612 results on '"Coles, Claire D."'
Search Results
2. Effectiveness of Psychotropic Medications in Children with Prenatal Alcohol and Drug Exposures: A Case Series and Model of Care
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Ritfeld, Gaby J., Kable, Julie A., Holton, Jennifer E., and Coles, Claire D.
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- 2024
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3. Characteristics of the Symptoms of the Proposed ND-PAE Disorder in First Grade Children in a Community Sample
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Kable, Julie A., Coles, Claire D., Holton, Jennifer E., Kalberg, Wendy O., May, Philip A., Chambers, Christina D., and Bandoli, Gretchen
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- 2024
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4. Behavioral Impact of Childhood Traumatic Stress in Children with Prenatal Substance Exposure
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Bowers, Philip, Kable, Julie, Millians, Molly, and Coles, Claire D.
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- 2023
5. Behavioral and Mental Health Disorders (Including Attentional Disorders)
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Rubin, I. Leslie, Coles, Claire D., Barnhill, Jarrett, Eisenstat, David D., editor, Goldowitz, Dan, editor, Oberlander, Tim F., editor, and Yager, Jerome Y., editor
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- 2023
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6. Secondary physical features in children with FASD
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del Campo, Miguel, Kable, Julie A., Coles, Claire D., Suttie, Michael, Chambers, Christina D., and Bandoli, Gretchen
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- 2024
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7. Polymorphisms in the choline transporter SLC44A1 are associated with reduced cognitive performance in normotypic but not prenatal alcohol-exposed children
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Smith, Susan M., Weathers, Torri D., Virdee, Manjot S., Schwantes-An, Tae-Hwi, Voruganti, Venkata Saroja, Mattson, Sarah N., Coles, Claire D., Kable, Julie A., Sowell, Elizabeth, Wozniak, Jeffrey R., and Wetherill, Leah
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- 2024
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8. Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children
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Coles, Claire D, Kable, Julie A, Granovska, Iryna V, Pashtepa, Ala O, Wertelecki, Wladimir, Chambers, Christina D, and CIFASD, The
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Clinical and Health Psychology ,Psychology ,Neurosciences ,Behavioral and Social Science ,Clinical Research ,Pediatric ,Conditions Affecting the Embryonic and Fetal Periods ,Alcoholism ,Alcohol Use and Health ,Mental Health ,Basic Behavioral and Social Science ,Substance Misuse ,Perinatal Period - Conditions Originating in Perinatal Period ,Mental health ,Child ,Child ,Preschool ,Executive Function ,Female ,Fetal Alcohol Spectrum Disorders ,Humans ,Memory ,Short-Term ,Neuropsychological Tests ,Pregnancy ,Prenatal Exposure Delayed Effects ,Prenatal alcohol exposure ,Fetal Alcohol Spectrum Disorder ,preschool assessment ,executive function ,CIFASD ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Operations Research ,Paediatrics ,Applied and developmental psychology - Abstract
Effects of prenatal alcohol exposure (PAE) are rarely measured in preschool children due to relative insensitivity of assessment methods at this age. To examine the potential of a nonverbal battery in early identification of cognitive problems in alcohol-exposed children, 291 prospectively identified Ukrainian children were evaluated using a test battery focusing on early executive functioning (EF) and visuospatial skills, areas of cognitive development particularly sensitive to PAE in older children. Tests included the Differential Ability Scales, 2nd Edition (DAS-2) and several NEPSY/NEPSY-II subtests, standardized in the United States. Others were adapted from commonly used non-standardized neuropsychological measures of EF (Preschool Spatial Span, Imitation Hand Game, A not B, Delayed Attention, Subject Ordered Pointing). Children in two sites in Ukraine, Rivne and Khmelnitsky, were tested at 3 ½-4 ½ years to identify effects of PAE. Although most children performed within the average range, Alcohol-Exposed preschoolers had lower scores on DAS-II Summary Scores as well as on specific subtests. To evaluate the effects of alcohol dose during the pre-pregnancy recognition period and during mid-gestation of pregnancy, generalized linear regression models were used controlling for demographic and individual variables. In addition to DAS-II variables, measures reflecting sustained attention, working memory and ability to shift cognitive set were impacted by alcohol dose. Early executive function appears to subsume these performance differences. In conclusion, findings indicate that the effects of PAE can be identified in the preschool period and reliably measured using tests assessing nonverbal and spatial skills supported by executive functioning.
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- 2021
9. Bayesian structural equation modeling for data from multiple cohorts
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Dang, Khue-Dung, Ryan, Louise M., Akkaya-Hocagil, Tugba, Cook, Richard J., Richardson, Gale A., Day, Nancy L., Coles, Claire D., Olson, Heather Carmichael, Jacobson, Sandra W., and Jacobson, Joseph L.
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Statistics - Applications - Abstract
While it is well known that high levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, the exact nature of the dose response is less well understood. In particular, there is a pressing need to identify the levels of PAE associated with an increased risk of clinically significant adverse effects. To address this issue, data have been combined from six longitudinal birth cohort studies in the United States that assessed the effects of PAE on cognitive outcomes measured from early school age through adolescence. Structural equation models (SEMs) are commonly used to capture the association among multiple observed outcomes in order to characterise the underlying variable of interest (in this case, cognition) and then relate it to PAE. However, it was not possible to apply classic SEM software in our context because different outcomes were measured in the six studies. In this paper we show how a Bayesian approach can be used to fit a multi-group multi-level structural model that maps cognition to a broad range of observed variables measured at multiple ages. These variables map to several different cognitive subdomains and are examined in relation to PAE after adjusting for confounding using propensity scores. The model also tests the possibility of a change point in the dose-response function.
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- 2020
10. A Hierarchical Meta-Analysis for Settings Involving Multiple Outcomes across Multiple Cohorts
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Hocagil, Tugba Akkaya, Ryan, Louise M., Cook, Richard J., Richardson, Gale A., Day, Nancy L., Coles, Claire D., Olson, Heather Carmichael, Jacobson, Sandra W., and Jacobson, Joseph L.
