1,672 results on '"Colby, C"'
Search Results
2. Suppression of Collisionless Magnetic Reconnection in the High Ion $\beta$, Strong Guide Field Limit
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Giai, Carlos A., Haggerty, Colby C., Shay, Michael A., and Cassak, Paul A.
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
In magnetic reconnection, the ion bulk outflow speed and ion heating have been shown to be set by the available reconnecting magnetic energy, i.e., the energy stored in the reconnecting magnetic field ($B_r$). However, recent simulations, observations, and theoretical works have shown that the released magnetic energy is inhibited by upstream ion plasma beta $\beta_{i}$ -- the relative ion thermal pressure normalized to magnetic pressure based on the reconnecting field -- for antiparallel magnetic field configurations. Using kinetic theory and hybrid particle-in-cell simulations, we investigate the effects of $\beta_{i}$ on guide field reconnection. While previous works have suggested that guide field reconnection is uninfluenced by $\beta_{i}$, we demonstrate that the reconnection process is modified and the outflow is reduced for sufficiently large $\beta_{i} > B_g^2/(B_r^2 + B_g^2)$. We develop a theoretical framework that shows that this reduction is consistent with an enhanced exhaust pressure gradient, which reduces the outflow speed as $v_0 \propto 1/\sqrt{\beta_{i}}$. These results apply to systems in which guide field reconnection is embedded in hot plasmas, such as reconnection at the boundary of eddies in fully developed turbulence like the solar wind or the magnetosheath as well as downstream of shocks such as the heliosheath or the mergers of galaxy clusters., Comment: 11 pages, 5 figures, submitted to ApJ
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- 2024
3. Density jump for oblique collisionless shocks in pair plasmas: physical solutions
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Bret, Antoine, Haggerty, Colby C., and Narayan, Ramesh
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Collisionless shocks are frequently analyzed using the magnetohydrodynamics (MHD) formalism, even though MHD assumes a small mean free path. Yet, isotropy of pressure, fruit of binary collisions and assumed in MHD, may not apply in collisionless shocks. This is especially true within a magnetized plasma, where the field can stabilize an anisotropy. In a previous article \citep{BretJPP2022b}, a model was presented capable of dealing with the anisotropies that may arise at the front crossing. It was solved for any orientation of the field with respect to the shock front. Yet, for some values of the upstream parameters, several downstream solutions were found. Here, we complete the work started in \cite{BretJPP2022b} by showing how to pick the physical solution out of the ones offered by the algebra. This is achieved by 2 means: 1) selecting the solution that has the downstream field obliquity closest to the upstream one. This criterion is exemplified on the parallel case and backed up by Particle-in-Cell simulations. 2) Filtering out solutions which do not satisfy a criteria already invoked to trim multiple solutions in MHD: the evolutionarity criterion, that we assume valid in the collisionless case. The end result is a model in which a given upstream configuration results in a unique, or none (like in MHD), downstream configuration. The largest departure from MHD is found for the case of a parallel shock., Comment: 22 pages, 9 figures, to appear in Journal of Plasma Physics
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- 2024
4. The Perturbed Full Two-Body Problem: Application to Post-DART Didymos
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Meyer, Alex J., Agrusa, Harrison F., Richardson, Derek C., Daly, R. Terik, Fuentes-Muñoz, Oscar, Hirabayashi, Masatoshi, Michel, Patrick, Merrill, Colby C., Nakano, Ryota, Cheng, Andrew F., Barbee, Brent, Barnouin, Olivier S., Chesley, Steven R., Ernst, Carolyn M., Gkolias, Ioannis, Moskovitz, Nicholas A., Naidu, Shantanu P., Pravec, Petr, Scheirich, Petr, Thomas, Cristina A., Tsiganis, Kleomenis, and Scheeres, Daniel J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
With the successful impact of the NASA DART spacecraft in the Didymos-Dimorphos binary asteroid system, we provide an initial analysis of the post-impact perturbed binary asteroid dynamics. To compare our simulation results with observations, we introduce a set of "observable elements" calculated using only the physical separation of the binary asteroid, rather than traditional Keplerian elements. Using numerical methods that treat the fully spin-orbit-coupled dynamics, we estimate the system's mass and the impact-induced changes in orbital velocity, semimajor axis, and eccentricity. We find that the changes to the mutual orbit depend strongly on the separation distance between Didymos and Dimorphos at the time of impact. If Dimorphos enters a tumbling state after the impact, this may be observable through changes in the system's eccentricity and orbit period. We also find that any DART-induced reshaping of Dimorphos would generally reduce the required change in orbital velocity to achieve the measured post-impact orbit period and will be assessed by the ESA Hera mission in 2027., Comment: Accepted for publication in PSJ
- Published
- 2023
5. The Importance of Heat Flux in Quasi-Parallel Collisionless Shocks
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Haggerty, Colby C., Caprioli, Damiano, Cassak, Paul A., Barbhuiya, M. Hasan, Wilson III, Lynn, and Turner, Drew
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Space Physics - Abstract
Collisionless plasma shocks are a common feature of many space and astrophysical systems and are sources of high-energy particles and non-thermal emission, channeling as much as 20\% of the shock's energy into non-thermal particles. The generation and acceleration of these non-thermal particles have been extensively studied, however, how these particles feed back on the shock hydrodynamics has not been fully treated. This work presents the results of self-consistent hybrid particle-in-cell simulations that show the effect of self-generated non-thermal particle populations on the nature of collisionless, quasi-parallel shocks. They contribute to a significant heat flux density upstream of the shock. Non-thermal particles downstream of the shock leak into the upstream region, taking energy away from the shock. This increases the compression ratio, slows the shock down, and flattens the non-thermal population's spectral index for lower Mach number shocks. We incorporate this into a revised theory for the Rankine-Hugoniot jump conditions that include this effect and it shows excellent agreement with simulations. The results have the potential to explain discrepancies between predictions and observations in a wide range of systems, such as inaccuracies of predictions of arrival times of coronal mass ejections and the conflicting radio and x-ray observations of intracluster shocks. These effects will likely need to be included in fluid modeling to accurately predict shock evolution., Comment: 7 pages, 3 figures, a lot of appendix
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- 2023
6. Isolation and Phase-Space Energization Analysis of the Instabilities in Collisionless Shocks
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Brown, Collin R., Juno, James, Howes, Gregory G., Haggerty, Colby C., and Constantinou, Sage
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Physics - Plasma Physics - Abstract
We analyze the generation of kinetic instabilities and their effect on the energization of ions in non-relativistic, oblique collisionless shocks using a 3D-3V simulation by $\texttt{dHybridR}$, a hybrid particle-in-cell code. At sufficiently high Mach number, quasi-perpendicular and oblique shocks can experience rippling of the shock surface caused by kinetic instabilities arising from free energy in the ion velocity distribution due to the combination of the incoming ion beam and the population of ions reflected at the shock front. To understand the role of the ripple on particle energization, we devise the new instability isolation method to identify the unstable modes underlying the ripple and interpret the results in terms of the governing kinetic instability. We generate velocity-space signatures using the field-particle correlation technique to look at energy transfer in phase space from the isolated instability driving the shock ripple, providing a viewpoint on the different dynamics of distinct populations of ions in phase space. We generate velocity-space signatures of the energy transfer in phase space of the isolated instability driving the shock ripple using the field-particle correlation technique. Together, the field-particle correlation technique and our new instability isolation method provide a unique viewpoint on the different dynamics of distinct populations of ions in phase space and allow us to completely characterize the energetics of the collisionless shock under investigation., Comment: 32 pages, 14 figures, accepted by the Journal of Plasma Physics
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- 2022
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7. Phase Space Energization of Ions in Oblique Shocks
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Juno, James, Brown, Collin R., Howes, Gregory G., Haggerty, Colby C., TenBarge, Jason M., Wilson III, Lynn B., Caprioli, Damiano, and Klein, Kristopher G.
