10 results on '"Colin Gold"'
Search Results
2. Spinal Nerve Sheath Tumors: Factors Associated with Postoperative Residual and Recurrent Tumors: A Single-Center Experience
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Brian J. Park, Jennifer Noeller, Colin Gold, Kirill V. Nourski, Girish Bathla, and Patrick W. Hitchon
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Surgery ,Neurology (clinical) - Abstract
Spinal schwannomas (SSs) are usually benign tumors with a good prognosis when treated by surgical excision. However, complete resection can be complicated by factors such as the tumor location and configuration. In the present study, we sought to identify the factors associated with incomplete surgical resection (residual) and the factors associated with tumor recurrence.We performed a retrospective review of 113 cases of SSs treated surgically from 2008 to 2021.Of the 113 SSs, 102 were benign and 2 were malignant nerve sheath tumors. Of the 102 benign SSs, gross total resection (GTR) was performed for 87, with 8 displaying residual and 7, recurrent tumor. We found a significantly higher ratio of cervical and sacral tumors (P = 0.008 and P = 0.004, respectively), dumbbell and foraminal configurations (P0.0001 and P = 0.0006, respectively), and larger tumor volumes (P = 0.003) in the residual and recurrent cohorts compared with the GTR cohort. A second operation was performed for 2 patients in the residual and 4 patients in the recurrent cohorts. The total complication rate was 6%.We found that most benign SSs will be amenable to GTR (85% of cases), with an excellent prognosis. The patients with residual or recurrent tumor were more likely to have had a cervical or sacral location, a dumbbell or foraminal configuration, and a larger tumor volume. Except for 1 new SS and 1 recurrent tumor that had necessitated a lateral approach, the remainder had been treated using a posterior approach. At surgery, ultrasonography of the canal is advisable to ensure that the intra- and extraspinal components of dumbbell lesions have both been entirely removed.
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- 2022
3. Risk factors for delirium in elderly patients after lumbar spinal fusion
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Colin Gold, Emanuel Ray, David Christianson, Brian Park, Ioannis A Kournoutas, Taimur A Kahn, Eli A. Perez, Joel I. Berger, Katie Sander, Cassim A. Igram, Andrew Pugely, Catherine R. Olinger, Ryan Carnahan, Pei-fu Chen, Rashmi Mueller, Patrick Hitchon, Matthew A. Howard, Matthew Banks, Robert D. Sanders, and Royce W. Woodroffe
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Pain, Postoperative ,Postoperative Complications ,Spinal Fusion ,Risk Factors ,Delirium ,Humans ,Surgery ,Neurology (clinical) ,General Medicine ,Aged ,Retrospective Studies - Abstract
Background ContextPostoperative delirium is a clinically significant acute disorder of consciousness especially prevalent in older adult patients, of which more than 100,000 per year undergo spinal fusion surgery. There are no proven preventative therapies, and delirium is associated with increased postoperative complications, functional decline, morbidity, and mortality.PurposeTo identify perioperative risk factors for postoperative delirium (POD) after lumbar spinal fusion procedures in patients aged 65 or older.Study DesignRetrospective ReviewPatient Sample702 patients who underwent lumbar spinal fusion surgery from 11/13/2017 to 1/30/2021.Outcome MeasuresThe primary outcome was the presence of postoperative delirium assessed by the Delirium Observation Screening Scale (DOSS) and Confusion Assessment Method for the ICU (CAM-ICU).MethodsDemographic, surgical, and perioperative data were obtained from the electronic medical records. The primary outcome was presence of postoperative delirium. Univariate and multivariate analyses were performed. A binomial logistic regression model was designed using a custom written MATLAB script.ResultsOf the 702 patients included in the study, 173 (24.6%) developed POD. Our analysis revealed that older age (p < 0.001), lower preoperative hemoglobin (p < 0.001), and higher ASA grade (p < 0.001), were significant preoperative risk factors for developing POD. The only significant intraoperative risk factor was a higher number of spinal levels that were instrumented (p < 0.001). Higher pain scores on postoperative day 1 (p < 0.001), and lower postoperative hemoglobin (p < 0.001) were associated with increased POD; as were ICU admission (p < 0.001) and increased length of ICU stay (p < 0.001). Patients who developed POD had a longer hospital stay (p < 0.001) with lower rates of discharge to home as opposed to an inpatient facility (p < 0.001).ConclusionsRisk factors for older adults undergoing lumbar spinal fusion surgery include advanced age, lower preoperative and postoperative hemoglobin, higher ASA grade, greater extent of surgery, and higher postoperative pain scores. Patients with delirium had a higher incidence of postoperative ICU admission, increased length of stay, decreased likelihood of discharge to home and increased mortality, all consistent with prior studies. Further studies will determine whether adequate management of anemia and pain lead to a reduction in the incidence of postoperative delirium in these patients.