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Statistics - Methodology - Abstract
Evidence from animal models and epidemiological studies has linked prenatal alcohol exposure (PAE) to a broad range of long-term cognitive and behavioral deficits. However, there is virtually no information in the scientific literature regarding the levels of PAE associated with an increased risk of clinically significant adverse effects. During the period from 1975-1993, several prospective longitudinal cohort studies were conducted in the U.S., in which maternal reports regarding alcohol use were obtained during pregnancy and the cognitive development of the offspring was assessed from early childhood through early adulthood. The sample sizes in these cohorts did not provide sufficient power to examine effects associated with different levels and patterns of PAE. To address this critical public health issue, we have developed a hierarchical meta-analysis to synthesize information regarding the effects of PAE on cognition, integrating data on multiple endpoints from six U.S. longitudinal cohort studies. Our approach involves estimating the dose-response coefficients for each endpoint and then pooling these correlated dose-response coefficients to obtain an estimated `global' effect of exposure on cognition. In the first stage, we use individual participant data to derive estimates of the effects of PAE by fitting regression models that adjust for potential confounding variables using propensity scores. The correlation matrix characterizing the dependence between the endpoint-specific dose-response coefficients estimated within each cohort is then run, while accommodating incomplete information on some endpoints. We also compare and discuss inferences based on the proposed approach to inferences based on a full multivariate analysis
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- 2020
11. Partner influence as a factor in maternal alcohol consumption and depressive symptoms, and maternal effects on infant neurodevelopmental outcomes
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Kautz‐Turnbull, Carson, Petrenko, Christie LM, Handley, Elizabeth D, Coles, Claire D, Kable, Julie A, Wertelecki, Wladimir, Yevtushok, Lyubov, Zymak‐Zakutnya, Natalya, Chambers, Christina D, and Disorders, the Collaborative Initiative on Fetal Alcohol Spectrum
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Biological Psychology ,Psychology ,Pediatric Research Initiative ,Behavioral and Social Science ,Perinatal Period - Conditions Originating in Perinatal Period ,Brain Disorders ,Substance Misuse ,Clinical Research ,Conditions Affecting the Embryonic and Fetal Periods ,Prevention ,Alcoholism ,Alcohol Use and Health ,Depression ,Pediatric ,Mental Health ,Aetiology ,2.2 Factors relating to the physical environment ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Adolescent ,Adult ,Alcohol Drinking ,Child Development ,Female ,Humans ,Infant ,Newborn ,Latent Class Analysis ,Marriage ,Maternal Exposure ,Nervous System ,Pregnancy ,Pregnancy Complications ,Prenatal Exposure Delayed Effects ,Prospective Studies ,Young Adult ,infant ,partner influence ,pregnancy ,prenatal alcohol ,relationship ,Collaborative Initiative on Fetal Alcohol Spectrum Disorders ,Clinical Sciences ,Neurosciences ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundFew studies have investigated the partner's influence on risk factors such as alcohol consumption and depression during pregnancy. Partner substance use and lower relationship satisfaction predict higher maternal alcohol use and depressive symptoms. Because prenatal alcohol use and maternal depression affect infant outcomes, it is imperative to examine how the partner affects these maternal risk factors. The current study examined the effect of a latent construct of partner influence on maternal alcohol use and depressive symptoms, and the effects on infant development of these maternal factors.MethodsParticipants were 246 pregnant women from 2 sites in Western Ukraine from whom longitudinal data were collected as part of a multisite study. In the first trimester, mothers reported on relationship satisfaction, partner substance use, and socioeconomic status (SES). In the third trimester, they reported on alcohol use and depressive symptoms. Infants were assessed using the Bayley Scale of Infant Development (average age = 6.93 months). A latent construct titled partner influence was formed using partner substance use and measures of relationship satisfaction, including the frequency of quarreling, happiness in the relationship, and the ease of talking with the partner. Using structural equation modeling, a model was specified in which partner influence and SES predicted maternal alcohol use and depressive symptoms, which in turn predicted infant neurodevelopmental outcomes.ResultsHigher partner influence significantly predicted lower prenatal alcohol use and lower depressive symptoms, controlling for the effect of SES. Higher maternal prenatal alcohol use significantly predicted lower infant mental and psychomotor development. Maternal depressive symptoms did not predict infant development over and above the effect of alcohol use.ConclusionsPartner influence is an important contributor to prenatal alcohol use and maternal depressive symptoms, over and above the effect of SES. The significant paths from prenatal alcohol exposure to infant neurodevelopmental outcomes underscore the importance of partner influence during pregnancy.
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- 2021
12. Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period
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Kable, Julie A, Coles, Claire D, Jones, Kenneth L, Yevtushok, Lyubov, Kulikovsky, Yaroslav, Zymak‐Zakutnya, Natalya, Dubchak, Iryna, Akhmedzhanova, Diana, Wertelecki, Wladimir, Chambers, Christina D, and CIFASD
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Cardiovascular ,Perinatal Period - Conditions Originating in Perinatal Period ,Intellectual and Developmental Disabilities (IDD) ,Alcoholism ,Alcohol Use and Health ,Fetal Alcohol Spectrum Disorders (FASD) ,Conditions Affecting the Embryonic and Fetal Periods ,Prevention ,Substance Misuse ,Pediatric ,Brain Disorders ,Mental health ,Good Health and Well Being ,Child ,Preschool ,Cohort Studies ,Female ,Fetal Alcohol Spectrum Disorders ,Follow-Up Studies ,Heart Rate ,Humans ,Infant ,Infant Behavior ,Male ,Predictive Value of Tests ,Pregnancy ,Prospective Studies ,Ukraine ,Information processing ,Early identification ,CIFASD ,Clinical Sciences ,Neurosciences ,Psychology ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundPrenatal alcohol exposure (PAE) has been identified as one of the leading preventable causes of developmental disabilities, but early identification of those impacted has been challenging. This study evaluated the use of infant cardiac orienting responses (CORs), which assess neurophysiological encoding of environmental events and are sensitive to the impact of PAE, to predict later fetal alcohol spectrum disorder (FASD) status.MethodsMother-infant dyads from Ukraine were recruited during pregnancy based on the mother's use of alcohol. Participants (n = 120) were then seen at 6 and 12 months when CORs were collected and in the preschool period when they were categorized as having (i) fetal alcohol syndrome (FAS), (ii) partial FAS (pFAS), (iii) alcohol-related neurodevelopmental disorder (ARND), (iv) PAE and no diagnosis, or (v) no PAE and no diagnosis. To assess CORs, stimuli (auditory tones and pictures) were presented using a fixed-trial habituation/dishabituation paradigm. Heart rate (HR) responses were aggregated across the first 3 habituation and dishabituation trials and converted to z-scores relative to the sample's mean response at each second by stimuli. Z-scores greater than 1 were then counted by condition (habituation or dishabituation) to compute a total risk index.ResultsSignificant group differences were found on total deviation scores of the CORs elicited from visual but not auditory stimuli. Those categorized as pFAS/FAS had significantly higher total deviation scores than did those categorized as ARND or as having no alcohol-related diagnosis with or without a history of PAE. Receiver operating characteristic curve analysis of the visual response yielded an area under the curve value of 0.765 for predicting to pFAS/FAS status.ConclusionsA score reflecting total deviation from typical HR during CORs elicited using visual stimuli in infancy may be useful in identifying individuals who need early intervention as a result of their PAE.
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- 2021
13. Best Practices for Engaging Pregnant and Postpartum Women at Risk of Substance Use in Longitudinal Research Studies: a Qualitative Examination of Participant Preferences
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Beasley, Lana O, Ciciolla, Lucia, Jespersen, Jens E, Chiaf, Ashleigh L, Schmidt, Mallory, Shreffler, Karina M, Breslin, Florence J, Bakhireva, Ludmila N, Sanjuan, Pilar M, Stephen, Julia M, Coles, Claire D, Chambers, Christina D, Kable, Julie A, Leeman, Lawrence, Singer, Lynn T, Zellner, Jennifer, Morris, Amanda S, and Croff, Julie M
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Health Services and Systems ,Health Sciences ,Pediatric ,Clinical Research ,Pediatric Research Initiative ,Behavioral and Social Science ,Prevention ,Basic Behavioral and Social Science ,Drug Abuse (NIDA only) ,Substance Misuse ,HIV/AIDS ,Reproductive health and childbirth ,Recruitment ,Research engagement ,Retention ,Substance use ,Substance use disorders - Abstract
There are significant barriers in engaging pregnant and postpartum women that are considered high-risk (e.g., those experiencing substance use and/or substance use disorders (SUD)) into longitudinal research studies. To improve recruitment and retention of this population in studies spanning from the prenatal period to middle childhood, it is imperative to determine ways to improve key research engagement factors. The current manuscript uses a qualitative approach to determine important factors related to recruiting, enrolling, and retaining high-risk pregnant and postpartum women. The current sample included 41 high-risk women who participated in focus groups or individual interviews. All interviews were analyzed to identify broad themes related to engaging high-risk pregnant and parenting women in a 10-year longitudinal research project. Themes were organized into key engagement factors related to the following: (1) recruitment strategies, (2) enrollment, and (3) retention of high-risk pregnant and parenting women in longitudinal research studies. Results indicated recruitment strategies related to ideal recruitment locations, material, and who should share research study information with high-risk participants. Related to enrollment, key areas disclosed focused on enrollment decision-making, factors that create interest in joining a research project, and barriers to joining a longitudinal research study. With regard to retention, themes focused on supports needed to stay in research, barriers to staying in research, and best ways to stay in contact with high-risk participants. Overall, the current qualitative data provide preliminary data that enhance the understanding of a continuum of factors that impact engagement of high-risk pregnant and postpartum women in longitudinal research with current results indicating the need to prioritize recruitment, enrollment, and retention strategies in order to effectively engage vulnerable populations in research.