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Space Physics - Abstract
Examining energization of kinetic plasmas in phase space is a growing topic of interest, owing to the wealth of data in phase space compared to traditional bulk energization diagnostics. Via the field-particle correlation (FPC) technique and using multiple means of numerically integrating the plasma kinetic equation, we have studied the energization of ions in phase space within oblique collisionless shocks. The perspective afforded to us with this analysis in phase space allows us to characterize distinct populations of energized ions. In particular, we focus on ions which reflect multiple times off the shock front through shock-drift acceleration, and how to distinguish these different reflected populations in phase space using the FPC technique. We further extend our analysis to simulations of three-dimensional shocks undergoing more complicated dynamics, such as shock ripple, to demonstrate the ability to recover the phase space signatures of this energization process in a more general system. This work thus extends previous applications of the FPC technique to more realistic collisionless shock environments, providing stronger evidence of the technique's utility for simulation, laboratory, and spacecraft analysis., Comment: 9 pages, 5 figures
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- 2022
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8. Advancing Theory and Modeling Efforts in Heliophysics
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Guo, Fan, Antiochos, Spiro, Cassak, Paul, Chen, Bin, Chen, Xiaohang, Dong, Chuanfei, Downs, Cooper, Giacalone, Joe, Haggerty, Colby C., Ji, Hantao, Karpen, Judith, Klimchuk, James, Li, Wen, Li, Xiaocan, Oka, Mitsuo, Reeves, Katharine K., Swisdak, Marc, and Tu, Weichao
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics ,Physics - Space Physics - Abstract
Heliophysics theory and modeling build understanding from fundamental principles to motivate, interpret, and predict observations. Together with observational analysis, they constitute a comprehensive scientific program in heliophysics. As observations and data analysis become increasingly detailed, it is critical that theory and modeling develop more quantitative predictions and iterate with observations. Advanced theory and modeling can inspire and greatly improve the design of new instruments and increase their chance of success. In addition, in order to build physics-based space weather forecast models, it is important to keep developing and testing new theories, and maintaining constant communications with theory and modeling. Maintaining a sustainable effort in theory and modeling is critically important to heliophysics. We recommend that all funding agencies join forces and consider expanding current and creating new theory and modeling programs--especially, 1. NASA should restore the HTMS program to its original support level to meet the critical needs of heliophysics science; 2. a Strategic Research Model program needs to be created to support model development for next-generation basic research codes; 3. new programs must be created for addressing mission-critical theory and modeling needs; and 4. enhanced programs are urgently required for training the next generation of theorists and modelers., Comment: White paper submitted to Heliophysics 2024 Decadal Survey
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- 2022
9. Recovery after neurologic injury in operative acetabular and pelvic fractures: Defining the natural history of foot drop
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Wollenman, Colby C., Morris, Cade A., Maxson, Ridge, Davidson, Claudia, Pennings, Jacquelyn S., and Mitchell, Phillip M.
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- 2024
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10. Outcomes and performance following posteromedial elbow débridement in Major League Baseball players
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Wollenman, Colby C., Davis, Phillip J., Lane, Gabriel C., Fox, Jake A., Bowman, Eric N., and LeClere, Lance E.
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- 2024
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11. Kinetic Simulations of Strongly-Magnetized Parallel Shocks: Deviations from MHD Jump Conditions
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Haggerty, Colby C., Bret, Antoine, and Caprioli, Damiano
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Shocks waves are a ubiquitous feature of many astrophysical plasma systems, and an important process for energy dissipation and transfer. The physics of these shock waves are frequently treated/modeled as a collisional, fluid MHD discontinuity, despite the fact that many shocks occur in the collisionless regime. In light of this, using fully kinetic, 3D simulations of non-relativistic, parallel propagating collisionless shocks comprised of electron-positron plasma, we detail the deviation of collisionless shocks form MHD predictions for varying magnetization/Alfv\'enic Mach numbers, with particular focus on systems with Alf\'enic Mach numbers much smaller than sonic Mach numbers. We show that the shock compression ratio decreases for sufficiently large upstream magnetic fields, in agreement with the predictions of Bret & Narayan (2018). Additionally, we examine the role of magnetic field strength on the shock front width. This work reinforces a growing body of work that suggest that modeling many astrophysical systems with only a fluid plasma description omits potentially important physics., Comment: 7 pages, 5 figures + a diagram, submitted to MNRAS
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- 2021
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12. Lepton-driven Non-resonant Streaming Instability
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Gupta, Siddhartha, Caprioli, Damiano, and Haggerty, Colby C.
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Plasma Physics - Abstract
A strong super-Alfv\'{e}nic drift of energetic particles (or cosmic rays, CRs) in a magnetized plasma can amplify the magnetic field significantly through non-resonant streaming instability (NRSI). While the traditional analysis is done for an ion current, here we use kinetic particle-in-cell simulations to study how the NRSI behaves when it is driven by electrons or by a mixture of electrons and positrons. In particular, we characterize growth rate, spectrum, and helicity of the unstable modes, as well the level of magnetic field at saturation. Our results are potentially relevant for several space/astrophysical environments (e.g, electron strahl in the solar wind, at oblique non-relativistic shocks, around pulsar wind nebulae) and also in laboratory experiments., Comment: 16 pages, 9 figures, 1 table; Submitted to ApJ; Comments welcome!
