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5. Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression

Author

Mota, Alba, Oltra, Sara S., Selenica, Pier, Moiola, Cristian P., Casas-Arozamena, Carlos, López-Gil, Carlos, Diaz, Eva, Gatius, Sonia, Ruiz-Miro, María, Calvo, Ana, Rojo-Sebastián, Alejandro, Hurtado, Pablo, Piñeiro, Roberto, Colas, Eva, Gil-Moreno, Antonio, Reis-Filho, Jorge S., Muinelo-Romay, Laura, Abal, Miguel, Matias-Guiu, Xavier, Weigelt, Britta, and Moreno-Bueno, Gema

Published
2022
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6. Screening Strategies to Improve Early Diagnosis in Endometrial Cancer.

Author

Cabrera, Silvia, de la Calle, Irene, Baulies, Sonia, Gil-Moreno, Antonio, and Colas, Eva

Subjects
ENDOMETRIAL cancer, MEDICAL screening, HIGH-income countries, AGE groups, CANCER diagnosis
Abstract

Endometrial cancer is the most common gynecological malignancy in high-income countries and the sixth most common cancer in women. Overall incidence has risen in the last few decades as a consequence of the increase in the prevalence of its risk factors, mainly obesity and the aging of the population, and although diagnoses have increased across all age groups, the incidence rates have doubled in women under the age of 40 years. The survival rates of endometrial cancer are highly dependent on its stage at diagnosis, bringing to the fore the importance of early diagnosis. The aim of a screening strategy in this type of tumor should be to detect the disease in the pre-invasive or early stage (before developing myometrial invasion), which would improve cure rates, reduce the morbidity associated with aggressive treatment and offer uterus-sparing management options for younger women. The ideal screening tool in this scenario would be a minimally invasive, inexpensive and easy-to-perform test or auto-test, which could be implemented in a routine gynecologic checkup of patients at-risk or in the general adult population. In this comprehensive review, we aim to define the populations at higher risk of developing endometrial cancer, to assess the performance of current diagnostic tools when used in a screening setting and to discuss the accuracy of new molecular screening strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Corrigendum: FXYD5/Dysadherin, a biomarker of endometrial cancer myometrial invasion and aggressiveness: its relationship with TGF-β1 and NF-κB pathways

Author

Besso, María José, primary, Rosso, Marina, additional, Lapyckyj, Lara, additional, Moiola, Cristian Pablo, additional, Matos, María Laura, additional, Mercogliano, María Florencia, additional, Schillaci, Roxana, additional, Reventos, Jaume, additional, Colas, Eva, additional, Gil-Moreno, Antonio, additional, Wernicke, Alejandra, additional, Orti, Roberto, additional, and Vazquez-Levin, Mónica Hebe, additional

Published
2024
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11. Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer

Author

Felip, Isidre, Moiola, Cristian Pablo, Megino-Luque, Cristina, Lopez-Gil, Carlos, Cabrera, Silvia, Solé-Sánchez, Sonia, Muñoz-Guardiola, Pau, Megias-Roda, Elisabet, Pérez-Montoyo, Héctor, Alfon, José, Yeste-Velasco, Marc, Santacana, María, Dolcet, Xavier, Reques, Armando, Oaknin, Ana, Rodríguez-Freixinos, Victor, Lizcano, José Miguel, Domènech, Carles, Gil-Moreno, Antonio, Matias-Guiu, Xavier, Colas, Eva, and Eritja, Nuria

Published
2019
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13. FXYD5/Dysadherin, a Biomarker of Endometrial Cancer Myometrial Invasion and Aggressiveness: Its Relationship With TGF-β1 and NF-κB Pathways.