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- 2020
14. Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure
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Bodnar, Tamara S, Raineki, Charlis, Wertelecki, Wladimir, Yevtushok, Lyubov, Plotka, Larisa, Granovska, Irina, Zymak-Zakutnya, Natalya, Pashtepa, Alla, Wells, Alan, Honerkamp-Smith, Gordon, Coles, Claire D, Kable, Julie A, Chambers, Christina D, and Weinberg, Joanne
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Substance Misuse ,Brain Disorders ,Pediatric Research Initiative ,Conditions Affecting the Embryonic and Fetal Periods ,Pediatric ,Clinical Research ,Intellectual and Developmental Disabilities (IDD) ,Neurosciences ,Alcoholism ,Alcohol Use and Health ,Perinatal Period - Conditions Originating in Perinatal Period ,Mental Health ,2.1 Biological and endogenous factors ,Aetiology ,2.3 Psychological ,social and economic factors ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Adult ,Alcohol Drinking ,Central Nervous System Depressants ,Child ,Preschool ,Cytokines ,Developmental Disabilities ,Ethanol ,Female ,Humans ,Immune System ,Infant ,Infant ,Newborn ,Longitudinal Studies ,Mothers ,Neuropsychological Tests ,Pregnancy ,Prenatal Exposure Delayed Effects ,Ukraine ,Immune networks ,Fetal alcohol spectrum disorders ,Development ,and the CIFASD ,Clinical Sciences ,Immunology ,Neurology & Neurosurgery - Abstract
BackgroundEvidence suggests that cytokine imbalances may be at the root of deficits that occur in numerous neurodevelopmental disorders, including schizophrenia and autism spectrum disorder. Notably, while clinical studies have demonstrated maternal cytokine imbalances with alcohol consumption during pregnancy-and data from animal models have identified immune disturbances in alcohol-exposed offspring-to date, immune alterations in alcohol-exposed children have not been explored. Thus, here we hypothesized that perturbations in the immune environment as a result of prenatal alcohol exposure will program the developing immune system, and result in immune dysfunction into childhood. Due to the important role of cytokines in brain development/function, we further hypothesized that child immune profiles might be associated with their neurodevelopmental status.MethodsAs part of a longitudinal study in Ukraine, children of mothers reporting low/no alcohol consumption or moderate-to-heavy alcohol consumption during pregnancy were enrolled in the study and received neurodevelopmental assessments. Group stratification was based on maternal alcohol consumption and child neurodevelopmental status resulting in the following groups: A/TD, alcohol-consuming mother, typically developing child; A/ND, alcohol-consuming mother, neurodevelopmental delay in the child; C/TD, control mother (low/no alcohol consumption), typically development child; and C/ND, control mother, neurodevelopmental delay in the child. Forty cytokines/chemokines were measured in plasma and data were analyzed using regression and constrained principle component analysis.ResultsAnalyses revealed differential cytokine network activity associated with both prenatal alcohol exposure and neurodevelopmental status. Specifically, alcohol-exposed children showed activation of a cytokine network including eotaxin-3, eotaxin, and bFGF, irrespective of neurodevelopmental status. However, another cytokine network was differentially activated based on neurodevelopmental outcome: A/TD showed activation of MIP-1β, MDC, and MCP-4, and inhibition of CRP and PlGF, with opposing pattern of activation/inhibition detected in the A/ND group. By contrast, in the absence of alcohol-exposure, activation of a network including IL-2, TNF-β, IL-10, and IL-15 was associated with neurodevelopmental delay.ConclusionsTaken together, this comprehensive assessment of immune markers allowed for the identification of unique immune milieus that are associated with alcohol exposure as well as both alcohol-related and alcohol-independent neurodevelopmental delay. These findings are a critical step towards establishing unique immune biomarkers for alcohol-related and alcohol-independent neurodevelopmental delay.
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- 2020
15. Characterizing Alcohol‐Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes
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Coles, Claire D, Kalberg, Wendy, Kable, Julie A, Tabachnick, Barbara, May, Philip A, and Chambers, Christina D
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Prevention ,Alcoholism ,Alcohol Use and Health ,Behavioral and Social Science ,Perinatal Period - Conditions Originating in Perinatal Period ,Intellectual and Developmental Disabilities (IDD) ,Conditions Affecting the Embryonic and Fetal Periods ,Basic Behavioral and Social Science ,Brain Disorders ,Neurosciences ,Fetal Alcohol Spectrum Disorders (FASD) ,Pediatric ,Substance Misuse ,Aetiology ,2.3 Psychological ,social and economic factors ,Good Health and Well Being ,Attention Deficit Disorder with Hyperactivity ,Child ,Preschool ,Cognition ,Disruptive ,Impulse Control ,and Conduct Disorders ,Executive Function ,Female ,Fetal Alcohol Spectrum Disorders ,Gestational Age ,Humans ,Intellectual Disability ,Learning Disabilities ,Logistic Models ,Male ,Memory Disorders ,Mood Disorders ,Neuropsychological Tests ,Pregnancy ,Prenatal Exposure Delayed Effects ,Problem Behavior ,Psychomotor Performance ,Severity of Illness Index ,Social Class ,Prenatal Alcohol Exposure ,Diagnosis ,Alcohol-Related Neurodevelopmental Disorder ,Clinical Sciences ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundThe effects of prenatal alcohol exposure (PAE) are conceptualized as fetal alcohol spectrum disorder, with fetal alcohol syndrome (FAS) as the most severe. Many find it more difficult to characterize behavioral and cognitive effects of exposure on the central nervous system when physical signs are not present. In the current study, an operational definition of alcohol-related neurodevelopmental disorder (ARND) was examined to determine its usefulness in discrimination of children classified as ARND based on behavior (ARND/B) and cognition (ARND/C) from children in 4 contrast groups: (i) children exposed to study-defined "risky drinking"; (ii) children with any reported PAE; (iii) children classified as "Higher Risk" for developmental problems; and (iv) children classified as "Lower Risk."MethodsA total of 1,842 children seen as part of a surveillance study (J Am Med Assoc, 319, 2018, 474) were evaluated for alcohol exposure and physical characteristics of FAS, and completed neurodevelopmental testing. Ninety-one were identified as either ARND/B or ARND/C and contrasted with other groups to further identify distinguishing patterns. Multinomial logistic regression (MLR) was used to examine the accuracy of classification and to identify factors contributing to such classification.ResultsChildren described as ARND/C were distinct from other groups based on cognition and behavior as well as demographic factors (e.g., age, race, SES), child characteristics (e.g., gestational age; sex), and other drug exposures, while those described as ARND/B differed only on behavior and other drug exposures. MLR models successfully discriminated ARND groups from children in other groups with accuracy ranging from 79% (Higher Risk) to 86.7% (Low Risk).ConclusionsARND has been a subject of debate. This analysis suggests the effects of alcohol on behavior and cognition even in the absence of the characteristic facial features and growth deficiency that can be identified. The results also indicate that it may be possible to distinguish such children from those in other high-risk groups.
