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1. Systematic acquisition of toxicity data in non- sentient models across animal phylogeny: implications for read- across and estimation of toxicity in humans

Author

Hayot, G., Massei, Riccardo, Lloyd, G., Keith, N., Diwan, G., Martinez Lopez, R., Barnard, M., Cramer von Clausbruch, C.A., Grasse, Nico, Smoot, S., Escher, Beate, Tennessen, J., Tindall, A., Oliver, B., Shaw, J., Scholz, Stefan, Freedman, J., Strähle, U., Colbourne, J., Weiss, C., Dickmeis, T., Hayot, G., Massei, Riccardo, Lloyd, G., Keith, N., Diwan, G., Martinez Lopez, R., Barnard, M., Cramer von Clausbruch, C.A., Grasse, Nico, Smoot, S., Escher, Beate, Tennessen, J., Tindall, A., Oliver, B., Shaw, J., Scholz, Stefan, Freedman, J., Strähle, U., Colbourne, J., Weiss, C., and Dickmeis, T.

Abstract

no abstract

Published
2024

3. P22-23: Expediting the uptake of Next-Generation Risk Assessment (NGRA) into EU chemicals legislation under PARC

Author

Herzler, M., primary, Apruzzese, I., additional, Bandow, N., additional, Busquet, F., additional, Cavoski, A., additional, Colbourne, J., additional, Di Consiglio, E., additional, Dusinska, M., additional, Flingelli, G., additional, Holden, L., additional, Hornek-Gausterer, R., additional, Kaiser, A., additional, Lee, R., additional, Vicente, J. Lobo, additional, L⊘fstedt, M., additional, Longhin, E., additional, Mouaziz, H., additional, Namorado, S., additional, von der Ohe, P., additional, Rolfheim-Bye, S., additional, Rousselle, C., additional, Tcheremenskaia, O., additional, Tsitsimpikou, C., additional, Uhl, M., additional, and Viegas, S., additional

Published
2023
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6. Phenotypic anchoring for OMICS-guided assessment of liver toxicity in zebrafish

Author

Hayot, G., von Clausbruch, C., Martinez Lopez, R., Scholz, Stefan, Colbourne, J., Strähle, U., Weiss, C., Peravali, R., Dickmeis, T., Hayot, G., von Clausbruch, C., Martinez Lopez, R., Scholz, Stefan, Colbourne, J., Strähle, U., Weiss, C., Peravali, R., and Dickmeis, T.

Abstract

no abstract

Published
2023

27. Development of an OECD two-generations reproduction test in Daphnia magna

Author

Barata, C., Campos, B., Schamphelaere, K., Coutellec, M., Lopes, I., Pestana, J., Soares, A. M., Brooks, Bryan W., Scott, W. C., Leblanc, G. A., Eytcheson, S., Martinez-Jeronimo, F., Choi, J., Arnaud Chaumot, Sarapultseva, E., Salice, C. J., Tatarazako, N., Tobor-Kaplon, M., Goncalves, C., Pascal PANDARD, Watanabe, H., Queau, H., Vries-Buitenweg, S., Geffard Olivier, Colbourne, J., Institut National de l'Environnement Industriel et des Risques (INERIS), and Civs, Gestionnaire

Subjects
[SDV.TOX.ECO] Life Sciences [q-bio]/Toxicology/Ecotoxicology, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
Abstract

Most eco-toxicological test guidelines only evaluate the effects observed within one generation, thus disregarding those potential detrimental effects that may appear across generations. The toxicological potential of contaminants may either decrease or increase across generations, or even remain unchanged. Reproductive toxicity in mammals monitors the effects on the parental generation as well as on their offspring. In fact, there are already standardized test procedures aimed to assess multigenerational effects for mammals and fish, but there are no equivalent tests for invertebrates, despite that their short life-cycles offer to cost-effectively monitor multigenerational effects of toxic substances in individuals and populations. Here we described the activities that are currently been conducted on behave of the SETAC EVOGENERATE Working Group to set up protocol for a two generation Daphnia magna reproduction test and to test the performance of that protocol across up to 20 different labs from Europe, America and Asia. Indeed this is one of the largest conducted intercalibration tests ever conducted using the OECD 2011 guideline. We aimed to develop a two generation test with only few amendments of the already existing guidelines. The few modifications included to start the second generation with third brood neonates collected from reproducing females from the first generation. We selected pyperonil butoxide as a test chemical based on previous studies that showed that this compound was the best candidate among other two compounds. To minimize interlab variability all laboratories used the same stock solutions, which were prepared by one of the partners and send it the rest of partners. The results obtained in this intercalibration test will be discussed in this poster.

