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3,691 results on '"Colantoni A"'

1. Evaluating radiation impact on transmon qubits in above and underground facilities

Author

De Dominicis, Francesco, Roy, Tanay, Mariani, Ambra, Bal, Mustafa, Casali, Nicola, Colantoni, Ivan, Crisa, Francesco, Cruciani, Angelo, Ferroni, Fernando, Helis, Dounia L, Pagnanini, Lorenzo, Pettinacci, Valerio, Pilipenko, Roman, Pirro, Stefano, Puiu, Andrei, Romanenko, Alexander, Vignati, Marco, Zanten, David v, Zhu, Shaojiang, Grassellino, Anna, and Cardani, Laura

Subjects
Quantum Physics
Abstract

Superconducting qubits can be sensitive to abrupt energy deposits caused by cosmic rays and ambient radioactivity. Previous studies have focused on understanding possible correlated effects over time and distance due to cosmic rays. In this study, for the first time, we directly compare the response of a transmon qubit measured initially at the Fermilab SQMS above-ground facilities and then at the deep underground Gran Sasso Laboratory (INFN-LNGS, Italy). We observe same average qubit lifetime T$_1$ of roughly 80 microseconds at above and underground facilities. We then apply a fast decay detection protocol and investigate the time structure, sensitivity and relative rates of triggered events due to radiation versus intrinsic noise, comparing above and underground performance of several high-coherence qubits. Using gamma sources of variable activity we calibrate the response of the qubit to different levels of radiation in an environment with minimal background radiation. Results indicate that qubits respond to a strong gamma source and it is possible to detect particle impacts. However, when comparing above and underground results, we do not observe a difference in radiation induced-like events for these sapphire and niobium-based transmon qubits. We conclude that the majority of these events are not radiation related and to be attributed to other noise sources which by far dominate single qubit errors in modern transmon qubits., Comment: 9+7 pages, 7+5 figures

Published
2024

2. Survey of 3D Human Body Pose and Shape Estimation Methods for Contemporary Dance Applications

Author

Venkatrayappa, Darshan, Tremeau, Alain, Muselet, Damien, and Colantoni, Philippe

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

3D human body shape and pose estimation from RGB images is a challenging problem with potential applications in augmented/virtual reality, healthcare and fitness technology and virtual retail. Recent solutions have focused on three types of inputs: i) single images, ii) multi-view images and iii) videos. In this study, we surveyed and compared 3D body shape and pose estimation methods for contemporary dance and performing arts, with a special focus on human body pose and dressing, camera viewpoint, illumination conditions and background conditions. We demonstrated that multi-frame methods, such as PHALP, provide better results than single-frame method for pose estimation when dancers are performing contemporary dances., Comment: arXiv admin note: text overlap with arXiv:2008.09062 by other authors

Published
2024

3. Non-local skew and non-local sticky Brownian motions

Author

Colantoni, Fausto

Subjects
Mathematics - Probability, Mathematics - Analysis of PDEs
Abstract

In this paper, we present a comprehensive study on the generalization of skew Brownian motion and two-sided sticky Brownian motion by considering non-local operators at the origin for the heat equations on the real line. To begin, we introduce Marchaud-type operators and Caputo-Dzherbashian-type operators, providing an in-depth exposition of their fundamental properties. Subsequently, we describe the two stochastic processes and the associated equations. The non-local skew Brownian motion exhibits jumps, as a subordinator, at zero where the sign of the jump is determined by a skew coin. Conversely, the non-local sticky Brownian motion displays stickiness at zero, behaving as the inverse of a subordinator, resulting in non-Markovian dynamics.

Published
2023

5. Transcriptional and epigenetic characterization of a new in vitro platform to model the formation of human pharyngeal endoderm

Author

Andrea Cipriano, Alessio Colantoni, Alessandro Calicchio, Jonathan Fiorentino, Danielle Gomes, Mahdi Moqri, Alexander Parker, Sajede Rasouli, Matthew Caldwell, Francesca Briganti, Maria Grazia Roncarolo, Antonio Baldini, Katja G. Weinacht, Gian Gaetano Tartaglia, and Vittorio Sebastiano

Subjects
Pharyngeal Endoderm, Retinoic Acid, Transcriptomics, Epigenomics, Transcription Factors, Human Development, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

Abstract Background The Pharyngeal Endoderm (PE) is an extremely relevant developmental tissue, serving as the progenitor for the esophagus, parathyroids, thyroids, lungs, and thymus. While several studies have highlighted the importance of PE cells, a detailed transcriptional and epigenetic characterization of this important developmental stage is still missing, especially in humans, due to technical and ethical constraints pertaining to its early formation. Results Here we fill this knowledge gap by developing an in vitro protocol for the derivation of PE-like cells from human Embryonic Stem Cells (hESCs) and by providing an integrated multi-omics characterization. Our PE-like cells robustly express PE markers and are transcriptionally homogenous and similar to in vivo mouse PE cells. In addition, we define their epigenetic landscape and dynamic changes in response to Retinoic Acid by combining ATAC-Seq and ChIP-Seq of histone modifications. The integration of multiple high-throughput datasets leads to the identification of new putative regulatory regions and to the inference of a Retinoic Acid-centered transcription factor network orchestrating the development of PE-like cells. Conclusions By combining hESCs differentiation with computational genomics, our work reveals the epigenetic dynamics that occur during human PE differentiation, providing a solid resource and foundation for research focused on the development of PE derivatives and the modeling of their developmental defects in genetic syndromes.

Published
2024
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7. Measurement of the 2$\nu\beta\beta$ Decay Half-Life of Se-82 with the Global CUPID-0 Background Model

Author

Azzolini, O., Beeman, J. W., Bellini, F., Beretta, M., Biassoni, M., Brofferio, C., Bucci, C., Capelli, S., Caracciolo, V., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Colantoni, I., Cremonesi, O., Cruciani, A., D'Addabbo, A., Dafinei, I., Di Domizio, S., Dompè, V., Fantini, G., Ferroni, F., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Keppel, G., Kotila, J., Martinez, M., Nagorny, S. S., Nastasi, M., Nisi, S., Nones, C., Orlandi, D., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Ressa, A., Rusconi, C., Schäffner, K., Tomei, C., Vignati, M., and Zolotarova, A. S.

Subjects
Nuclear Experiment
Abstract

We report on the results obtained with the global CUPID-0 background model, which combines the data collected in the two measurement campaigns for a total exposure of 16.6 kg$\times$yr. We identify with improved precision the background sources in the region of interest for neutrinoless double $\beta$-decay, making more solid the foundations for the background budget of the next-generation CUPID experiment. Relying on the excellent data reconstruction, we measure the two-neutrino double $\beta$-decay half-life of $^{82}$Se with unprecedented accuracy: $T_{1/2}^{2\nu} = [8.69 \pm 0.05 \textrm{(stat.)}~^{+0.09}_{-0.06} \textrm{(syst.)}] \times 10^{19}~\textrm{yr}$.

Published
2023

8. A first test of CUPID prototypal light detectors with NTD-Ge sensors in a pulse-tube cryostat

Author

CUPID collaboration, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

CUPID is a next-generation bolometric experiment aiming at searching for neutrinoless double-beta decay with ~250 kg of isotopic mass of $^{100}$Mo. It will operate at $\sim$10 mK in a cryostat currently hosting a similar-scale bolometric array for the CUORE experiment at the Gran Sasso National Laboratory (Italy). CUPID will be based on large-volume scintillating bolometers consisting of $^{100}$Mo-enriched Li$_2$MoO$_4$ crystals, facing thin Ge-wafer-based bolometric light detectors. In the CUPID design, the detector structure is novel and needs to be validated. In particular, the CUORE cryostat presents a high level of mechanical vibrations due to the use of pulse tubes and the effect of vibrations on the detector performance must be investigated. In this paper we report the first test of the CUPID-design bolometric light detectors with NTD-Ge sensors in a dilution refrigerator equipped with a pulse tube in an above-ground lab. Light detectors are characterized in terms of sensitivity, energy resolution, pulse time constants, and noise power spectrum. Despite the challenging noisy environment due to pulse-tube-induced vibrations, we demonstrate that all the four tested light detectors comply with the CUPID goal in terms of intrinsic energy resolution of 100 eV RMS baseline noise. Indeed, we have measured 70--90 eV RMS for the four devices, which show an excellent reproducibility. We have also obtained outstanding energy resolutions at the 356 keV line from a $^{133}$Ba source with one light detector achieving 0.71(5) keV FWHM, which is -- to our knowledge -- the best ever obtained when compared to $\gamma$ detectors of any technology in this energy range., Comment: Prepared for submission to JINST; 16 pages, 7 figures, and 1 table

