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2. Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, Tasian, Sarah K, Sulis, Maria Luisa, Stevenson, Kristen, Blonquist, Traci M, Apsel Winger, Beth, Cooper, Todd M, Pauly, Melinda, Maloney, Kelly W, Burke, Michael J, Brown, Patrick A, Gossai, Nathan, McNeer, Jennifer L, Shukla, Neerav N, Cole, Peter D, Kahn, Justine M, Chen, Jing, Barth, Matthew J, Magee, Jeffrey A, Gennarini, Lisa, Adhav, Asmani A, Clinton, Catherine M, Ocasio-Martinez, Nicole, Gotti, Giacomo, Li, Yuting, Lin, Shan, Imamovic, Alma, Tognon, Cristina E, Patel, Tasleema, Faust, Haley L, Contreras, Cristina F, Cremer, Anjali, Cortopassi, Wilian A, Garrido Ruiz, Diego, Jacobson, Matthew P, Dharia, Neekesh V, Su, Angela, Robichaud, Amanda L, Saur Conway, Amy, Tarlock, Katherine, Stieglitz, Elliot, Place, Andrew E, Puissant, Alexandre, Hunger, Stephen P, Kim, Annette S, Lindeman, Neal I, Gore, Lia, Janeway, Katherine A, Silverman, Lewis B, Tyner, Jeffrey W, Harris, Marian H, Loh, Mignon L, and Stegmaier, Kimberly

Subjects
Cancer, Rare Diseases, Human Genome, Genetics, Clinical Trials and Supportive Activities, Orphan Drug, Biotechnology, Hematology, Clinical Research, Pediatric Cancer, Childhood Leukemia, Pediatric, Development of treatments and therapeutic interventions, Aetiology, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Good Health and Well Being, Biomarkers, Tumor, Child, Cohort Studies, Disease Progression, Feasibility Studies, Female, Humans, Leukemia, Male, Molecular Targeted Therapy, Neoplasm Recurrence, Local, Prospective Studies, United States, Oncology and Carcinogenesis
Abstract

Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. Eighteen percent of patients had a high confidence Tier 1 or 2 recommendation. We describe clinical responses in the 14% of patients with relapsed/refractory leukemia who received the matched targeted therapy. Further, in order to inform future targeted therapy for patients, we validated variants of uncertain significance, performed ex vivo drug-sensitivity testing in patient leukemia samples, and identified new combinations of targeted therapies in cell lines and patient-derived xenograft models. These data and our collaborative approach should inform the design of future precision medicine trials. SIGNIFICANCE: Patients with relapsed/refractory leukemias face limited treatment options. Systematic integration of precision medicine efforts can inform therapy. We report the feasibility of identifying targetable mutations in children with leukemia and describe correlative biology studies validating therapeutic hypotheses and novel mutations.See related commentary by Bornhauser and Bourquin, p. 1322.This article is highlighted in the In This Issue feature, p. 1307.

Published
2021

3. Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults

Author

Harker-Murray, Paul, Mauz-Körholz, Christine, Leblanc, Thierry, Mascarin, Maurizio, Michel, Gérard, Cooper, Stacy, Beishuizen, Auke, Leger, Kasey J., Amoroso, Loredana, Buffardi, Salvatore, Rigaud, Charlotte, Hoppe, Bradford S., Lisano, Julie, Francis, Stephen, Sacchi, Mariana, Cole, Peter D., Drachtman, Richard A., Kelly, Kara M., and Daw, Stephen

Published
2023
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7. Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001

Author

Tran, Thai Hoa, Langlois, Sylvie, Meloche, Caroline, Caron, Maxime, Saint-Onge, Pascal, Rouette, Alexandre, Bataille, Alain R., Jimenez-Cortes, Camille, Sontag, Thomas, Bittencourt, Henrique, Laverdière, Caroline, Lavallée, Vincent-Philippe, Leclerc, Jean-Marie, Cole, Peter D., Gennarini, Lisa M., Kahn, Justine M., Kelly, Kara M., Michon, Bruno, Santiago, Raoul, Stevenson, Kristen E., Welch, Jennifer J.G., Schroeder, Kaitlin M., Koch, Victoria, Cellot, Sonia, Silverman, Lewis B., and Sinnett, Daniel

Published
2022
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10. Genetic ancestry and skeletal toxicities among childhood acute lymphoblastic leukemia patients in the DFCI 05-001 cohort

Author

Yao, Song, Zhu, Qianqian, Cole, Peter D., Stevenson, Kristen, Harris, Marian H., Schultz, Emily, Kahn, Justine M., Ladas, Elena J., Athale, Uma H., Clavell, Luis A., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Welch, Jennifer J.G., Sallan, Stephen E., Silverman, Lewis B., and Kelly, Kara M.