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- 2022
4. Cervical alignment in the obese population following posterior cervical fusion for cervical myelopathy
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Brian J. Park, Eli A. Perez, Royce W. Woodroffe, Colin Gold, Scott C. Seaman, Logan C. Helland, and Patrick W. Hitchon
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,Radiography ,Population ,Comorbidity ,Spinal Cord Diseases ,Body Mass Index ,Myelopathy ,Outcome Assessment, Health Care ,medicine ,Humans ,Obesity ,education ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Retrospective cohort study ,General Medicine ,Perioperative ,Middle Aged ,Overweight ,medicine.disease ,Decompression, Surgical ,Sagittal plane ,Surgery ,medicine.anatomical_structure ,Spinal Fusion ,Cohort ,Cervical Vertebrae ,Female ,Neurology (clinical) ,Spondylosis ,business ,Body mass index ,Follow-Up Studies - Abstract
Retrospective cohort study OBJECTIVE: The aim of this study was to investigate the effect of body mass index (BMI) on the reoperation rate and cervical sagittal alignment of patients who underwent posterior cervical decompression and fusion for cervical spondylotic myelopathy (CSM).Cervical sagittal balance has been correlated with postoperative clinical outcomes. Previous studies have shown worse postoperative sagittal alignment and higher reoperation rates in patients with high BMI undergoing anterior decompression and fusion. Similar evidence for the impact of obesity in postoperative sagittal alignment for patients with (CSM) undergoing posterior cervical decompression and fusion (PCF) is lacking.A retrospective analysis of 198 patients who underwent PCF for cervical myelopathy due to degenerative spine disease was performed. Demographics, need for reoperation, and perioperative radiographic parameters were collected. Cervical lordosis (CL), C2-7 sagittal vertical axis (SVA), and T1 slope (T1S) was measured on standing lateral radiographs. Comparative analysis of the patient cohort was performed by stratifying the sample population into three BMI categories (25, 25-30, ≥30).Of the 198 patients that met inclusion criteria, 53 had BMI normal (25), 65 were overweight (25-30), and 80 were obese (≥30). Mean SVA increased postoperatively in all groups, 4 mm in the normal group, 13 mm in the overweight group, and 13 mm in the obese group (p = 0.003). There was no significant difference in the postoperative change of cervical lordosis or T1 slope between the groups. Multivariate analysis demonstrated fusions involving the cervicothoracic junction and those involving 5 or more levels significantly affected alignment parameters. There were 27 complications requiring reoperation (14%) with no significant differences among the groups stratified by BMI (p = 0.386).Overweight patients (BMI25) with CSM undergoing PCF had a greater increase in SVA than normal weight patients while reoperation rates were similar. In addition, preoperative CL increased with increasing BMI, although this trend was not Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation significant and there was not found to be a significant difference between the change in CL from baseline to post-fusion between BMI cohorts. This study further highlights the importance of considering BMI when attempting to optimize sagittal alignment in patients undergoing PCF.
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- 2021
5. Bone flap management strategies for postcraniotomy surgical site infection
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Jeremy D.W. Greenlee, Ioannis Kournoutas, Scott C. Seaman, and Colin Gold
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medicine.medical_specialty ,Bone flap ,medicine.medical_treatment ,Wound Breakdown ,Single Center ,Cranioplasty ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Antibiotic prophylaxis ,Sinus (anatomy) ,Craniotomy ,business.industry ,Postoperative complication ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Original Article ,Neurology (clinical) ,business ,Infection ,030217 neurology & neurosurgery ,Surgical site infection - Abstract
Background: Surgical site infection (SSI) after a craniotomy is traditionally treated with wound debridement and disposal of the bone flap, followed by intravenous antibiotics. The goal of this study is to evaluate the safety of replacing the bone flap or performing immediate titanium cranioplasty. Methods: All craniotomies at single center between 2008 and 2020 were examined to identify 35 patients with postoperative SSI. Patients were grouped by bone flap management: craniectomy (22 patients), bone flap replacement (seven patients), and titanium cranioplasty (six patients). Retrospective chart review was performed to identify patient age, gender, index surgery indication and duration, diffusion restriction on MRI, presence of gross purulence, bacteria cultured, sinus involvement, implants used during surgery, and antibiotic prophylaxis/ treatment. These variables were compared to future infection recurrence and wound breakdown. Results: There was no significant difference in infection recurrence or future wound breakdown among the three bone flap management groups (P = 0.21, P = 0.25). None of the variables investigated had any significant relation to infection recurrence when all patients were included in the analysis. However, when only the bone flap replacement group was analyzed, there was significantly higher infection recurrence when there was frank purulence present (P = 0.048). Conclusion: Replacing the bone flap or performing an immediate titanium cranioplasty is safe alternatives to discarding the bone flap after postoperative craniotomy SSI. When there is gross purulence present, caution should be used in replacing the bone flap, as infection recurrence is significantly higher in this subgroup of patients.