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- 2021
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13. Kinetic Simulations of Cosmic-Ray-Modified Shocks II: Particle Spectra
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Caprioli, Damiano, Haggerty, Colby C., and Blasi, Pasquale
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Plasma Physics - Abstract
Diffusive shock acceleration is a prominent mechanism for producing energetic particles in space and in astrophysical systems. Such energetic particles have long been predicted to affect the hydrodynamic structure of the shock, in turn leading to CR spectra flatter than the test-particle prediction. However, in this work along with a companion paper, C. C. Haggerty and D. Caprioli, 2020, arXiv:2008.12308 [astro-ph.HE], we use self-consistent hybrid (kinetic ions-fluid electrons) simulations to show for the first time how CR-modified shocks actually produce steeper spectra. The steepening is driven by the enhanced advection of CRs embedded in magnetic turbulence downstream of the shock, in what we call the "postcursor". These results are consistent with multi-wavelength observations of supernovae and supernova remnants and have significant phenomenological implications for space/astrophysical shocks in general., Comment: 10 pages, 5 figures, submitted to ApJ, Paper II of a series of 2 (Paper I: Kinetic Simulations of Cosmic-Ray-Modified Shocks II: Hydrodynamics, arXiv:2008.12308 [astro-ph], arXiv:2008.12308)
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- 2020
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14. Kinetic Simulations of Cosmic-Ray-Modified Shocks I: Hydrodynamics
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Haggerty, Colby C. and Caprioli, Damiano
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Plasma Physics - Abstract
Collisionless plasma shocks are efficient sources of non-thermal particle acceleration in space and astrophysical systems. We use hybrid (kinetic ions -- fluid electrons) simulations to examine the non-linear feedback of the self-generated energetic particles (cosmic rays, CRs) on the shock hydrodynamics. When CR acceleration is efficient, we find evidence of both an upstream precursor, where the inflowing plasma is compressed and heated, and a downstream postcursor, where the energy flux in CRs and amplified magnetic fields play a dynamical role. For the first time, we assess how non-linear magnetic fluctuations in the postcursor preferentially travel away from the shock at roughly the local Alfv\'en speed with respect to the downstream plasma. The drift of both magnetic and CR energy with respect to the thermal plasma substantially increases the shock compression ratio with respect to the standard prediction, in particular exceeding 4 for strong shocks. Such modifications also have implications for the spectrum of the particles accelerated via diffusive shock acceleration, a significant result detailed in a companion paper, Caprioli, Haggerty & Blasi 2020, arXiv:2009.00007 [astro-ph.HE]., Comment: Paper 1 of 2, 15 pages, 11 figures, companion paper to arXiv:2009.00007 [astro-ph.HE], arXiv:2009.00007
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- 2020
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15. Creating a contact binary via spacecraft impact to near-Earth binary asteroid (350751) 2002 AW
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Merrill, Colby C., Geiger, Carl J., Tahsin, Abu T.M., Savransky, Dmitry, and Peck, Mason
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- 2024
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16. The Issue with Diffusive Shock Acceleration
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Caprioli, Damiano and Haggerty, Colby C.
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Plasma Physics ,Physics - Space Physics - Abstract
We discuss the recent developments in the theory of diffusive shock acceleration (DSA) by using both first-principle kinetic plasma simulations and analytical theory based on the solution of the convection/diffusion equation. In particular, we show how simulations reveal that the spectra of accelerated particles are significantly steeper than the $E^{-2}$ predicted by the standard theory of DSA for strong shocks, in agreement with several observational pieces of evidence. We single out which standard assumptions of test-particle and non-linear DSA are violated in the presence of strong (self-generated) magnetic turbulence and put forward a novel theory in better agreement with the particle spectra inferred with multi-wavelength observations of young SN remnants, radio-supernovae, and Galactic cosmic rays., Comment: 8 pages, 2 figures, 36th International Cosmic Ray Conference (ICRC2019), held July 24th-August 1st, 2019 in Madison, WI, U.S.A
- Published
- 2019
17. dHybridR: a Hybrid--Particle-in-Cell Code Including Relativistic Ion Dynamics
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Haggerty, Colby C. and Caprioli, Damiano
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Plasma Physics - Abstract
We present the first plasma simulations obtained with the code dHybridR, a hybrid particle-in-cell code with fluid electrons and both thermal and energetic ions that retain relativistic dynamics. dHybridR is constructed to study astrophysical and space-physics problems where a few energetic non-thermal particles (i.e., cosmic rays, CRs) affect the overall dynamics of a non-relativistic plasma, such as CR-driven instabilities, collisionless shocks, magnetic reconnection, turbulence, etc.In this method paper we provide some applications to linear (resonant/non-resonant CR streaming instability) and strongly non-linear (parallel shocks) problems that show the capabilities of the code. In particular, we provide the first self-consistent hybrid runs that show the acceleration of relativistic ions at non-relativistic shocks; CRs develop a power-law in momentum, which translates to a broken power law in energy that exhibits a steepening around the ion rest mass, as predicted by the theory of diffusive shock acceleration. We present examples of 2D dHybridR runs relevant for fast shocks in radio supernovae, whose evolution can be followed in real time, and 3D runs of low-Mach-number heliospheric shocks, which can be compared with in-situ spacecraft observations., Comment: 14 pages, 12 figures, 1 table
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- 2019
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18. The Reduction of Magnetic Reconnection Outflow Jets to Sub-Alfv\'enic Speeds
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Haggerty, Colby C., Shay, Michael A., Chasapis, Alexandros, Phan, Tai D., Drake, James F., Malakit, Kittipat, Cassak, Paul A., and Kieokaew, Rungployphan
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Physics - Plasma Physics - Abstract
The outflow velocity of jets produced by collisionless magnetic reconnection is shown to be reduced by the ion exhaust temperature in simulations and observations. We derive a scaling relationship for the outflow velocity based on the upstream Alfv\'en speed and the parallel ion exhaust temperature, which is verified in kinetic simulations and observations. The outflow speed reduction is shown to be due to the firehose instability criterion, and so for large enough guide fields this effect is suppressed and the outflow speed reaches the upstream Alfv\'en speed based on the reconnecting component of the magnetic field.
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- 2018
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19. Exome sequencing of Finnish isolates enhances rare-variant association power
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Locke, Adam E, Steinberg, Karyn Meltz, Chiang, Charleston WK, Service, Susan K, Havulinna, Aki S, Stell, Laurel, Pirinen, Matti, Abel, Haley J, Chiang, Colby C, Fulton, Robert S, Jackson, Anne U, Kang, Chul Joo, Kanchi, Krishna L, Koboldt, Daniel C, Larson, David E, Nelson, Joanne, Nicholas, Thomas J, Pietilä, Arto, Ramensky, Vasily, Ray, Debashree, Scott, Laura J, Stringham, Heather M, Vangipurapu, Jagadish, Welch, Ryan, Yajnik, Pranav, Yin, Xianyong, Eriksson, Johan G, Ala-Korpela, Mika, Järvelin, Marjo-Riitta, Männikkö, Minna, Laivuori, Hannele, Dutcher, Susan K, Stitziel, Nathan O, Wilson, Richard K, Hall, Ira M, Sabatti, Chiara, Palotie, Aarno, Salomaa, Veikko, Laakso, Markku, Ripatti, Samuli, Boehnke, Michael, and Freimer, Nelson B
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Medical Biochemistry and Metabolomics ,Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Alleles ,Cholesterol ,HDL ,Cluster Analysis ,Endpoint Determination ,Finland ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genetic Variation ,Geographic Mapping ,Humans ,Multifactorial Inheritance ,Quantitative Trait Loci ,Reproducibility of Results ,Exome Sequencing ,FinnGen Project ,General Science & Technology - Abstract
Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here, using exome sequencing of nearly 20,000 individuals from these regions, we investigate the role of rare coding variants in clinically relevant quantitative cardiometabolic traits. Exome-wide association studies for 64 quantitative traits identified 26 newly associated deleterious alleles. Of these 26 alleles, 19 are either unique to or more than 20 times more frequent in Finnish individuals than in other Europeans and show geographical clustering comparable to Mendelian disease mutations that are characteristic of the Finnish population. We estimate that sequencing studies of populations without this unique history would require hundreds of thousands to millions of participants to achieve comparable association power.