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- 2020
16. Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders
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Sowell, Krista D, Holt, Roberta R, Uriu-Adams, Janet Y, Chambers, Christina D, Coles, Claire D, Kable, Julie A, Yevtushok, Lyubov, Zymak-Zakutnya, Natalya, Wertelecki, Wladimir, Keen, Carl L, and CIFASD, the
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Substance Misuse ,Prevention ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,Fetal Alcohol Spectrum Disorders (FASD) ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Conditions Affecting the Embryonic and Fetal Periods ,Reproductive health and childbirth ,Cancer ,Good Health and Well Being ,Adult ,Alcohol Drinking ,Birth Weight ,Fatty Acids ,Female ,Fetal Alcohol Spectrum Disorders ,Gestational Age ,Humans ,Infant ,Newborn ,Maternal Behavior ,Maternal Health ,Neurodevelopmental Disorders ,Pregnancy ,Pregnancy Trimester ,Third ,Smoking ,Ukraine ,Fatty acids ,alcohol ,cigarettes ,fetal alcohol spectrum disorder ,DHA ,CIFASD ,Nutrition and Dietetics ,Nutrition & Dietetics ,Nutrition and dietetics - Abstract
Objective: Polyunsaturated fatty acids are vital for optimal fetal neuronal development. The relationship between maternal alcohol consumption and smoking with third trimester plasma fatty acids were examined and their association with Fetal Alcohol Spectrum Disorders (FASD).Methods: Moderate to heavy alcohol-using and low/unexposed comparison women were recruited during mid-pregnancy from two prenatal clinics in Ukraine. The participants' infants underwent physical and neurobehavioral exams prior to one-year of age and classified as having FASD by maternal alcohol consumption and neurobehavioral scores. A subset of mother-child pairs was selected representing three groups of cases and controls: Alcohol-Exposed with FASD (AE-FASD, n = 30), Alcohol-Exposed Normally Developing (AE-ND, n = 33), or Controls (n = 46). Third trimester maternal plasma samples were analyzed for fatty acids and levels were compared across groups.Results: The percent of C18:0 (p
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- 2020
17. The Relationship Between Socioeconomic Status and Brain Volume in Children and Adolescents With Prenatal Alcohol Exposure
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Uban, Kristina A, Kan, Eric, Wozniak, Jeffrey R, Mattson, Sarah N, Coles, Claire D, and Sowell, Elizabeth R
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Biological Psychology ,Psychology ,Basic Behavioral and Social Science ,Pediatric ,Neurosciences ,Substance Misuse ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,Perinatal Period - Conditions Originating in Perinatal Period ,Rare Diseases ,Behavioral and Social Science ,Aetiology ,Underpinning research ,1.2 Psychological and socioeconomic processes ,2.1 Biological and endogenous factors ,Neurological ,Mental health ,Good Health and Well Being ,brain volume ,subcortical ,brain development ,adoption ,collaborative initiative ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Cognitive and computational psychology - Abstract
The positive relationship between socioeconomic status (SES) and cognitive performance is mediated, in part, by differences in brain structure in typically developing youth. Associations between brain regions that relate to SES overlap with brain regions known to be sensitive to prenatal alcohol exposure (PAE). Animal models demonstrate that PAE attenuates neural and cognitive benefits of early life enrichment. However, whether or not environmental factors related to SES are associated with brain development in youth affected by PAE remains unknown in humans.MethodsT1-weighted magnetic resonance imaging (MRI) scans were obtained in participants with PAE and compared to age- and sex- matched Controls (n = 197, 48% with PAE, 44% girls, 6.5-17.7 years old). General linear modeling was utilized to examine associations between SES and subcortical brain volumes for youth with PAE compared to Controls.ResultsGroup by SES interactions were observed within the hippocampus (HPC), nucleus accumbens (NAc) and ventral diencephalon (vDC) (corrected p values
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- 2020
18. Benchmark dose profiles for bivariate exposures
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Akkaya Hocagil, Tugba, primary, Ryan, Louise M., additional, Cook, Richard J., additional, Dang, Khue‐Dung, additional, Carter, R. Colin, additional, Richardson, Gale A., additional, Day, Nancy L., additional, Coles, Claire D., additional, Carmichael Olson, Heather, additional, Jacobson, Sandra W., additional, and Jacobson, Joseph L., additional
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- 2024
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19. Psychopharmacological Treatments in Children with Fetal Alcohol Spectrum Disorders: A Review
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Ritfeld, Gaby J., Kable, Julie A., Holton, Jennifer E., and Coles, Claire D.
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- 2022
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20. Gestational age and socioeconomic status as mediators for the impact of prenatal alcohol exposure on development at 6 months
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Coles, Claire D, Kable, Julie A, Granovska, Irina V, Pashtepa, Ala O, Plotka, Larisa D, Dolhov, Victor B, Wertelecki, Wladimir, Jones, Kenneth L, Chambers, Christina D, and CIFASD, the
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Preterm ,Low Birth Weight and Health of the Newborn ,Substance Misuse ,Pediatric ,Alcoholism ,Alcohol Use and Health ,Basic Behavioral and Social Science ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Brain Disorders ,Clinical Research ,Intellectual and Developmental Disabilities (IDD) ,Infant Mortality ,Behavioral and Social Science ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Child Development ,Female ,Follow-Up Studies ,Gestational Age ,Humans ,Infant ,Infant ,Newborn ,Infant ,Premature ,Infant ,Premature ,Diseases ,Longitudinal Studies ,Male ,Pregnancy ,Prenatal Exposure Delayed Effects ,Social Class ,Ukraine ,child development ,prenatal alcohol exposure ,preterm birth ,smoking in pregnancy ,CIFASD - Abstract
BackgroundOf the many negative outcomes associated with gestational alcohol use, one that has received relatively little attention is preterm birth and its possible contribution to effects of prenatal alcohol exposure (PAE) on development. To examine the increased risk for premature delivery associated with PAE and the joint influence of preterm birth and alcohol on child outcomes, analysis was carried out in a longitudinal cohort recruited in Western Ukraine.MethodsAlcohol-using women and low or nondrinking controls were identified prenatally for a clinical trial of multivitamins and minerals (MVM) in ameliorating effects of PAE. Women were interviewed to provide information about medical and social status and other drug use. At delivery, information was collected about infant (N = 686) status including gestational age (GA) in weeks. Finally, 441 infants were followed to 6 months of age and cognitive (Mental Developmental Index [MDI]) and motor development (Psychomotor Developmental Index [PDI]) (measured using the Bayley Scales of Infant Development, second Ed (BSID-II).ResultsSeven percent infants were born at
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- 2019
21. Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development
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Bandoli, Gretchen, Coles, Claire D, Kable, Julie A, Wertelecki, Wladimir, Yevtushok, Lyubov, Zymak-Zakutnya, Natalya, Wells, Alan, Granovska, Irina V, Pashtepa, Alla O, and Chambers, Christina D
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Paediatrics ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Conditions Affecting the Embryonic and Fetal Periods ,Mental Health ,Brain Disorders ,Clinical Research ,Prevention ,Substance Misuse ,Alcoholism ,Alcohol Use and Health ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Infant Mortality ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Adult ,Alcohol Drinking ,Birth Weight ,Child Development ,Developmental Disabilities ,Female ,Follow-Up Studies ,Forecasting ,Humans ,Infant ,Longitudinal Studies ,Male ,Pregnancy ,Prenatal Exposure Delayed Effects ,Prospective Studies ,Ukraine ,CIFASD ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Pediatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
Previous studies have had inconsistent findings regarding the quantity and frequency of prenatal alcohol exposure (PAE) that lead to deficits in growth and neurodevelopment. This may be due to imprecise methods of exposure classification. Our objective in this study was to employ longitudinal trajectory modeling of maternal drinking patterns associated with infant growth or neurodevelopmental deficits to a homogenous sample of mothers and infants. From a sample of 471 pregnant women prospectively enrolled in a longitudinal study in the Ukraine, we performed a longitudinal cluster analysis of drinking patterns across gestation. We employed multivariable regression analyses to determine if each trajectory group was associated with infant weight, length, or head circumference at birth or psychomotor or mental deficits in infancy. We identified 5 distinct PAE trajectory groups: minimal or no PAE throughout gestation, low-to-moderate PAE with discontinuation early in gestation, low-to-moderate PAE sustained across gestation, moderate-to-high PAE with reduction early in gestation, and high PAE sustained across gestation. The highest-trajectory group was associated with deficits in infant weight and length at birth and deficits in psychomotor and mental performance at 6 to 12 months of age. Although confidence intervals overlapped, low-to-moderate sustained use was more strongly associated with most negative infant outcomes than moderate-to-high PAE with early reduction. With these findings, we confirm that high, sustained PAE confers the highest risk for adverse infant outcomes but demonstrate that even low-to-moderate PAE continued across gestation is associated with certain deficits. This approach may be used to help clinicians identify high-risk infants for targeted early intervention.
