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169 results on '"Coindre J.M"'

1. Improved nationwide survival of sarcoma patients with a network of reference centers

Author

Blay, J.Y., Penel, N., Valentin, T., Anract, P., Duffaud, F., Dufresne, A., Verret, B., Cordoba, A., Italiano, A., Brahmi, M., Henon, C., Amouyel, T., Ray-Coquard, I., Ferron, G., Boudou-Rouquette, P., Tlemsani, C., Salas, S., Rochwerger, R., Faron, M., Bompas, E., Ducassou, A., Gangloff, D., Gouin, F., Firmin, N., Piperno-Neumann, S., Rios, M., Ropars, M., Kurtz, J.E., Le Nail, L.R., Bertucci, F., Carrere, S., Llacer, C., Watson, S., Bonvalot, S., Leroux, A., Perrin, C., Gantzer, J., Pracht, M., Narciso, B., Monneur, A., Lebbe, C., Hervieu, A., Saada-Bouzid, E., Dubray-Longeras, P., Fiorenza, F., Chaigneau, L., Nevieres, Z.-M., Soibinet, P., Bouché, O., Guillemet, C., Spano, J.P., Ruzic, J.C., Isambert, N., Vaz, G., Meeus, P., Karanian, M., Ngo, C., Coindre, J.M., De Pinieux, G., Le Loarer, F., Ducimetiere, F., Chemin, C., Morelle, M., Toulmonde, M., and Le Cesne, A.

Published
2024
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2. Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the French Sarcoma Group (FSG) database

Author

Salas, S., Resseguier, N., Blay, J.Y., Le Cesne, A., Italiano, A., Chevreau, C., Rosset, P., Isambert, N., Soulie, P., Cupissol, D., Delcambre, C., Bay, J.O., Dubray-Longeras, P., Krengli, M., De Bari, B., Villa, S., Kaanders, J.H.A.M., Torrente, S., Pasquier, D., Thariat, J.O., Myroslav, L., Sole, C.V., Dincbas, H.F., Habboush, J.Y., Zilli, T., Dragan, T., Khanfir, K., Ugurluer, G., Cena, T., Duffaud, F., Penel, N., Bertucci, F., Ranchere-Vince, D., Terrier, P., Bonvalot, S., Macagno, N., Lemoine, C., Lae, M., Coindre, J.M., and Bouvier, C.

Published
2017
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5. 1484O Deep learning predicts patients’ outcome and mutations from H&E slides in gastrointestinal stromal tumor (GIST)

Author

Italiano, A., primary, Fu, Y., additional, Karanian, M., additional, Perret, R., additional, Camara, A., additional, Le Loarer, F., additional, Jean-Denis, M., additional, Hostein, I., additional, Michot, A., additional, Ducimetiere, F., additional, Giraud, A., additional, Courreges, J-B., additional, Courtet, K., additional, Laizet, Y., additional, du Terrail, J.O., additional, Schmauch, B., additional, Maussion, C., additional, Blay, J-Y., additional, and Coindre, J.M., additional

Published
2022
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23. Improved overall and progression free survival after surgery in expert sites for sarcoma patients: A nationwide study of FSG-GETO/NETSARC

Author

Blay, J.-Y., primary, Stoeckle, E., additional, Italiano, A., additional, Rochwerger, R.A., additional, Duffaud, F., additional, Bonvalot, S., additional, Honore, C., additional, Decanter, G., additional, Maynou, C., additional, Anract, P., additional, Ferron, G., additional, Guillemin, F., additional, Gouin, F., additional, Rios, M., additional, Kurtz, J.E., additional, Meeus, P., additional, Coindre, J.M., additional, Ray-Coquard, I., additional, Penel, N., additional, and Le Cesne, A., additional

Published
2017
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24. Sarcoma in irradiated area (SARI): radiation-induced CD8 T-lymphocytes apoptosis as a potential predisposition factor: results of the SARI trial

Author

Maingon, P., primary, Mirjolet, C., additional, Truc, G., additional, Karine, P.C., additional, Nöel, G., additional, Thariat, J., additional, Le Pechoux, C., additional, Sargos, P., additional, Marchal, C., additional, Blay, J.Y., additional, Salas, S., additional, Delannes, M., additional, Lagrange, J.L., additional, Mahé, M.A., additional, Coindre, J.M., additional, Collin, F., additional, Chibon, F., additional, Grisi, C., additional, Gauthier, M., additional, and Merlin, J.L., additional

Published
2017
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29. Alternatively spliced NKp30 isoforms influence the prognosis of gastrointestinal stromal tumors