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- 2019
20. Exploring the Statistics of Magnetic Reconnection X-points in Kinetic Particle-in-Cell (PIC) Turbulence
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Haggerty, Colby C., Parashar, Tulasi N., Matthaeus, William H., Shay, Michael A., Yang, Yan, Wan, Minping, Wu, Penny, and Servidio, Sergio
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Physics - Space Physics - Abstract
Magnetic reconnection is a ubiquitous phenomenon in turbulent plasmas. It is an important part of the turbulent dynamics and heating of space and astrophysical plasmas. We examine the statistics of magnetic reconnection using a quantitative local analysis of the magnetic vector potential, previously used in magnetohydrodynamics simulations, and now generalized to fully kinetic PIC simulations. Different ways of reducing the particle noise for analysis purposes including multiple smoothing techniques are explored. We find that a Fourier filter applied at the Debye scale is an optimal choice for analyzing PIC data. Finlay, we find a broader distribution of normalized reconnection rates compared to the MHD limit with rates as large as 0.5 but with an average of approximately 0.1.
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- 2017
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21. Suppression of Collisionless Magnetic Reconnection in the High Ion β, Strong Guide Field Limit
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Carlos A. Giai, Colby C. Haggerty, Michael A. Shay, Paul A. Cassak, and Zachary K. Davis
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Solar magnetic reconnection ,Interplanetary turbulence ,Plasma physics ,Plasma astrophysics ,Magnetohydrodynamical simulations ,Astrophysics ,QB460-466 - Abstract
In magnetic reconnection, the ion bulk outflow speed and ion heating have been shown to be set by the available reconnecting magnetic energy, i.e., the energy stored in the reconnecting magnetic field ( B _r ). However, recent simulations, observations, and theoretical works have shown that the released magnetic energy is inhibited by upstream ion plasma beta β _i —the relative ion thermal pressure normalized to magnetic pressure based on the reconnecting field—for antiparallel magnetic field configurations. Using kinetic theory and hybrid particle-in-cell simulations, we investigate the effects of β _i on guide field reconnection. While previous works have suggested that guide field reconnection is uninfluenced by β _i , we demonstrate that the reconnection process is modified and the outflow is reduced for sufficiently large ${\beta }_{i}\gt ({B}_{r}^{2}+{B}_{g}^{2})/{B}_{r}^{2}$ . We develop a theoretical framework that shows that this reduction is consistent with an enhanced exhaust pressure gradient, which reduces the outflow speed as ${v}_{\mathrm{out}}\propto 1/\sqrt{{\beta }_{i}}$ . These results apply to systems in which guide field reconnection is embedded in hot plasmas, such as reconnection at the boundary of eddies in fully developed turbulence like the solar wind or the magnetosheath as well as downstream of shocks such as the heliosheath or the mergers of galaxy clusters.
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- 2024
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22. The Secular Dynamical Evolution of Binary Asteroid System (65803) Didymos Post-DART
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Rachel H. Cueva, Jay W. McMahon, Alex J. Meyer, Daniel J. Scheeres, Masatoshi Hirabayashi, Sabina D. Raducan, Seth A. Jacobson, and Colby C. Merrill
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Asteroid dynamics ,Asteroid rotation ,Asteroid satellites ,Asteroid surfaces ,Asteroids ,Near-Earth objects ,Astronomy ,QB1-991 - Abstract
The successful impact of NASA’s DART mission with Dimorphos, the secondary body of binary asteroid system (65803) Didymos, altered the attitude, shape, and orbit of Dimorphos. In addition to perturbing the immediate short-term dynamics of the system, these changes have major implications for the binary Yarkovsky–O’Keefe–Radzievskii–Paddack (BYORP) effect and resulting long-term secular evolution. In this study, we assess the range of possible reshaping-induced changes in BYORP. We produce high-fidelity numerical simulations of the orbit-attitude coupled tidal-BYORP dynamical evolution of the Didymos system to constrain how the secular evolution changed from its preimpact behavior. We find that the nature of the dynamics is highly dependent on a variety of initial conditions and assumptions, and it is difficult to fully predict how the system will secularly evolve following the impact. Rather, we provide a range of feasible possibilities within the bounds of observations and current best estimates of the Didymos system parameters. ESA’s Hera mission will help reduce uncertainties surrounding the postimpact state and shape of Dimorphos in 2027, allowing our predictions of the secular evolutionary effects and long-term fate of the Didymos system to be better refined.
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- 2024
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23. Achievement of the Planetary Defense Investigations of the Double Asteroid Redirection Test (DART) Mission
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Nancy L. Chabot, Andrew S. Rivkin, Andrew F. Cheng, Olivier S. Barnouin, Eugene G. Fahnestock, Derek C. Richardson, Angela M. Stickle, Cristina A. Thomas, Carolyn M. Ernst, R. Terik Daly, Elisabetta Dotto, Angelo Zinzi, Steven R. Chesley, Nicholas A. Moskovitz, Brent W. Barbee, Paul Abell, Harrison F. Agrusa, Michele T. Bannister, Joel Beccarelli, Dmitriy L. Bekker, Megan Bruck Syal, Bonnie J. Buratti, Michael W. Busch, Adriano Campo Bagatin, Joseph P. Chatelain, Sidney Chocron, Gareth S. Collins, Luca Conversi, Thomas M. Davison, Mallory E. DeCoster, J. D. Prasanna Deshapriya, Siegfried Eggl, Raymond C. Espiritu, Tony L. Farnham, Marin Ferrais, Fabio Ferrari, Dora Föhring, Oscar Fuentes-Muñoz, Igor Gai, Carmine Giordano, David A. Glenar, Edward Gomez, Dawn M. Graninger, Simon F. Green, Sarah Greenstreet, Pedro H. Hasselmann, Isabel Herreros, Masatoshi Hirabayashi, Marek Husárik, Simone Ieva, Stavro L. Ivanovski, Samuel L. Jackson, Emmanuel Jehin, Martin Jutzi, Ozgur Karatekin, Matthew M. Knight, Ludmilla Kolokolova, Kathryn M. Kumamoto, Michael Küppers, Fiorangela La Forgia, Monica Lazzarin, Jian-Yang Li, Tim A. Lister, Ramin Lolachi, Michael P. Lucas, Alice Lucchetti, Robert Luther, Rahil Makadia, Elena Mazzotta Epifani, Jay McMahon, Gianmario Merisio, Colby C. Merrill, Alex J. Meyer, Patrick Michel, Marco Micheli, Alessandra Migliorini, Kate Minker, Dario Modenini, Fernando Moreno, Naomi Murdoch, Brian Murphy, Shantanu P. Naidu, Hari Nair, Ryota Nakano, Cyrielle Opitom, Jens Ormö, J. Michael Owen, Maurizio Pajola, Eric E. Palmer, Pasquale Palumbo, Paolo Panicucci, Laura M. Parro, Jason M. Pearl, Antti Penttilä, Davide Perna, Elisabeta Petrescu, Petr Pravec, Sabina D. Raducan, K. T. Ramesh, Ryan Ridden-Harper, Juan L. Rizos, Alessandro Rossi, Nathan X. Roth, Agata Rożek, Benjamin Rozitis, Eileen V. Ryan, William H. Ryan, Paul Sánchez, Toni Santana-Ros, Daniel J. Scheeres, Peter Scheirich, Cem Berk Senel, Colin Snodgrass, Stefania Soldini, Damya Souami, Thomas S. Statler, Rachel Street, Timothy J. Stubbs, Jessica M. Sunshine, Nicole J. Tan, Gonzalo Tancredi, Calley L. Tinsman, Paolo Tortora, Filippo Tusberti, James D. Walker, C. Dany Waller, Kai Wünnemann, Marco Zannoni, and Yun Zhang
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Asteroids ,Small Solar System bodies ,Near-Earth objects ,Asteroid satellites ,Planetary science ,Solar system astronomy ,Astronomy ,QB1-991 - Abstract
NASA's Double Asteroid Redirection Test (DART) mission was the first to demonstrate asteroid deflection, and the mission's Level 1 requirements guided its planetary defense investigations. Here, we summarize DART's achievement of those requirements. On 2022 September 26, the DART spacecraft impacted Dimorphos, the secondary member of the Didymos near-Earth asteroid binary system, demonstrating an autonomously navigated kinetic impact into an asteroid with limited prior knowledge for planetary defense. Months of subsequent Earth-based observations showed that the binary orbital period was changed by –33.24 minutes, with two independent analysis methods each reporting a 1 σ uncertainty of 1.4 s. Dynamical models determined that the momentum enhancement factor, β , resulting from DART's kinetic impact test is between 2.4 and 4.9, depending on the mass of Dimorphos, which remains the largest source of uncertainty. Over five dozen telescopes across the globe and in space, along with the Light Italian CubeSat for Imaging of Asteroids, have contributed to DART's investigations. These combined investigations have addressed topics related to the ejecta, dynamics, impact event, and properties of both asteroids in the binary system. A year following DART's successful impact into Dimorphos, the mission has achieved its planetary defense requirements, although work to further understand DART's kinetic impact test and the Didymos system will continue. In particular, ESA's Hera mission is planned to perform extensive measurements in 2027 during its rendezvous with the Didymos–Dimorphos system, building on DART to advance our knowledge and continue the ongoing international collaboration for planetary defense.
