con ECM o sospecha de ECM (síndrome nefrótico idiopático [SNI]) y en 18 individuos sanos. Resultados: Los ratones inyectados con LPS desarrollaron cambios morfológicos (fusión de pedicelos, con apariencia normal de los glomérulos) y moleculares (pérdida de la expresión de sinaptopodina, cambio en la localización de la nefrina fosforilada y fosforilzación de FAK), que son característicos de la ECM en humanos. La administración de un inhibidor de la integrina β1 en ratones disminuyó la fosforilación de FAK, proteinuria y daño podocitario que ocurre tras la inyección de LPS. En niños con ECM/SNI, los niveles séricos de LPS fueron más elevados que en controles. En cultivos de podocitos humanos, la adicción de un inhibidor de la integrina β1 al suero de niños con ECM en recaída evitó cambios en el citoesqueleto. Conclusiones: La integrina β1 de los podocitos actúa como mediador de la activación de la FAK y del daño podocitario en modelos experimentales de la ECM.

Introducción/objetivo: la economía informal se suele presentar como una entrada al emprendimiento, donde el único objetivo para los emprendedores es la de salir adelante, pasando por encima de las leyes impuestas en el país. Este estudio tiene como finalidad determinar la percepción de los comerciantes sobre la relación entre la informalidad de las empresas de la región Lima Provincias y el desempeño de la economía del Perú. Metodología: se desarrolló un estudio cuantitativo, de diseño no experimental transeccional y alcance correlacional. Se elaboró y administró un cuestionario a los dueños de 380 empresas informales ubicadas en la región Lima Provincias, con un margen de error del 5 % y un nivel de confianza del 95 %. Resultados: mediante el estadístico no paramétrico de Rho de Spearman, se halló una correlación negativa y significativa de −0.415 (p < 0.05) para la percepción de la informalidad empresarial y la economía. Conclusiones: se comprobó que a medida que la percepción de los comerciantes de la región Lima Provincias sobre la informalidad empresarial aumenta, la evaluación de estos sobre la economía tiende a disminuir. Introduction/Objective: The informal economy is often presented as a gateway to entrepreneurship, where the only objective for entrepreneurs is to get ahead, bypassing the laws imposed in the country. The purpose of this study was to determine the perception of traders on the relationship between the informality of businesses in the Lima Provinces region and the performance of the Peruvian economy. Methodology: A quantitative study was developed, with a non-experimental, cross-sectional design and correlational scope. A questionnaire was prepared and administered to the owners of 380 informal enterprises located in the Lima Provinces region, with a margin of error of 5 % and a confidence level of 95 %. Results: Using Spearman’s non-parametric Rho statistic, a negative and significant correlation of −0.415 (p < 0.05) was found for the perception of business informality and the economy. Conclusions: It was found that as the perception of traders in the Lima Provinces Region regarding business informality increases, their evaluation of the economy tends to decrease.

Given an autonomous second-order ordinary differential equation (ODE), we define a Riemannian metric on an open subset of the first-order jet bundle. A relationship is established between the solutions of the ODE and the geodesic curves with respect to the defined metric. We introduce the notion of energy foliation for autonomous ODEs and highlight its connection to the classical energy concept. Additionally, we explore the geometry of the leaves of the foliation. Finally, the results are applied to the analysis of Lagrangian mechanical systems. In particular, we provide an autonomous Lagrangian for a damped harmonic oscillator.

The intraspecific variability among Neospora caninum isolates in their in vitro behaviour and in vivo virulence has been widely studied. In particular, transcriptomic and proteomic analyses have shown a higher expression/abundance of specific genes/proteins in high-virulence isolates. Consequently, the dense granule protein NcGRA7 and the rhoptry protein NcROP40 were proposed as potential virulence factors. The objective of this study was to characterize the role of these proteins using CRISPR/Cas9 knockout (KO) parasites in a well-established pregnant BALB/c mouse model of N. caninum infection at midgestation. The deletion of NcGRA7 and NcROP40 was associated with a reduction of virulence, as infected dams displayed milder clinical signs, lower parasite burdens in the brain, and reduced mortality rates compared to those infected with the wild-type parasite (Nc-Spain7). Specifically, those infected with the NcGRA7 KO parasites displayed significantly milder clinical signs and a lower brain parasite burden. The median survival time of the pups from dams infected with the two KO parasites was significantly increased, but differences in neonatal mortality rates were not detected. Overall, the present study indicates that the disruption of NcGRA7 considerably impairs virulence in mice, while the impact of NcROP40 deletion was more modest. Further research is needed to understand the role of these virulence factors during N. caninum infection.

This work analyses the use of Spanish (mother tongue) by pre-service teachers (N=55) during a class activity that consists of explaining and solving Primary Education (6-12) mathematical problems in English (foreign language). The objectives are established in the form of three research questions about the amount of frequency of Spanish; its functional categories according to the original classification of De la Campa and Nassaji (2009); and the lack of competence in English of the participants. This is a mixed-method research since it includes both quantitative and qualitative data, collected through a questionnaire; the recordings of the pre-service teachers' discourse; and a virtual interview. The novelty of the study lies in a new functional category: lack of foreign language competence, which precedes others such as personal comment, activity instruction, arbitrary code-mixing, and translation, for instance. Likewise, 78.18% used Spanish at least once during the activity, although this is limited to 2.13/person. This works sheds light not only on the low amount of Spanish but especially on its functional categories, revealing a lack of language competence and pedagogical skills among the pre-service teachers. The paper ends with some recommendations for language teachers.