Published
2016

28. The ecoresponsive genome of Daphnia pulex

Author

Colbourne, J. K., Pfrender, M. E., Gilbert, D., Thomas, W. K., Tucker, A., Oakley, T. H., Tokishita, S., Aerts, A., Arnold, G. J., Basu, M. K., Bauer, D. J., C當eres, C. E., Carmel, L., Casola, C., Choi, J. H., Detter, J. C., Dong, Q., Dusheyko, S., Eads, B. D., Frlich, T., Geiler-Samerotte, K. A., Gerlach, D., Hatcher, P., Jogdeo, S., Krijgsveld, J., Kriventseva, E. V., K�ltz, D., Laforsch, C., Lindquist, E., Lopez, J., Manak, J. R., Muller, J., Pangilinan, J., Patwardhan, R. P., Pitluck, S., Pritham, E. J., Rechtsteiner, A., Rho, M., Rogozin, I. B., Sakarya, O., Salamov, A., Schaack, S., Shapiro, H., Shiga, Y., Skalitzky, C., Smith, Z., Souvorov, A., Sung, W., Tang, Z., Tsuchiya, D., Tu, H., Vos, H., Wang, M., Wolf, Y. I., Yamagata, H., Yamada, Takuji, Ye, Y., Shaw, J. R., Andrews, J., Crease, T. J., Tang, H., Lucas, S. M., Robertson, H. M., Bork, P., Koonin, E. V., Zdobnov, E. M., Grigoriev, I. V., Lynch, M., Boore, J. L., Gerlach, Daniel, Kriventseva, Evgenia, and Zdobnov, Evgeny

Subjects
0106 biological sciences, Molecular Sequence Data, Gene Conversion, Gene Expression, Biology, Environment, 010603 evolutionary biology, 01 natural sciences, Genome, Daphnia pulex, Evolution, Molecular, 03 medical and health sciences, Genes, Duplicate, Gene Duplication, Gene duplication, Gene family, Animals, ddc:576.5, Gene conversion, Amino Acid Sequence, Gene, Ecosystem, Phylogeny, 030304 developmental biology, Regulation of gene expression, Genetics, 0303 health sciences, Multidisciplinary, Base Sequence, Daphnia/genetics/physiology, Metabolic Networks and Pathways/genetics, Gene Expression Profiling, fungi, Chromosome Mapping, Molecular Sequence Annotation, Sequence Analysis, DNA, biology.organism_classification, Adaptation, Physiological, Gene expression profiling, Daphnia, Gene Expression Regulation, Genes, Multigene Family, Metabolic Networks and Pathways
Abstract

We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200 megabases and contains at least 30,907 genes. The high gene count is a consequence of an elevated rate of gene duplication resulting in tandem gene clusters. More than a third of Daphnia's genes have no detectable homologs in any other available proteome, and the most amplified gene families are specific to the Daphnia lineage. The coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random, and the analysis of gene expression under different environmental conditions reveals that numerous paralogs acquire divergent expression patterns soon after duplication. Daphnia-specific genes, including many additional loci within sequenced regions that are otherwise devoid of annotations, are the most responsive genes to ecological challenges.

Published
2011
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30. Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