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- 2024
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24. Dimorphos’s Orbit Period Change and Attitude Perturbation due to Its Reshaping after the DART Impact
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Ryota Nakano, Masatoshi Hirabayashi, Sabina D. Raducan, Petr Pravec, Shantanu P. Naidu, Harrison F. Agrusa, Steven Chesley, Fabio Ferrari, Martin Jutzi, Colby C. Merrill, Alex J. Meyer, Patrick Michel, Derek C. Richardson, Paul Sánchez, Peter Scheirich, Stephen R. Schwartz, Yun Zhang, Adriano Campo Bagatin, Po-Yen Liu, and Andrew F. Cheng
- Subjects
Near-Earth objects ,Asteroid satellites ,Asteroid dynamics ,Two-body problem ,Asteroid rotation ,Gravitational interaction ,Astronomy ,QB1-991 - Abstract
On 2022 September 26 (UTC), NASA's Double Asteroid Redirection Test (DART) mission achieved a successful impact on Dimorphos, the secondary component of the near-Earth binary asteroid system (65803) Didymos. Subsequent ground-based observations suggest a significant reshaping of Dimorphos, with its equatorial axis ratio changing from 1.06 to ∼1.3. Here we report the effects of this reshaping event on Dimorphos's orbit and attitude. Given the reported reshaping magnitude, our mutual dynamics simulations show that approximately 125 s of the observed 33 minute orbit period change after the DART impact may have resulted from reshaping. This value, however, is sensitive to the precise values of Dimorphos's post-impact axis ratios and may vary by up to 2 times that amount, reaching approximately 250 s within the current uncertainty range. While the rotational state of the body is stable at the currently estimated axis ratios, even minor changes in these ratios or the introduction of shape asymmetry can render its attitude unstable. The perturbation to Dimorphos’s orbital and rotational state delivered by the impact directly, combined with any reshaping, leads to a strong possibility for a tumbling rotation state. To accurately determine the momentum enhancement factor ( β ) through measurements by the European Space Agency’s Hera spacecraft and to evaluate the effectiveness of the kinetic deflection technique for future planetary defense initiatives, the effects of reshaping should not be overlooked.
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- 2024
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- View/download PDF
25. The Dynamical State of the Didymos System before and after the DART Impact
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Derek C. Richardson, Harrison F. Agrusa, Brent Barbee, Rachel H. Cueva, Fabio Ferrari, Seth A. Jacobson, Rahil Makadia, Alex J. Meyer, Patrick Michel, Ryota Nakano, Yun Zhang, Paul Abell, Colby C. Merrill, Adriano Campo Bagatin, Olivier Barnouin, Nancy L. Chabot, Andrew F. Cheng, Steven R. Chesley, R. Terik Daly, Siegfried Eggl, Carolyn M. Ernst, Eugene G. Fahnestock, Tony L. Farnham, Oscar Fuentes-Muñoz, Edoardo Gramigna, Douglas P. Hamilton, Masatoshi Hirabayashi, Martin Jutzi, Josh Lyzhoft, Riccardo Lasagni Manghi, Jay McMahon, Fernando Moreno, Naomi Murdoch, Shantanu P. Naidu, Eric E. Palmer, Paolo Panicucci, Laurent Pou, Petr Pravec, Sabina D. Raducan, Andrew S. Rivkin, Alessandro Rossi, Paul Sánchez, Daniel J. Scheeres, Peter Scheirich, Stephen R. Schwartz, Damya Souami, Gonzalo Tancredi, Paolo Tanga, Paolo Tortora, Josep M. Trigo-Rodríguez, Kleomenis Tsiganis, John Wimarsson, and Marco Zannoni
- Subjects
Asteroids ,Asteroid dynamics ,Asteroid satellites ,Astronomy ,QB1-991 - Abstract
NASA’s Double Asteroid Redirection Test (DART) spacecraft impacted Dimorphos, the natural satellite of (65803) Didymos, on 2022 September 26, as a first successful test of kinetic impactor technology for deflecting a potentially hazardous object in space. The experiment resulted in a small change to the dynamical state of the Didymos system consistent with expectations and Level 1 mission requirements. In the preencounter paper, predictions were put forward regarding the pre- and postimpact dynamical state of the Didymos system. Here we assess these predictions, update preliminary findings published after the impact, report on new findings related to dynamics, and provide implications for ESA’s Hera mission to Didymos, scheduled for launch in 2024 October with arrival in 2026 December. Preencounter predictions tested to date are largely in line with observations, despite the unexpected, flattened appearance of Didymos compared to the radar model and the apparent preimpact oblate shape of Dimorphos (with implications for the origin of the system that remain under investigation). New findings include that Dimorphos likely became prolate due to the impact and may have entered a tumbling rotation state. A possible detection of a postimpact transient secular decrease in the binary orbital period suggests possible dynamical coupling with persistent ejecta. Timescales for damping of any tumbling and clearing of any debris are uncertain. The largest uncertainty in the momentum transfer enhancement factor of the DART impact remains the mass of Dimorphos, which will be resolved by the Hera mission.
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- 2024
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26. Evaluating natural experiments in ecology : using synthetic controls in assessments of remotely sensed land treatments
- Author
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Fick, Stephen E., Nauman, Travis W., Brungard, Colby C., and Duniway, Michael C.