Author

Delahaye N.F, Rusakiewicz S, Martins I, Mxe9nard C, Roux S, Lyonnet L, Paul P, Sarabi M, Chaput N, Semeraro M, Minard-Colin V, Poirier-Colame V, Chaba K, Flament C, Baud V, Authier H, Kerdine-Rxf6mer S, Pallardy M, Crxe9mer I, Peaudecerf L, Rocha B, Valteau-Couanet D, Gutierrez J.C, Nunxe8s J.A, Commo F, Ibrahim N, Terrier P, Opolon P, Bottino C, Moretta A, Tavernier J, Rihet P, Coindre J.M, Blay J.Y, Isambert N, Emile J.F, Vivier E, Le Cesne A, Kroemer G, and Zitvogel L.

Published
2011

30. Coactivated Platelet-Derived Growth Factor Receptor alpha and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, B., Floris, G., Finalet-Ferreiro, J., Fletcher, C.D., Coindre, J.M., Guillou, L., Hogendoorn, P.C.W., Wozniak, A., Vanspauwen, V., Schoffski, P., Marynen, P., Vandenberghe, P., Sciot, R., and Debiec-Rychter, M.

Subjects
comparative-genomic-hybridization gastrointestinal stromal tumors squamous-cell carcinoma human colon-carcinoma kinase-inhibitor pulmonary-artery tyrosine-kinases lung-cancer pdgfr-alpha kit, digestive system diseases
Abstract

Intimal sarcoma (IS) is a rare, malignant, and aggressive tumor that shows a relentless course with a concomitant low survival rate and for which no effective treatment is available. In this study, 21 cases of large arterial blood vessel IS were analyzed by immunohistochemistry and fluorescence in situ hybridization and selectively by karyotyping, array comparative genomic hybridization, sequencing, phospho-kinase antibody arrays, and Western immunoblotting in search for novel diagnostic markers and potential molecular therapeutic targets. Ex vivo immunoassays were applied to test the sensitivity of IS primary tumor cells to the receptor tyrosine kinase (RTK) inhibitors imatinib and dasatinib. We showed that amplification of platelet-derived growth factor receptor a (PDGFRA) is a common finding in IS, which should be considered as a molecular hallmark of this entity. This amplification is consistently associated with PDGFRA activation. Furthermore, the tumors reveal persistent activation of the epidermal growth factor receptor (EGFR), concurrent to PDGFRA activation. Activated PDGFRA and EGFR frequently coexist with amplification and overexpression of the MDM2 oncogene. Ex vivo immunoassays on primary IS cells from one case showed the potency of dasatinib to inhibit PDGFRA and downstream signaling pathways. Our findings provide a rationale for investigating therapies that target PDGFRA, EGFR, or MDM2 in IS. Given the clonal heterogeneity of this tumor type and the potential cross-talk between the PDGFRA and EGFR signaling pathways, targeting multiple RTKs and aberrant downstream effectors might be required to improve the therapeutic outcome for patients with this disease. Cancer Res; 70(18); 7304-14. (C) 2010 AACR.

Published
2010

31. 302 A phase 1 study of EPZ-6438 (E7438), an Enhancer of Zeste-Homolog 2 (EZH2) inhibitor: Preliminary activity in INI1-negative tumors

Author

Italiano, A., primary, Keilhack, H., additional, Toulmonde, M., additional, Coindre, J.M., additional, Michot, J.M., additional, Massard, C., additional, Ottesen, L., additional, Reyderman, L., additional, Blakemore, S.J., additional, Kraljevic, S., additional, Thomson, B., additional, McDonald, A., additional, Ho, P.T., additional, and Ribrag, V., additional

Published
2015
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32. 3400 Management of Desmoid Tumours (DT): A nationwide survey after labeling of 2 expert networks (RRePS and NetSarc)

Author

Penel, N., primary, Coindre, J.M., additional, Cesne, A. Le, additional, Italiano, A., additional, Neuville, A., additional, Bonvalot, S., additional, Terrier, P., additional, Ray-Coquard, I., additional, Ranchere-Vince, D., additional, Robin, Y.M., additional, Isambert, N., additional, Chevreau, C., additional, Duffaud, F., additional, Bertucci, F., additional, Rios, M., additional, Toulmonde, M., additional, Péchoux, C. Le, additional, Guillement, C., additional, Courréges, J.B., additional, and Blay, J.Y., additional

Published
2015
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33. 3402 Time interval (TI) between surgery and start of adjuvant radiotherapy (RT): A retrospective analysis of 1150 cases from the French Sarcoma Group