Author

Besso, María José, Rosso, Marina, Lapyckyj, Lara, Moiola, Cristian Pablo, Matos, María Laura, Mercogliano, María Florencia, Schillaci, Roxana, Reventos, Jaume, Colas, Eva, Gil-Moreno, Antonio, Wernicke, Alejandra, Orti, Roberto, and Vazquez-Levin, Mónica Hebe

Subjects
ENDOMETRIAL cancer, GENE expression, TRANSFORMING growth factors, PLASMINOGEN activator inhibitors, SMALL interfering RNA, GYNECOLOGIC cancer, ENDOMETRIAL hyperplasia
Abstract

Objective: Endometrial cancer (EC) is the second most common gynecological cancer worldwide. Myometrial invasion (MI) is a key event in EC dissemination. This study aimed to evaluate FXYD5/dysadherin (FXYD5/Dys) expression in EC tissue and uterine aspirate (UA) biopsies and to assess molecular/functional changes associated with its expression in cellular models. Methods: FXYD5/Dys messenger RNA (mRNA) levels were determined in EC tissue and UA biopsies. FXYD5/Dys expression was evaluated in EC RNAseq data from The Cancer Genome Atlas (TCGA) and GENEVESTIGATOR tools. FXYD5/Dys impact on E-cadherin expression and cell behavior was assessed in EC Hec1a cells treated with transforming growth factor (TGF)-b1, stably transfected with ETV5, and transiently transfected with FXYD5/Dys small interfering RNA (siRNA) or pcDNA3-FXYD5/Dys plasmid. Results: FXYD5/Dys was associated with EC aggressiveness, finding high mRNA levels in tumors depicting MI > 50%, Grade 3, and intermediate/high risk of recurrence. FXYD5/Dys was highly expressed at the tumor invasive front compared to the superficial area. Most results were recapitulated in UA biopsies. FXYD5/Dys modulation in Hec1a cells altered cell migration/adhesion and E-cadherin expression. TGF-β1 treatment of Hec1a cells induced FXYD5/Dys expression. TCGA-UCEC RNAseq analysis revealed a positive correlation between FXYD5/Dys, TGF-b1, and plasminogen activator inhibitor (PAI)-1 mRNA levels. FXYD5/Dys induced nuclear factor (NF)-κB pathway activation in Hec1a cells. FXYD5/Dys mRNA levels positively correlated with transcriptional activation of NF-κB p65-regulated genes. Survival analysis revealed patient segregation into low- and high-risk groups, the latter depicting the highest FXYD5/Dys, PAI-1, tumor necrosis factor (TNF)-α, and TGF-β1 mRNA levels and shorter survival rates. Conclusion: FXYD5/Dys is a novel biomarker of EC progression related to TGF-β1 and NF-κB pathways that collectively promote tumor dissemination and result in poor patient prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers

Author

Mota, Alba, Colás, Eva, García-Sanz, Pablo, Campoy, Irene, Rojo-Sebastián, Alejandro, Gatius, Sonia, García, Ángel, Chiva, Luis, Alonso, Sonsoles, Gil-Moreno, Antonio, González-Tallada, Xavier, Díaz-Feijoo, Berta, Vidal, August, Ziober-Malinowska, Patrycja, Bobiński, Marcin, López-López, Rafael, Abal, Miguel, Reventós, Jaume, Matias-Guiu, Xavier, and Moreno-Bueno, Gema

Published
2017
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16. Supplementary Figure Legend from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion

Author

Muinelo-Romay, Laura, primary, Colas, Eva, primary, Barbazan, Jorge, primary, Alonso-Alconada, Lorena, primary, Alonso-Nocelo, Marta, primary, Bouso, Marta, primary, Curiel, Teresa, primary, Cueva, Juan, primary, Anido, Urbano, primary, Forteza, Jeronimo, primary, Gil-Moreno, Antonio, primary, Reventos, Jaume, primary, Lopez-Lopez, Rafael, primary, and Abal, Miguel, primary

Published
2023
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17. Data from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion

Author

Muinelo-Romay, Laura, primary, Colas, Eva, primary, Barbazan, Jorge, primary, Alonso-Alconada, Lorena, primary, Alonso-Nocelo, Marta, primary, Bouso, Marta, primary, Curiel, Teresa, primary, Cueva, Juan, primary, Anido, Urbano, primary, Forteza, Jeronimo, primary, Gil-Moreno, Antonio, primary, Reventos, Jaume, primary, Lopez-Lopez, Rafael, primary, and Abal, Miguel, primary

Published
2023
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18. Supplementary Figure 1 from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion

Author

Muinelo-Romay, Laura, primary, Colas, Eva, primary, Barbazan, Jorge, primary, Alonso-Alconada, Lorena, primary, Alonso-Nocelo, Marta, primary, Bouso, Marta, primary, Curiel, Teresa, primary, Cueva, Juan, primary, Anido, Urbano, primary, Forteza, Jeronimo, primary, Gil-Moreno, Antonio, primary, Reventos, Jaume, primary, Lopez-Lopez, Rafael, primary, and Abal, Miguel, primary

Published
2023
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19. Supplementary Table 1 from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion

Author

Muinelo-Romay, Laura, primary, Colas, Eva, primary, Barbazan, Jorge, primary, Alonso-Alconada, Lorena, primary, Alonso-Nocelo, Marta, primary, Bouso, Marta, primary, Curiel, Teresa, primary, Cueva, Juan, primary, Anido, Urbano, primary, Forteza, Jeronimo, primary, Gil-Moreno, Antonio, primary, Reventos, Jaume, primary, Lopez-Lopez, Rafael, primary, and Abal, Miguel, primary

Published
2023
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20. Supplementary Table 2 from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion

Author

Muinelo-Romay, Laura, primary, Colas, Eva, primary, Barbazan, Jorge, primary, Alonso-Alconada, Lorena, primary, Alonso-Nocelo, Marta, primary, Bouso, Marta, primary, Curiel, Teresa, primary, Cueva, Juan, primary, Anido, Urbano, primary, Forteza, Jeronimo, primary, Gil-Moreno, Antonio, primary, Reventos, Jaume, primary, Lopez-Lopez, Rafael, primary, and Abal, Miguel, primary

Published
2023
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21. Supplementary figure 1 from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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22. Supplementary Figure S1 from Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment

Author

Martinez-Garcia, Elena, primary, Lesur, Antoine, primary, Devis, Laura, primary, Cabrera, Silvia, primary, Matias-Guiu, Xavier, primary, Hirschfeld, Marc, primary, Asberger, Jasmin, primary, van Oostrum, Jan, primary, Casares de Cal, María de los Ángeles, primary, Gómez-Tato, Antonio, primary, Reventos, Jaume, primary, Domon, Bruno, primary, Colas, Eva, primary, and Gil-Moreno, Antonio, primary

Published
2023
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23. Supplementary figure 2 from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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24. Supplementary Table S5 from Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment

Author

Martinez-Garcia, Elena, primary, Lesur, Antoine, primary, Devis, Laura, primary, Cabrera, Silvia, primary, Matias-Guiu, Xavier, primary, Hirschfeld, Marc, primary, Asberger, Jasmin, primary, van Oostrum, Jan, primary, Casares de Cal, María de los Ángeles, primary, Gómez-Tato, Antonio, primary, Reventos, Jaume, primary, Domon, Bruno, primary, Colas, Eva, primary, and Gil-Moreno, Antonio, primary

Published
2023
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25. Supplementary figure 4 from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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26. Supplementary figure 3 from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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27. Supplementary methods from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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28. Supplementary data from Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Author

Cuppens, Tine, primary, Annibali, Daniela, primary, Coosemans, An, primary, Trovik, Jone, primary, ter Haar, Natalja, primary, Colas, Eva, primary, Garcia-Jimenez, Angel, primary, Van de Vijver, Koen, primary, Kruitwagen, Roy P.M., primary, Brinkhuis, Mariël, primary, Zikan, Michal, primary, Dundr, Pavel, primary, Huvila, Jutta, primary, Carpén, Olli, primary, Haybaeck, Johannes, primary, Moinfar, Farid, primary, Salvesen, Helga B., primary, Stukan, Maciej, primary, Mestdagh, Carole, primary, Zweemer, Ronald P., primary, Massuger, Leonardus F., primary, Mallmann, Michael R., primary, Wardelmann, Eva, primary, Mints, Miriam, primary, Verbist, Godelieve, primary, Thomas, Debby, primary, Gommé, Ellen, primary, Hermans, Els, primary, Moerman, Philippe, primary, Bosse, Tjalling, primary, and Amant, Frédéric, primary

Published
2023
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29. Supplementary legend from Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment