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- 2019
22. Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy
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Bodnar, Tamara S, Raineki, Charlis, Wertelecki, Wladimir, Yevtushok, Lyubov, Plotka, Larisa, Zymak-Zakutnya, Natalya, Honerkamp-Smith, Gordon, Wells, Alan, Rolland, Matthieu, Woodward, Todd S, Coles, Claire D, Kable, Julie A, Chambers, Christina D, Weinberg, Joanne, and Disorders, Collaborative Initiative on Fetal Alcohol Spectrum
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Pediatric ,Alcoholism ,Alcohol Use and Health ,Neurosciences ,Autism ,Mental Health ,Substance Misuse ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Alcohol Drinking ,Chemokines ,Cytokines ,Developmental Disabilities ,Ethanol ,Female ,Humans ,Immunity ,Maternally-Acquired ,Infant ,Infant ,Newborn ,Longitudinal Studies ,Male ,Mothers ,Neurodevelopmental Disorders ,Pregnancy ,Prenatal Exposure Delayed Effects ,Neurodevelopment ,Immune ,Alcohol ,Fetal alcohol spectrum disorders ,Collaborative Initiative on Fetal Alcohol Spectrum Disorders ,Immunology ,Neurology & Neurosurgery ,Biological psychology - Abstract
Cytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course of typical brain development, and putting the individual on a "pathway to pathology". In the current study, we used a multi-variate approach to evaluate networks of interacting cytokines and investigated whether alterations in the maternal immune milieu could be linked to alcohol-related and alcohol-independent child neurodevelopmental delay. This was achieved through the measurement of 40 cytokines/chemokines from maternal blood samples collected during the second and third trimesters of pregnancy. Importantly, during the second trimester we identified network enrichment in levels of cytokines including IFN-ɣ, IL-10, TNF-β, TNF-α, and CRP associated with offspring neurodevelopmental delay. However, as elevations in levels of these cytokines have previously been reported in a wide range of neurodevelopmental disorders including autism spectrum disorder and schizophrenia, we suggest that this cytokine profile is likely not disorder specific, but rather may be an indicator of neurodevelopmental delay in general. By contrast, distinct clusters of activated/inhibited cytokines were identified based on maternal alcohol consumption and child neurodevelopmental outcome. Specifically, cytokines including IL-15, IL-10, MDC, and members of the VEGF sub-family were highest in alcohol-consuming mothers of children with neurodevelopmental delay and were identified in both network analyses and examination of individual cytokines, whereas a differential and unique cytokine profile was identified in the case of alcohol-independent child neurodevelopmental delay. We propose that the current findings could provide a critical step towards the development of early biomarkers and possibly interventions for alcohol-related neurodevelopmental delay. Importantly, the current approach could be informative for understanding mechanisms linking maternal immune system dysfunction and adverse child outcomes in a range of other neurodevelopmental disorders.
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- 2018
23. Early Neurobehavioral Assessment of Children Prenatally Exposed to Alcohol
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Coles, Claire D., primary
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- 2022
- Full Text
- View/download PDF
24. Parenting with fetal alcohol spectrum disorders and neurobehavioral outcomes in offspring
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Ritfeld, Gaby J., primary, Wang, Michael, additional, Shapiro, Zvi, additional, Kable, Julie A., additional, and Coles, Claire D., additional
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- 2023
- Full Text
- View/download PDF
25. Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers
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Kable, Julie A, Coles, Claire D, Jones, Kenneth L, Yevtushok, Lyubov, Kulikovsky, Yaroslav, Wertelecki, Wladimir, Chambers, Christina D, and CIFASD, the
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Clinical Trials and Supportive Activities ,Perinatal Period - Conditions Originating in Perinatal Period ,Cardiovascular ,Clinical Research ,Pediatric ,Neurosciences ,Good Health and Well Being ,Adult ,Female ,Fetal Alcohol Spectrum Disorders ,Habituation ,Psychophysiologic ,Heart ,Heart Rate ,Humans ,Infant ,Male ,Pregnancy ,Randomized Controlled Trials as Topic ,Young Adult ,Prenatal Alcohol ,Cardiac Orienting ,Toddlers ,CIFASD ,Clinical Sciences ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundPrenatal alcohol exposure (PAE) has been found to impact neurophysiological encoding of environmental events negatively in the first year of life but has not been evaluated in older infants or toddlers. Cardiac orienting responses (ORs) collected during a habituation/dishabituation learning paradigm were obtained from 12- to 18-month-olds to assess the impact of PAE beyond the first year of life.MethodsParticipants included women and their toddlers who differed in PAE histories and enrolled in a randomized clinical trial of multivitamin/mineral usage during pregnancy. Those who were randomly assigned to the no intervention group were used for this analysis. The habituation/dishabituation paradigm consisted of 10 habituation and 5 dishabituation trials. Baseline heart rate (HR) was collected for 30 seconds prior to stimulus onset, and responses to the stimuli were assessed by sampling HR for 12 seconds poststimulus onset.ResultsThe speed of the OR in response to auditory stimuli in the dishabituation condition was found to be altered as a function of maternal alcohol use around conception. For visual stimuli, positive histories of PAE were predictive of the magnitude but not the speed of the response on habituation and dishabituation trials. A history of binge drinking was associated with reduced magnitude of the OR response on visual encoding trials, and level of alcohol exposure at the time of conception was predictive of the magnitude of the response on visual dishabituation trials.ConclusionsCardiac ORs collected in the toddler period were sensitive to the effects of PAE. The magnitude of the OR was more sensitive to the impact of PAE than in previous research with younger infants, and this may be a function of brain maturation. Additional research assessing the predictive utility of using ORs in making decisions about individual risk was recommended.
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- 2016
26. A dose-response analysis of the effects of prenatal alcohol exposure on cognitive development.
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Jacobson, Joseph L., Akkaya-Hocagil, Tugba, Jacobson, Sandra W., Coles, Claire D., Richardson, Gale A., Olson, Heather Carmichael, Day, Nancy L., Carter, R. Colin, Dodge, Neil C., Khue-Dung Dang, Cook, Richard J., and Ryan, Louise M.
