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39 results on '"Coleman, Matthew J"'

1. Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development

Author

Kaspi, Antony, Hildebrand, Michael S., Jackson, Victoria E., Braden, Ruth, van Reyk, Olivia, Howell, Tegan, Debono, Simone, Lauretta, Mariana, Morison, Lottie, Coleman, Matthew J., Webster, Richard, Coman, David, Goel, Himanshu, Wallis, Mathew, Dabscheck, Gabriel, Downie, Lilian, Baker, Emma K., Parry-Fielder, Bronwyn, Ballard, Kirrie, Harrold, Eva, Ziegenfusz, Shaun, Bennett, Mark F., Robertson, Erandee, Wang, Longfei, Boys, Amber, Fisher, Simon E., Amor, David J., Scheffer, Ingrid E., Bahlo, Melanie, and Morgan, Angela T.

Published
2023
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2. Correction: Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development

Author

Kaspi, Antony, Hildebrand, Michael S., Jackson, Victoria E., Braden, Ruth, van Reyk, Olivia, Howell, Tegan, Debono, Simone, Lauretta, Mariana, Morison, Lottie, Coleman, Matthew J., Webster, Richard, Coman, David, Goel, Himanshu, Wallis, Mathew, Dabscheck, Gabriel, Downie, Lilian, Baker, Emma K., Parry-Fielder, Bronwyn, Ballard, Kirrie, Harrold, Eva, Ziegenfusz, Shaun, Bennett, Mark F., Robertson, Erandee, Wang, Longfei, Boys, Amber, Fisher, Simon E., Amor, David J., Scheffer, Ingrid E., Bahlo, Melanie, and Morgan, Angela T.

Published
2023
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3. Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development

Author

Kaspi, Antony, primary, Hildebrand, Michael S., additional, Jackson, Victoria E., additional, Braden, Ruth, additional, van Reyk, Olivia, additional, Howell, Tegan, additional, Debono, Simone, additional, Lauretta, Mariana, additional, Morison, Lottie, additional, Coleman, Matthew J., additional, Webster, Richard, additional, Coman, David, additional, Goel, Himanshu, additional, Wallis, Mathew, additional, Dabscheck, Gabriel, additional, Downie, Lilian, additional, Baker, Emma K., additional, Parry-Fielder, Bronwyn, additional, Ballard, Kirrie, additional, Harrold, Eva, additional, Ziegenfusz, Shaun, additional, Bennett, Mark F., additional, Robertson, Erandee, additional, Wang, Longfei, additional, Boys, Amber, additional, Fisher, Simon E., additional, Amor, David J., additional, Scheffer, Ingrid E., additional, Bahlo, Melanie, additional, and Morgan, Angela T., additional

Published
2022
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4. Association of SLC32A1 Missense Variants With Genetic Epilepsy With Febrile Seizures Plus

Author

Heron, Sarah E., primary, Regan, Brigid M., additional, Harris, Rebekah V., additional, Gardner, Alison E., additional, Coleman, Matthew J., additional, Bennett, Mark F., additional, Grinton, Bronwyn E., additional, Helbig, Katherine L., additional, Sperling, Michael R., additional, Haut, Sheryl, additional, Geller, Eric B., additional, Widdess-Walsh, Peter, additional, Pelekanos, James T., additional, Bahlo, Melanie, additional, Petrovski, Slavé, additional, Heinzen, Erin L., additional, Hildebrand, Michael S., additional, Corbett, Mark A., additional, Scheffer, Ingrid E., additional, Gécz, Jozef, additional, and Berkovic, Samuel F., additional

Published
2021
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5. Transcriptome analysis of a ring chromosome 20 patient cohort

Author

Myers, Kenneth A., primary, Bennett, Mark F., additional, Hildebrand, Michael S., additional, Coleman, Matthew J., additional, Zhou, Geyu, additional, Hollingsworth, Georgie, additional, Cairns, Anita, additional, Riney, Kate, additional, Berkovic, Samuel F., additional, Bahlo, Melanie, additional, and Scheffer, Ingrid E., additional

Published
2020
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7. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

Author

Johnson, Jennifer L., primary, Stoica, Loredana, additional, Liu, Yuwei, additional, Zhu, Ping Jun, additional, Bhattacharya, Abhisek, additional, Buffington, Shelly A., additional, Huq, Redwan, additional, Eissa, N. Tony, additional, Larsson, Ola, additional, Porse, Bo T., additional, Domingo, Deepti, additional, Nawaz, Urwah, additional, Carroll, Renee, additional, Jolly, Lachlan, additional, Scerri, Tom S., additional, Kim, Hyung-Goo, additional, Brignell, Amanda, additional, Coleman, Matthew J., additional, Braden, Ruth, additional, Kini, Usha, additional, Jackson, Victoria, additional, Baxter, Anne, additional, Bahlo, Melanie, additional, Scheffer, Ingrid E., additional, Amor, David J., additional, Hildebrand, Michael S., additional, Bonnen, Penelope E., additional, Beeton, Christine, additional, Gecz, Jozef, additional, Morgan, Angela T., additional, and Costa-Mattioli, Mauro, additional

Published
2019
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8. Sympathoinhibition evoked from caudal midline medulla is mediated by GABA receptors in rostral VLM

Author

Coleman, Matthew J. and Dampney, Roger L.A.