Author

Martinez-Garcia, Elena, primary, Lesur, Antoine, primary, Devis, Laura, primary, Cabrera, Silvia, primary, Matias-Guiu, Xavier, primary, Hirschfeld, Marc, primary, Asberger, Jasmin, primary, van Oostrum, Jan, primary, Casares de Cal, María de los Ángeles, primary, Gómez-Tato, Antonio, primary, Reventos, Jaume, primary, Domon, Bruno, primary, Colas, Eva, primary, and Gil-Moreno, Antonio, primary

Published
2023
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30. Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer

Author

Monge, Marta, primary, Colas, Eva, primary, Doll, Andreas, primary, Gonzalez, Marta, primary, Gil-Moreno, Antonio, primary, Planaguma, Jesus, primary, Quiles, Maite, primary, Arbos, Maria Antonia, primary, Garcia, Angel, primary, Castellvi, Josep, primary, Llaurado, Marta, primary, Rigau, Marina, primary, Alazzouzi, Hafid, primary, Xercavins, Jordi, primary, Alameda, Francesc, primary, Reventos, Jaume, primary, and Abal, Miguel, primary

Published
2023
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31. Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer

Author

Monge, Marta, primary, Colas, Eva, primary, Doll, Andreas, primary, Gonzalez, Marta, primary, Gil-Moreno, Antonio, primary, Planaguma, Jesus, primary, Quiles, Maite, primary, Arbos, Maria Antonia, primary, Garcia, Angel, primary, Castellvi, Josep, primary, Llaurado, Marta, primary, Rigau, Marina, primary, Alazzouzi, Hafid, primary, Xercavins, Jordi, primary, Alameda, Francesc, primary, Reventos, Jaume, primary, and Abal, Miguel, primary

Published
2023
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32. Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer

Author

Monge, Marta, primary, Colas, Eva, primary, Doll, Andreas, primary, Gonzalez, Marta, primary, Gil-Moreno, Antonio, primary, Planaguma, Jesus, primary, Quiles, Maite, primary, Arbos, Maria Antonia, primary, Garcia, Angel, primary, Castellvi, Josep, primary, Llaurado, Marta, primary, Rigau, Marina, primary, Alazzouzi, Hafid, primary, Xercavins, Jordi, primary, Alameda, Francesc, primary, Reventos, Jaume, primary, and Abal, Miguel, primary

Published
2023
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33. Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer

Author

Monge, Marta, primary, Colas, Eva, primary, Doll, Andreas, primary, Gonzalez, Marta, primary, Gil-Moreno, Antonio, primary, Planaguma, Jesus, primary, Quiles, Maite, primary, Arbos, Maria Antonia, primary, Garcia, Angel, primary, Castellvi, Josep, primary, Llaurado, Marta, primary, Rigau, Marina, primary, Alazzouzi, Hafid, primary, Xercavins, Jordi, primary, Alameda, Francesc, primary, Reventos, Jaume, primary, and Abal, Miguel, primary

Published
2023
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34. MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists and Natural Killer cells

Author

Espinosa-Gil, Sergio, primary, Ivanova, Saska, additional, Alari-Pahissa, Elisenda, additional, Denizli, Melek, additional, Villafranca-Magdalena, Beatriz, additional, Viñas-Casas, Maria, additional, Bolinaga-Ayala, Idoia, additional, Gámez-García, Andrés, additional, Colas, Eva, additional, Lopez-Botet, Miguel, additional, Zorzano, Antonio, additional, and Lizcano, José Miguel, additional

Published
2023
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35. Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition.