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READING ,INFANT development ,PRENATAL exposure delayed effects ,COGNITIVE testing ,SECONDARY analysis ,MATHEMATICS ,RESEARCH funding ,MULTIPLE regression analysis ,PROBABILITY theory ,CHILD health services ,EXECUTIVE function ,PARENTING ,LEARNING ,DESCRIPTIVE statistics ,DOSE-response relationship in biochemistry ,FETAL alcohol syndrome ,ACHIEVEMENT tests ,ALCOHOL drinking ,SUBSTANCE abuse in pregnancy ,ALCOHOLISM ,FACTOR analysis ,MOTHERHOOD ,PSYCHOLOGICAL tests ,NONPARAMETRIC statistics ,PREGNANCY - Abstract
Background: Most studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose-response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose-response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency. Methods: We performed second-order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function. Regression models were constructed to examine effects of PAE on cognitive function, adjusted for propensity scores. Analyses based on a single predictor (absolute alcohol (AA)/day) were compared with analyses based on two predictors (dose/occasion and drinking frequency), using (1) linear models and (2) nonparametric general additive models (GAM) that allow for both linear and nonlinear effects. Results: The single-predictor GAM model showed virtually no nonlinearity in the effect of AA/day on cognitive function. However, the two-predictor GAM model revealed differential effects of maternal drinking pattern. Among offspring of infrequent drinkers, PAE effects on cognitive function were markedly stronger in those whose mothers drank more than ~3 drinks/occasion, and the effect of dose/occasion was strongest among the very frequent drinkers. Frequency of drinking did not appear to alter the PAE effect on cognitive function among participants born to mothers who limited their drinking to ~1 drink/occasion or less. Conclusions: These findings suggest that linear models based on total AA/day are appropriate for assessing whether PAE affects a given cognitive outcome. However, examination of alcohol dose/occasion and drinking frequency is needed to fully characterize the impact of different levels of alcohol intake on cognitive impairment. [ABSTRACT FROM AUTHOR]
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- 2024
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- View/download PDF
27. Principles for Guiding the Selection of Early Childhood Neurodevelopmental Risk and Resilience Measures: HEALthy Brain and Child Development Study as an Exemplar
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Morris, Amanda Sheffield, Wakschlag, Lauren, Krogh-Jespersen, Sheila, Fox, Nathan, Planalp, Beth, Perlman, Susan B., Shuffrey, Lauren C., Smith, Beth, Lorenzo, Nicole E., Amso, Dima, Coles, Claire D., and Johnson, Scott P.
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- 2020
- Full Text
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28. Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders
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Hoyme, H Eugene, Kalberg, Wendy O, Elliott, Amy J, Blankenship, Jason, Buckley, David, Marais, Anna-Susan, Manning, Melanie A, Robinson, Luther K, Adam, Margaret P, Abdul-Rahman, Omar, Jewett, Tamison, Coles, Claire D, Chambers, Christina, Jones, Kenneth L, Adnams, Colleen M, Shah, Prachi E, Riley, Edward P, Charness, Michael E, Warren, Kenneth R, and May, Philip A
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,Fetal Alcohol Spectrum Disorders (FASD) ,Neurosciences ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Intellectual and Developmental Disabilities (IDD) ,Substance Misuse ,Pediatric ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Mental health ,Reproductive health and childbirth ,Good Health and Well Being ,Adolescent ,Alcohol Drinking ,Child ,Child ,Preschool ,Diagnosis ,Differential ,Fetal Alcohol Spectrum Disorders ,Humans ,Infant ,Infant ,Newborn ,Maternal Behavior ,Neuropsychological Tests ,Pediatrics ,Physical Examination ,Physician's Role ,Sensitivity and Specificity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
The adverse effects of prenatal alcohol exposure constitute a continuum of disabilities (fetal alcohol spectrum disorders [FASD]). In 1996, the Institute of Medicine established diagnostic categories delineating the spectrum but not specifying clinical criteria by which diagnoses could be assigned. In 2005, the authors published practical guidelines operationalizing the Institute of Medicine categories, allowing for standardization of FASD diagnoses in clinical settings. The purpose of the current report is to present updated diagnostic guidelines based on a thorough review of the literature and the authors' combined expertise based on the evaluation of >10 000 children for potential FASD in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholism-funded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence. The guidelines were formulated through conference calls and meetings held at National Institute on Alcohol Abuse and Alcoholism offices in Rockville, MD. Specific areas addressed include the following: precise definition of documented prenatal alcohol exposure; neurobehavioral criteria for diagnosis of fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder; revised diagnostic criteria for alcohol-related birth defects; an updated comprehensive research dysmorphology scoring system; and a new lip/philtrum guide for the white population, incorporating a 45-degree view. The guidelines reflect consensus among a large and experienced cadre of FASD investigators in the fields of dysmorphology, epidemiology, neurology, psychology, developmental/behavioral pediatrics, and educational diagnostics. Their improved clarity and specificity will guide clinicians in accurate diagnosis of infants and children prenatally exposed to alcohol.
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- 2016
29. Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes
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Bandoli, Gretchen, Coles, Claire D, Kable, Julie A, Wertelecki, Wladimir, Granovska, Irina V, Pashtepa, Alla O, Chambers, Christina D, and CIFASD, the
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Clinical Research ,Prevention ,Depression ,Pediatric ,Mental Health ,Behavioral and Social Science ,Conditions Affecting the Embryonic and Fetal Periods ,Clinical Trials and Supportive Activities ,Neurosciences ,Perinatal Period - Conditions Originating in Perinatal Period ,Serious Mental Illness ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Adult ,Alcohol Drinking ,Brain ,Case-Control Studies ,Child Development ,Female ,Humans ,Infant ,Male ,Pregnancy ,Prenatal Exposure Delayed Effects ,Sex Characteristics ,Young Adult ,Prenatal Alcohol Exposure ,Prenatal Depression ,Infant Neurodevelopment ,CIFASD ,Psychology ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundPrenatal alcohol exposure (PAE) is an established risk factor for neurodevelopmental deficits in the offspring. Prenatal depression has been associated with neurodevelopmental deficits in the offspring, although investigations into unmedicated prenatal depression have been inconsistent. We hypothesized that unmedicated prenatal depressive symptoms would independently and jointly with PAE predict neurodevelopmental outcomes in infant offspring.MethodsWe studied 344 participants from a randomized clinical trial of multivitamin supplements in pregnant women in Ukraine. Women were recruited based upon periconceptional alcohol use and followed up to 12 months postpartum. Prenatal depressive symptoms were assessed at approximately 32 weeks of gestation using the Beck Depression Inventory score. Neurodevelopment was assessed with the Bayley Scales of Infant Development II Mental Development Index (MDI) and Psychomotor Development Index (PDI) at 6 and 12 months postpartum. Generalized linear regression models were constructed to assess the independent and joint effects of prenatal depressive symptoms and PAE in models adjusted for sociodemographic and pregnancy characteristics.ResultsPAE was independently associated with deficits in neurodevelopmental outcomes at 6 and 12 months, however, level of prenatal depressive symptoms was not. We found marginal evidence of synergism of depressive symptoms and PAE, with larger deficits in those with both exposures observed for the PDI-6 months (p = 0.05) and MDI-12 months (p = 0.09). Additionally, there was a suggestion of sexual dimorphism; females had stronger deficits from joint exposures than males (depressive symptom [MDI-6 months] female: -8.28, 95% CI -13.06, -3.49; male: 0.68, 95% CI -4.58, 5.94; p for interaction 0.04). While not statistically significant for the MDI or PDI at 12 months, the trend persisted.ConclusionsInfants exposed to PAE and prenatal depression may be at an increased risk of neurodevelopmental deficits. Healthcare providers should be aware of this possible synergism in their efforts to mitigate the neurodevelopmental effects of these co-occurring exposures.