Author

Werren, J. H., Richards, S., Desjardins, C. A., Niehuis, O., Gadau, J., Colbourne, J. K., Beukeboom, L. W., Desplan, C., Elsik, C. G., Grimmelikhuijzen, C. J., Kitts, P., Lynch, J. A., Murphy, T., Oliveira, D. C., Smith, C. D., van de Zande, L., Worley, K. C., Zdobnov, E. M., Aerts, M., Albert, S., Anaya, V. H., Anzola, J. M., Barchuk, A. R., Behura, S. K., Bera, A. N., Berenbaum, M. R., Bertossa, R. C., Bitondi, M. M., Bordenstein, S. R., Bork, P., Bornberg-Bauer, E., Brunain, M., Cazzamali, G., Chaboub, L., Chacko, J., Chavez, D., Childers, C. P., Choi, J. H., Clark, M. E., Claudianos, C., Clinton, R. A., Cree, A. G., Cristino, A. S., Dang, P. M., Darby, A. C., de Graaf, D. C., Devreese, B., Dinh, H. H., Edwards, R., Elango, N., Elhaik, E., Ermolaeva, O., Evans, J. D., Foret, S., Fowler, G. R., Gerlach, D., Gibson, J. D., Gilbert, D. G., Graur, D., Gr�nder, S., Hagen, D. E., Han, Y., Hauser, F., Hultmark, D., Hunter, H. C., Hurst, G. D., Jhangian, S. N., Jiang, H., Johnson, R. M., Jones, A. K., Junier, T., Kadowaki, T., Kamping, A., Kapustin, Y., Kechavarzi, B., Kim, J., Kiryutin, B., Koevoets, T., Kovar, C. L., Kriventseva, E. V., Kucharski, R., Lee, H., Lee, S. L., Lees, K., Lewis, L. R., Loehlin, D. W., Logsdon, J. M., Lopez, J. A., Lozado, R. J., Maglott, D., Maleszka, R., Mayampurath, A., Mazur, D. J., McClure, M. A., Moore, A. D., Morgan, M. B., Muller, J., Munoz-Torres, M. C., Muzny, D. M., Nazareth, L. V., Neupert, S., Nguyen, N. B., Nunes, F. M., Oakeshott, J. G., Okwuonu, G. O., Pannebakker, B. A., Pejaver, V. R., Peng, Z., Pratt, S. C., Predel, R., Pu, L. L., Ranson, H., Raychoudhury, R., Rechtsteiner, A., Reese, J. T., Reid, J. G., Riddle, M., Robertson, H. M., Romero-Severson, J., Rosenberg, M., Sackton, T. B., Sattelle, D. B., Schl�ns, H., Schmitt, T., Schneider, M., Sch�ler, A., Schurko, A. M., Shuker, D. M., Sims, Z. L., Sinha, S., Smith, Z., Solovyev, V., Souvorov, A., Springauf, A., Stafflinger, E., Stage, D. E., Stanke, M., Tanaka, Y., Telschow, A., Trent, C., Vattathil, S., Verhulst, E. C., Viljakainen, L., Wanner, K. W., Waterhouse, R. M., Whitfield, J. B., Wilkes, T. E., Williamson, M., Willis, J. H., Wolschin, F., Wyder, S., Yamada, Takuji, Yi, S. V., Zecher, C. N., Zhang, L., Gibbs, R. A., Group, Nasonia Genome Working, Zdobnov, Evgeny, Gerlach, Daniel, Junier, Thomas, Muller, Jean, Beukeboom lab, and Van de Zande lab

Subjects
0106 biological sciences, Male, Wasp Venoms/chemistry/toxicity, Insecta, Insect Viruses/genetics, PARASITOLOGIA, VITRIPENNIS, Wasps, Genome, Insect, HYMENOPTERA, Wasp Venoms, Genes, Insect, 01 natural sciences, Genome, Nasonia vitripennis, HONEYBEE, PTEROMALIDAE, Wasps/ genetics/physiology, Arthropods/parasitology, Pteromalidae, DNA METHYLATION, ddc:616, Recombination, Genetic, 0303 health sciences, Multidisciplinary, biology, Ecology, WASP NASONIA, Biological Evolution, 3. Good health, Insects, DROSOPHILA, APIS-MELLIFERA, Insect Proteins, Wolbachia, Female, Wolbachia/genetics, Nasonia, GENES, Gene Transfer, Horizontal, Evolution, Genetic Speciation, Molecular Sequence Data, Quantitative Trait Loci, Insect Viruses, Quantitative trait locus, 010603 evolutionary biology, Article, Host-Parasite Interactions, 03 medical and health sciences, Genetic model, Animals, Life Science, Arthropods, 030304 developmental biology, fungi, Genetic Variation, Sequence Analysis, DNA, DNA Methylation, biology.organism_classification, SOCIAL INSECTS, Insects/genetics, Evolutionary biology, DNA Transposable Elements, Insect Proteins/genetics/metabolism
Abstract

Parasitoid Wasp Genomes Parasitoid wasps, which prey on and reproduce in host insect species, play important roles in plant herbivore interactions, and may provide valuable tools in the biological control of pest species. The Nasonia Genome Working Group (p. 343 ; see the news story by Pennisi ) presents the genome of three very closely related species: Nasonia vitripennis, N. giraulti , and N. longicornis . The findings document rapid evolution between a host and endosymbiont that can cause nuclear-cytoplasmic incompatibilities that may affect speciation.

Published
2010

36. Recent advances in crustacean genomics

Author

Stillman, J. H., primary, Colbourne, J. K., additional, Lee, C. E., additional, Patel, N. H., additional, Phillips, M. R., additional, Towle, D. W., additional, Eads, B. D., additional, Gelembuik, G. W., additional, Henry, R. P., additional, Johnson, E. A., additional, Pfrender, M. E., additional, and Terwilliger, N. B., additional

Published
2008
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