Author

Sengal, Asmerom, primary, Bonazzi, Vanessa, additional, Smith, Deborah, additional, Moiola, Cristian, additional, Lourie, Rohan, additional, Rogers, Rebecca, additional, Colas, Eva, additional, Gil-Moreno, Antonio, additional, Frentzas, Sophia, additional, Chetty, Naven, additional, Perrin, Lewis, additional, and Pollock, Pamela, additional

Published
2023
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39. Relevance of Molecular Profiling in Patients With Low-Grade Endometrial Cancer

Author

Vrede, Stephanie W., primary, Kasius, Jenneke, additional, Bulten, Johan, additional, Teerenstra, Steven, additional, Huvila, Jutta, additional, Colas, Eva, additional, Gil-Moreno, Antonio, additional, Boll, Dorry, additional, Vos, Maria Caroline, additional, van Altena, Anne M., additional, Asberger, Jasmin, additional, Sweegers, Sanne, additional, van Weelden, Willem Jan, additional, van der Putten, Louis J. M., additional, Amant, Frédéric, additional, Visser, Nicole C. M., additional, Snijders, Marc P. L. M., additional, Küsters-Vandevelde, Heidi V. N., additional, Kruitwagen, Roy, additional, Matias-Guiu, Xavier, additional, Weinberger, Vit, additional, Reijnen, Casper, additional, and Pijnenborg, Johanna M. A., additional

Published
2022
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40. 37/#877 Hormonal biomarkers remain prognostic relevant within the molecular classification in endometrial cancer

Author

Vrede, Stephanie, primary, Weelden, Willem Jan, additional, Bulten, Hans, additional, Huvila, Jutta, additional, Matias-Guiu, Xavier, additional, Gil-Moreno, Antonio, additional, Asberger, Jasmin, additional, Sweegers, Sanne, additional, Putten, Louis, additional, Küsters-Vandevelde, Heidi, additional, Eijkelenboom, Astrid, additional, Reijnen, Casper, additional, Colas, Eva, additional, Weinberger, Vit, additional, Snijders, Marc, additional, Kruitwagen, Roy, additional, and Pijnenborg, Johanna, additional

Published
2022
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41. Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study

Author

Reijnen, Casper, Gogou, Evangelia, Visser, Nicole C. M., Engerud, Hilde, Ramjith, Jordache, van der Putten, Louis J. M., van de Vijver, Koen, Santacana, Maria, Bronsert, Peter, Bulten, Johan, Hirschfeld, Marc, Colas, Eva, Gil-Moreno, Antonio, Reques, Armando, Mancebo, Gemma, Krakstad, Camilla, Trovik, Jone, Haldorsen, Ingfrid S., Huvila, Jutta, Koskas, Martin, Weinberger, Vit, Bednarikova, Marketa, Hausnerova, Jitka, van der Wurff, Anneke A. M., Matias-Guiu, Xavier, Amant, Frederic, Massuger, Leon F. A. G., Snijders, Marc P. L. M., Küsters-Vandevelde, Heidi V. N., Lucas, Peter J. F., and Pijnenborg, Johanna M. A.

Subjects
Cancer treatment -- Health aspects, Tumor proteins -- Care and treatment -- Risk factors -- Prognosis, Machine learning -- Health aspects, Cancer -- Care and treatment -- Risk factors -- Prognosis, Endometrial cancer -- Prognosis -- Care and treatment -- Risk factors, Cancer research -- Health aspects, Estrogens -- Health aspects, Progesterone -- Health aspects, Cancer metastasis -- Care and treatment -- Prognosis -- Risk factors, Biological sciences
Abstract