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- 2016
30. Polymorphisms in the choline transporter SLC44A1 are associated with reduced cognitive performance in normotypic but not prenatal alcohol-exposed children
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Smith, Susan M., primary, Weathers, Torri D., additional, Virdee, Manjot S., additional, Schwantes-An, Tae-Hwi, additional, Voruganti, Venkata Saroja, additional, Mattson, Sarah N., additional, Coles, Claire D., additional, Kable, Julie A., additional, Sowell, Elizabeth, additional, Wozniak, Jeffrey R., additional, and Wetherill, Leah, additional
- Published
- 2023
- Full Text
- View/download PDF
31. Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants
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Coles, Claire D, Kable, Julie A, Keen, Carl L, Jones, Kenneth Lyons, Wertelecki, Wladimir, Granovska, Irina V, Pashtepa, Alla O, Chambers, Christina D, and the CIFASD
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Biomedical and Clinical Sciences ,Clinical Research ,Pediatric ,Conditions Affecting the Embryonic and Fetal Periods ,Alcoholism ,Alcohol Use and Health ,Intellectual and Developmental Disabilities (IDD) ,Nutrition ,Prevention ,Brain Disorders ,Substance Misuse ,Perinatal Period - Conditions Originating in Perinatal Period ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Child Development ,Dietary Supplements ,Female ,Fetal Alcohol Spectrum Disorders ,Humans ,Infant ,Male ,Pregnancy ,Prenatal Exposure Delayed Effects ,Psychomotor Performance ,Prenatal alcohol exposure ,Fetal alcohol spectrum disorders ,Multivitamin supplement ,Choline ,Infant development ,CIFASD ,Medical and Health Sciences ,Studies in Human Society ,Public Health ,Biomedical and clinical sciences ,Health sciences ,Human society - Abstract
ObjectivesFetal alcohol spectrum disorders are more common in disadvantaged populations. Environmental factors, like suboptimal nutrition, may potentiate the developmental effects of prenatal alcohol exposure. To evaluate the impact of micronutrients, including choline, on reduction of effects of exposure, we examined timing and dose of alcohol and effects of nutritional supplementation at two OMNI-Net sites in Western Ukraine that included high and low risk individuals.MethodsAlcohol-using and nondrinking women were randomized to one of three multivitamin/mineral supplement groups: none, multivitamins/minerals (MVM), and multivitamin/minerals plus choline. Children (N = 367) were tested at 6 months with the Bayley Scales of Infant Development (2nd ED) yielding standard scores for Mental Development Index (MDI), Psychomotor Development Index (PDI) and Behavior.ResultsGeneralized linear modeling was used: (1) for factorial analysis of effects of alcohol group, multivitamin/minerals, and choline supplementation; and (2) to examine the relationship between amount and timing of alcohol (ounces of absolute alcohol/day [ozAA/day] peri-conception and on average in the second trimester) and MVM supplementation on developmental outcomes while controlling sex, social class, and smoking. MDI was significantly impacted by peri-conceptual alcohol dose (X2(1), p < .001) with more alcohol associated with lower scores and males more negatively affected than females (X2(1), p < .002). Micronutrient supplementation had a protective effect; those receiving supplements performed better ([Formula: see text], p < .005). The PDI motor scores did not differ by group but were affected by peri-conceptual alcohol dose (X2(1), p < .04).Conclusions for practiceMultivitamin/mineral supplementation can reduce the negative impact of alcohol use during pregnancy on specific developmental outcomes.
- Published
- 2015
32. Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine
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Li, Zhihao, Lei, Kaikai, Coles, Claire D., Lynch, Mary Ellen, and Hu, Xiaoping
- Published
- 2019
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33. Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy
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Bodnar, Tamara S., Raineki, Charlis, Wertelecki, Wladimir, Yevtushok, Lyubov, Plotka, Larisa, Zymak-Zakutnya, Natalya, Honerkamp-Smith, Gordon, Wells, Alan, Rolland, Matthieu, Woodward, Todd S., Coles, Claire D., Kable, Julie A., Chambers, Christina D., and Weinberg, Joanne
- Published
- 2018
- Full Text
- View/download PDF
34. Parenting by individuals with fetal alcohol spectrum disorders and neurobehavioral outcomes in their offspring.
- Author
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Ritfeld, Gaby J., Wang, Michael, Shapiro, Zvi, Kable, Julie A., and Coles, Claire D.
- Subjects
COGNITION disorder risk factors ,ADVERSE childhood experiences ,FAMILY support ,INTERVIEWING ,PARENTING ,NEUROLOGIC manifestations of general diseases ,SOCIOECONOMIC factors ,RISK assessment ,CHILD Behavior Checklist ,CHILDREN'S health ,RESEARCH funding ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,SCALE analysis (Psychology) ,STATISTICAL hypothesis testing ,CHI-squared test ,PARENT-child relationships ,POVERTY ,FETAL alcohol syndrome ,EDUCATIONAL attainment ,LONGITUDINAL method ,DISEASE risk factors ,DISEASE complications ,CHILDREN - Abstract
Background: The neurobehavioral health impairments associated with prenatal alcohol exposure are now known to persist through adulthood. However, little is known about how these impairments affect individuals' parenting abilities and the neurobehavioral health of their offspring. This study compares parents with fetal alcohol spectrum disorder (FASD) with socioeconomically matched, nonexposed parents on measures of parenting and family support and assesses the neurobehavioral health of the children in both groups. Methods: Forty‐nine parent–child dyads were recruited from a longitudinal cohort of low socioeconomic status. Measures included the Parenting Styles and Dimensions Questionnaire, Family Support Scale, an in‐depth psychosocial history, the Pediatric Symptom Checklist (PSC; parent and child reports), the Achenbach Child Behavior Checklist (CBCL), a screening psychiatric evaluation of the child, the NIH Toolbox Cognition Battery for Children, The Vineland Adaptive Behavior Scales‐Third Edition caregiver rating form, and the Traumatic Events Screening Inventory (parent and child reports). Results: Cognitive functioning was impaired for both offspring of parents with FASD (x¯ = 81.1, SD = 13.0) and control parents (x¯ = 79.9, SD = 16.1), but despite similar impairments, children of parents with FASD were less likely to have an Individualized Education Plan than controls. Adaptive functioning was adequate for both groups (x¯ = 92.1, SD = 15.4 in exposed vs. x¯ = 94.3, SD = 12.3 in controls) and CBCL and PSC scores in both groups were within normal limits. Parents in both groups showed a predominantly authoritative parenting style. Despite a similar frequency of adverse childhood experiences in both groups, parents with FASD were less likely to recognize their child's adverse experiences. Conclusion: Parents with FASD display notable strengths including a predominantly authoritative parenting style. However, parents with FASD underrecognize child trauma and underutilize developmental services compared to socioeconomically matched controls, despite similar neurocognitive impairments. Impairments in adaptive functioning in parents with FASD may translate into difficulties with child–parent communication and limit both insight into neurobehavioral problems and advocacy skills. There is a need to identify and support parents with FASD to optimize their parenting abilities in the context of their individual strengths and difficulties. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Developmental outcomes of children with Duarte galactosemia: exploring the bases of an apparent contradiction in the literature
- Author
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Fridovich-Keil, Judith L., Carlock, Grace, Coles, Claire D., Lynch, Mary Ellen, Millians, Molly N., Potter, Nancy L., Powell, Kimberly, Richards, Peter, Singh, Rani, and Wittenauer, Angela
- Published
- 2019
- Full Text
- View/download PDF
36. Mathematics intervention for children with fetal alcohol spectrum disorder: A replication and extension of the math interactive learning experience (MILE) program
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Kully-Martens, Katrina, Pei, Jacqueline, Kable, Julie, Coles, Claire D., Andrew, Gail, and Rasmussen, Carmen
- Published
- 2018
- Full Text
- View/download PDF
37. Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study
- Author
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Kable, Julie A. and Coles, Claire D.