Published
2021
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12. Genome‐wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia.

Author

Zhu, Qianqian, Nambiar, Ram, Schultz, Emily, Gao, Xinyu, Liang, Shuyi, Flamand, Yael, Stevenson, Kristen, Cole, Peter D., Gennarini, Lisa, Harris, Marian H., Kahn, Justine M., Ladas, Elena J., Athale, Uma H., Hoa Tran, Thai, Michon, Bruno, Welch, Jennifer J. G., Sallan, Stephen E., Silverman, Lewis B., Kelly, Kara M., and Yao, Song

Subjects
GENETIC risk score, CHILD patients, LYMPHOBLASTIC leukemia, SPEED of sound, ACUTE leukemia
Abstract

Summary: Bone toxicities are common among paediatric patients treated for acute lymphoblastic leukaemia (ALL) with potentially major negative impact on patients' quality of life. To identify the underlying genetic contributors, we conducted a genome‐wide association study (GWAS) and a transcriptome‐wide association study (TWAS) in 260 patients of European‐descent from the DFCI 05–001 ALL trial, with validation in 101 patients of European‐descent from the DFCI 11–001 ALL trial. We identified a significant association between rs844882 on chromosome 20 and bone toxicities in the DFCI 05–001 trial (p = 1.7 × 10−8). In DFCI 11–001 trial, we observed a consistent trend of this variant with fracture. The variant was an eQTL for two nearby genes, CD93 and THBD. In TWAS, genetically predicted ACAD9 expression was associated with an increased risk of bone toxicities, which was confirmed by meta‐analysis of the two cohorts (meta‐p = 2.4 × 10−6). In addition, a polygenic risk score of heel quantitative ultrasound speed of sound was associated with fracture risk in both cohorts (meta‐p = 2.3 × 10−3). Our findings highlight the genetic influence on treatment‐related bone toxicities in this patient population. The genes we identified in our study provide new biological insights into the development of bone adverse events related to ALL treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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13. ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients

Author

Pearson, Andrew D.J., Rossig, Claudia, Lesa, Giovanni, Diede, Scott J., Weiner, Susan, Anderson, John, Gray, Juliet, Geoerger, Birgit, Minard-Colin, Veronique, Marshall, Lynley V., Smith, Malcolm, Sondel, Paul, Bajars, Marcis, Baldazzi, Claudia, Barry, Elly, Blackman, Sam, Blanc, Patricia, Capdeville, Renaud, Caron, Hubert, Cole, Peter D., Jiménez, Jorge Camarero, Demolis, Pierre, Donoghue, Martha, Elgadi, Mabrouck, Gajewski, Thomas, Galluzzo, Sara, Ilaria, Robert, Jr., Jenkner, Alessandro, Karres, Dominik, Kieran, Mark, Ligas, Franca, Lowy, Israel, Meyers, Michael, Oprea, Corina, Peddareddigari, Vijay G.R., Sterba, Jaroslav, Stockman, Paul K., Suenaert, Peter, Tabori, Uri, van Tilburg, Cornelis, Yancey, Todd, Weigel, Brenda, Norga, Koenraad, Reaman, Gregory, and Vassal, Gilles

Published
2020
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14. Exposure-Response and Subgroup Analyses to Support Body Weight-Based Dosing of Brentuximab Vedotin in Children and Young Adults with Newly Diagnosed High-Risk Classical Hodgkin Lymphoma

Author

Zhang, Zufei, primary, Zhang, Daping, additional, Guo, Wenchuan, additional, Fenton, Keenan, additional, Narayanan, Sujata, additional, Jain, Shweta, additional, Jiang, Joy, additional, Castellino, Sharon M., additional, Kelly, Kara M., additional, Cole, Peter D., additional, Keller, Frank G., additional, Garg, Amit, additional, and Chia, Yen Lin, additional

Published
2024
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16. Inequitable Poverty Exposures: A Subspecialty Opportunity to Address Disparities