Background Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical decision-making. Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer, and although several biomarkers are related to LNM, none of them are incorporated in clinical practice. The aim of this study was to develop and externally validate a preoperative BN to predict LNM and outcome in endometrial cancer patients. Methods and findings Within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC), we performed a retrospective multicenter cohort study including 763 patients, median age 65 years (interquartile range [IQR] 58-71), surgically treated for endometrial cancer between February 1995 and August 2013 at one of the 10 participating European hospitals. A BN was developed using score-based machine learning in addition to expert knowledge. Our main outcome measures were LNM and 5-year disease-specific survival (DSS). Preoperative clinical, histopathological, and molecular biomarkers were included in the network. External validation was performed using 2 prospective study cohorts: the Molecular Markers in Treatment in Endometrial Cancer (MoMaTEC) study cohort, including 446 Norwegian patients, median age 64 years (IQR 59-74), treated between May 2001 and 2010; and the PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study cohort, including 384 Dutch patients, median age 66 years (IQR 60-73), treated between September 2011 and December 2013. A BN called ENDORISK (preoperative risk stratification in endometrial cancer) was developed including the following predictors: preoperative tumor grade; immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), p53, and L1 cell adhesion molecule (L1CAM); cancer antigen 125 serum level; thrombocyte count; imaging results on lymphadenopathy; and cervical cytology. In the MoMaTEC cohort, the area under the curve (AUC) was 0.82 (95% confidence interval [CI] 0.76-0.88) for LNM and 0.82 (95% CI 0.77-0.87) for 5-year DSS. In the PIPENDO cohort, the AUC for 5-year DSS was 0.84 (95% CI 0.78-0.90). The network was well-calibrated. In the MoMaTEC cohort, 249 patients (55.8%) were classified with Conclusions In this study, we illustrated how BNs can be used for individualizing clinical decision-making in oncology by incorporating easily accessible and multimodal biomarkers. The network shows the complex interactions underlying the carcinogenetic process of endometrial cancer by its graphical representation. A prospective feasibility study will be needed prior to implementation in the clinic., Author(s): Casper Reijnen 1,2,*, Evangelia Gogou 3, Nicole C. M. Visser 4, Hilde Engerud 5,6, Jordache Ramjith 7, Louis J. M. van der Putten 1, Koen van de Vijver 8, [...]

Published
2020
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42. 2022-RA-1475-ESGO Impact of molecular profiling on endometrial cancer staging: towards a personalized surgery

Author

Cabrera, Silvia, primary, López-Gil, Carlos, additional, Bebia, Vicente, additional, Luzarraga, Anna, additional, Coll, Eva, additional, Villafranca, Beatriz, additional, Hernandez-Losa, Javier, additional, García-Jiménez, Ángel, additional, Castellví, Josep, additional, Colas, Eva, additional, and Gil-Moreno, Antonio, additional

Published
2022
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43. 2022-RA-997-ESGO Lung recurrence of endometrial adenocarcinoma: impact of molecular profile and role of local therapies on prognosis

Author

Luzarraga, Ana, primary, Bebia, Vicente, additional, Lopez-Gil, Carlos, additional, Montoya, Maria Pilar, additional, Giraldo, Alexandra, additional, Jauregui, Alberto, additional, Verges, Ramona, additional, Castellvi, Josep, additional, Garcia-Jimenez, Angel, additional, Colas, Eva, additional, Gil, Antonio, additional, and Cabrera, Silvia, additional

Published
2022
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45. Added Value of Estrogen Receptor, Progesterone Receptor, and L1 Cell Adhesion Molecule Expression to Histology-Based Endometrial Carcinoma Recurrence Prediction Models: An ENITEC Collaboration Study

Author

van der Putten, Louis J.M., Visser, Nicole C.M., van de Vijver, Koen, Santacana, Maria, Bronsert, Peter, Bulten, Johan, Hirschfeld, Marc, Colas, Eva, Gil-Moreno, Antonio, Garcia, Angel, Mancebo, Gemma, Alameda, Fransesc, Trovik, Jone, Kopperud, Reidun K., Huvila, Jutta, Schrauwen, Stefanie, Koskas, Martin, Walker, Francine, Weinberger, Vit, Minar, Lubos, Jandakova, Eva, Snijders, Marc P.L.M., van den Berg-van Erp, Saskia, Matias-Guiu, Xavier, Salvesen, Helga B., Werner, Henrica M.J., Amant, Frederic, Massuger, Leon F.A.G., and Pijnenborg, Johanna M.A.

Published
2018
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46. Endometrial Carcinoma: Specific Targeted Pathways

Author

Eritja, Nuria, primary, Yeramian, Andree, additional, Chen, Bo-Juen, additional, Llobet-Navas, David, additional, Ortega, Eugenia, additional, Colas, Eva, additional, Abal, Miguel, additional, Dolcet, Xavier, additional, Reventos, Jaume, additional, and Matias-Guiu, Xavier, additional

Published
2016
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47. Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer.