Published
2023
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9. Twelve-crystal prototype of Li$_2$MoO$_4$ scintillating bolometers for CUPID and CROSS experiments

Author

CUPID, collaborations, CROSS, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Bandac, I. C., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Calvo-Mozota, J. M., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Ianni, A., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marrache-Kikuchi, C. A., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

An array of twelve 0.28 kg lithium molybdate (LMO) low-temperature bolometers equipped with 16 bolometric Ge light detectors, aiming at optimization of detector structure for CROSS and CUPID double-beta decay experiments, was constructed and tested in a low-background pulse-tube-based cryostat at the Canfranc underground laboratory in Spain. Performance of the scintillating bolometers was studied depending on the size of phonon NTD-Ge sensors glued to both LMO and Ge absorbers, shape of the Ge light detectors (circular vs. square, from two suppliers), in different light collection conditions (with and without reflector, with aluminum coated LMO crystal surface). The scintillating bolometer array was operated over 8 months in the low-background conditions that allowed to probe a very low, $\mu$Bq/kg, level of the LMO crystals radioactive contamination by $^{228}$Th and $^{226}$Ra., Comment: Prepared for submission to JINST; 23 pages, 9 figures, and 4 tables

Published
2023
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10. Chemical Risk Management in Agriculture and Climate Change: A Review from a 'One Health' Perspective

Author

Cioccolo, Elisa, Rossi, Pierluigi, Bianchini, Leonardo, Colantoni, Andrea, Gherardi, Monica, Cecchini, Massimo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Berruto, Remigio, editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2024
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11. Lights and Shadows of Agricultural Workplace Safety Legislation in the Main EU Member States

Author

Di Stefano, Valerio, Colantoni, Andrea, Di Domenico, Giorgia, Cecchini, Massimo, Monarca, Danilo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Berruto, Remigio, editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2024
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15. Gene expression profiles of antigenic proteins of third stage larvae of the zoonotic nematode Anisakis pegreffii in response to temperature conditions

Author

Palomba Marialetizia, Paoletti Michela, Colantoni Alessandra, Rughetti Aurelia, Nascetti Giuseppe, and Mattiucci Simonetta

Subjects
Anisakis pegreffii, Gene expression, Immune-related genes, qRT-PCR, Temperature conditions, Infectious and parasitic diseases, RC109-216
Abstract

Anisakis pegreffii, a recognised etiological agent of human anisakiasis, is a parasite of homeothermic hosts at the adult stage and of ectothermic hosts at the third larval stage. Among distinct factors, temperature appears to be crucial in affecting parasite hatching, moulting and to modulate parasite-host interaction. In the present study, we investigated the gene transcripts of proteins having an antigenic role among excretory secretory products (ESPs) (i.e., a Kunitz-type trypsin inhibitor, A.peg-1; a glycoprotein, A.peg-7; and the myoglobin, A.peg-13) after 24 h, in A. pegreffii larvae maintained in vitro, under controlled temperature conditions. Temperatures were 37 °C and 20 °C, resembling respectively homeothermic and ectothermic hosts conditions, and 7 °C, the cold stress condition post mortem of the fish host. Primers of genes coding for these ESPs to be used in quantitative real-time PCR were newly designed, and qRT-PCR conditions developed. Expression profiles of the genes A.peg-1 and A.peg-13 were significantly up-regulated at 20 °C and 37 °C, with respect to the control (larvae kept at 2 °C for 24 h). Conversely, transcript profiles of A.peg-7 did not significantly change among the chosen temperature conditions. In accordance with the observed transcript profiles, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) revealed the presence of the three target ESPs at 37 °C, while only A.peg-13 was observed at 7 °C. The results suggest that temperature conditions do regulate the gene expression profiles of A.peg-1 and A.peg-13 in A. pegreffii larvae. However, regulation of the glycoprotein A.peg-7 is likely to be related to other factors such as the host’s immune response.

Published
2019
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16. Lipid-based insulin-resistance markers predict cardiovascular events in metabolic dysfunction associated steatotic liver disease

Author

Alessandra Colantoni, Tommaso Bucci, Nicholas Cocomello, Francesco Angelico, Evaristo Ettorre, Daniele Pastori, Gregory Y.H. Lip, Maria Del Ben, and Francesco Baratta

Subjects
MASLD, Cardiovascular events, Insulin resistance, TyG index, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being the key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing the predictive values of different markers of insulin resistance (IR) in identifying the presence of MASLD and the associated risk of cardiovascular events (CVEs). Methods Post hoc analysis of the prospective Plinio Study, involving dysmetabolic patients evaluated for the presence of MASLD. The IR markers considered were Homeostatic Model Assessment for IR (HOMA-IR), Triglycerides-Glycemia (TyG) index, Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C), Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI). Receiver operative characteristic (ROC) analyses were performed to find the optimal cut-offs of each IR marker for detecting MASLD and predicting CVEs in MASLD patients. Logistic and Cox multivariable regression analyses were performed, after dichotomizing the IR markers based on the optimal cut-offs, to assess the factors independently associated with MASLD and the risk of CVEs. Results The study included 772 patients (age 55.6 ± 12.1 years, 39.4% women), of whom 82.8% had MASLD. VAI (Area Under the Curve [AUC] 0.731), TyG Index (AUC 0.723), and TG/HDL-C ratio (AUC: 0.721) predicted MASLD but was greater with HOMA-IR (AUC: 0.792) and LAP (AUC: 0.787). After a median follow-up of 48.7 (25.4–75.8) months, 53 MASLD patients experienced CVEs (1.8%/year). TyG index (AUC: 0.630), LAP (AUC: 0.626), TG/HDL-C (AUC: 0.614), and VAI (AUC: 0.590) demonstrated comparable, modest predictive values in assessing the CVEs risk in MASLD patients. Conclusion In dysmetabolic patients HOMA-IR and LAP showed the best accuracy in detecting MASLD. The possible use of lipid-based IR markers in stratifying the CV risk in patients with MASLD needs further validation in larger cohorts.

Published
2024
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17. A first test of CUPID prototypal light detectors with NTD-Ge sensors in a pulse-tube cryostat

Author

Alfonso, K, Armatol, A, Augier, C, Avignone, FT, Azzolini, O, Balata, M, Barabash, AS, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Berest, V, Beretta, M, Bettelli, M, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Campani, A, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chang, C, Chiesa, D, Clemenza, M, Colantoni, I, Copello, S, Craft, E, Cremonesi, O, Creswick, RJ, Cruciani, A, D'Addabbo, A, D'Imperio, G, Dabagov, S, Dafinei, I, Danevich, FA, De Jesus, M, de Marcillac, P, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompé, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Foggetta, L, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gallas, A, Gascon, J, Ghislandi, S, Giachero, A, Gianvecchio, A, Girola, M, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Grant, C, Gras, P, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Kowalski, R, Langford, T, Lefevre, M, Liu, R, Liu, Y, Loaiza, P, and Ma, L

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Cryogenic detectors, Gamma detectors, Photon detectors for UV, visible and IR photons, X-ray detectors, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

CUPID is a next-generation bolometric experiment aiming at searching for neutrinoless double-beta decay with ∼250 kg of isotopic mass of 100Mo. It will operate at ∼10 mK in a cryostat currently hosting a similar-scale bolometric array for the CUORE experiment at the Gran Sasso National Laboratory (Italy). CUPID will be based on large-volume scintillating bolometers consisting of 100Mo-enriched Li2MoO4 crystals, facing thin Ge-wafer-based bolometric light detectors. In the CUPID design, the detector structure is novel and needs to be validated. In particular, the CUORE cryostat presents a high level of mechanical vibrations due to the use of pulse tubes and the effect of vibrations on the detector performance must be investigated. In this paper we report the first test of the CUPID-design bolometric light detectors with NTD-Ge sensors in a dilution refrigerator equipped with a pulse tube in an above-ground lab. Light detectors are characterized in terms of sensitivity, energy resolution, pulse time constants, and noise power spectrum. Despite the challenging noisy environment due to pulse-tube-induced vibrations, we demonstrate that all the four tested light detectors comply with the CUPID goal in terms of intrinsic energy resolution of 100 eV RMS baseline noise. Indeed, we have measured 70-90 eV RMS for the four devices, which show an excellent reproducibility. We have also obtained high energy resolutions at the 356 keV line from a 133Ba source, as good as Ge semiconductor γ detectors in this energy range.