- Published
- 2017
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38. Prenatal Cocaine Exposure: A Comparison of 2-Year-Old Children in Parental and Nonparental Care
- Author
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Brown, Josephine V., Bakeman, Roger, Coles, Claire D., Platzman, Kathleen A., and Lynch, Mary Ellen
- Published
- 2004
39. Polymorphisms in the choline transporter SLC44A1are associated with reduced cognitive performance in normotypic but not prenatal alcohol-exposed children
- Author
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Smith, Susan M., Weathers, Torri D., Virdee, Manjot S., Schwantes-An, Tae-Hwi, Voruganti, Venkata Saroja, Mattson, Sarah N., Coles, Claire D., Kable, Julie A., Sowell, Elizabeth, Wozniak, Jeffrey R., and Wetherill, Leah
- Abstract
Choline is essential for healthy cognitive development. Single nucleotide polymorphisms (SNPs; rs3199966(G), rs2771040(G)) within the choline transporter SLC44A1increase risk for choline deficiency. In a choline intervention trial of children who experienced prenatal alcohol exposure (PAE), these alleles are associated with improved cognition.
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- 2024
- Full Text
- View/download PDF
40. Bayesian modelling of effects of prenatal alcohol exposure on child cognition based on data from multiple cohorts.
- Author
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Dang, Khue‐Dung, Ryan, Louise M., Akkaya Hocagil, Tugba, Cook, Richard J., Richardson, Gale A., Day, Nancy L., Coles, Claire D., Carmichael Olson, Heather, Jacobson, Sandra W., and Jacobson, Joseph L.
- Subjects
PRENATAL alcohol exposure ,COGNITION in children ,STRUCTURAL equation modeling ,LATENT variables ,CONFOUNDING variables ,COHORT analysis - Abstract
Summary: High levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, but the exact nature of the dose‐response relationship is less well understood. To investigate this relationship, data were assembled from six longitudinal birth cohort studies examining the effects of PAE on cognitive outcomes from early school age through adolescence. Structural equation models (SEMs) are a natural approach to consider, because of the way they conceptualise multiple observed outcomes as relating to an underlying latent variable of interest, which can then be modelled as a function of exposure and other predictors of interest. However, conventional SEMs could not be fitted in this context because slightly different outcome measures were used in the six studies. In this paper we propose a multi‐group Bayesian SEM that maps the unobserved cognition variable to a broad range of observed outcomes. The relation between these variables and PAE is then examined while controlling for potential confounders via propensity score adjustment. By examining different possible dose‐response functions, the proposed framework is used to investigate whether there is a threshold PAE level that results in minimal cognitive deficit. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. Effects of fetal tobacco exposure on focused attention in infancy
- Author
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Shisler, Shannon, Eiden, Rina D., Molnar, Danielle S., Schuetze, Pamela, Coles, Claire D., Huestis, Marilyn, and Colder, Craig R.
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- 2016
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42. A Decision Tree to Identify Children Affected by Prenatal Alcohol Exposure
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Goh, Patrick K., Doyle, Lauren R., Glass, Leila, Jones, Kenneth L., Riley, Edward P., Coles, Claire D., Hoyme, H. Eugene, Kable, Julie A., May, Philip A., Kalberg, Wendy O., Sowell, Elizabeth, R., Wozniak, Jeffrey R., and Mattson, Sarah N.
- Published
- 2016
- Full Text
- View/download PDF
43. Developmental Outcomes of School-Age Children with Duarte Galactosemia: A Pilot Study
- Author
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Lynch, Mary Ellen, Potter, Nancy L., Coles, Claire D., Fridovich-Keil, Judith L., Zschocke, Johannes, Editor-in-chief, Baumgartner, Matthias, editor, Morava, Eva, editor, Patterson, Marc, editor, Rahman, Shamima, editor, and Peters, Verena, editor
- Published
- 2015
- Full Text
- View/download PDF
44. Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure
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Gross, Lauren A., Moore, Eileen M., Wozniak, Jeffrey R., Coles, Claire D., Kable, Julie A., Sowell, Elizabeth R., Jones, Kenneth L., Riley, Edward P., Mattson, Sarah N., and the CIFASD
- Published
- 2018
- Full Text
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45. Evidence Supporting the Internal Validity of the Proposed ND-PAE Disorder
- Author
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Kable, Julie A. and Coles, Claire D.
- Published
- 2018
- Full Text
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46. Comparison of three systems for the diagnosis of fetal alcohol spectrum disorders in a community sample
- Author
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Coles, Claire D., primary, Bandoli, Gretchen, additional, Kable, Julie A., additional, del Campo, Miguel, additional, Suttie, Michael, additional, and Chambers, Christina D., additional
- Published
- 2023
- Full Text
- View/download PDF
47. A hierarchical meta-analysis for settings involving multiple outcomes across multiple cohorts
- Author
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Hocagil, Tugba Akkaya, Ryan, Louise M., Cook, Richard J., Richardson, Gale A., Day, Nancy L., Coles, Claire D., Olson, Heather Carmichael, Jacobson, Sandra W., and Jacobson, Joseph L.
- Subjects
Methodology (stat.ME) ,FOS: Computer and information sciences ,0104 Statistics ,Statistics - Methodology - Abstract
Evidence from animal models and epidemiological studies has linked prenatal alcohol exposure (PAE) to a broad range of long-term cognitive and behavioral deficits. However, there is virtually no information in the scientific literature regarding the levels of PAE associated with an increased risk of clinically significant adverse effects. During the period from 1975-1993, several prospective longitudinal cohort studies were conducted in the U.S., in which maternal reports regarding alcohol use were obtained during pregnancy and the cognitive development of the offspring was assessed from early childhood through early adulthood. The sample sizes in these cohorts did not provide sufficient power to examine effects associated with different levels and patterns of PAE. To address this critical public health issue, we have developed a hierarchical meta-analysis to synthesize information regarding the effects of PAE on cognition, integrating data on multiple endpoints from six U.S. longitudinal cohort studies. Our approach involves estimating the dose-response coefficients for each endpoint and then pooling these correlated dose-response coefficients to obtain an estimated `global' effect of exposure on cognition. In the first stage, we use individual participant data to derive estimates of the effects of PAE by fitting regression models that adjust for potential confounding variables using propensity scores. The correlation matrix characterizing the dependence between the endpoint-specific dose-response coefficients estimated within each cohort is then run, while accommodating incomplete information on some endpoints. We also compare and discuss inferences based on the proposed approach to inferences based on a full multivariate analysis
- Published
- 2022
48. Community translation of the Math Interactive Learning Experience Program for children with FASD
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Kable, Julie A., Taddeo, Elles, Strickland, Dorothy, and Coles, Claire D.
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- 2015
- Full Text
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49. Path analysis of the impact of prenatal alcohol on adult vascular function
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Kable, Julie A., primary, Mehta, Puja K., additional, Rashid, Fauzia, additional, and Coles, Claire D., additional
- Published
- 2022
- Full Text
- View/download PDF
50. Effectiveness of Psychotropic Medications in Children with Prenatal Alcohol and Drug Exposures: A Case Series and Model of Care
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Ritfeld, Gaby J., primary, Kable, Julie A., additional, Holton, Jennifer E., additional, and Coles, Claire D., additional
- Published
- 2022
- Full Text
- View/download PDF
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