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- 2021
6. Acupuncture for the treatment of TMD, headache, and cervical spine pain
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Colin Gold
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medicine.medical_specialty ,Neck Pain ,business.industry ,Acupuncture Therapy ,Headache ,Cervical spine pain ,MEDLINE ,Traditional Chinese medicine ,medicine.anatomical_structure ,stomatognathic system ,Otorhinolaryngology ,Cervical Vertebrae ,Acupuncture ,Physical therapy ,Acupuncture therapy ,Humans ,Medicine ,business ,General Dentistry ,Cervical vertebrae - Abstract
Acupuncture, derived from Traditional Chinese Medicine (TCM), involves the insertion of filiform needles into areas of the body to elicit a therapeutic response. Since the widespread introduction o...
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- 2021
7. Climate Variability Leads to Multiple Oxygenation Episodes Across the Great Oxidation Event
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Daniel Garduno Ruiz, Colin Goldblatt, and Anne‐Sofie Ahm
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Great Oxidation Event ,snowball Earth ,oxygen ,MIF‐S ,ozone ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract The temporal relationship between global glaciations and the Great Oxidation Event (GOE) suggests that climate change played an important role in Earth's oxygenation. The potential role of temperature is captured by the stratigraphic proximity between glacial deposits and sediments containing mass‐independent fractionation of sulfur isotopes (MIF‐S). We use a time‐dependent one‐dimensional photochemical model to investigate whether temperature changes associated with global glaciations can drive oscillations in atmospheric O2 levels and MIF‐S production across the GOE. We find that extreme climate change can cause atmospheric O2 to oscillate between pre (10−5 PAL) levels. Post‐glacial hot‐moist greenhouse climates lead to post‐GOE O2 levels because the abundant H2O vapor and oxidizing radicals drive the depletion of reduced species. This pattern is generally consistent with the MIF‐S signal observed in the sedimentary record, suggesting a link between global glaciations and O2 oscillations across the GOE.
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- 2024
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8. Systematic Occurrence Cycle of Typical RH‐Profiles During the MJO: Evidence for Ubiquitous Pre‐Moistening
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Carsten Abraham, Colin Goldblatt, and Adrian J. Matthews
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MJO ,water vapor distribution ,satellite observations ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract We describe how typical relative humidity (RH) profiles change systematically through the phases of the Madden–Julian Oscillation (MJO). We use 18 years of classified RH‐profiles from the Atmospheric Infrared Sounder, clustered without prior knowledge of large‐scale dynamics or occurrence‐region. Occurrence probability (OP) anomalies of RH‐profiles classes exhibit classical MJO patterns: Large positive OP anomalies of the RH‐profile class with most moisture in the free troposphere are co‐located with the largest positive precipitation anomalies. About 10 days prior to this deep convective core large OP anomalies of a RH‐profile class occur consistent with lower atmospheric moistening, supporting a ubiquitous role of pre‐moistening in MJO propagation. Since each RH‐profile class is associated with distinct dynamics (most of which are subgrid‐scale to climate models) our results can serve as process‐based diagnostics to investigate parameterization shortcomings of climate models preventing them to simulate the MJO accurately.
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- 2023
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9. EarthN: A New Earth System Nitrogen Model
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Benjamin W. Johnson and Colin Goldblatt
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nitrogen ,Earth system ,model ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
Abstract The amount of nitrogen in the atmosphere, oceans, crust, and mantle have important ramifications for Earth's biologic and geologic history. Despite this importance, the history and cycling of nitrogen in the Earth system is poorly constrained over time. For example, various models and proxies contrastingly support atmospheric mass stasis, net outgassing, or net ingassing over time. In addition, the amount available to and processing of nitrogen by organisms is intricately linked with and provides feedbacks on oxygen and nutrient cycles. To investigate the Earth system nitrogen cycle over geologic history, we have constructed a new nitrogen cycle model: EarthN. This model is driven by mantle cooling, links biologic nitrogen cycling to phosphate and oxygen, and incorporates geologic and biologic fluxes. Model output is consistent with large (2‐4x) changes in atmospheric mass over time, typically indicating atmospheric drawdown and nitrogen sequestration into the mantle and continental crust. Critical controls on nitrogen distribution include mantle cooling history, weathering, and the total Bulk Silicate Earth + atmosphere nitrogen budget. Linking the nitrogen cycle to phosphorous and oxygen levels, instead of carbon as has been previously done, provides new and more dynamic insight into the history of nitrogen on the planet.
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- 2018
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10. Marine oxygen production and open water supported an active nitrogen cycle during the Marinoan Snowball Earth
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Benjamin W. Johnson, Simon W. Poulton, and Colin Goldblatt
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Science - Abstract
Snowball Earth glaciations were some of the most extreme climate events in Earth history, and are temporally linked to major biogeochemical changes. Here, using geochemical proxies, the authors show that during the Marinoan glaciation, there was likely open water, active oxygen production, and nitrogen cycling.
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- 2017
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