Published
2023

18. Twelve-crystal prototype of Li2MoO4 scintillating bolometers for CUPID and CROSS experiments

Author

Alfonso, K, Armatol, A, Augier, C, Avignone, FT, Azzolini, O, Balata, M, Bandac, IC, Barabash, AS, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Berest, V, Beretta, M, Bettelli, M, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Calvo-Mozota, JM, Camilleri, J, Campani, A, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chang, C, Chiesa, D, Clemenza, M, Colantoni, I, Copello, S, Craft, E, Cremonesi, O, Creswick, RJ, Cruciani, A, D'Addabbo, A, D'Imperio, G, Dabagov, S, Dafinei, I, Danevich, FA, De Jesus, M, de Marcillac, P, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompé, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Foggetta, L, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gallas, A, Gascon, J, Ghislandi, S, Giachero, A, Gianvecchio, A, Girola, M, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Grant, C, Gras, P, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Ianni, A, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Kowalski, R, Langford, T, Lefevre, M, and Liu, R

Subjects
Nuclear and Plasma Physics, Physical Sciences, Cryogenic detectors, Double-beta decay detectors, Particle identification methods, Scintillators, scintillation and light emission processes, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

An array of twelve 0.28 kg lithium molybdate (LMO) low-temperature bolometers equipped with 16 bolometric Ge light detectors, aiming at optimization of detector structure for CROSS and CUPID double-beta decay experiments, was constructed and tested in a low-background pulse-tube-based cryostat at the Canfranc underground laboratory in Spain. Performance of the scintillating bolometers was studied depending on the size of phonon NTD-Ge sensors glued to both LMO and Ge absorbers, shape of the Ge light detectors (circular vs. square, from two suppliers), in different light collection conditions (with and without reflector, with aluminum coated LMO crystal surface). The scintillating bolometer array was operated over 8 months in the low-background conditions that allowed to probe a very low, μBq/kg, level of the LMO crystals radioactive contamination by 228Th and 226Ra.

Published
2023

19. CUPID: The Next-Generation Neutrinoless Double Beta Decay Experiment

Author

Alfonso, K, Armatol, A, Augier, C, Avignone, FT, Azzolini, O, Balata, M, Barabash, AS, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bettelli, M, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Campani, A, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chang, C, Chiesa, D, Clemenza, M, Colantoni, I, Copello, S, Craft, E, Cremonesi, O, Creswick, RJ, Cruciani, A, D’Addabbo, A, D’Imperio, G, Dabagov, S, Dafinei, I, Danevich, FA, De Jesus, M, De Marcillac, P, Dell’Oro, S, Domizio, S Di, Lorenzo, S Di, Dixon, T, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Foggetta, L, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gallas, A, Gascon, J, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Grant, C, Gras, P, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Kowalski, R, Langford, T, Lefevre, M, Liu, R, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, and Mancarella, F

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Neutrinoless double beta decay, Bolometers, Low radioactivity, Cryostat, Next-generation bolometric experiment, Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics
Abstract

CUPID is a next-generation tonne-scale bolometric neutrinoless double beta decay experiment that will probe the Majorana nature of neutrinos and discover lepton number violation in case of observation of this singular process. CUPID will be built on experience, expertise and lessons learned in CUORE and will be installed in the current CUORE infra-structure in the Gran Sasso underground laboratory. The CUPID detector technology, successfully tested in the CUPID-Mo experiment, is based on scintillating bolometers of Li2MoO4 enriched in the isotope of interest 100Mo. In order to achieve its ambitious science goals, the CUPID collaboration aims to reduce the backgrounds in the region of interest by a factor 100 with respect to CUORE. This performance will be achieved by introducing the high efficient α/β discrimination demonstrated by the CUPID-0 and CUPID-Mo experiments, and using a high transition energy double beta decay nucleus such as 100Mo to minimize the impact of the gamma background. CUPID will consist of about 1500 hybrid heat-light detectors for a total isotope mass of 250 kg. The CUPID scientific reach is supported by a detailed and safe background model based on CUORE, CUPID-Mo and CUPID-0 results. The required performances have already been demonstrated and will be presented.

Published
2023

21. Disentangling the sources of ionizing radiation in superconducting qubits

Author

Cardani, L., Colantoni, I., Cruciani, A., De Dominicis, F., D'Imperio, G., Laubenstein, M., Mariani, A., Pagnanini, L., Pirro, S., Tomei, C., Casali, N., Ferroni, F., Frolov, D., Gironi, L., Grassellino, A., Junker, M., Kopas, C., Lachman, E., McRae, C. R. H., Mutus, J., Nastasi, M., Pappas, D. P., Pilipenko, R., Sisti, M., Pettinacci, V., Romanenko, A., Van Zanten, D., Vignati, M., Withrow, J. D., and Zhelev, N. Z.

Subjects
Quantum Physics, Physics - Instrumentation and Detectors
Abstract

Radioactivity was recently discovered as a source of decoherence and correlated errors for the real-world implementation of superconducting quantum processors. In this work, we measure levels of radioactivity present in a typical laboratory environment (from muons, neutrons, and gamma's emitted by naturally occurring radioactive isotopes) and in the most commonly used materials for the assembly and operation of state-of-the-art superconducting qubits. We develop a GEANT-4 based simulation to predict the rate of impacts and the amount of energy released in a qubit chip from each of the mentioned sources. We finally propose mitigation strategies for the operation of next-generation qubits in a radio-pure environment.

Published
2022
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22. Exploring coherent elastic neutrino-nucleus scattering of reactor neutrinos with the NUCLEUS experiment

Author

The NUCLEUS collaboration, Goupy, C., Abele, H., Angloher, G., Bento, A., Canonica, L., Cappella, F., Cardani, L., Casali, N., Cerulli, R., Colantoni, I., Cruciani, A., Del Castello, G., Roccagiovine, M. del Gallo, Doblhammer, A., Dorer, S., Erhart, A., Friendl, M., Garai, A., Ghete, V. M., Hauff, D., Jeanneau, F., Jericha, E., Kaznacheeva, M., Kinast, A., Kluck, H., Langenkämper, A., Lasserre, T., Lhuillier, D., Mancuso, M., Mauri, B., Mazzolari, A., Mazzucato, E., Neyrial, H., Nones, C., Oberauer, L., Ortmann, T., Pattavina, L., Peters, L., Petricca, F., Potzel, W., Pröbst, F., Pucci, F., Riendl, F., Rogly, R., Romagnoni, M., Rothe, J., Schermer, N., Schieck, J., Schönert, S., Schwertner, C., Scola, L., Sidikov, G. Soum, Stodolsky, L., Strauss, R., Tamisari, M., Tomei, C., Vignati, M., Vivier, M., Wagner, V., and Wex, A.