Author

Karvonen, Kristine A., primary, Umaretiya, Puja J., additional, Koch, Victoria B., additional, Flamand, Yael, additional, Aziz-Bose, Rahela, additional, Ilcisin, Lenka, additional, Valenzuela, Ariana, additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, Justine M., additional, Kelly, Kara M., additional, Tran, Thai Hoa, additional, Michon, Bruno, additional, Welch, Jennifer J.G., additional, Wolfe, Joanne, additional, Silverman, Lewis B., additional, Rosenberg, Abby R., additional, and Bona, Kira, additional

Published
2024
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20. Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001

Author

Vrooman, Lynda M., Blonquist, Traci M., Harris, Marian H., Stevenson, Kristen E., Place, Andrew E., Hunt, Sarah K., O'Brien, Jane E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Sulis, Maria Luisa, Welch, Jennifer J.G., Neuberg, Donna S., Sallan, Stephen E., and Silverman, Lewis B.

Published
2018
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21. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia

Author

Tran, Thai Hoa, Harris, Marian H., Nguyen, Jonathan V., Blonquist, Traci M., Stevenson, Kristen E., Stonerock, Eileen, Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Cole, Peter D., Kelly, Kara M., Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A., Welch, Jennifer J.G., Reshmi, Shalini C., Neuberg, Donna S., Sallan, Stephen E., Loh, Mignon L., and Silverman, Lewis B.

Published
2018
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22. The selective cyclooxygenase-2 inhibitor NS398 ameliorates cisplatin-induced impairments in mitochondrial and cognitive function

Author

Rashid, Mohammad Abdur, primary, Tang, Jason J., additional, Yoo, Ki-Hyun, additional, Corujo-Ramirez, Ana, additional, Oliveros, Alfredo, additional, Kim, Sang Hoon, additional, Ullah, Faheem, additional, Altawell, Raad, additional, Hawse, John R., additional, Cole, Peter D., additional, and Jang, Mi-Hyeon, additional

Published
2023
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24. Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia

Author

Umaretiya, Puja J, primary, Koch, Victoria B, additional, Flamand, Yael, additional, Aziz-Bose, Rahela, additional, Ilcisin, Lenka, additional, Valenzuela, Ariana, additional, Cole, Peter D, additional, Gennarini, Lisa M, additional, Kahn, Justine M, additional, Kelly, Kara M, additional, Tran, Thai Hoa, additional, Michon, Bruno, additional, Welch, Jennifer J G, additional, Wolfe, Joanne, additional, Silverman, Lewis B, additional, and Bona, Kira, additional

Published
2023
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26. Prognostic value of chest x‐ray‐ and CT‐defined large mediastinal adenopathy in high‐risk pediatric Hodgkin lymphoma: A report from the Children's Oncology Group Study AHOD0831

Author

Lo, Andrea C., primary, Lee, Inki, additional, Pei, Qinglin, additional, Wu, Yue, additional, McCarten, Kathleen M., additional, Hoppe, Bradford S., additional, Hodgson, David C., additional, Roberts, Kenneth, additional, Milgrom, Sarah, additional, Kessel, Sandy, additional, Cole, Peter D., additional, Kelly, Kara M., additional, and Cho, Steve Y., additional

Published
2023
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27. Abstract 6737: Exposure-response and age subgroup analyses to support body-weight (BW) dosing of brentuximab vedotin (BV) in newly diagnosed high-risk classical Hodgkin lymphoma (cHL) in children and young adults (aged 2-21 years [y]): A randomized children’s oncology group phase 3 trial (AHOD1331)

Author

Zhang, Zufei, primary, Zhang, Daping, additional, Guo, Wenchuan, additional, Fenton, Keenan, additional, Narayanan, Sujata, additional, Jain, Shweta, additional, Jiang, Joy, additional, Castellino, Sharon M., additional, Kelly, Kara M., additional, Cole, Peter D., additional, Keller, Frank G., additional, Garg, Amit, additional, and Chia, Yen Lin, additional