Author

Fourquet, J., primary, Vilotte, F., additional, Sunyach, M.P., additional, LePéchoux, C., additional, Ranchère-Vince, D., additional, Bonvalot, S., additional, Coindre, J.M., additional, Terrier, P., additional, Meeus, P., additional, Kao, W., additional, Biau, J., additional, Helfre, S., additional, Martin, E., additional, Vogin, G., additional, Penel, N., additional, Stoeckle, E., additional, and Sargos, P., additional

Published
2015
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36. Economic Impact of Centralized Histological Reviews in Patients with Sarcoma, Gist, and Desmoid Tumors

Author

Perrier, L., primary, Kembou, Nzale S., additional, Rascle, P., additional, Bui, B., additional, Morelle, M., additional, Ranchère, Vince D., additional, Terrier, P., additional, Neuville, A., additional, Decouvelaere, A.V., additional, Le Cesne, A., additional, Gomez, F., additional, de la Fouchardière, C., additional, Meeus, P., additional, Trédan, O., additional, Pérol, M., additional, Fayette, J., additional, Neidhardt, E.M., additional, Biron, P., additional, Boyle, H.J., additional, Marec, Bérard P., additional, Farsi, F., additional, Ducimetière, F., additional, Blay, J.Y., additional, Ray, Coquard I., additional, and Coindre, J.M., additional

Published
2014
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37. Cost of Discordant Diagnoses in Sarcoma, Gist, and Desmoid Tumors in France: Results From the RREPS (Reseau De Reference En Pathologie Des Sarcomes) Network

Author

Perrier, L., primary, Rascle, P., additional, Ray-Coquard, I., additional, Bui Nguyen, B., additional, Morelle, M., additional, Ranchère Vince, D., additional, Terrier, P., additional, Neuville, A., additional, Decouvelaere, A.V., additional, Le Cesne, A., additional, Gomez, F., additional, de la Fouchardière, C., additional, Meeus, P., additional, Trédan, O., additional, Pérol, M., additional, Fayette, J., additional, Neidhardt, E.M., additional, Biron, P., additional, Boyle, H.J., additional, Marec-Bérard, P., additional, Farsi, F., additional, Ducimetière, F., additional, Blay, J.Y., additional, and Coindre, J.M., additional

Published
2014
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40. Lipoblastoma in adolescents and youg adults: report of six cases with FISH analysis

Author

De Saint Aubain, Nicolas, Coindre, J.M., Debiec-Rychter, Maria, Delplace, J., Sciot, Raf, De Saint Aubain, Nicolas, Coindre, J.M., Debiec-Rychter, Maria, Delplace, J., and Sciot, Raf

Abstract

Aims: Lipoblastoma is a rare benign adipocytic neoplasm that occurs primarily in infancy and early childhood. Histologically, there is some morphological overlap with atypical lipomatous tumour and myxoid liposarcoma and the age at presentation is often regarded as a major diagnostic criterion. However, we recently encountered several cases of lipoblastoma occurring in adolescents and young adults. The aim was to document the occurrence of lipoblastoma in older patients, with cytogenetic confirmation.Methods and results: Six cases of lipoblastoma in patients >12 years old were identified. The tumours occurred in four male and two female patients ranging from 14 to 24 years old. Our cases showed the classical histological features of lipoblastoma. Three tumours were composed predominantly of mature adipocytes and the three other cases showed an immature appearance, with a prominent myxoid matrix. Fluorescence in situ hybridization (FISH) demonstrated rearrangements of the PLAG1 region in two cases and polysomy for chromosome 8 in three other cases. None of the tumours had amplification of MDM2 or CDK4.Conclusions: Lipoblastoma occurs rarely in young adults and should enter into the differential diagnosis of ‘atypical’ fatty tumours in adults. Our report underscores the diagnostic value of FISH analysis., FLWIN, info:eu-repo/semantics/published

Published
2008

42. CA1 Discordant Diagnoses in Sarcoma, GIST and Desmoide Tumour in France: Results From the Network RREPS

Author

Perrier, L., primary, Ranchr̀e Vince, D., additional, Terrier, P., additional, Neuville, A., additional, Decouvelaere, A.V., additional, Bui, B., additional, Le Cesne, A., additional, Ray Coquard, I., additional, Ducimetière, F., additional, Jean-Denis, M., additional, Courrèges, J.B., additional, Mesli, N., additional, Morelle, M., additional, Plommet, N., additional, Blay, J.Y., additional, and Coindre, J.M., additional

Published
2012
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