Subjects
Medulla oblongata -- Physiological aspects, Nervous system, Sympathetic -- Physiological aspects, Dopaminergic mechanisms -- Research, Biological sciences
Abstract

The hypotensive and sympathoinhibitory activity of the caudal midline medulla is mediated by the neurotransmitter gamma-amino butyric acid-based inhibition of the excitatory neurons on the rostral ventrolateral medulla as revealed in studies done on barointact and barodenervated rabbits. Blocking the sympathoinhibitory neurons in the caudal midline medulla revealed the presence of a population of excitatory neurons.

Published
1998

9. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

Author

Johnson, Jennifer L, Stoica, Loredana, Liu, Yuwei, Zhu, Ping Jun, Bhattacharya, Abhisek, Buffington, Shelly, Huq, Redwan, Eissa, N Tony, Larsson, Ola, Porse, Bo T, Domingo, Deepti, Nawaz, Urwah, Carroll, Renee, Jolly, Lachlan, Scerri, Tom S, Kim, Hyung-Goo, Brignell, Amanda, Coleman, Matthew J, Braden, Ruth, Kini, Usha, Jackson, Victoria, Baxter, Anne, Bahlo, Melanie, Scheffer, Ingrid E, Amor, David J, Hildebrand, Michael S, Bonnen, Penelope E, Beeton, Christine, Gecz, Jozef, Morgan, Angela T, Costa-Mattioli, Mauro, Johnson, Jennifer L, Stoica, Loredana, Liu, Yuwei, Zhu, Ping Jun, Bhattacharya, Abhisek, Buffington, Shelly, Huq, Redwan, Eissa, N Tony, Larsson, Ola, Porse, Bo T, Domingo, Deepti, Nawaz, Urwah, Carroll, Renee, Jolly, Lachlan, Scerri, Tom S, Kim, Hyung-Goo, Brignell, Amanda, Coleman, Matthew J, Braden, Ruth, Kini, Usha, Jackson, Victoria, Baxter, Anne, Bahlo, Melanie, Scheffer, Ingrid E, Amor, David J, Hildebrand, Michael S, Bonnen, Penelope E, Beeton, Christine, Gecz, Jozef, Morgan, Angela T, and Costa-Mattioli, Mauro

Abstract

In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorder and intellectual disability. However, the mechanism by which deficient NMD leads to neurodevelopmental dysfunction remains unknown, preventing development of targeted therapies. Here we identified novel protein-coding UPF2 (UP-Frameshift 2) variants in humans with NDD, including speech and language deficits. In parallel, we found that mice lacking Upf2 in the forebrain (Upf2 fb-KO mice) show impaired NMD, memory deficits, abnormal long-term potentiation (LTP), and social and communication deficits. Surprisingly, Upf2 fb-KO mice exhibit elevated expression of immune genes and brain inflammation. More importantly, treatment with two FDA-approved anti-inflammatory drugs reduced brain inflammation, restored LTP and long-term memory, and reversed social and communication deficits. Collectively, our findings indicate that impaired UPF2-dependent NMD leads to neurodevelopmental dysfunction and suggest that anti-inflammatory agents may prove effective for treatment of disorders with impaired NMD.

Published
2019

10. Association of Missense Variants With Genetic Epilepsy With Febrile Seizures Plus.

Author

Heron, Sarah E, Regan, Brigid M, Harris, Rebekah V, Gardner, Alison E, Coleman, Matthew J, Bennett, Mark F, Grinton, Bronwyn E, Helbig, Katherine L, Sperling, Michael R, Haut, Sheryl, Geller, Eric B, Widdess-Walsh, Peter, Pelekanos, James T, Bahlo, Melanie, Petrovski, Slavé, Heinzen, Erin L, Hildebrand, Michael S, Corbett, Mark A, Scheffer, Ingrid E, and Gécz, Jozef

Published
2021
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11. Transcriptome analysis of a ring chromosome 20 patient cohort.