Published
2023
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29. Supplementary Data from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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30. Data from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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31. Figure S5 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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32. Table S1 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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33. Supplementary Methods from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Pikman, Yana, primary, Tasian, Sarah K., primary, Sulis, Maria Luisa, primary, Stevenson, Kristen, primary, Blonquist, Traci M., primary, Apsel Winger, Beth, primary, Cooper, Todd M., primary, Pauly, Melinda, primary, Maloney, Kelly W., primary, Burke, Michael J., primary, Brown, Patrick A., primary, Gossai, Nathan, primary, McNeer, Jennifer L., primary, Shukla, Neerav N., primary, Cole, Peter D., primary, Kahn, Justine M., primary, Chen, Jing, primary, Barth, Matthew J., primary, Magee, Jeffrey A., primary, Gennarini, Lisa, primary, Adhav, Asmani A., primary, Clinton, Catherine M., primary, Ocasio-Martinez, Nicole, primary, Gotti, Giacomo, primary, Li, Yuting, primary, Lin, Shan, primary, Imamovic, Alma, primary, Tognon, Cristina E., primary, Patel, Tasleema, primary, Faust, Haley L., primary, Contreras, Cristina F., primary, Cremer, Anjali, primary, Cortopassi, Wilian A., primary, Garrido Ruiz, Diego, primary, Jacobson, Matthew P., primary, Dharia, Neekesh V., primary, Su, Angela, primary, Robichaud, Amanda L., primary, Saur Conway, Amy, primary, Tarlock, Katherine, primary, Stieglitz, Elliot, primary, Place, Andrew E., primary, Puissant, Alexandre, primary, Hunger, Stephen P., primary, Kim, Annette S., primary, Lindeman, Neal I., primary, Gore, Lia, primary, Janeway, Katherine A., primary, Silverman, Lewis B., primary, Tyner, Jeffrey W., primary, Harris, Marian H., primary, Loh, Mignon L., primary, and Stegmaier, Kimberly, primary

Published
2023
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34. Baseline metabolic tumour burden improves risk stratification in Hodgkin lymphoma: A Children's Oncology Group study

Author

Milgrom, Sarah A., primary, Kim, Jihyun, additional, Pei, Qinglin, additional, Lee, Inki, additional, Hoppe, Bradford S., additional, Wu, Yue, additional, Hodgson, David, additional, Kessel, Sandy, additional, McCarten, Kathleen M., additional, Roberts, Kenneth, additional, Lo, Andrea C., additional, Cole, Peter D., additional, Kelly, Kara M., additional, and Cho, Steve Y., additional

Published
2023
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35. Intravenous pegylated asparaginase versus intramuscular native Escherichia colil-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial

Author

Place, Andrew E, Stevenson, Kristen E, Vrooman, Lynda M, Harris, Marian H, Hunt, Sarah K, O'Brien, Jane E, Supko, Jeffrey G, Asselin, Barbara L, Athale, Uma H, Clavell, Luis A, Cole, Peter D, Kelly, Kara M, Laverdiere, Caroline, Leclerc, Jean-Marie, Michon, Bruno, Schorin, Marshall A, Welch, Jennifer J G, Lipshultz, Steven E, Kutok, Jeffery L, Blonquist, Traci M, Neuberg, Donna S, Sallan, Stephen E, and Silverman, Lewis B

Published
2015
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36. Role of Cytotoxic Therapy with Hematopoietic Cell Transplantation in the Treatment of Hodgkin Lymphoma: Guidelines from the American Society for Blood and Marrow Transplantation

Author

Perales, Miguel-Angel, Ceberio, Izaskun, Armand, Philippe, Burns, Linda J., Chen, Robert, Cole, Peter D., Evens, Andrew M., Laport, Ginna G., Moskowitz, Craig H., Popat, Uday, Reddy, Nishitha M., Shea, Thomas C., Vose, Julie M., Schriber, Jeffrey, Savani, Bipin N., and Carpenter, Paul A.

Published
2015
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38. Abstract B096: Food insecurity and receipt of Supplemental Nutrition Assistance Program (SNAP) benefits among income-eligible US pediatric acute lymphoblastic leukemia patients enrolled on a multi-center clinical trial

Author

Aziz-Bose, Rahela, primary, Flamand, Yael, additional, Umaretiya, Puja J., additional, Ilcisin, Lenka, additional, Valenzuela, Ariana, additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, Justine M., additional, Kelly, Kara M., additional, Michon, Bruno, additional, Tran, Thai-Hoa, additional, Welch, Jennifer J. G., additional, Silverman, Lewis B., additional, and Bona, Kira, additional

Published
2023
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39. Nivolumab, Brentuximab Vedotin, +/- Bendamustine For R/R Hodgkin Lymphoma in Children, Adolescents, and Young Adults