Background: X-linked hypophosphatemia (XLH) is a rare, progressive disorder characterized by excess fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D synthesis. Burosumab is a recombinant human monoclonal antibody that inhibits FGF23, restoring patient serum phosphate levels. Safety data on long-term burosumab treatment are currently limited. Objectives: This post-authorization safety study (PASS) aims to monitor long-term safety outcomes in children and adolescents (1–17 years) treated with burosumab for XLH. This first interim analysis reports the initial PASS safety outcomes. Design: A 10-year retrospective and prospective cohort study. Methods: This PASS utilizes International XLH Registry (NCT03193476) data, which includes standard diagnostic and monitoring practice data at participating European centers. Results: At data cut-off (13 May 2021), 647 participants were included in the International XLH Registry; 367 were receiving burosumab, of which 67 provided consent to be included in the PASS. Mean (SD) follow-up time was 2.2 (1.0) years. Mean (SD) age was 7.3 (4.3) years (range 1.0–17.5 years). Mean duration of burosumab exposure was 29.7 (25.0) months. Overall, 25/67 participants (37.3%) experienced ⩾1 adverse event (AE) during follow-up; 83 AEs were reported. There were no deaths, no AEs leading to treatment withdrawal, nor serious AEs related to treatment. The most frequently reported AEs were classified as ‘musculoskeletal and connective tissue disorders’, with ‘pain in extremity’ most frequently reported, followed by ‘infections and infestations’, with ‘tooth abscess’ the most frequently reported. Conclusion: In this first interim analysis of the PASS, covering the initial 2 years of data collection, the safety profile of burosumab is consistent with previously reported safety data. The PASS will provide long-term safety data over its 10-year duration for healthcare providers and participants with XLH that contribute to improvements in the knowledge of burosumab safety. Trial registration: European Union electronic Register of Post-Authorisation Studies: EUPAS32190.

Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3).Results Over 4790 years of follow-up, there were 34 CV events, resulting in a linearised rate of 7.10 per 1000 person-years (95% CI 4.92 to 9.92). The four CV risk scales showed strong correlations and all showed significant associations with CV events (p

Reseñas iberoamericanas

Abstract Purpose To determine whether hypercapnia is associated with risk of hospital readmission related to anorexia nervosa (AN) in children and adolescents. Methods We performed a prospective study of patients ≤ 18 years old admitted due to AN decompensation from November 2018 to October 2019. Both subtypes of AN, restricting subtype (AN-R) and binge-eating/purging subtype (AN-BP), were included. Study participants were evaluated upon admission, at discharge and six months after discharge. T-tests or Mann–Whitney U tests was used to compare means values. Pearson or Spearman correlations were used to measure the association between two variables. Logistic regression models were developed to evaluate the relationship between scoring methods and readmission. Results Of the 154 persons admitted during the study period, 131 met the inclusion criteria. Median age was 15.1 years. At admission, 71% of participants were malnourished and 33 (25%) had been previously admitted. We observed a marked decrease in venous pH and stable pCO2 elevation during follow-up period. Hypercapnia at discharge was associated with a twofold increased likelihood of readmission and the odds of readmission increased as discharge pCO2 rose. These findings did not depend on AN subtype or participant sex. Electrolytes persisted within the normal range. Conclusion Hypercapnia and respiratory acidosis are common alterations in children and adolescents hospitalized due to AN decompensation. Hypercapnia persists for at least 6 months after discharge despite clinical improvement and is associated with higher odds of readmission. This is the first study to identify an abnormal laboratory finding as a potential predictor of readmission in AN. Level of evidence IV: Multiple time series without intervention.

Abstract Background X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive, renal phosphate-wasting disorder characterized by a pathological increase in FGF23 concentration and activity. Due to its rarity, diagnosis may be delayed, which can adversely affect outcomes. As a chronic disease resulting in progressive accumulation of musculoskeletal manifestations, it is important to understand the natural history of XLH over the patient’s lifetime and the impact of drug treatments and other interventions. This multicentre, international patient registry (International XLH Registry) was established to address the paucity of these data. Here we present the findings of the first interim analysis of the registry. Results The International XLH Registry was initiated in August 2017 and includes participants of all ages diagnosed with XLH, regardless of their treatment and management. At the database lock for this first interim analysis (29 March 2021), 579 participants had entered the registry before 30 November 2020 and are included in the analysis (360 children [62.2%], 217 adults [37.5%] and 2 whose ages were not recorded [0.3%]; 64.2% were female). Family history data were available for 319/345 (92.5%) children and 145/187 (77.5%) adults; 62.1% had biological parents affected by XLH. Genetic testing data were available for 341 (94.7%) children and 203 (93.5%) adults; 370/546 (67.8%) had genetic test results; 331/370 (89.5%) had a confirmed PHEX mutation. A notably longer time to diagnosis was observed in adults ≥ 50 years of age (mean [median] duration 9.4 [2.0] years) versus all adults (3.7 [0.1] years) and children (1.0 [0.2] years). Participants presented with normal weight, shorter length or height and elevated body mass index (approximately − 2 and + 2 Z-scores, respectively) versus the general population. Clinical histories were collected for 349 participants (239 children and 110 adults). General data trends for prevalence of bone, dental, renal and joint conditions in all participants were aligned with expectations for a typical population of people with XLH. Conclusion The data collected within the International XLH Registry, the largest XLH registry to date, provide substantial information to address the paucity of natural history data, starting with demographic, family history, genetic testing, diagnosis, auxology and baseline data on clinical presentation.