Subjects
Physics - Instrumentation and Detectors
Abstract

The NUCLEUS experiment aims to perform a high-precision measurement of Coherent Elastic Neutrino-Nucleus Scattering (CEvNS) at the EdF Chooz B nuclear power plant in France. CEvNS is a unique process to study neutrino properties and to search for physics beyond the Standard Model. The study of CEvNS is also important for light Dark-Matter searches. It could be a possible irreducible background for high-sensitivity Dark-Matter searches. NUCLEUS is an experiment under construction based on ultra-low threshold (20 eVnr) cryogenic calorimeters, operated at tens-of-mK temperatures., Comment: Procceding for 14th International Conference on Identification of Dark Matter Vienna, Austria, 18-22 July 2022 - Submitted to SciPost

Published
2022

23. Observation of a nuclear recoil peak at the 100 eV scale induced by neutron capture

Author

CRAB Collaboration, NUCLEUS Collaboration, Abele, H., Angloher, G., Bento, A., Canonica, L., Cappella, F., Cardani, L., Casali, N., Cerulli, R., Chalil, A., Chebboubi, A., Colantoni, I., Crocombette, J. -P., Cruciani, A., Del Castello, G., Roccagiovine, M. del Gallo, Desforge, D., Doblhammer, A., Dumonteil, E., Dorer, S., Erhart, A., Fuss, A., Friedl, M., Garai, A., Ghete, V. M., Giuliani, A., Goupy, C., Gunsing, F., Hauff, D., Jeanneau, F., Jericha, E., Kaznacheeva, M., Kinast, A., Kluck, H., Langenkämper, A., Lasserre, T., Letourneau, A., Lhuillier, D., Litaize, O., Mancuso, M., de Marcillac, P., Marnieros, S., Materna, T., Mauri, B., Mazzolari, A., Mazzucato, E., Neyrial, H., Nones, C., Oberauer, L., Ortmann, T., Ouzriat, A., Pattavina, L., Peters, L., Petricca, F., Poda, D. V., Potzel, W., Pröbst, F., Reindl, F., Rogly, R., Romagnoni, M., Rothe, J., Schermer, N., Schieck, J., Schönert, S., Schwertner, C., Scola, L., Serot, O., Soum-Sidikov, G., Stodolsky, L., Strauss, R., Tamisari, M., Thulliez, L., Tomei, C., Vignati, M., Vivier, M., Wagner, V., and Wex, A.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

Coherent elastic neutrino-nucleus scattering and low-mass Dark Matter detectors rely crucially on the understanding of their response to nuclear recoils. We report the first observation of a nuclear recoil peak at around 112 eV induced by neutron capture. The measurement was performed with a CaWO$_4$ cryogenic detector from the NUCLEUS experiment exposed to a $^{252}$Cf source placed in a compact moderator. The measured spectrum is found in agreement with simulations and the expected peak structure from the single-$\gamma$ de-excitation of $^{183}$W is identified with 3 $\sigma$ significance. This result demonstrates a new method for precise, in-situ, and non-intrusive calibration of low-threshold experiments.

Published
2022
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24. Variance Gamma (non-local) equations

Author

Colantoni, Fausto

Subjects
Mathematics - Probability
Abstract

We provide some equations for the Variance Gamma process due to the fact that we do not consider only the definition as a time-changed Brownian motion. This brings us to a new non-local equation, even true in the drifted case, involving generalized Weyl derivatives. Then we focus on the connection to special functions and we study a space equation for our process. At the end, we conclude by observing the convergence in distribution of a compound Poisson process to the Variance Gamma process.

Published
2022

25. BRANQUITUDE CRÍTICA

Author

Ana Gabriela Colantoni

Subjects
Branquitude Crítica, Apropriação Cultural, Desconstrução, Philosophy. Psychology. Religion
Abstract

Esse trabalho tem como objetivo geral a construção de ações antirracistas executadas por pessoas brancas, de maneira mais coerente. Como objetivo específico pretendemos apresentar as fases vivenciadas por pessoas brancas dispostas às transformações práticas a partir da necessidade da justiça. A hipótese é a de que, pelo menos, duas dessas fases são obrigatórias para a mudança do paradigma do/a branco/a “salvador” para a do/a branco/a capaz de compreender sua obrigação enquanto cidadã/ão. Essas fases são as seguintes: a vergonha, a negação e a responsabilização.

Published
2024

26. BULLKID: Monolithic array of particle absorbers sensed by Kinetic Inductance Detectors

Author

Cruciani, A., Bandiera, L., Calvo, M., Casali, N., Colantoni, I., Del Castello, G., Roccagiovine, M. del Gallo, Delicato, D., Giammei, M., Guidi, V., Goupy, J., Pettinacci, V., Pettinari, G., Romagnoni, M., Tamisari, M., Mazzolari, A., Monfardini, A., and Vignati, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We introduce BULLKID, an innovative phonon detector consisting of an array of dices acting as particle absorbers sensed by multiplexed Kinetic Inductance Detectors (KIDs). The dices are carved in a thick crystalline wafer and form a monolithic structure. The carvings leave a thin common disk intact in the wafer, acting both as holder for the dices and as substrate for the KID lithography. The prototype presented consists of an array of 64 dices of 5.4x5.4x5 mm$^3$ carved in a 3" diameter, 5 mm thick silicon wafer, with a common disk 0.5 mm thick hosting a 60 nm patterned aluminum layer. The resulting array is highly segmented but avoids the use of dedicated holding structures for each unit. Despite the fact that the uniformity of the KID electrical response across the array needs optimization, the operation of 8 units with similar features shows, on average, a baseline energy resolution of $26\pm7$ eV. This makes it a suitable detector for low-energy processes such as direct interactions of dark matter and coherent elastic neutrino-nucleus scattering.

Published
2022
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27. Non-local Boundary Value Problems for Brownian motions

Author

Colantoni, Fausto and D'Ovidio, Mirko

Subjects
Mathematics - Probability, Mathematics - Analysis of PDEs
Abstract

We consider dynamic boundary conditions involving non-local operators. Our analysis includes a detailed description of such operators together with their relations with random times and random (additive) functionals. We provide some new characterizations for the boundary behaviour of the Brownian motion based on the interplay between non-local operators and boundary value problems. Although our main focus is about Feller diffusions on bounded domains whose boundary is a set of positive Lebesgue measure, due to the novelty of such results we present here a first study concerned with the motions on the positive real line. In our view, also for the real line, the results appears stimulating and they anticipate interesting applications.

Published
2022

28. Search for Majoron-like particles with CUPID-0

Author

Collaboration, CUPID-0, Azzolini, O., Beeman, J. W., Bellini, F., Beretta, M., Biassoni, M., Brofferio, C., Bucci, C., Capelli, S., Caracciolo, V., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Colantoni, I., Cremonesi, O., Cruciani, A., D'Addabbo, A., Dafinei, I., Di Domizio, S., Dompè, V., Fantini, G., Ferroni, F., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Keppel, G., Kotila, J., Martinez, M., Nagorny, S., Nastasi, M., Nisi, S., Nones, C., Orlandi, D., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Ressa, A., Rusconi, C., Schäffner, K., Tomei, C., Vignati, M., and Zolotarova, A. S.

Subjects
High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

We present the first search for the Majoron-emitting modes of the neutrinoless double $\beta$ decay ($0\nu\beta\beta\chi_0$) using scintillating cryogenic calorimeters. We analysed the CUPID-0 Phase I data using a Bayesian approach to reconstruct the background sources activities, and evaluate the potential contribution of the $^{82}$Se $0\nu\beta\beta\chi_0$. We considered several possible theoretical models which predict the existence of a Majoron-like boson coupling to the neutrino. The energy spectra arising from the emission of such bosons in the neutrinoless double $\beta$ decay have spectral indices $n=$ 1, 2, 3 or 7. We found no evidence of any of these decay modes, setting a lower limit (90% of credibility interval) on the half-life of 1.2 $\times$ 10$^{23}$ yr in the case of $n=$ 1, 3.8 $\times$ 10$^{22}$ yr for $n=$ 2, 1.4 $\times$ 10$^{22}$ yr for $n=$ 3 and 2.2 $\times$ 10$^{21}$ yr for $n=$ 7. These are the best limits on the $0\nu\beta\beta\chi_0$ half-life of the $^{82}$Se, and demonstrate the potentiality of the CUPID-0 technology in this field.

Published
2022
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29. Final Result on the Neutrinoless Double Beta Decay of $^{82}$Se with CUPID-0

Author

Azzolini, O., Beeman, J. W., Bellini, F., Beretta, M., Biassoni, M., Brofferio, C., Bucci, C., Capelli, S., Caracciolo, V., Cardani, L., Carniti, P., Casali, N., Chiesa, D., Clemenza, M., Colantoni, I., Cremonesi, O., Cruciani, A., D'Addabbo, A., Dafinei, I., De Dominics, F., Di Domizio, S., Ferroni, F., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Keppel, G., Martinez, M., Nagorny, S., Nastasi, M., Nisi, S., Nones, C., Orlandi, D., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Rusconi, C., Schaeffner, K., Tomei, C., Vignati, M., and Zolotarova, A. S.