Author

Lombaers, Marike S., Cornel, Karlijn M. C., Visser, Nicole C. M., Bulten, Johan, Küsters-Vandevelde, Heidi V. N., Amant, Frédéric, Boll, Dorry, Bronsert, Peter, Colas, Eva, Geomini, Peggy M. A. J., Gil-Moreno, Antonio, van Hamont, Dennis, Huvila, Jutta, Krakstad, Camilla, Kraayenbrink, Arjan A., Koskas, Martin, Mancebo, Gemma, Matías-Guiu, Xavier, Ngo, Huy, and Pijlman, Brenda M.

Subjects
RESEARCH, PREDICTIVE tests, PREOPERATIVE period, MULTIVARIATE analysis, LYMPH nodes, METASTASIS, RETROSPECTIVE studies, ACQUISITION of data, RISK assessment, CANCER patients, COMPARATIVE studies, ENDOMETRIAL tumors, MEDICAL records, DESCRIPTIVE statistics, TUMOR antigens, TUMOR markers, COMPUTED tomography, LOGISTIC regression analysis, OVERALL survival
Abstract

Simple Summary: Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. Studies on CA125 and its association with tumor spread within low-grade UC exist but are limited for high-grade UC. The primary aim of this retrospective study was to assess whether elevated CA125 is predictive for UC spread and survival. Secondarily, we studied the additional value of preoperative imaging by CT scan in relation to CA125 specifically in high-grade UC. We observed that elevated CA125 was related to advanced stage and LNM in high-grade UC and a worse prognosis. If CA125 was normal, the additional value of CT to predict lymph node spread was limited. Patients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in high-grade EC are limited, we aimed to study primarily the predictive value of CA125, and secondarily the contributive value of computed tomography (CT) for advanced stage and LNM. Patients with high-grade EC (n = 333) and available preoperative CA125 were included retrospectively. The association of CA125 and CT findings with LNM was analyzed by logistic regression. Elevated CA125 ((>35 U/mL), (35.2% (68/193)) was significantly associated with stage III-IV disease (60.3% (41/68)) compared with normal CA125 (20.8% (26/125), [p < 0.001]), and with reduced disease-specific—(DSS) (p < 0.001) and overall survival (OS) (p < 0.001). The overall accuracy of predicting LNM by CT resulted in an area under the curve (AUC) of 0.623 (p < 0.001) independent of CA125. Stratification by CA125 resulted in an AUC of 0.484 (normal), and 0.660 (elevated). In multivariate analysis elevated CA125, non-endometrioid histology, pathological deep myometrial invasion ≥50%, and cervical involvement were significant predictors of LNM, whereas suspected LNM on CT was not. This shows that elevated CA125 is a relevant independent predictor of advanced stage and outcome specifically in high-grade EC. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Prospective Randomized Trial Comparing Transperitoneal Versus Extraperitoneal Laparoscopic Aortic Lymphadenectomy for Surgical Staging of Endometrial and Ovarian Cancer: The STELLA Trial

Author

Díaz-Feijoo, Berta, Correa-Paris, Alejandro, Pérez-Benavente, Assumpció, Franco-Camps, Silvia, Sánchez-Iglesias, José Luis, Cabrera, Silvia, de la Torre, Javier, Centeno, Cristina, Puig, Oriol Puig, Gil-Ibañez, Blanca, Colas, Eva, Magrina, Javier, and Gil-Moreno, Antonio

Published
2016
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49. Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool

Author

Villafranca-Magdalena, Beatriz, primary, Masferrer-Ferragutcasas, Carina, additional, Lopez-Gil, Carlos, additional, Coll-de la Rubia, Eva, additional, Rebull, Marta, additional, Parra, Genis, additional, García, Ángel, additional, Reques, Armando, additional, Cabrera, Silvia, additional, Colas, Eva, additional, Gil-Moreno, Antonio, additional, and Moiola, Cristian P., additional

Published
2022
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50. The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival

Author

Diéguez-Martínez, Nora, primary, Espinosa-Gil, Sergio, additional, Yoldi, Guillermo, additional, Megías-Roda, Elisabet, additional, Bolinaga-Ayala, Idoia, additional, Viñas-Casas, Maria, additional, Domingo-Ortí, Inés, additional, Pérez-Montoyo, Héctor, additional, Bayascas, Jose R, additional, Colas, Eva, additional, Dolcet, Xavier, additional, and Lizcano, Jose M, additional

Published
2022
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