- Published
- 2021
27. Dimorphos’s Orbit Period Change and Attitude Perturbation due to Its Reshaping after the DART Impact
- Author
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Nakano, Ryota, primary, Hirabayashi, Masatoshi, additional, Raducan, Sabina D., additional, Pravec, Petr, additional, Naidu, Shantanu P., additional, Agrusa, Harrison F., additional, Chesley, Steven, additional, Ferrari, Fabio, additional, Jutzi, Martin, additional, Merrill, Colby C., additional, Meyer, Alex J., additional, Michel, Patrick, additional, Richardson, Derek C., additional, Sánchez, Paul, additional, Scheirich, Peter, additional, Schwartz, Stephen R., additional, Zhang, Yun, additional, Bagatin, Adriano Campo, additional, Liu, Po-Yen, additional, and Cheng, Andrew F., additional
- Published
- 2024
- Full Text
- View/download PDF
28. Venous thromboembolism After Knee Arthroscopy: Incidence, Risk Factors, Prophylaxis, and Management.
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Wollenman, Colby C., Cox, Charles L., Schoenecker, Jonathan G., and Wright, Rick W.
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- 2024
- Full Text
- View/download PDF
29. Age of (152830) Dinkinesh I Selam constrained by secular tidal-BYORP theory
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Merrill, Colby C., primary, Kubas, Alexia R., additional, Meyer, J. Alex J., additional, and Raducan, Sabina D., additional
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- 2024
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30. Human Lung Spheroid Cell Exosomes Protect Against Lung Ischemia-Reperfusion Injury in a Prolonged Warm Ischemia Porcine DCD Model
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Ribeiro, R.V., primary, Segamanasinghe, D.L., additional, Aldin, S.T., additional, Altarabsheh, S., additional, Knop, G., additional, Al-Azzam, F., additional, Reynolds, F.A., additional, Richman, A., additional, Colby, C., additional, Zeman, H.L., additional, Mallea, J., additional, Jing, Y., additional, Cheng, K., additional, and Saddoughi, S., additional
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- 2024
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31. Advancing Theory and Modeling Efforts in Heliophysics
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Fan Guo, Spiro Antiochos, Paul Cassak, Bin Chen, Xiaohang Chen, Chuanfei Dong, Cooper Downs, Joe Giacalone, Colby C. Hagerty, Hantao Ji, Judith Karpen, James Klimchuk, Wen Li, Xiaocan Li, Mitsuo Oka, Katharine K. Reeves, Marc Swisdak, and Weichao Tu
- Abstract
Heliophysics theory and modeling build understanding from fundamental principles to motivate, interpret, and predict observations. Together with observational analysis, they constitute a comprehensive scientific program in heliophysics. As observations and data analysis become increasingly detailed, it is critical that theory and modeling develop more quantitative predictions and iterate with observations. Advanced theory and modeling can inspire and greatly improve the design of new instruments and increase their chance of success. In addition, in order to build physics based space weather forecast models, it is important to keep developing and testing new theories, and maintaining constant communications with theory and modeling. Maintaining a sustainable effort in theory and modeling is critically important to heliophysics. We recommend that all funding agencies join forces and consider expanding current and creating new theory and modeling programs–especially, 1. NASA should restore the HTMS program to its original support level to meet the critical needs of heliophysics science; 2. a Strategic Research Model program needs to be created to support model development for next-generation basic research codes; 3. new programs must be created for addressing mission-critical theory and modeling needs; and 4. enhanced programs are urgently required for training the next generation of theorists and modelers.
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- 2022
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32. The Perturbed Full Two-body Problem: Application to Post-DART Didymos
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Alex J. Meyer, Harrison F. Agrusa, Derek C. Richardson, R. Terik Daly, Oscar Fuentes-Muñoz, Masatoshi Hirabayashi, Patrick Michel, Colby C. Merrill, Ryota Nakano, Andrew F. Cheng, Brent Barbee, Olivier S. Barnouin, Steven R. Chesley, Carolyn M. Ernst, Ioannis Gkolias, Nicholas A. Moskovitz, Shantanu P. Naidu, Petr Pravec, Petr Scheirich, Cristina A. Thomas, Kleomenis Tsiganis, and Daniel J. Scheeres
- Published
- 2023
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33. Plasmin drives burn-induced systemic inflammatory response syndrome
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Breanne H. Y. Gibson, Colby C. Wollenman, Stephanie N. Moore-Lotridge, Patrick R. Keller, J. Blair Summitt, Alexey R. Revenko, Matthew J. Flick, Timothy S. Blackwell, and Jonathan G. Schoenecker
- Subjects
Inflammation ,Medicine - Abstract
Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse outcome of plasmin activation in severe injury is compromised hemostasis, plasmin also possesses proinflammatory properties. We hypothesized that, following a severe injury, early activation of plasmin drives SIRS. Plasmin activation was measured and related to injury severity, SIRS, coagulopathy, and outcomes prospectively in burn patients who are not at risk of hemorrhage. Patients exhibited early, significant activation of plasmin that correlated with burn severity, cytokines, coagulopathy, and death. Burn with a concomitant, remote muscle injury was employed in mice to determine the role of plasmin in the cytokine storm and inflammatory cascades in injured tissue distant from the burn injury. Genetic and pharmacologic inhibition of plasmin reduced the burn-induced cytokine storm and inflammatory signaling in injured tissue. These findings demonstrate (a) that severe injury–induced plasmin activation is a key pathologic component of the SIRS-driven cytokine storm and SIRS-activated inflammatory cascades in tissues distant from the inciting injury and (b) that targeted inhibition of plasmin activation may be effective for limiting both hemorrhage and tissue-damaging inflammation following injury.