Subjects
High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

CUPID-0, an array of Zn$^{82}$Se cryogenic calorimeters, was the first medium-scale demonstrator of the scintillating bolometers technology. The first project phase (March 2017 - December 2018) allowed the most stringent limit on the neutrinoless double beta decay half-life of the isotope of interest, $^{82}$Se, to be set. After a six months long detector upgrade, CUPID-0 began its second and last phase (June 2019 - February 2020). In this letter, we describe the search for neutrinoless double beta decay of $^{82}$Se with a total exposure (phase I + II) of 8.82 kg$\times$yr of isotope. We set a limit on the half-life of $^{82}$Se to the ground state of $^{82}$Kr of T$^{0\nu}_{1/2}$($^{82}$Se)$>$ 4.6$\times \mathrm{10}^{24}$ yr (90\% credible interval), corresponding to an effective Majorana neutrino mass m$_{\beta\beta} <$ (263 -- 545) meV. We also set the most stringent lower limits on the neutrinoless decays of $^{82}$Se to the 0$_1^+$, 2$_1^+$ and 2$_2^+$ excited states of $^{82}$Kr, finding 1.8$\times$10$^{23}$ yr, 3.0$\times$10$^{23}$ yr, 3.2$\times$10$^{23}$ yr (90$\%$ credible interval) respectively.

Published
2022
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30. Machine Learning Techniques for Pile-Up Rejection in Cryogenic Calorimeters

Author

Fantini, G, Armatol, A, Armengaud, E, Armstrong, W, Augier, C, Avignone, FT, Azzolini, O, Barabash, A, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bergé, L, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Cazes, A, Celi, E, Chang, C, Chapellier, M, Charrier, A, Chiesa, D, Clemenza, M, Colantoni, I, Collamati, F, Copello, S, Cova, F, Cremonesi, O, Creswick, RJ, Cruciani, A, D’Addabbo, A, D’Imperio, G, Dafinei, I, Danevich, FA, de Combarieu, M, De Jesus, M, de Marcillac, P, Dell’Oro, S, Domizio, S Di, Dompè, V, Drobizhev, A, Dumoulin, L, Fasoli, M, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gascon, J, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gras, P, Gros, M, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Huang, RG, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, S, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, Mancarella, F, Mariam, R, Marini, L, Marnieros, S, Martinez, M, Maruyama, RH, Mauri, B, and Mayer, D

Subjects
Convolutional neural networks, Machine learning, Cryogenic calorimeters, CUPID, Neutrinoless double beta decay, Majorana, Pile-up, Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics
Abstract

CUORE Upgrade with Particle IDentification (CUPID) is a foreseen ton-scale array of Li2MoO4 (LMO) cryogenic calorimeters with double readout of heat and light signals. Its scientific goal is to fully explore the inverted hierarchy of neutrino masses in the search for neutrinoless double beta decay of 100Mo. Pile-up of standard double beta decay of the candidate isotope is a relevant background. We generate pile-up heat events via injection of Joule heater pulses with a programmable waveform generator in a small array of LMO crystals operated underground in the Laboratori Nazionali del Gran Sasso, Italy. This allows to label pile-up pulses and control both time difference and underlying amplitudes of individual heat pulses in the data. We present the performance of supervised learning classifiers on data and the attained pile-up rejection efficiency.

Published
2022

32. m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication

Author

Sabrina Garbo, Daniel D’Andrea, Alessio Colantoni, Francesco Fiorentino, Antonello Mai, Andres Ramos, Gian Gaetano Tartaglia, Andrea Tancredi, Marco Tripodi, and Cecilia Battistelli

Subjects
CP: Molecular biology, Biology (General), QH301-705.5
Abstract

Summary: Epitranscriptomics represents a further layer of gene expression regulation. Specifically, N6-methyladenosine (m6A) regulates RNA maturation, stability, degradation, and translation. Regarding microRNAs (miRNAs), while it has been reported that m6A impacts their biogenesis, the functional effects on mature miRNAs remain unclear. Here, we show that m6A modification on specific miRNAs weakens their coupling to AGO2, impairs their function on target mRNAs, determines their delivery into extracellular vesicles (EVs), and provides functional information to receiving cells. Mechanistically, the intracellular functional impairment is caused by m6A-mediated inhibition of AGO2/miRNA interaction, the EV loading is favored by m6A-mediated recognition by the RNA-binding protein (RBP) hnRNPA2B1, and the EV-miRNA function in the receiving cell requires their FTO-mediated demethylation. Consequently, cells express specific miRNAs that do not impact endogenous transcripts but provide regulatory information for cell-to-cell communication. This highlights that a further level of complexity should be considered when relating cellular dynamics to specific miRNAs.

Published
2024
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33. Morphological and chemical changes in nuclear graphite target under vacuum and high-temperature conditions

Author

Stefania De Rosa, Elisabetta Colantoni, Paolo Branchini, Domizia Orestano, Antonio Passeri, Gianlorenzo Bussetti, Lisa Centofante, Stefano Corradetti, Martina Marsotto, Chiara Battocchio, Cristina Riccucci, and Luca Tortora

Subjects
Nuclear graphite, High-energy reactions, EDM, HTR, MSR, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Nuclear-grade graphite is a high-efficiency material, widely used for vacuum applications in nuclear reactors and accelerators as targets facing particle beams. In these contexts, graphite is often exposed to extreme thermal stresses altering its physical and chemical properties. The thermal-induced release of volatile contaminants from targets and the damage of structural components are critical issues that can affect the safety and operation efficiency of beamline facilities. Here, we provide for the first time a detailed picture of the chemical and morphological changes occurring in a nuclear-grade graphite target, obtained through Electrical Discharge Machining (EDM), when exposed in vacuum to high temperatures. The radial temperature gradient induced by the impact of a pulsed energetic (MeV- GeV range) focused particle beams was reproduced by cyclically heating, in the 1300–1800 K temperature range, a disc-shaped graphite target in a vacuum setup. An accurate surface and in-depth chemical analysis of the graphite target was obtained thanks to the high sensitivity (ppm/ppb) of the Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) technique. The chemical maps clearly show the presence of several metal oxides and impurities in the surface and subsurface regions of the untreated sample. Such contaminants were removed because of the thermal treatment in vacuum more or less efficiently, as demonstrated by Thermogravimetric analysis (TGA), X-ray Photoelectron Spectroscopy (XPS), and ToF-SIMS. However, Raman spectroscopy and SEM-EDS revealed that the high-temperature treatment induces a decrease in the crystallite size of the graphite as well as changes in the target surface porosity with the appearance of microvoids, leading the graphite target to be more prone to the breakage.

Published
2024
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34. Toward CUPID-1T

Author

Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Nuclear Experiment
Abstract

Current experiments to search for broken lepton-number symmetry through the observation of neutrinoless double-beta decay ($0\mathrm{\nu\beta\beta}$) provide the most stringent limits on the Majorana nature of neutrinos and the effective Majorana neutrino mass ($m_{\beta\beta}$). The next-generation experiments will focus on the sensitivity to the $0\mathrm{\nu\beta\beta}$ half-life of $\mathcal{O}(10^{27}$--$10^{28}$~years$)$ and $m_{\beta\beta}\lesssim15$~meV, which would provide complete coverage of the so-called Inverted Ordering region of the neutrino mass parameter space. By taking advantage of recent technological breakthroughs, new, future calorimetric experiments at the 1-ton scale can increase the sensitivity by at least another order of magnitude, exploring the large fraction of the parameter space that corresponds to the Normal neutrino mass ordering. In case of a discovery, such experiments could provide important insights toward a new understanding of the mechanism of $0\mathrm{\nu\beta\beta}$. We present here a series of projects underway that will provide advancements in background reduction, cryogenic readout, and physics searches beyond $0\mathrm{\nu\beta\beta}$, all moving toward the next-to-next generation CUPID-1T detector., Comment: contribution to Snowmass 2021