Author

Harker-Murray, Paul, primary, Mauz-Körholz, Christine, additional, Leblanc, Thierry M, additional, Mascarin, Maurizio, additional, Michel, Gérard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Amoroso, Loredana, additional, Buffardi, Salvatore, additional, Rigaud, Charlotte, additional, Hoppe, Bradford S., additional, Lisano, Julie M, additional, Francis, Stephen, additional, Sacchi, Mariana, additional, Cole, Peter D., additional, Drachtman, Richard A., additional, Kelly, Kara M., additional, and Daw, Stephen, additional

Published
2022
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44. Oral Mercaptopurine Adherence in Pediatric Acute Lymphoblastic Leukemia: A Survey Study From the Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium

Author

Kahn, Justine M., primary, Stevenson, Kristen, additional, Beauchemin, Melissa, additional, Koch, Victoria B., additional, Cole, Peter D., additional, Welch, Jennifer J. G., additional, Gage-Bouchard, Elizabeth, additional, Karsenty, Cecile, additional, Silverman, Lewis B., additional, Kelly, Kara M., additional, and Bona, Kira, additional

Published
2022
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45. P107: Effect of Brentuximab Vedotin Addition to Chemotherapy and Prognostic Factors in Patients with Relapsed/Refractory Hodgkin Lymphoma: a Large Multi-Trial Analysis Based on Individual Patient Data

Author

Driessen, Julia, primary, De Wit, Fer, additional, Herrera, Alex F., additional, Zinzani, Pier Luigi, additional, Lacasce, Ann S., additional, Cole, Peter D., additional, Moskowitz, Craig H., additional, Sanz, Ramón. García, additional, Fuchs, Michael, additional, Müller, Horst, additional, Borchmann, Peter, additional, Santoro, Armando, additional, Schöder, Heiko, additional, Zijlstra, Josée. M., additional, Hutten, Barbara A., additional, Moskowitz, Alison J., additional, and Kersten, Marie José, additional

Published
2022
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46. Feasibility of oncology clinical trial‐embedded evaluation of social determinants of health

Author

Aziz‐Bose, Rahela, primary, Zheng, Daniel J., additional, Umaretiya, Puja J., additional, Ilcisin, Lenka, additional, Stevenson, Kristen, additional, Koch, Victoria, additional, Valenzuela, Ariana, additional, Cole, Peter D., additional, Gennarini, Lisa M., additional, Kahn, Justine M., additional, Kelly, Kara M., additional, Tran, Thai‐Hoa, additional, Michon, Bruno, additional, Welch, Jennifer J. G., additional, Silverman, Lewis B., additional, Wolfe, Joanne, additional, and Bona, Kira, additional

Published
2022
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47. Delayed Neurotoxicity Associated with Therapy for Children with Acute Lymphoblastic Leukemia

Author

Cole, Peter D. and Kamen, Barton A.

Abstract

Most children diagnosed today with acute lymphoblastic leukemia (ALL) will be cured. However, treatment entails risk of neurotoxicity, causing deficits in neurocognitive function that can persist in the years after treatment is completed. Many of the components of leukemia therapy can contribute to adverse neurologic sequelae, including craniospinal irradiation, nucleoside analogs, corticosteroids, and antifolates. In this review, we describe the characteristic radiographic findings and neurocognitivie deficits seen among survivors of childhood ALL. We summarize what is known about the pathophysiology of delayed treatment-related neurotoxicity, with a focus on the toxicity resulting from pharmacologic disruption of folate physiology within the central nervous system. Finally, we suggest testable strategies to ameliorate the symptoms of treatment-related neurotoxicity or decrease its incidence. (Contains 2 tables and 3 figures.)

Published
2006
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49. The low incidence of secondary acute myelogenous leukaemia in children and adolescents treated with dexrazoxane for acute lymphoblastic leukaemia: A report from the Dana-Farber Cancer Institute ALL Consortium

Author

Vrooman, Lynda M., Neuberg, Donna S., Stevenson, Kristen E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis, Cole, Peter D., Kelly, Kara M., Larsen, Eric C., Laverdière, Caroline, Michon, Bruno, Schorin, Marshall, Schwartz, Cindy L., Cohen, Harvey J., Lipshultz, Steven E., Silverman, Lewis B., and Sallan, Stephen E.

Published
2011
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