- Published
- 2021
- Full Text
- View/download PDF
34. Achievement of the Planetary Defense Investigations of the Double Asteroid Redirection Test (DART) Mission
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Chabot, Nancy L., primary, Rivkin, Andrew S., additional, Cheng, Andrew F., additional, Barnouin, Olivier S., additional, Fahnestock, Eugene G., additional, Richardson, Derek C., additional, Stickle, Angela M., additional, Thomas, Cristina A., additional, Ernst, Carolyn M., additional, Terik Daly, R., additional, Dotto, Elisabetta, additional, Zinzi, Angelo, additional, Chesley, Steven R., additional, Moskovitz, Nicholas A., additional, Barbee, Brent W., additional, Abell, Paul, additional, Agrusa, Harrison F., additional, Bannister, Michele T., additional, Beccarelli, Joel, additional, Bekker, Dmitriy L., additional, Bruck Syal, Megan, additional, Buratti, Bonnie J., additional, Busch, Michael W., additional, Campo Bagatin, Adriano, additional, Chatelain, Joseph P., additional, Chocron, Sidney, additional, Collins, Gareth S., additional, Conversi, Luca, additional, Davison, Thomas M., additional, DeCoster, Mallory E., additional, Prasanna Deshapriya, J. D., additional, Eggl, Siegfried, additional, Espiritu, Raymond C., additional, Farnham, Tony L., additional, Ferrais, Marin, additional, Ferrari, Fabio, additional, Föhring, Dora, additional, Fuentes-Muñoz, Oscar, additional, Gai, Igor, additional, Giordano, Carmine, additional, Glenar, David A., additional, Gomez, Edward, additional, Graninger, Dawn M., additional, Green, Simon F., additional, Greenstreet, Sarah, additional, Hasselmann, Pedro H., additional, Herreros, Isabel, additional, Hirabayashi, Masatoshi, additional, Husárik, Marek, additional, Ieva, Simone, additional, Ivanovski, Stavro L., additional, Jackson, Samuel L., additional, Jehin, Emmanuel, additional, Jutzi, Martin, additional, Karatekin, Ozgur, additional, Knight, Matthew M., additional, Kolokolova, Ludmilla, additional, Kumamoto, Kathryn M., additional, Küppers, Michael, additional, La Forgia, Fiorangela, additional, Lazzarin, Monica, additional, Li, Jian-Yang, additional, Lister, Tim A., additional, Lolachi, Ramin, additional, Lucas, Michael P., additional, Lucchetti, Alice, additional, Luther, Robert, additional, Makadia, Rahil, additional, Mazzotta Epifani, Elena, additional, McMahon, Jay, additional, Merisio, Gianmario, additional, Merrill, Colby C., additional, Meyer, Alex J., additional, Michel, Patrick, additional, Micheli, Marco, additional, Migliorini, Alessandra, additional, Minker, Kate, additional, Modenini, Dario, additional, Moreno, Fernando, additional, Murdoch, Naomi, additional, Murphy, Brian, additional, Naidu, Shantanu P., additional, Nair, Hari, additional, Nakano, Ryota, additional, Opitom, Cyrielle, additional, Ormö, Jens, additional, Michael Owen, J., additional, Pajola, Maurizio, additional, Palmer, Eric E., additional, Palumbo, Pasquale, additional, Panicucci, Paolo, additional, Parro, Laura M., additional, Pearl, Jason M., additional, Penttilä, Antti, additional, Perna, Davide, additional, Petrescu, Elisabeta, additional, Pravec, Petr, additional, Raducan, Sabina D., additional, Ramesh, K. T., additional, Ridden-Harper, Ryan, additional, Rizos, Juan L., additional, Rossi, Alessandro, additional, Roth, Nathan X., additional, Rożek, Agata, additional, Rozitis, Benjamin, additional, Ryan, Eileen V., additional, Ryan, William H., additional, Sánchez, Paul, additional, Santana-Ros, Toni, additional, Scheeres, Daniel J., additional, Scheirich, Peter, additional, Berk Senel, Cem, additional, Snodgrass, Colin, additional, Soldini, Stefania, additional, Souami, Damya, additional, Statler, Thomas S., additional, Street, Rachel, additional, Stubbs, Timothy J., additional, Sunshine, Jessica M., additional, Tan, Nicole J., additional, Tancredi, Gonzalo, additional, Tinsman, Calley L., additional, Tortora, Paolo, additional, Tusberti, Filippo, additional, Walker, James D., additional, Waller, C. Dany, additional, Wünnemann, Kai, additional, Zannoni, Marco, additional, and Zhang, Yun, additional
- Published
- 2024
- Full Text
- View/download PDF
35. CRP Predicts the Need to Escalate Care After Initial Debridement for Musculoskeletal Infection
- Author
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Moore-Lotridge, Stephanie N., primary, Daryoush, Joshua R., additional, Wollenman, Colby C., additional, Gibian, Joseph T., additional, Johnson, Samuel R., additional, Thomsen, Isaac P., additional, and Schoenecker, Jonathan G., additional
- Published
- 2023
- Full Text
- View/download PDF
36. CRP Predicts the Need to Escalate Care After Initial Debridement for Musculoskeletal Infection.
- Author
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Moore-Lotridge, Stephanie N., Daryoush, Joshua R., Wollenman, Colby C., Gibian, Joseph T., Johnson, Samuel R., Thomsen, Isaac P., and Schoenecker, Jonathan G.
- Published
- 2024
- Full Text
- View/download PDF
37. The Heterogeneity of Pediatric Knee Infections: A Retrospective Analysis
- Author
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Gibian, Joseph T., Daryoush, Joshua R., Wollenman, Colby C., Johnson, Samuel R., Henry, Abigail, Koehler, Ryan J., Moore-Lotridge, Stephanie N., and Schoenecker, Jonathan G.
- Published
- 2019
- Full Text
- View/download PDF
38. The Perturbed Full Two-body Problem: Application to Post-DART Didymos
- Author
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Meyer, Alex J., primary, Agrusa, Harrison F., additional, Richardson, Derek C., additional, Daly, R. Terik, additional, Fuentes-Muñoz, Oscar, additional, Hirabayashi, Masatoshi, additional, Michel, Patrick, additional, Merrill, Colby C., additional, Nakano, Ryota, additional, Cheng, Andrew F., additional, Barbee, Brent, additional, Barnouin, Olivier S., additional, Chesley, Steven R., additional, Ernst, Carolyn M., additional, Gkolias, Ioannis, additional, Moskovitz, Nicholas A., additional, Naidu, Shantanu P., additional, Pravec, Petr, additional, Scheirich, Petr, additional, Thomas, Cristina A., additional, Tsiganis, Kleomenis, additional, and Scheeres, Daniel J., additional
- Published
- 2023
- Full Text
- View/download PDF
39. Chapter 8 - Resistance of prostate cancer to kinase inhibitors
- Author
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Patel, Palak A., Patel, Prakash A., Moelis, Samuel D., Ivenitsky, Anna G., and Robinson, Colby C.
- Published
- 2024
- Full Text
- View/download PDF
40. The state and consequences of dermatology drug prices in the United States
- Author
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Albrecht, Joerg, Lebwohl, Mark, Asgari, Maryam M., Bennett, Daniel D., Cook, Ashley, Evans, Colby C., Green, Lawrence J., Hodge, Julie A., Kourosh, Arianne S., Maloney, Mary E., Howard, Leah M., Olsen, Elise A., Rosenberg, Steven P., Rubin, Adam, Stough, Dow B., Taylor, Susan C., and Brod, Bruce Alan
- Published
- 2016
- Full Text
- View/download PDF
41. Phase-space Energization of Ions in Oblique Shocks
- Author
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Juno, James, primary, Brown, Collin R., additional, Howes, Gregory G., additional, Haggerty, Colby C., additional, TenBarge, Jason M., additional, Wilson III, Lynn B., additional, Caprioli, Damiano, additional, and Klein, Kristopher G., additional
- Published
- 2023
- Full Text
- View/download PDF
42. Association of Sickle Cell Trait and Hemoglobin S Percentage with Physical Fitness
- Author
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WEBBER, BRYANT J., UPTEGRAFT, COLBY C., NYE, NATHANIEL S., and O’Connor, Francis G.
- Published
- 2018
- Full Text
- View/download PDF
43. The Brownian bridge synoptic model of habitat selection and space use for animals using GPS telemetry data
- Author
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Wells, Adam G., Blair, Colby C., Garton, Edward O., Rice, Clifford G., Horne, Jon S., Rachlow, Janet L., and Wallin, David O.
- Published
- 2014
- Full Text
- View/download PDF
44. Strategies for Computational Efficiency in Continuum Structural Topology Optimization
- Author
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Swan, Colby C., Rahmatalla, Salam F., Gladwell, G. M. L., editor, Pandey, M., editor, Xie, Wei-Chau, editor, and Xu, Lei, editor
- Published
- 2006
- Full Text
- View/download PDF
45. Use of Nanofiltration for Tartrate Stabilisation of Wine
- Author
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Chemeca (2006 : Auckland, N.Z.), Low, L, Colby, C, O'Neill, B, Ford, C, Godden, J, and Gishen, M
- Published
- 2006
46. P1.01A.04 Point-of-care Nicotine Replacement for the Treatment of Nicotine Addiction in a Provincial Cancer System
- Author
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Myers, R.L., Colby, C., Crosby, M., Freeman, B., Bartolomeu, C., Lam, S., and Feldman, F.