Published
2022

35. Coherent elastic neutrino-nucleus scattering: Terrestrial and astrophysical applications

Author

Abdullah, M., Abele, H., Akimov, D., Angloher, G., Aristizabal-Sierra, D., Augier, C., Balantekin, A. B., Balogh, L., Barbeau, P. S., Baudis, L., Baxter, A. L., Beaufort, C., Beaulieu, G., Belov, V., Bento, A., Berge, L., Bernardi, I. A., Billard, J., Bolozdynya, A., Bonhomme, A., Bres, G., Bret, J-. L., Broniatowski, A., Brossard, A., Buck, C., Cadeddu, M., Calvo, M., Canonica, L., Cappella, F., Cardani, L., Casali, N., Cazes, A., Cerulli, R., Chaize, D., Chang, C., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colantoni, I., Colas, J., Coloma, P., Corcoran, E. C., Crawford, S., Cruciani, A., Fard, A. Dastgheibi, De Jesus, M., de Marcillac, P., De Romeri, V., del Castello, G., del GalloRoccagiovine, M., Delicato, D., Demarteau, M., Deng, Y., Dent, J. B., Denton, P. B., Dering, K., Doblhammer, A., Dordei, F., Dorer, S., Dumoulin, L., Dunford, D., Dutta, B., Erhart, A., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J. B., Flores, L . J., Formaggio, J. A., Friedl, M., Fuard, S., Gao, F., Garai, A., Garces, E. A., Gascon, J., Gehrlein, J., Gerbier, G., Ghete, V. M., Giomataris, I., Giroux, G., Giuliani, A., Giunti, C., Gorel, P., Goupy, C., Goupy, J., Goy, C., Green, M. P., Gros, M., Guerin, C., Guidi, V., Guillaudin, O., Guy, E., Ha, C., Hauff, D., Hakenmuller, J., Harrington, P. M., Hedges, S., Heine, S. T., Hertel, S., Heusch, M., Hoarau, C., Hoferichter, M., Hoppe, E. W., Hong, Z., Horiuchi, S., Huber, P., Ianigro, J. C., Jachowicz, N., Jericha, E., Jin, Y., Johnston, J. P., Juillard, A., Katsioulas, I., Kazarcev, S., Kaznacheeva, M., Kelly, F., Kelly, K. J., Kim, D., Kinast, A., Klinkenberg, L., Kluck, H., Knights, P., Ko, Y. J., Kosmas, T. S., Kwon, L., Lamblin, J., Lang, R. F., Langenkamper, A., Langrock, S., Lasserre, T., Lattaud, H., Lautridou, P., Lee, H. S., Lenardo, B. G., Lhuillier, D., Li, M., Li, S. C., Li, Y. F., Li, Z., Lindner, M., Liu, J., Loomba, D., Lubashevskiy, A., Machado, P. A. N., Mancuso, M., Maneschg, W., Markoff, D. M., Marnieros, S., Martin, R., Martin, R. D., Mauri, B., Mayer, D. W., Mazzolari, A., Mazzucato, E., Menendez, J., Minet, J., Miranda, O. G., Misiak, D., Mols, J. -P., Monfardini, A., Mounier, F., Muraz, J. F., Neep, T., Neilson, R., Newby, J., Newstead, J. L., Neyrial, H., Ni, K., Nikolopoulos, K., Nones, C., Norcini, D., Pandey, V., O'Brien, P., O'Hare, C. A. J., Oberauer, L., Oliver, W., Olivieri, E., Onillon, A., Oriol, C., Ortmann, T., Owen, R., Palladino, K. J., Papoulias, D. K., Park, J. C., Parno, D. S., Patel, P. K., Pattavina, L., Peinado, E., Perbet, E., Peters, L., Petricca, F., Pinckney, H. D., Piro, M. -C., Ponomarev, D., Poda, D., Potzel, W., Probst, F., Pucci, F., Rarbi, F., Rapp, R., Ray, H., Real, J. -S., Reindl, F., Rich, G. C., Ricol, J. S., Rink, T., Redon, T., Rogly, R., Robert, A., Rothe, J., Rozov, S., Rozova, I., Salagnac, T., Garcia, E. Sanchez, Garcia, G. Sanchez, Sanders, O., Sanglard, V., Santos, D., Sarkis, Y., Savu, V., Savvidis, G., Savvidis, I., Schermer, N., Schieck, J., Schmidt, B., Schonert, S., Scholberg, K., Schwenk, A., Schwertner, C., Scola, L., Shevchik, Ye., Shin, S., Sibille, V., Shoemaker, I. M., Snowden-Ifft, D. P., Soldner, T., Soum, G., Spooner, N. J. C., Stachurska, J., Stodolsky, L., Strauss, R., Strigari, L. E., Stutz, A., Suh, B. D., Suhonen, J., Tabrizi, Z., Takhistov, V., Thompson, A., Tomei, C., Tortola, M., Tripathi, M., Vagneron, L., Valle, J. W. F., Mirbach, K. v., Van De Ponteseele, W., Vignati, M., Vivier, M., Fernandez, F. Vazquez de Sola, Vezzu, F., Vidal, M., Wagner, V., Walker, J. W., Ward, R., Wex, A., Winslow, L., Wong, H. T., Wood, M. H., Xu, J., Yang, L., Yakushev, E., Zampaolo, M., Zettlemoyer, J., Zhang, Y. Y., and Zinatulina, D.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) is a process in which neutrinos scatter on a nucleus which acts as a single particle. Though the total cross section is large by neutrino standards, CE$\nu$NS has long proven difficult to detect, since the deposited energy into the nucleus is $\sim$ keV. In 2017, the COHERENT collaboration announced the detection of CE$\nu$NS using a stopped-pion source with CsI detectors, followed up the detection of CE$\nu$NS using an Ar target. The detection of CE$\nu$NS has spawned a flurry of activities in high-energy physics, inspiring new constraints on beyond the Standard Model (BSM) physics, and new experimental methods. The CE$\nu$NS process has important implications for not only high-energy physics, but also astrophysics, nuclear physics, and beyond. This whitepaper discusses the scientific importance of CE$\nu$NS, highlighting how present experiments such as COHERENT are informing theory, and also how future experiments will provide a wealth of information across the aforementioned fields of physics., Comment: contribution to Snowmasss 2021. Contact authors: P. S. Barbeau, R. Strauss, L. E. Strigari

Published
2022

36. Optimization of the first CUPID detector module

Author

CUPID collaboration, Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M ., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

CUPID will be a next generation experiment searching for the neutrinoless double $\beta$ decay, whose discovery would establish the Majorana nature of the neutrino. Based on the experience achieved with the CUORE experiment, presently taking data at LNGS, CUPID aims to reach a background free environment by means of scintillating Li$_{2}$$^{100}$MoO$_4$ crystals coupled to light detectors. Indeed, the simultaneous heat and light detection allows us to reject the dominant background of $\alpha$ particles, as proven by the CUPID-0 and CUPID-Mo demonstrators. In this work we present the results of the first test of the CUPID baseline module. In particular, we propose a new optimized detector structure and light sensors design to enhance the engineering and the light collection, respectively. We characterized the heat detectors, achieving an energy resolution of (5.9 $\pm$ 0.2) keV FWHM at the $Q$-value of $^{100}$Mo (about 3034 keV). We studied the light collection of the baseline CUPID design with respect to an alternative configuration which features gravity-assisted light detectors' mounting. In both cases we obtained an improvement in the light collection with respect to past measures and we validated the particle identification capability of the detector, which ensures an $\alpha$ particle rejection higher than 99.9%, fully satisfying the requirements for CUPID., Comment: 10 pages, 5 figures