Author

Myers, Kenneth A., Bennett, Mark F., Hildebrand, Michael S., Coleman, Matthew J., Zhou, Geyu, Hollingsworth, Georgie, Cairns, Anita, Riney, Kate, Berkovic, Samuel F., Bahlo, Melanie, and Scheffer, Ingrid E.

Subjects
CHROMOSOME analysis, CHROMOSOME abnormalities, POLYMERASE chain reaction, CHROMOSOMES, GENE expression, CHROMOSOME duplication
Abstract

Ring chromosomes occur when the ends of normally rod‐shaped chromosomes fuse. In ring chromosome 20 (ring 20), intellectual disability and epilepsy are usually present, even if there is no deleted coding material; the mechanism by which individuals with complete ring chromosomes develop seizures and other phenotypic abnormalities is not understood. We investigated altered gene transcription as a contributing factor by performing RNA‐sequencing (RNA‐seq) analysis on blood from seven patients with ring 20, and 11 first‐degree relatives (all parents). Geographic analysis did not identify altered expression in peritelomeric or other specific chromosome 20 regions. RNA‐seq analysis revealed 97 genes potentially differentially expressed in ring 20 patients. These included one epilepsy gene, NPRL3, but this finding was not confirmed on reverse transcription Droplet Digital polymerase chain reaction analysis. Molecular studies of structural chromosomal anomalies such as ring chromosome are challenging and often difficult to interpret because many patients are mosaic, and there may be genome‐wide chromosomal instability affecting gene expression. Our findings nevertheless suggest that peritelomeric altered transcription is not the likely pathogenic mechanism in ring 20. Underlying genetic mechanisms are likely complex and may involve differential expression of many genes, the majority of which may not be located on chromosome 20. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Association of SLC32A1Missense Variants With Genetic Epilepsy With Febrile Seizures Plus

Author

Heron, Sarah E., Regan, Brigid M., Harris, Rebekah V., Gardner, Alison E., Coleman, Matthew J., Bennett, Mark F., Grinton, Bronwyn E., Helbig, Katherine L., Sperling, Michael R., Haut, Sheryl, Geller, Eric B., Widdess-Walsh, Peter, Pelekanos, James T., Bahlo, Melanie, Petrovski, Slavé, Heinzen, Erin L., Hildebrand, Michael S., Corbett, Mark A., Scheffer, Ingrid E., Gécz, Jozef, and Berkovic, Samuel F.

Published
2021
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13. Camvac's presence in metallized paper market expands with new mill

Author

Coleman, Matthew J.

Subjects
Camvac International Inc. -- Management, Paper industry -- Equipment and supplies, Paper finishing -- Equipment and supplies, Papermaking machinery -- Innovations, Paper coatings -- Equipment and supplies, Business, Forest products industry
Published
1985

14. Paper industry engineers not happy with image or prospects

Author

Coleman, Matthew J.

Subjects
Pulp and Paper (Periodical) -- Surveys, Paper industry -- Officials and employees, Paper industry workers -- Compensation and benefits, Engineers -- Beliefs, opinions and attitudes, Business, Forest products industry
Published
1985

20. Hammermill ups finishing capacity with new sheeter and wrapping line

Author

Coleman, Matthew J.

Subjects
Hammermill Paper Co. -- Equipment and supplies, Paper finishing -- Equipment and supplies, Paper mills -- Equipment and supplies, Paper converting machinery -- Innovations, Paper industry workers -- Beliefs, opinions and attitudes, Business, Forest products industry
Published
1985

22. Engineers change jobs for two main reasons: money, mobility

Author

Coleman, Matthew J.

Subjects
Paper industry -- Employment, Paper industry workers -- Employment, Career changes -- Causes of, Paper industry workers -- Compensation and benefits, Engineers -- Surveys, Occupational mobility -- Planning, Business, Forest products industry
Published
1985

27. Survey indicates strong need for industry modernization, tax relief

Author

Lowe, Kenneth E. and Coleman, Matthew J.

Subjects
Paper industry -- Investments, Depreciation -- Economic aspects, Replacement of industrial equipment -- Economic aspects, Papermaking machinery -- Statistics, Business, Forest products industry
Published
1981

28. Powerful depressor and sympathoinhibitory effects evoked from neurons in the caudal raphe...

Author

Coleman, Matthew J. and Dampney, Roger A.L.

Subjects
*MEDULLA oblongata, *BARORECEPTORS, *PHYSIOLOGY
Abstract

Presents a study of the depressor region in the medullary raphe nuclei in the medulla oblongata. Functional properties of region; Spatial relationship with caudal ventrolateral medulla (CVLM); Arterial and cardiopulmonary baroreceptor reflex; Contribution of cardiac vagal and sympathetic effects to bradycardic component of the response.

Published
1995

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