- Published
- 2024
- Full Text
- View/download PDF
47. The COSEHC™ Global Vascular Risk Management quality improvement program: first follow-up report
- Author
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Ferrario CM, Joyner J, Colby C, Exuzides A, Moore M, Simmons D, Bestermann Jr W, and Frech-Tamas F
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Carlos M Ferrario,1 JaNae Joyner,2 Chris Colby,3 Alex Exuzides,3 Michael Moore,2,6 Debra Simmons,2 William Bestermann Jr,4 Feride Frech-Tamas51Department of Surgery, Internal Medicine–Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 2Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 3ICON Late Phase and Outcomes Research, San Francisco, CA, USA; 4Vascular Medicine Center, Holston Medical Group, Kingsport, TN, USA; 5Department of Health Economics, Daiichi Sankyo, Inc, Parsippany, NJ, USA; 6Danville Regional Medical Center, Danville, VA, USAAbstract: The Global Vascular Risk Management (GVRM) Study is a 5-year prospective observational study of 87,863 patients (61% females) with hypertension and associated cardiovascular risk factors began January 1, 2010. Data are gathered electronically and cardiovascular risk is evaluated using the Consortium for Southeastern Hypertension Control™ (COSEHC™)-11 risk score. Here, we report the results obtained at the completion of 33 months since study initiation. De-identified electronic medical records of enrolled patients were used to compare clinical indicators, antihypertensive medication usage, and COSEHC™ risk scores across sex and diabetic status subgroups. The results from each subgroup, assessed at baseline and at regular follow-up periods, are reported since the project initiation. Inference testing was performed to look for statistically significant differences between goal attainments rates between sexes. At-goal rates for systolic blood pressure (SBP) were improved during the 33 months of the study, with females achieving higher goal rates when compared to males. On the other hand, at-goal control rates for total and low-density lipoprotein (LDL) cholesterol (chol) were better in males compared to females. Diabetic patients had lower at-goal rates for SBP and triglycerides but higher rates for LDL-chol. The LDL-chol at-goal rates were higher for males, while high-density lipoprotein (HDL)-chol rates were higher for females. Utilization of antihypertensive medications was similar during and after the baseline period for both men and women. Patients taking two or more antihypertensive medications had higher mean COSEHC™-11 scores compared to those on monotherapy. With treatment, hypertensive patients can reach SBP and cholesterol goals; however, population-wide improvement in treatment goal adherence continues to be a challenge for physicians. The COSEHC™ GVRM Study shows, however, that continuous monitoring and feedback to physicians of accurate longitudinal data is an effective tool in achieving better control rates of cardiovascular risk factors.Keywords: cardiovascular risk, coronary heart disease, dyslipidemia, electronic medical records, hypertension, metabolic syndrome
- Published
- 2013
48. Energy transfer, pressure tensor, and heating of kinetic plasma
- Author
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Yan Yang, William H. Matthaeus, Tulasi N. Parashar, Colby C. Haggerty, Vadim Roytershteyn, William Daughton, Minping Wan, Yipeng Shi, and Shiyi Chen
- Published
- 2017
- Full Text
- View/download PDF
49. Digitizing U.S. Air Force Medical Standards for the Creation and Validation of a Readiness Decision Support System
- Author
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Colby C Uptegraft, Christopher M McLaughlin, Kevin D Alford, Matthew G Barnes, and Jonathan D. Hron
- Subjects
Decision support system ,Databases, Factual ,Computer science ,Unified Medical Language System ,Public Health, Environmental and Occupational Health ,Specialty ,Reproducibility of Results ,General Medicine ,Directory ,Reference Standards ,030230 surgery ,03 medical and health sciences ,Inter-rater reliability ,Military Personnel ,0302 clinical medicine ,Workflow ,International Classification of Diseases ,Humans ,Operations management ,030212 general & internal medicine ,Diagnosis code ,Medical diagnosis - Abstract
Introduction Deployment-limiting medical conditions are the primary reason why service members are not medically ready. Service-specific standards guide clinicians in what conditions are restrictive for duty, fitness, and/or deployment requirements. The Air Force (AF) codifies most standards in the Medical Standards Directory (MSD). Providers manually search this document, among others, to determine if any standards are violated, a tedious and error-prone process. Digitized, standards-based decision-support tools for providers would ease this workflow. This study digitized and mapped all AF occupations to MSD occupational classes and all MSD standards to diagnosis codes and created and validated a readiness decision support system (RDSS) around this mapping. Materials and Methods A medical coder mapped all standards within the May 2018 v2 MSD to 2018 International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes. For the publication of new MSDs, we devised an automated update process using Amazon Web Service’s Comprehend Medical and the Unified Medical Language System’s Metathesaurus. We mapped Air Force Specialty Codes to occupational classes using the MSD and AF classification directories. We uploaded this mapping to a cloud-based MySQL (v5.7.23) database and built a web application to interface with it using R (v3.5+). For validation, we compared the RDSS to the record review of two subject-matter experts (SMEs) for 200 outpatient encounters in calendar year 2018. We performed four separate analyses: (1) SME vs. RDSS for any restriction; (2) SME interrater reliability for any restriction; (3) SME vs. RDSS for specific restriction(s); and (4) SME interrater reliability for categorical restriction(s). This study was approved as “Not Human Subjects Research” by the Air Force Research Laboratory (FWR20190100N) and Boston Children’s Hospital (IRB-P00031397) review boards. Results Of the 709 current medical standards in the September 2019 MSD, 631 (89.0%) were mapped to ICD-10-CM codes. These 631 standards mapped to 42,810 unique ICD codes (59.5% of all active 2019 codes) and covered 72.3% (7,823/10,821) of the diagnoses listed on AF profiles and 92.8% of profile days (90.7/97.8 million) between February 1, 2007 and January 31, 2017. The RDSS identified diagnoses warranting any restrictions with 90.8% and 90.0% sensitivity compared to SME A and B. For specific restrictions, the sensitivity was 85.0% and 44.8%. The specificity was poor for any restrictions (20.5%–43.4%) and near perfect for specific restrictions (99.5+%). The interrater reliability between SMEs for all comparisons ranged from minimal to moderate (κ = 0.33–0.61). Conclusion This study demonstrated key pilot steps to digitizing and mapping AF readiness standards to existing terminologies. The RDSS showed one potential application. The sensitivity between the SMEs and RDSS demonstrated its viability as a screening tool with further refinement and study. However, its performance was not evenly distributed by special duty status or for the indication of specific restrictions. With machine consumable medical standards integrated within existing digital infrastructure and clinical workflows, RDSSs would remove a significant administrative burden from providers and likely improve the accuracy of readiness metrics.
- Published
- 2020
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- View/download PDF
50. PlasmaPy: an open source community-developed Python package for plasma physics
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Murphy, Nicholas A., primary, Leonard, Andrew J., additional, Stanczak, Dominik, additional, Kozlowski, Pawel M., additional, Langendorf, Samuel, additional, Haggerty, Colby C., additional, Beckers, Jasper P., additional, Mumford, Stuart J., additional, Parashar, Tulasi N., additional, and Huang, Yi -Min, additional
- Published
- 2018
- Full Text
- View/download PDF
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