Published
2022

37. EXCESS workshop: Descriptions of rising low-energy spectra

Author

Adari, P., Aguilar-Arevalo, A., Amidei, D., Angloher, G., Armengaud, E., Augier, C., Balogh, L., Banik, S., Baxter, D., Beaufort, C., Beaulieu, G., Belov, V., Gal, Y. Ben, Benato, G., Benoît, A., Bento, A., Bergé, L., Bertolini, A., Bhattacharyya, R., Billard, J., Bloch, I. M., Botti, A., Breier, R., Bres, G., Bret, J-. L., Broniatowski, A., Brossard, A., Bucci, C., Bunker, R., Cababie, M., Calvo, M., Camus, P., Cancelo, G., Canonica, L., Cappella, F., Cardani, L., Caron, J. -F., Casali, N., del Castello, G., Cazes, A., Cerulli, R., Vergara, B. A. Cervantes, Chaize, D., Chapellier, M., Chaplinsky, L., Charlieux, F., Chaudhuri, M., Chavarria, A. E., Chemin, G., Chen, R., Chen, H., Chierchie, F., Colantoni, I., Colas, J., Cooley, J., Coquillat, J. -M., Corcoran, E. C., Crawford, S., Crisler, M., Cruciani, A., Cushman, P., D'Addabbo, A., D'Olivo, J. C., Dastgheibi-Fard, A., De Jésus, M., Deng, Y., Dent, J. B., Depaoli, E. L., Dering, K., Dharani, S., Di Lorenzo, S., Drlica-Wagner, A., Dumoulin, L., Durnford, D., Dutta, B., Einfalt, L., Erb, A., Erhart, A., Essig, R., Estrada, J., Etzion, E., Exshaw, O., Favela-Perez, F., Feilitzsch, F. v., Moroni, G. Fernandez, Iachellini, N. Ferreiro, Ferriol, S., Fichtinger, S., Figueroa-Feliciano, E., Filippini, J. -B., Filosofov, D., Formaggio, J. A., Friedl, M., Fuard, S., Fuchs, D., Fuss, A., Gaïor, R., Garai, A., Garrah, C., Gascon, J., Gerbier, G., Ghaith, M., Ghete, V. M., Gift, D., Giomataris, I., Giroux, G., Giuliani, A., Gorel, P., Gorla, P., Goupy, C., Goupy, J., Goy, C., Gros, M., Gros, P., Guardincerri, Y., Guerin, C., Guidi, V., Guillaudin, O., Gupta, S., Guy, E., Harrington, P., Hauff, D., Heine, S. T., Hertel, S. A., Holland, S. E., Hong, Z., Hoppe, E. W., Hossbach, T. W., Ianigro, J. -C., Iyer, V., Jastram, A., Ješkovský, M., Jin, Y., Jochum, J., Johnston, J. P., Juillard, A., Karaivanov, D., Kashyap, V., Katsioulas, I., Kazarcev, S., Kaznacheeva, M., Kelly, F., Kilminster, B., Kinast, A., Klinkenberg, L., Kluck, H., Knights, P., Korn, Y., Kraus, H., von Krosigk, B., Kubik, A., Kurinsky, N. A., Lamblin, J., Langenkämper, A., Langrock, S., Lasserre, T., Lattaud, H., Lautridou, P., Lawson, I., Lee, S. J., Lee, M., Letessier-Selvon, A., Lhuillier, D., Li, M., Lin, Y. -T., Lubashevskiy, A., Mahapatra, R., Maludze, S., Mancuso, M., Manthos, I., Marini, L., Marnieros, S., Martin, R. D., Matalon, A., Matthews, J., Mauri, B., Mayer, D. W., Mazzolari, A., Mazzucato, E., Theenhausen, H. Meyer zu, Michielin, E., Minet, J., Mirabolfathi, N., Mirbach, K. v., Misiak, D., Mitra, P., Mocellin, J-. L., Mohanty, B., Mokina, V., Mols, J. -P., Monfardini, A., Mounier, F., Munagavalasa, S., Muraz, J. -F., Navick, X. -F., Neep, T., Neog, H., Neyrial, H., Nikolopoulos, K., Nilima, A., Nones, C., Novati, V., O'Brien, P., Oberauer, L., Olivieri, E., Olmi, M., Onillon, A., Oriol, C., Orly, A., Orrell, J. L., Ortmann, T., Overman, C. T., Pagliarone, C., Palušová, V., Pari, P., Patel, P. K., Pattavina, L., Petricca, F., Piers, A., Pinckney, H. D., Piro, M. -C., Platt, M., Poda, D., Ponomarev, D., Potzel, W., Povinec, P., Pröbst, F., Privitera, P., Pucci, F., Ramanathan, K., Real, J. -S., Redon, T., Reindl, F., Ren, R., Robert, A., Da Rocha, J., Rodrigues, D., Rogly, R., Rothe, J., Rowe, N., Rozov, S., Rozova, I., Saab, T., Saffold, N., Salagnac, T., Sander, J., Sanglard, V., Santos, D., Sarkis, Y., Savu, V., Savvidis, G., Savvidis, I., Schönert, S., Schäffner, K., Schermer, N., Schieck, J., Schmidt, B., Schmiedmayer, D., Schwertner, C., Scola, L., Settimo, M., Shevchik, Ye., Sibille, V., Sidelnik, I., Singal, A., Smida, R., Haro, M. Sofo, Soldner, T., Stachurska, J., Stahlberg, M., Stefanazzi, L., Stodolsky, L., Strandhagen, C., Strauss, R., Stutz, A., Thomas, R., Thompson, A., Tiffenberg, J., Tomei, C., Traina, M., Uemura, S., Usherov, I., Vagneron, L., Van De Pontseele, W., Fernandez, F. A. Vazquez de Sola, Vidal, M., Vignati, M., Virto, A. L., Vivier, M., Volansky, T., Wagner, V., Wagner, F., Walker, J., Ward, R., Watkins, S. L., Wex, A., Willers, M., Wilson, M. J., Winslow, L., Yakushev, E., Yu, T. -T., Zampaolo, M., Zaytsev, A., Zema, V., Zinatulina, D., and Zolotarova, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

Many low-threshold experiments observe sharply rising event rates of yet unknown origins below a few hundred eV, and larger than expected from known backgrounds. Due to the significant impact of this excess on the dark matter or neutrino sensitivity of these experiments, a collective effort has been started to share the knowledge about the individual observations. For this, the EXCESS Workshop was initiated. In its first iteration in June 2021, ten rare event search collaborations contributed to this initiative via talks and discussions. The contributing collaborations were CONNIE, CRESST, DAMIC, EDELWEISS, MINER, NEWS-G, NUCLEUS, RICOCHET, SENSEI and SuperCDMS. They presented data about their observed energy spectra and known backgrounds together with details about the respective measurements. In this paper, we summarize the presented information and give a comprehensive overview of the similarities and differences between the distinct measurements. The provided data is furthermore publicly available on the workshop's data repository together with a plotting tool for visualization., Comment: 44 pages, 20 figures; Editors: A. Fuss, M. Kaznacheeva, F. Reindl, F. Wagner; updated copyright statements and funding information

Published
2022
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38. Development of a compact muon veto for the NUCLEUS experiment

Author

Wagner, V., Rogly, R., Erhart, A., Savu, V., Goupy, C., Lhuillier, D., Vivier, M., Klinkenberg, L., Angloher, G., Bento, A., Canonica, L., Cappella, F., Cardani, L., Casali, N., Cerulli, R., Colantoni, I., Cruciani, A., del Castello, G., Friedl, M., Garai, A., Ghete, V. M., Guidi, V., Hauff, D., Kaznacheeva, M., Kinast, A., Kluck, H., Langenkämper, A., Lasserre, T., Mancuso, M., Mauri, B., Mazzolari, A., Mazzucato, E., Neyrial, H., Nones, C., Oberauer, L., Onillon, A., Ortmann, T., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Pucci, F., Reindl, F., Rothe, J., Schermer, N., Schieck, J., Schönert, S., Schwertner, C., Scola, L., Stodolsky, L., Strauss, R., Tomei, C., Mirbach, K. v., Vignati, M., and Wex, A.

Subjects
Physics - Instrumentation and Detectors
Abstract

The NUCLEUS experiment aims to measure coherent elastic neutrino nucleus scattering of reactor anti-neutrinos using cryogenic calorimeters. Operating at an overburden of 3 m.w.e., muon-induced backgrounds are expected to be one of the dominant background contributions. Besides a high efficiency to identify muon events passing the experimental setup, the NUCLEUS muon veto has to fulfill tight spatial requirements to fit the constraints given by the experimental site and to minimize the induced detector dead-time. We developed highly efficient and compact muon veto modules based on plastic scintillators equipped with wavelength shifting fibers and silicon photo multipliers to collect and detect the scintillation light. In this paper, we present the full characterization of a prototype module with different light read-out configurations. We conclude that an efficient and compact muon veto system can be built for the NUCLEUS experiment from a cube assembly of the developed modules. Simulations show that an efficiency for muon identification of >99 % and an associated rate of 325 Hz is achievable, matching the requirements of the NUCLEUS experiment.

Published
2022
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39. Operating in a deep underground facility improves the locking of gradiometric fluxonium qubits at the sweet spots

Author

Gusenkova, Daria, Valenti, Francesco, Spiecker, Martin, Günzler, Simon, Paluch, Patrick, Rieger, Dennis, Pioraş-Ţimbolmaş, Larisa-Milena, Zârbo, Liviu P., Casali, Nicola, Colantoni, Ivan, Cruciani, Angelo, Pirro, Stefano, Cardani, Laura, Petrescu, Alexandru, Wernsdorfer, Wolfgang, Winkel, Patrick, and Pop, Ioan M.

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We demonstrate flux-bias locking and operation of a gradiometric fluxonium artificial atom using two symmetric granular aluminum (grAl) loops to implement the superinductor. The gradiometric fluxonium shows two orders of magnitude suppression of sensitivity to homogeneous magnetic fields, which can be an asset for hybrid quantum systems requiring strong magnetic field biasing. By cooling down the device in an external magnetic field while crossing the metal-to-superconductor transition, the gradiometric fluxonium can be locked either at $0$ or $\Phi_0/2$ effective flux bias, corresponding to an even or odd number of trapped fluxons, respectively. At mK temperatures, the fluxon parity prepared during initialization survives to magnetic field bias exceeding $100 \,\Phi_0$. However, even for states biased in the vicinity of $1 \,\Phi_0$, we observe unexpectedly short fluxon lifetimes of a few hours, which cannot be explained by thermal or quantum phase slips. When operating in a deep-underground cryostat of the Gran Sasso laboratory, the fluxon lifetimes increase to days, indicating that ionizing events activate phase slips in the grAl superinductor.

Published
2022
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43. On the inverse gamma subordinator

Author

Colantoni, Fausto and D'Ovidio, Mirko

Subjects
Mathematics - Probability
Abstract

In this paper we deal with some open problems concerned with gamma subordinators. In particular, we provide a representation for the moments of the inverse gamma subordinator. Then, we focus on $\lambda$-potentials and we study the governing equations associated with gamma subordinators and inverse processes. Such representations are given in terms of higher transcendental functions, also known as Volterra functions.

Published
2021

48. Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties

Author

Maria Cristina Benedetti, Tiziano D'andrea, Alessio Colantoni, Denis Silachev, Valeria de Turris, Zaira Boussadia, Valentina A. Babenko, Egor A. Volovikov, Lilia Belikova, Alexandra N. Bogomazova, Rita Pepponi, Dosh Whye, Elizabeth D. Buttermore, Gian Gaetano Tartaglia, Maria A. Lagarkova, Vladimir L. Katanaev, Ilya Musayev, Simone Martinelli, Sergio Fucile, and Alessandro Rosa

Subjects
GNAO1, Induced pluripotent stem cell, Encephalopathy, Movement disorder, wnt, neural rosette, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Pathogenic variants in the GNAO1 gene, encoding the alpha subunit of an inhibitory heterotrimeric guanine nucleotide-binding protein (Go) highly expressed in the mammalian brain, have been linked to encephalopathy characterized by different combinations of neurological symptoms, including developmental delay, hypotonia, epilepsy and hyperkinetic movement disorder with life-threatening paroxysmal exacerbations. Currently, there are only symptomatic treatments, and little is known about the pathophysiology of GNAO1-related disorders. Here, we report the characterization of a new in vitro model system based on patient-derived induced pluripotent stem cells (hiPSCs) carrying the recurrent p.G203R amino acid substitution in Gαo, and a CRISPR-Cas9-genetically corrected isogenic control line. RNA-Seq analysis highlighted aberrant cell fate commitment in neuronal progenitor cells carrying the p.G203R pathogenic variant. Upon differentiation into cortical neurons, patients’ cells showed reduced expression of early neural genes and increased expression of astrocyte markers, as well as premature and defective differentiation processes leading to aberrant formation of neuronal rosettes. Of note, comparable defects in gene expression and in the morphology of neural rosettes were observed in hiPSCs from an unrelated individual harboring the same GNAO1 variant. Functional characterization showed lower basal intracellular free calcium concentration ([Ca2+]i), reduced frequency of spontaneous activity, and a smaller response to several neurotransmitters in 40- and 50-days differentiated p.G203R neurons compared to control cells. These findings suggest that the GNAO1 pathogenic variant causes a neurodevelopmental phenotype characterized by aberrant differentiation of both neuronal and glial populations leading to a significant alteration of neuronal communication and signal transduction.

Published
2024
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49. Optimization of the first CUPID detector module

Author

collaboration, CUPID, Armatol, A, Augier, C, III, FT Avignone, Azzolini, O, Balata, M, Ballen, K, Barabash, AS, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bettelli, M, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chang, C, Chiesa, D, Clemenza, M, Colantoni, I, Copello, S, Craft, E, Cremonesi, O, Creswick, RJ, Cruciani, A, D'Addabbo, A, D'Imperio, G, Dabagov, S, Dafinei, I, Danevich, FA, Jesus, M De, Marcillac, P de, Dell'Oro, S, Domizio, S Di, Lorenzo, S Di, Dixon, T, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Foggetta, L, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gallas, A, Gascon, J, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Grant, C, Gras, P, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Huang, RG, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Kowalski, R, Langford, T, Lefevre, M, Liu, R, Liu, Y, Loaiza, P, Ma, L, and Madhukuttan, M

Subjects
physics.ins-det, nucl-ex
Abstract

CUPID will be a next generation experiment searching for the neutrinolessdouble $\beta$ decay, whose discovery would establish the Majorana nature ofthe neutrino. Based on the experience achieved with the CUORE experiment,presently taking data at LNGS, CUPID aims to reach a background freeenvironment by means of scintillating Li$_{2}$$^{100}$MoO$_4$ crystals coupledto light detectors. Indeed, the simultaneous heat and light detection allows usto reject the dominant background of $\alpha$ particles, as proven by theCUPID-0 and CUPID-Mo demonstrators. In this work we present the results of thefirst test of the CUPID baseline module. In particular, we propose a newoptimized detector structure and light sensors design to enhance theengineering and the light collection, respectively. We characterized the heatdetectors, achieving an energy resolution of (5.9 $\pm$ 0.2) keV FWHM at the$Q$-value of $^{100}$Mo (about 3034 keV). We studied the light collection ofthe baseline CUPID design with respect to an alternative configuration whichfeatures gravity-assisted light detectors' mounting. In both cases we obtainedan improvement in the light collection with respect to past measures and wevalidated the particle identification capability of the detector, which ensuresan $\alpha$ particle rejection higher than 99.9%, fully satisfying therequirements for CUPID.

Published
2022

50. Optimization of the first CUPID detector module

Author

Alfonso, K, Armatol, A, Augier, C, Avignone, FT, Azzolini, O, Balata, M, Barabash, AS, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bettelli, M, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Campani, A, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chang, C, Chiesa, D, Clemenza, M, Colantoni, I, Copello, S, Craft, E, Cremonesi, O, Creswick, RJ, Cruciani, A, D’Addabbo, A, D’Imperio, G, Dabagov, S, Dafinei, I, Danevich, FA, De Jesus, M, de Marcillac, P, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Foggetta, L, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gallas, A, Gascon, J, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Grant, C, Gras, P, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Kowalski, R, Langford, T, Lefevre, M, Liu, R, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, and Mancarella, F

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

CUPID will be a next generation experiment searching for the neutrinoless double β decay, whose discovery would establish the Majorana nature of the neutrino. Based on the experience achieved with the CUORE experiment, presently taking data at LNGS, CUPID aims to reach a background free environment by means of scintillating Li2100MoO4 crystals coupled to light detectors. Indeed, the simultaneous heat and light detection allows us to reject the dominant background of α particles, as proven by the CUPID-0 and CUPID-Mo demonstrators. In this work we present the results of the first test of the CUPID baseline module. In particular, we propose a new optimized detector structure and light sensors design to enhance the engineering and the light collection, respectively. We characterized the heat detectors, achieving an energy resolution of (5.9 ± 0.2) keV FWHM at the Q-value of 100Mo (about 3034 keV). We studied the light collection of the baseline CUPID design with respect to an alternative configuration which features gravity-assisted light detectors’ mounting. In both cases we obtained an improvement in the light collection with respect to past measures and we validated the particle identification capability of the detector, which ensures an α particle rejection higher than 99.9%, fully satisfying the requirements for CUPID.

Published
2022

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